Výsledky vyhledávání - "Reprogramming efficiency"

Direct Reprogramming of Mouse Fibroblasts to Osteoblast-like Cells Using Runx2/Dlx5 Factors on Engineered Stiff Hydrogels Autor Zhang, Junwei, Wang, Yao, Guo, Jing, Zhang, Nihui, He, Jing, Zhou, Zongke, Wu, Fang

“…Direct reprogramming of somatic cells into functional cells still faces major limitations in terms of efficiency and achieving functional maturity of the…”
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Unlocking cellular plasticity: enhancing human iPSC reprogramming through bromodomain inhibition and extracellular matrix gene expression regulation Autor Yang, Jun, Kinyamu, H Karimi, Ward, James M, Scappini, Erica, Muse, Ginger, Archer, Trevor K

“…The transformation from a fibroblast mesenchymal cell state to an epithelial-like state is critical for induced pluripotent stem cell (iPSC) reprogramming. In…”
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N‑Cadherin Nanoantagonist Driven Mesenchymal-to-Epithelial Transition in Fibroblasts for Improving Reprogramming Efficiency Autor Meng, Xia, Zhou, Anwei, Huang, Yu, Zhang, Yu, Xu, Yurui, Shao, Kaifeng, Ning, Xinghai

“…Induced pluripotent stem cells (iPSCs) hold promise in revolutionizing medicine; however, their application potential is limited because of low reprogramming…”
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Effect of Additional Cytoplasm of Cloned Embryo on In Vitro Developmental Competence and Reprogramming Efficiency in Mice Autor Song, Seok-Hwan, Oh, Seon-Hwa, Xu, Lianguang, Lee, Kyeong-Lim, Hwang, Ji-Yoon, Joo, Myeong-Don, Kong, Il-Keun

“…Somatic cell nuclear transfer (SCNT) is an important technique for biological science research. Cytoplasm injection cloning technology (CICT) was developed to…”
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NuRD Blocks Reprogramming of Mouse Somatic Cells into Pluripotent Stem Cells Autor Luo, Min, Ling, Te, Xie, Wenbing, Sun, He, Zhou, Yonggang, Zhu, Qiaoyun, Shen, Meili, Zong, Le, Lyu, Guoliang, Zhao, Yun, Ye, Tao, Gu, Jun, Tao, Wei, Lu, Zhigang, Grummt, Ingrid

“…Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by overexpression of a defined set of transcription factors requires epigenetic…”
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Metabolome Profiling of Partial and Fully Reprogrammed Induced Pluripotent Stem Cells Autor Park, Soon-Jung, Lee, Sang A, Prasain, Nutan, Bae, Daekyeong, Kang, Hyunsu, Ha, Taewon, Kim, Jong Soo, Hong, Ki-Sung, Mantel, Charlie, Moon, Sung-Hwan, Broxmeyer, Hal E, Lee, Man Ryul

“…Acquisition of proper metabolomic fate is required to convert somatic cells toward fully reprogrammed pluripotent stem cells. The majority of induced…”
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LMCD1 facilitates the induction of pluripotency via cell proliferation, metabolism, and epithelial‐mesenchymal transition Autor Ye, Zhikai, Chen, Ge, Hou, Cuicui, Jiang, Zhenlong, Wang, Erkang, Wang, Jin

“…Somatic cell reprogramming was achieved by lentivirus mediated overexpression of four transcription factors called OSKM: OCT3/4, SOX2, KLF4, and c‐MYC but it…”
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NANOG and LIN28 dramatically improve human cell reprogramming by modulating LIN41 and canonical WNT activities Autor Wang, Ling, Su, Yue, Huang, Chang, Yin, Yexuan, Chu, Alexander, Knupp, Alec, Tang, Young

“…Human cell reprogramming remains extremely inefficient and the underlying mechanisms by different reprogramming factors are elusive. We found that NANOG and…”
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Improves the In Vitro Developmental Competence and Reprogramming Efficiency of Cloned Bovine Embryos by Additional Complimentary Cytoplasm Autor Xu, Lianguang, Mesalam, Ayman, Lee, Kyeong-Lim, Song, Seok-Hwan, Khan, Imran, Chowdhury, M M R, Lv, Wenfa, Kong, Il-Keun

“…Somatic cell nuclear transfer (SCNT) is a useful technology; however, its efficiency is low. In this study, we investigated the effects of cytoplasmic transfer…”
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CXCR2 Ligands and mTOR Activation Enhance Reprogramming of Human Somatic Cells to Pluripotent Stem Cells Autor Lee, Seung-Jin, Kang, Ka-Won, Kim, Ji-Hea, Lee, Byung-Hyun, Jung, Ji-Hye, Park, Yong, Hong, Soon-Cheol, Kim, Byung-Soo

“…Induced pluripotent stem cell (iPSC) technology has great promise in regenerative medicine and disease modeling. In this study, we show that human…”
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Induction of integration-free human-induced pluripotent stem cells under serum- and feeder-free conditions Autor Hamada, Atsuko, Akagi, Eri, Yamasaki, Sachiko, Nakatao, Hirotaka, Obayashi, Fumitaka, Ohtaka, Manami, Nishimura, Ken, Nakanishi, Mahito, Toratani, Shigeaki, Okamoto, Tetsuji

“…Human-induced pluripotent stem cells (hiPSCs) have shown great potential toward practical and scientific applications. We previously reported the generation of…”
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Mitochondrial Spare Respiratory Capacity Is Negatively Correlated with Nuclear Reprogramming Efficiency Autor Zhou, Yan, Al-Saaidi, Rasha Abdelkadhem, Fernandez-Guerra, Paula, Freude, Kristine K, Olsen, Rikke Katrine Jentoft, Jensen, Uffe Birk, Gregersen, Niels, Hyttel, Poul, Bolund, Lars, Aagaard, Lars, Bross, Peter, Luo, Yonglun

“…Nuclear reprogramming efficiency has been shown to be highly variable among different types of somatic cells and different individuals, yet the underlying…”
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ReLog: A systematic approach for supporting efficient reprogramming in wireless sensor networks Autor Zhu, Xiaorui, Tao, Xianping, Gu, Tao, Lu, Jian

“…Wireless sensor networks are shifting to application platforms that poses several challenges on reprogramming efficiency. To better support the efficient…”
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miR-524-5p of the primate-specific C19MC miRNA cluster targets TP53IPN1- and EMT-associated genes to regulate cellular reprogramming Autor Nguyen, Phan Nguyen Nhi, Choo, Kong Bung, Huang, Chiu-Jung, Sugii, Shigeki, Cheong, Soon Keng, Kamarul, Tunku

“…Background Introduction of the transcription factors Oct4, Sox2, Klf4, and c-Myc (OSKM) is able to ‘reprogram’ somatic cells to become induced pluripotent stem…”
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Optimal reprogramming factor stoichiometry increases colony numbers and affects molecular characteristics of murine induced pluripotent stem cells Autor Tiemann, Ulf, Sgodda, Malte, Warlich, Eva, Ballmaier, Matthias, Schöler, Hans R., Schambach, Axel, Cantz, Tobias

“…Somatic cells can be reprogrammed toward pluripotency by overexpression of a set of transcription factors, yielding induced pluripotent stem cells (iPSCs) with…”
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Increased reprogramming of human fetal hepatocytes compared with adult hepatocytes in feeder-free conditions Autor Hansel, Marc C, Gramignoli, Roberto, Blake, William, Davila, Julio, Skvorak, Kristen, Dorko, Kenneth, Tahan, Veysel, Lee, Brian R, Tafaleng, Edgar, Guzman-Lepe, Jorge, Soto-Gutierrez, Alejandro, Fox, Ira J, Strom, Stephen C

“…Hepatocyte transplantation has been used to treat liver disease. The availability of cells for these procedures is quite limited. Human embryonic stem cells…”
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Human menstrual blood-derived mesenchymal cells as a cell source of rapid and efficient nuclear reprogramming Autor de Carvalho Rodrigues, Deivid, Asensi, Karina Dutra, Vairo, Leandro, Azevedo-Pereira, Ricardo Luiz, Silva, Rosane, Rondinelli, Edson, Goldenberg, Regina Coeli, Campos de Carvalho, Antonio Carlos, Urményi, Turán Péter

“…Induced pluripotent stem cells (iPSCs) were originally generated by forced ectopic expression of four transcription factors genes-OCT4, KLF4, SOX2, and…”
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Comparing the reprogramming efficiency of mouse embryonic fibroblasts, mouse bone marrow mesenchymal stem cells and bone marrow mononuclear cells to iPSCs Autor Wang, Lei, Zhu, Mingyan, Guo, Qingsong, Fan, Xiangjun, Lu, Yuhua, Zhu, Shajun, Wang, Yao, Huang, Yan, Wang, Zhiwei

“…Induced pluripotent stem cells have been derived from various cell types via the ectopic expression of a cocktail of transcription factors. Previous studies…”
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Muse cells as a robust source of induced pluripotent stem cells

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Chapter 7 - Muse cells as a robust source of induced pluripotent stem cells Autor Li, Gen, Wakao, Shohei, Kuroda, Yasumasa, Kushida, Yoshihiro, Dezawa, Mari

“…Multilineage-differentiating stress enduring (Muse) cells are present in the bone marrow, peripheral blood, and organ connective tissue as cells positive for…”
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