Výsledky vyhľadávania - "Reprogramming efficiency"

Imidazopyridines as Potent KDM5 Demethylase Inhibitors Promoting Reprogramming Efficiency of Human iPSCs Autor Dabiri, Yasamin, Gama-Brambila, Rodrigo A., Taškova, Katerina, Herold, Kristina, Reuter, Stefanie, Adjaye, James, Utikal, Jochen, Mrowka, Ralf, Wang, Jichang, Andrade-Navarro, Miguel A., Cheng, Xinlai

“… Our high-throughput screening of drug-like hits showed that imidazopyridines-analogs of zolpidem, a sedative-hypnotic drug-are able to improve reprogramming efficiency and facilitate reprogramming…”
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Blockade of senescence‐associated microRNA‐195 in aged skeletal muscle cells facilitates reprogramming to produce induced pluripotent stem cells Autor Kondo, Hideyuki, Kim, Ha Won, Wang, Lei, Okada, Motoi, Paul, Christian, Millard, Ronald W., Wang, Yigang

“…Summary The low reprogramming efficiency in cells from elderly patients is a challenge that must be overcome…”
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An Overview on Promising Somatic Cell Sources Utilized for the Efficient Generation of Induced Pluripotent Stem Cells Autor Ray, Arnab, Joshi, Jahnavy Madhukar, Sundaravadivelu, Pradeep Kumar, Raina, Khyati, Lenka, Nibedita, Kaveeshwar, Vishwas, Thummer, Rajkumar P

“… on the reprogramming efficiency, kinetics, and quality of iPSCs. Therefore, numerous groups have explored various somatic cell sources to identify the promising sources for reprogramming into iPSCs with different…”
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The aging signature: a hallmark of induced pluripotent stem cells? Autor Rohani, Leili, Johnson, Adiv A., Arnold, Antje, Stolzing, Alexandra

“…Summary The discovery that somatic cells can be induced into a pluripotent state by the expression of reprogramming factors has enormous potential for…”
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Effective culture conditions for the induction of pluripotent stem cells Autor Okada, Minoru, Oka, Masahiro, Yoneda, Yoshihiro

“… However, the reprogramming efficiency is extremely low, and optimal culture conditions for iPS cell derivation have not been clearly defined…”
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Is aging a barrier to reprogramming? Lessons from induced pluripotent stem cells Autor Phanthong, Phetcharat, Raveh-Amit, Hadas, Li, Tong, Kitiyanant, Yindee, Dinnyes, Andras

“… However, two major hurdles need to be resolved in order to reach the later goal: the low reprogramming efficiency and the safety risks, such as the…”
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MicroRNAs: Important Regulators of Induced Pluripotent Stem Cell Generation and Differentiation Autor Zeng, Zhao-Lin, Lin, Xiao-Long, Tan, Li-Lan, Liu, Ya-Mi, Qu, Kai, Wang, Zuo

“… Numerous techniques have been formulated in the past decade to improve reprogramming efficiency and safety, including the use of different transcription factors, small molecule compounds and non-coding RNAs…”
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The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells Autor Sharma, Amit, Diecke, Sebastian, Zhang, Wendy Y, Lan, Feng, He, Chunjiang, Mordwinkin, Nicholas M, Chua, Katrin F, Wu, Joseph C

“…) from older human subjects were more resistant to reprogramming by classic Yamanaka factors than those from younger human subjects, but the addition of SIRT6 during reprogramming improved…”
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Generation of Induced Pluripotent Stem Cells from Human Nasal Epithelial Cells Using a Sendai Virus Vector Autor Ono, Mizuho, Hamada, Yuko, Horiuchi, Yasue, Matsuo-Takasaki, Mami, Imoto, Yoshimasa, Satomi, Kaishi, Arinami, Tadao, Hasegawa, Mamoru, Fujioka, Tsuyoshi, Nakamura, Yukio, Noguchi, Emiko

“… The multiplicity of SeV infection ranged from 3 to 4, and the reprogramming efficiency of HNECs was 0.08-0.10%. iPSCs derived from HNECs…”
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Study of mitochondrial respiratory defects on reprogramming to human induced pluripotent stem cells Autor Hung, Sandy S C, Van Bergen, Nicole J, Jackson, Stacey, Liang, Helena, Mackey, David A, Hernández, Damián, Lim, Shiang Y, Hewitt, Alex W, Trounce, Ian, Pébay, Alice, Wong, Raymond C B

“…) defects in reprogramming. We obtained fibroblasts from a total of 6 LHON patients and control subjects, and showed a significant defect in complex I respiration in LHON fibroblasts by high-resolution respiratory analysis…”
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Melatonin Augments the Expression of Core Transcription Factors in Aged and Alzheimer’s Patient Skin Fibroblasts Autor Shukla, Mayuri, Duangrat, Raphiporn, Nopparat, Chutikorn, Sotthibundhu, Areechun, Govitrapong, Piyarat

“…Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. Altered neurogenesis and the appearance of AD pathological hallmarks are fundamental to…”
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P135. Transient Rho kinase inhibition enhance the generation of human induced pluripotent stem cells in feeder-independent, serum-free culture system Autor Kevin, Wing-Hon Lai, Jenny, Chung-Yee Ho, Kong, Chi-Wing, Lee, Yee-Ki, Ng, Kwong-Man, Au, Ka-Wing, Chan, Yau-Chi, Lau, Chu-Pak, Tse, Hung-Fat, Siu, Chung-Wah

“… subjects, thus hindering the potential therapeutic applications. Our aim was to generate patient-specific human induced pluripotent stem cells in a feeder-independent culture system with defined factors…”
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Enhanced maintenance of genetic integrity in induced pluripotent stem cells Autor Chen, I-Chung

“… Additionally, it has been shown that the reprogramming efficiency of somatic cells to form iPSCs is increased by repression of p53…”
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Direct cell reprogramming for tissue engineering and regenerative medicine Autor Grath, Alexander, Dai, Guohao

“…Direct cell reprogramming, also called transdifferentiation, allows for the reprogramming of one somatic cell type directly into another, without the need to…”
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