Výsledky vyhľadávania - "Rezaie, Alireza R"

Anticoagulant and signaling functions of antithrombin Autor Rezaie, Alireza R., Giri, Hemant

“…Antithrombin (AT) is a major plasma glycoprotein of the serpin superfamily that regulates the proteolytic activity of the procoagulant proteases of both…”
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Thrombomodulin: a multifunctional receptor modulating the endothelial quiescence Autor Giri, Hemant, Biswas, Indranil, Rezaie, Alireza R.

“…Thrombomodulin (TM) is a type 1 receptor best known for its function as an anticoagulant cofactor for thrombin activation of protein C on the surface of…”
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Antithrombin: An anticoagulant, anti‐inflammatory and antibacterial serpin Autor Rezaie, Alireza R., Giri, Hemant

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Thrombomodulin is essential for maintaining quiescence in vascular endothelial cells Autor Giri, Hemant, Panicker, Sumith R, Cai, Xiaofeng, Biswas, Indranil, Weiler, Hartmut, Rezaie, Alireza R

“…Thrombomodulin (TM) is a thrombin receptor on endothelial cells that is involved in promoting activation of the anticoagulant protein C pathway during blood…”
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Activated protein C inhibits high mobility group box 1 signaling in endothelial cells Autor Bae, Jong-Sup, Rezaie, Alireza R

“…A pathogenic role for high-mobility group box 1 (HMGB1) protein has been postulated in severe sepsis. Activated protein C (APC) is the only drug approved by…”
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Adenosine Regulates the Proinflammatory Signaling Function of Thrombin in Endothelial Cells Autor Hassanian, Seyed Mahdi, Dinarvand, Peyman, Rezaie, Alireza R.

“…The plasma level of the regulatory metabolite adenosine increases during the activation of coagulation and inflammation. Here we investigated the effect of…”
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Activated protein C inhibits lipopolysaccharide‐mediated acetylation and secretion of high‐mobility group box 1 in endothelial cells Autor Cai, Xiaofeng, Biswas, Indranil, Panicker, Sumith R., Giri, Hemant, Rezaie, Alireza R.

“…Essentials APC elicits cytoprotective responses in endothelial cells via EPCR‐dependent cleavage of PAR1. APC inhibits LPS‐mediated translocation and…”
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The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells Autor Bae, Jong-Sup, Yang, Likui, Manithody, Chandrashekhara, Rezaie, Alireza R

“…Recent studies have indicated that activated protein C (APC) may exert its cytoprotective and anti-inflammatory activities through the endothelial protein C…”
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Inorganic Polyphosphate Amplifies High Mobility Group Box 1-Mediated Von Willebrand Factor Release and Platelet String Formation on Endothelial Cells Autor Biswas, Indranil, Panicker, Sumith R, Cai, Xiaofeng, Mehta-D'souza, Padmaja, Rezaie, Alireza R

“…Objective- Inorganic polyphosphate (polyP) is known to modulate coagulation, inflammation, and metabolic pathways. It also amplifies inflammatory responses of…”
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Extracellular Histones Bind Vascular Glycosaminoglycans and Inhibit the Anti-Inflammatory Function of Antithrombin Autor Biswas, Indranil, Panicker, Sumith R, Cai, Xiaofeng S, Giri, Hemant, Rezaie, Alireza R

“…Binding of histones to molecular pattern recognition receptors on endothelial cells and leukocytes provokes proinflammatory responses and promotes activation…”
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Protease activated receptor 1 (PAR-1) activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial protein C receptor is occupied by its natural ligand Autor Bae, Jong-Sup, Rezaie, Alireza R

“…We recently demonstrated that the occupancy of endothelial protein C receptor (EPCR) by its natural ligand activated protein C (APC)/protein C switches the…”
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Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells Autor Bae, Jong-Sup, Yang, Likui, Rezaie, Alireza R

“…Ever-increasing evidence in the literature suggests that the antiinflammatory and cytoprotective properties of activated protein C (APC) are mediated through…”
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Intraperitoneal administration of activated protein C prevents postsurgical adhesion band formation Autor Dinarvand, Peyman, Hassanian, Seyed Mahdi, Weiler, Hartmut, Rezaie, Alireza R

“…Postsurgical peritoneal adhesion bands are the most important causes of intestinal obstruction, pelvic pain, and female infertility. In this study, we used a…”
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Physiological significance of antithrombin D-helix interaction with vascular GAGs Autor Biswas, Indranil, Panicker, Sumith R., Lupu, Florea, Rezaie, Alireza R.

“…•Interaction of D-helix of AT with therapeutic heparins promotes the protease-inhibitory function of the serpin.•Interaction of D-helix of AT with vascular…”
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Thrombomodulin Regulation of Mitogen-Activated Protein Kinases Autor Giri, Hemant, Cai, Xiaofeng, Panicker, Sumith R., Biswas, Indranil, Rezaie, Alireza R.

“…The multifaceted role of mitogen-activated protein kinases (MAPKs) in modulating signal transduction pathways in inflammatory conditions such as infection,…”
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Ile73Asn mutation in protein C introduces a new N-linked glycosylation site on the first EGF-domain of protein C and causes thrombosis Autor Lu, Yeling, Mehta-D’souza, Padmaja, Biswas, Indranil, Villoutreix, Bruno O., Wang, Xuefeng, Ding, Qiulan, Rezaie, Alireza R.

“…Activated protein C exerts its anticoagulant activity by protein S-dependent inactivation of factors Va and VIIIa by limited proteolysis. We identified a…”
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Activated Protein C Attenuates Severe Inflammation by Targeting VLA-3high Neutrophil Subpopulation in Mice Autor Sarangi, Pranita P, Lee, Hyun-Wook, Lerman, Yelena V, Trzeciak, Alissa, Harrower, Eric J, Rezaie, Alireza R, Kim, Minsoo

“…The host injury involved in multiorgan system failure during severe inflammation is mediated, in part, by massive infiltration and sequestration of hyperactive…”
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Analysis of protein missense alterations by combining sequence‐ and structure‐based methods Autor Gyulkhandanyan, Aram, Rezaie, Alireza R., Roumenina, Lubka, Lagarde, Nathalie, Fremeaux‐Bacchi, Veronique, Miteva, Maria A., Villoutreix, Bruno O.

“…Background Different types of in silico approaches can be used to predict the phenotypic consequence of missense variants. Such algorithms are often…”
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L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus Autor Kondo, Yuji, Larabee, Jason L., Gao, Liang, Shi, Huiping, Shao, Bojing, Hoover, Christopher M., McDaniel, J. Michael, Ho, Yen-Chun, Silasi-Mansat, Robert, Archer-Hartmann, Stephanie A., Azadi, Parastoo, Srinivasan, R. Sathish, Rezaie, Alireza R., Borczuk, Alain, Laurence, Jeffrey C., Lupu, Florea, Ahamed, Jasimuddin, McEver, Rodger P., Papin, James F., Yu, Zhongxin, Xia, Lijun

“…Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a pandemic. Severe disease is associated…”
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Engineering a disulfide bond to stabilize the calcium-binding loop of activated protein C eliminates its anticoagulant but not its protective signaling properties Autor Bae, Jong-Sup, Yang, Likui, Manithody, Chandrashekhara, Rezaie, Alireza R

“…In addition to an anticoagulant activity, activated protein C (APC) also exhibits anti-inflammatory and cytoprotective properties. These properties may…”
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