Výsledky vyhľadávania - "Reprogramming"

A decade of transcription factor-mediated reprogramming to pluripotency Autor Takahashi, Kazutoshi, Yamanaka, Shinya

“…This year marks the tenth anniversary of the generation of induced pluripotent stem cells (iPSCs) by transcription factor-mediated somatic cell reprogramming…”
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Epigenetic rejuvenation by partial reprogramming Autor Puri, Deepika, Wagner, Wolfgang

“…Rejuvenation of cells by reprogramming toward the pluripotent state raises increasing attention. In fact, generation of induced pluripotent stem cells (iPSCs)…”
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Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State Autor Li, Xiang, Liu, Defang, Ma, Yantao, Du, Xiaomin, Jing, Junzhan, Wang, Lipeng, Xie, Bingqing, Sun, Da, Sun, Shaoqiang, Jin, Xueqin, Zhang, Xu, Zhao, Ting, Guan, Jingyang, Yi, Zexuan, Lai, Weifeng, Zheng, Ping, Huang, Zhuo, Chang, Yanzhong, Chai, Zhen, Xu, Jun, Deng, Hongkui

“…Direct lineage reprogramming, including with small molecules, has emerged as a promising approach for generating desired cell types. We recently found that…”
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Chemical reprogramming for cell fate manipulation: Methods, applications, and perspectives Autor Wang, Jinlin, Sun, Shicheng, Deng, Hongkui

“…Chemical reprogramming offers an unprecedented opportunity to control somatic cell fate and generate desired cell types including pluripotent stem cells for…”
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Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes Autor Wang, Haofei, Keepers, Benjamin, Qian, Yunzhe, Xie, Yifang, Colon, Marazzano, Liu, Jiandong, Qian, Li

“…Direct reprogramming has revolutionized the fields of stem cell biology and regenerative medicine. However, the common mechanisms governing how reprogramming…”
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Revisiting astrocyte to neuron conversion with lineage tracing in vivo Autor Wang, Lei-Lei, Serrano, Carolina, Zhong, Xiaoling, Ma, Shuaipeng, Zou, Yuhua, Zhang, Chun-Li

“…In vivo cell fate conversions have emerged as potential regeneration-based therapeutics for injury and disease. Recent studies reported that ectopic expression…”
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TBX20 Improves Contractility and Mitochondrial Function During Direct Human Cardiac Reprogramming Autor Tang, Yawen, Aryal, Sajesan, Geng, Xiaoxiao, Zhou, Xinyue, Fast, Vladimir G, Zhang, Jianyi, Lu, Rui, Zhou, Yang

“…Direct cardiac reprogramming of fibroblasts into cardiomyocytes has emerged as a promising strategy to remuscularize injured myocardium. However, it is…”
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Glycosphingolipid metabolic reprogramming drives neural differentiation Autor Russo, Domenico, Della Ragione, Floriana, Rizzo, Riccardo, Sugiyama, Eiji, Scalabrì, Francesco, Hori, Kei, Capasso, Serena, Sticco, Lucia, Fioriniello, Salvatore, De Gregorio, Roberto, Granata, Ilaria, Guarracino, Mario R, Maglione, Vittorio, Johannes, Ludger, Bellenchi, Gian Carlo, Hoshino, Mikio, Setou, Mitsutoshi, D'Esposito, Maurizio, Luini, Alberto, D'Angelo, Giovanni

“…Neural development is accomplished by differentiation events leading to metabolic reprogramming. Glycosphingolipid metabolism is reprogrammed during neural…”
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Efficient in vivo direct conversion of fibroblasts into cardiomyocytes using a nanoparticle-based gene carrier Autor Chang, Yujung, Lee, Euiyeon, Kim, Junyeop, Kwon, Yoo-Wook, Kwon, Youngeun, Kim, Jongpil

“…The reprogramming of induced cardiomyocytes (iCMs) has shown potential in regenerative medicine. However, in vivo reprogramming of iCMs is significantly…”
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Direct Neuronal Reprogramming: Achievements, Hurdles, and New Roads to Success Autor Gascón, Sergio, Masserdotti, Giacomo, Russo, Gianluca Luigi, Götz, Magdalena

“…The ability to directly reprogram mature cells to alternative fates challenges concepts of how cell identities are maintained, erased, and acquired. Recent…”
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mRNA-Based Genetic Reprogramming Autor Warren, Luigi, Lin, Cory

“…The discovery that ordinary skin cells can be turned into pluripotent stem cells by the forced expression of defined factors has raised hopes that personalized…”
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Cellular reprogramming and epigenetic rejuvenation Autor Simpson, Daniel J., Olova, Nelly N., Chandra, Tamir

“…Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered…”
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Redox and metabolic reprogramming in breast cancer and cancer‐associated adipose tissue Autor Zakic, Tamara, Pekovic‐Vaughan, Vanja, Cvoro, Aleksandra, Korac, Aleksandra, Jankovic, Aleksandra, Korac, Bato

“…Redox and metabolic processes are tightly coupled in both physiological and pathological conditions. In cancer, their integration occurs at multiple levels and…”
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Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming Autor Zhou, Yang, Liu, Ziqing, Welch, Joshua D, Gao, Xu, Wang, Li, Garbutt, Tiffany, Keepers, Benjamin, Ma, Hong, Prins, Jan F, Shen, Weining, Liu, Jiandong, Qian, Li

“…Direct cellular reprogramming provides a powerful platform to study cell plasticity and dissect mechanisms underlying cell fate determination. Here, we report…”
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Direct Cardiac Epigenetic Reprogramming through Codelivery of 5′Azacytidine and miR-133a Nanoformulation Autor Muniyandi, Priyadharshni, Palaninathan, Vivekanandan, Hanajiri, Tatsuro, Maekawa, Toru

“…Direct reprogramming of cardiac fibroblasts to induced cardiomyocytes (iCMs) is a promising approach to cardiac regeneration. However, the low yield of…”
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Age reprogramming: cell rejuvenation by partial reprogramming Autor Singh, Prim B, Zhakupova, Assem

“…'Age reprogramming' refers to the process by which the molecular and cellular pathways of a cell that are subject to age-related decline are rejuvenated…”
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Strategies to Improve the Efficiency of Somatic Cell Nuclear Transfer Autor Srirattana, Kanokwan, Kaneda, Masahiro, Parnpai, Rangsun

“…Mammalian oocytes can reprogram differentiated somatic cells into a totipotent state through somatic cell nuclear transfer (SCNT), which is known as cloning…”
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Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential Autor Ohnuki, Mari, Tanabe, Koji, Sutou, Kenta, Teramoto, Ito, Sawamura, Yuka, Narita, Megumi, Nakamura, Michiko, Tokunaga, Yumie, Nakamura, Masahiro, Watanabe, Akira, Yamanaka, Shinya, Takahashi, Kazutoshi

“…Pluripotency can be induced in somatic cells by overexpressing transcription factors, including POU class 5 homeobox 1 (OCT3/4), sex determining region Y-box 2…”
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Abstract 2938 Dissecting the Epigenetic and Transcriptional Dynamics of Somatic-to-iPS Reprogramming at Single-Cell Resolution Autor Petenkaya, Aydolun, Menhart, Mary, Leung, Eva, Joves, Ken, Plath, Kathrin, Dror, Iris, Chronis, Constantinos

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Metabolic Reprogramming of GMP Grade Cord Tissue Derived Mesenchymal Stem Cells Enhances Their Suppressive Potential in GVHD Autor Mendt, Mayela, Daher, May, Basar, Rafet, Shanley, Mayra, Kumar, Bijender, Wei Inng, Francesca Lim, Acharya, Sunil, Shaim, Hila, Fowlkes, Natalie, Tran, Jamie P., Gokdemir, Elif, Uprety, Nadima, Nunez-Cortes, Ana K., Ensley, Emily, Mai, Thao, Kerbauy, Lucila N., Melo-Garcia, Luciana, Lin, Paul, Shen, Yifei, Mohanty, Vakul, Lu, JunJun, Li, Sufang, Nandivada, Vandana, Wang, Jing, Banerjee, Pinaki, Reyes-Silva, Francia, Liu, Enli, Ang, Sonny, Gilbert, April, Li, Ye, Wan, Xinhai, Gu, Jun, Zhao, Ming, Baran, Natalia, Muniz-Feliciano, Luis, Wilson, Jeffrey, Kaur, Indreshpal, Gagea, Mihai, Konopleva, Marina, Marin, David, Tang, Guilin, Chen, Ken, Champlin, Richard, Rezvani, Katayoun, Shpall, Elizabeth J.

“…Acute graft-vs.-host (GVHD) disease remains a common complication of allogeneic stem cell transplantation with very poor outcomes once the disease becomes…”
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