Suchergebnisse - "Reyzer, Michelle"

MALDI imaging mass spectrometry: molecular snapshots of biochemical systems von Cornett, Dale S, Reyzer, Michelle L, Chaurand, Pierre, Caprioli, Richard M

“… Matrix-assisted laser desorption/ionization ( MALDI ) imaging mass spectrometry (IMS) is emerging as a powerful tool for investigating the distribution of …”
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Absolute Quantitative MALDI Imaging Mass Spectrometry: A Case of Rifampicin in Liver Tissues von Chumbley, Chad W, Reyzer, Michelle L, Allen, Jamie L, Marriner, Gwendolyn A, Via, Laura E, Barry, 3rd, Clifton E, Caprioli, Richard M

“… Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) elucidates molecular distributions in thin tissue sections. Absolute …”
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Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer von Nagathihalli, Nagaraj S, Castellanos, Jason A, Shi, Chanjuan, Beesetty, Yugandhar, Reyzer, Michelle L, Caprioli, Richard, Chen, Xi, Walsh, Alex J, Skala, Melissa C, Moses, Harold L, Merchant, Nipun B

“… A hallmark of pancreatic ductal adenocarcinoma (PDAC) is the presence of a dense desmoplastic reaction (stroma) that impedes drug delivery to the tumor …”
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Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice von Ullman, Julie C, Arguello, Annie, Getz, Jennifer A, Bhalla, Akhil, Mahon, Cathal S, Wang, Junhua, Giese, Tina, Bedard, Catherine, Kim, Do Jin, Blumenfeld, Jessica R, Liang, Nicholas, Ravi, Ritesh, Nugent, Alicia A, Davis, Sonnet S, Ha, Connie, Duque, Joseph, Tran, Hai L, Wells, Robert C, Lianoglou, Steve, Daryani, Vinay M, Kwan, Wanda, Solanoy, Hilda, Nguyen, Hoang, Earr, Timothy, Dugas, Jason C, Tuck, Michael D, Harvey, Jennifer L, Reyzer, Michelle L, Caprioli, Richard M, Hall, Sejal, Poda, Suresh, Sanchez, Pascal E, Dennis, Mark S, Gunasekaran, Kannan, Srivastava, Ankita, Sandmann, Thomas, Henne, Kirk R, Thorne, Robert G, Di Paolo, Gilbert, Astarita, Giuseppe, Diaz, Dolores, Silverman, Adam P, Watts, Ryan J, Sweeney, Zachary K, Kariolis, Mihalis S, Henry, Anastasia G

“… Most lysosomal storage diseases (LSDs) involve progressive central nervous system (CNS) impairment, resulting from deficiency of a lysosomal enzyme. Treatment …”
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Oncogenic Fatty Acid Metabolism Rewires Energy Supply Chain in Gastric Carcinogenesis von Won, Yoonkyung, Jang, Bogun, Lee, Su-Hyung, Reyzer, Michelle L, Presentation, Kimberly S, Kim, Hyesung, Caldwell, Brianna, Zhang, Changqing, Lee, Hye Seung, Lee, Cheol, Trinh, Vincent Q, Tan, Marcus C B, Kim, Kwangho, Caprioli, Richard M, Choi, Eunyoung

“… Gastric carcinogenesis develops within a sequential carcinogenic cascade from precancerous metaplasia to dysplasia and adenocarcinoma, and oncogenic gene …”
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Helicobacter pylori CagA and Cag type IV secretion system activity have key roles in triggering gastric transcriptional and proteomic alterations von Shuman, Jennifer H. B., Lin, Aung Soe, Westland, Mandy D., Bryant, Kaeli N., Fortier, Gabrielle E., Piazuelo, M. Blanca, Reyzer, Michelle L., Judd, Audra M., Tsui, Tina, McDonald, W. Hayes, McClain, Mark S., Schey, Kevin L., Algood, Holly M., Cover, Timothy L.

“… Helicobacter pylori colonizes the stomachs of about half of humans worldwide, and its presence is the primary risk factor for the development of stomach …”
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Combined Src/EGFR Inhibition Targets STAT3 Signaling and Induces Stromal Remodeling to Improve Survival in Pancreatic Cancer von Dosch, Austin R, Dai, Xizi, Reyzer, Michelle L, Mehra, Siddharth, Srinivasan, Supriya, Willobee, Brent A, Kwon, Deukwoo, Kashikar, Nilesh, Caprioli, Richard, Merchant, Nipun B, Nagathihalli, Nagaraj S

“… Lack of durable response to cytotoxic chemotherapy is a major contributor to the dismal outcomes seen in pancreatic ductal adenocarcinoma (PDAC). Extensive …”
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MALDI-MS-based imaging of small molecules and proteins in tissues von Reyzer, Michelle L, Caprioli, Richard M

“… The direct analysis of tissues using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) enables both endogenous and exogenous compounds …”
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A derivatization and validation strategy for determining the spatial localization of endogenous amine metabolites in tissues using MALDI imaging mass spectrometry von Manier, M. Lisa, Spraggins, Jeffrey M., Reyzer, Michelle L., Norris, Jeremy L., Caprioli, Richard M.

“… Imaging mass spectrometry (IMS) studies increasingly focus on endogenous small molecular weight metabolites and consequently bring special analytical …”
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Pharmacokinetics, Tissue Localization, Toxicity, and Treatment Efficacy in the First Small Animal (Rabbit) Model of Intra-Arterial Chemotherapy for Retinoblastoma von Daniels, Anthony B., Froehler, Michael T., Pierce, Janene M., Nunnally, Amy H., Calcutt, M. Wade, Bridges, Thomas M., LaNeve, David C., Williams, Phillip E., Boyd, Kelli L., Reyzer, Michelle L., Lindsley, Craig W., Friedman, Debra L., Richmond, Ann

“… Current intra-arterial chemotherapy (IAC) drug regimens for retinoblastoma have ocular and vascular toxicities. No small-animal model of IAC exists to test …”
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Pyridine nucleotide redox potential in coronary smooth muscle couples myocardial blood flow to cardiac metabolism von Dwenger, Marc M., Raph, Sean M., Reyzer, Michelle L., Lisa Manier, M., Riggs, Daniel W., Wohl, Zachary B., Ohanyan, Vahagn, Mack, Gregory, Pucci, Thomas, Moore, Joseph B., Hill, Bradford G., Chilian, William M., Caprioli, Richard M., Bhatnagar, Aruni, Nystoriak, Matthew A.

“… Adequate oxygen delivery to the heart during stress is essential for sustaining cardiac function. Acute increases in myocardial oxygen demand evoke coronary …”
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Pyruvate induces torpor in obese mice von Soto, Marion, Orliaguet, Lucie, Reyzer, Michelle L, Manier, M Lisa, Caprioli, Richard M, Kahn, C Ronald

“… Mice subjected to cold or caloric deprivation can reduce body temperature and metabolic rate and enter a state of torpor. Here we show that administration of …”
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Creatine riboside is a cancer cell–derived metabolite associated with arginine auxotrophy von Parker, Amelia L., Toulabi, Leila, Oike, Takahiro, Kanke, Yasuyuki, Patel, Daxeshkumar, Tada, Takeshi, Taylor, Sheryse, Beck, Jessica A., Bowman, Elise, Reyzer, Michelle L., Butcher, Donna, Kuhn, Skyler, Pauly, Gary T., Krausz, Kristopher W., Gonzalez, Frank J., Hussain, S. Perwez, Ambs, Stefan, Ryan, Bríd M., Wang, Xin Wei, Harris, Curtis C.

“… The metabolic dependencies of cancer cells have substantial potential to be exploited to improve the diagnosis and treatment of cancer. Creatine riboside (CR) …”
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Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions von Cassat, James E, Moore, Jessica L, Wilson, Kevin J, Stark, Zach, Prentice, Boone M, Van de Plas, Raf, Perry, William J, Zhang, Yaofang, Virostko, John, Colvin, Daniel C, Rose, Kristie L, Judd, Audra M, Reyzer, Michelle L, Spraggins, Jeffrey M, Grunenwald, Caroline M, Gore, John C, Caprioli, Richard M, Skaar, Eric P

“… Diseases are characterized by distinct changes in tissue molecular distribution. Molecular analysis of intact tissues traditionally requires preexisting …”
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Direct tissue analysis using matrix-assisted laser desorption/ionization mass spectrometry: practical aspects of sample preparation von Schwartz, Sarah A., Reyzer, Michelle L., Caprioli, Richard M.

“… Practical guidelines for the preparation of tissue sections for direct analysis by matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry are …”
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Fundamental aspects of long-acting tenofovir alafenamide delivery from subdermal implants for HIV prophylaxis von Gunawardana, Manjula, Remedios-Chan, Mariana, Sanchez, Debbie, Webster, Simon, Castonguay, Amalia E., Webster, Paul, Buser, Christopher, Moss, John A., Trinh, MyMy, Beliveau, Martin, Hendrix, Craig W., Marzinke, Mark A., Tuck, Michael, Caprioli, Richard M., Reyzer, Michelle L., Kuo, Joseph, Gallay, Philippe A., Baum, Marc M.

“… Global efforts aimed at preventing human immunodeficiency virus type one (HIV-1) infection in vulnerable populations appear to be stalling, limiting our …”
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Metformin effects on head and neck squamous carcinoma microenvironment: Window of opportunity trial von Curry, Joseph, Johnson, Jennifer, Tassone, Patrick, Vidal, Marina Domingo, Menezes, Diana Whitaker, Sprandio, John, Mollaee, Mehri, Cotzia, Paolo, Birbe, Ruth, Lin, Zhao, Gill, Kurren, Duddy, Elizabeth, Zhan, Tingting, Leiby, Benjamin, Reyzer, Michelle, Cognetti, David, Luginbuhl, Adam, Tuluc, Madalina, Martinez‐Outschoorn, Ubaldo

“… Objective The tumor microenvironment frequently displays abnormal cellular metabolism, which contributes to aggressive behavior. Metformin inhibits …”
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Regional differences in brain glucose metabolism determined by imaging mass spectrometry von Kleinridders, André, Ferris, Heather A., Reyzer, Michelle L., Rath, Michaela, Soto, Marion, Manier, M. Lisa, Spraggins, Jeffrey, Yang, Zhihong, Stanton, Robert C., Caprioli, Richard M., Kahn, C. Ronald

“… Glucose is the major energy substrate of the brain and crucial for normal brain function. In diabetes, the brain is subject to episodes of hypo- and …”
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Imaging Mass Spectrometry Is an Accurate Tool in Differentiating Clear Cell Renal Cell Carcinoma and Chromophobe Renal Cell Carcinoma: A Proof-of-concept Study von Lu, Hsiang-Chih, Patterson, Nathan Heath, Judd, Audra M, Reyzer, Michelle L, Sehn, Jennifer K

“… Clear cell renal cell carcinoma (ccRCC) and chromophobe renal cell carcinoma (chRCC) are relatively common tumors that can have significant risk for mortality …”
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Cecum axis (CecAx) preservation reveals physiological and pathological gradients in mouse gastrointestinal epithelium von Lunnemann, Hannah M., Shealy, Nicolas G., Reyzer, Michelle L., Shupe, John A., Green, Emily H., Siddiqi, Uswah, Lacy, D. Borden, Byndloss, Mariana X., Markham, Nicholas O.

“… The mouse cecum has emerged as a model system for studying microbe-host interactions, immunoregulatory functions of the microbiome, and metabolic contributions …”
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