Výsledky vyhľadávania - "Reardon, John E."

Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis Autor Shepherd, Emma L., Saborano, Raquel, Northall, Ellie, Matsuda, Kae, Ogino, Hitomi, Yashiro, Hiroaki, Pickens, Jason, Feaver, Ryan E., Cole, Banumathi K., Hoang, Stephen A., Lawson, Mark J., Olson, Matthew, Figler, Robert A., Reardon, John E., Nishigaki, Nobuhiro, Wamhoff, Brian R., Günther, Ulrich L., Hirschfield, Gideon, Erion, Derek M., Lalor, Patricia F.

“…Increasing evidence highlights dietary fructose as a major driver of non-alcoholic fatty liver disease (NAFLD) pathogenesis, the majority of which is cleared…”
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CXL-1020, a Novel Nitroxyl (HNO) Prodrug, Is More Effective than Milrinone in Models of Diastolic Dysfunction—A Cardiovascular Therapeutic: An Efficacy and Safety Study in the Rat Autor Roof, Steve R., Ueyama, Yukie, Mazhari, Reza, Hamlin, Robert L., Hartman, J. Craig, Ziolo, Mark T., Reardon, John E., del Rio, Carlos L.

“…The nitroxyl (HNO) prodrug, CXL-1020, induces vasorelaxation and improves cardiac function in canine models and patients with systolic heart failure (HF)…”
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Intravenous Infusion of the Novel HNO Donor BMS-986231 Is Associated With Beneficial Inotropic, Lusitropic, and Vasodilatory Properties in 2 Canine Models of Heart Failure Autor Hartman, J. Craig, del Rio, Carlos L., Reardon, John E., Zhang, Kefei, Sabbah, Hani N.

“…[Display omitted] •1. Mechanism of action: Nitroxyl (HNO) enhances SR calcium uptake and release in cardiomyocytes, and improves myofilament calcium…”
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Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia Autor Armstrong, Allison J, Henke, Brad R, Collado, Maria Sol, Taylor, Justin M, Pourtaheri, Taylor D, Dillberger, John E, Roper, Thomas D, Wamhoff, Brian R, Olson, Matthew W, Figler, Robert A, Hoang, Stephen A, Reardon, John E, Johns, Brian A

“…Propionic acidemia (PA) and methylmalonic acidemia (MMA) are rare autosomal recessive disorders of propionyl-CoA (P-CoA) catabolism, caused by a deficiency in…”
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A novel small molecule approach for the treatment of propionic and methylmalonic acidemias Autor Armstrong, Allison J., Collado, Maria Sol, Henke, Brad R., Olson, Matthew W., Hoang, Stephen A., Hamilton, Christin A., Pourtaheri, Taylor D., Chapman, Kimberly A., Summar, Marshall M., Johns, Brian A., Wamhoff, Brian R., Reardon, John E., Figler, Robert A.

“…Propionic Acidemia (PA) and Methylmalonic Acidemia (MMA) are inborn errors of metabolism affecting the catabolism of valine, isoleucine, methionine, threonine…”
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Laboratory evaluation and transfusion support of patients with autoimmune hemolytic anemia Autor Reardon, John E, Marques, Marisa B

“…Although some autoantibodies do not cause hemolysis and their workup is performed routinely, others might lead to life-threatening hemolysis. In the latter…”
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Human immunodeficiency virus reverse transcriptase: steady-state and pre-steady-state kinetics of nucleotide incorporation Autor Reardon, J E

“…Steady-state and pre-steady-state kinetic constants were determined for reverse transcriptase catalyzed incorporation of nucleotides and nucleotide analogues…”
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Mechanism of action of isopentenyl pyrophosphate isomerase: evidence for a carbonium ion intermediate Autor Reardon, J E, Abeles, R H

“…Isopentenyl pyrophosphate isomerase catalyzes the interconversion of isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The isomerase from yeast has…”
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Inhibition of cholesterol biosynthesis by fluorinated mevalonate analogues Autor Reardon, J E, Abeles, R H

“…The conversion of mevalonate to cholesterol in rat liver homogenates (IC50 = 0.01-1.0 mM) is inhibited by 6- (I), 6,6-di- (II), and 6,6,6-trifluoromevalonate…”
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2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies Autor Lambe, C U, Averett, D R, Paff, M T, Reardon, J E, Wilson, J G, Krenitsky, T A

“…Earlier studies have shown guanine arabinoside (ara-G) is an effective agent against growth of T-cell lines and freshly isolated human T-leukemic cells…”
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Purification and characterization of a rat liver enzyme that hydrolyzes valaciclovir, the L-valyl ester prodrug of acyclovir Autor Burnette, T C, Harrington, J A, Reardon, J E, Merrill, B M, de Miranda, P

“…Valaciclovir is an oral prodrug of the antiherpetic agent acyclovir. An enzyme that hydrolyzes valaciclovir to acyclovir, valaciclovir hydrolase (VACVase), was…”
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Acyclovir: mechanism of antiviral action and potentiation by ribonucleotide reductase inhibitors Autor Reardon, J E, Spector, T

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Synthesis of undecagold cluster molecules as biochemical labeling reagents. 1. Monoacyl and mono[N-(succinimidooxy)succinyl] undecagold clusters Autor Reardon, J E, Frey, P A

“…This paper describes the synthesis and characterization of succinyl, phthalyl, and N-(succinimidooxy)-succinyl derivatives of the undecagold cluster complex…”
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Biospecific labeling with undecagold: visualization of the biotin-binding site on avidin Autor Safer, D, Hainfeld, J, Wall, J S, Reardon, J E

“…The biotin-binding site on avidin has been labeled with biotin conjugated to undecagold, an organometallic cluster compound containing 11 gold atoms in a core…”
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1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity Autor Daluge, S M, Good, S S, Faletto, M B, Miller, W H, St Clair, M H, Boone, L R, Tisdale, M, Parry, N R, Reardon, J E, Dornsife, R E, Averett, D R, Krenitsky, T A

“…1592U89, (-)-(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclo pentene-1-methanol, is a carbocyclic nucleoside with a unique biological profile…”
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Human immunodeficiency virus reverse transcriptase. A kinetic analysis of RNA-dependent and DNA-dependent DNA polymerization Autor Reardon, J E

“…A minimal kinetic mechanism for HIV reverse transcriptase (RT)-catalyzed RNA-dependent and DNA-dependent DNA polymerization was determined by pre-steady-state…”
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Human immunodeficiency virus type-1 reverse transcriptase. Contribution of Met-184 to binding of nucleoside 5'-triphosphate Autor Wilson, J E, Aulabaugh, A, Caligan, B, McPherson, S, Wakefield, J K, Jablonski, S, Morrow, C D, Reardon, J E, Furman, P A

“…Mutations were made in recombinant human immunodeficiency virus type-1 reverse transcriptase (RT) by substituting methionine 184 with alanine (M184A) or valine…”
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Human immunodeficiency virus reverse transcriptase. Substrate and inhibitor kinetics with thymidine 5'-triphosphate and 3'-azido-3'-deoxythymidine 5'-triphosphate Autor Reardon, J E, Miller, W H

“…3'-Azido-3'-deoxythymidine 5'-triphosphate (AZTTP) was an efficient substrate for the human immunodeficiency virus 1 reverse transcriptase. It was incorporated…”
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Human immunodeficiency virus reverse transcriptase ribonuclease H: specificity of tRNA(Lys3)-primer excision Autor Furfine, E S, Reardon, J E

“…Two model substrates were prepared to examine the mechanism of tRNA-primer excision catalyzed by reverse transcriptase associated ribonuclease H (RT-RNase H)…”
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Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3'-azido-3'-deoxythymidine Autor Lacey, S F, Reardon, J E, Furfine, E S, Kunkel, T A, Bebenek, K, Eckert, K A, Kemp, S D, Larder, B A

“…A series of biochemical investigations to compare the DNA polymerase and RNase H functions of the reverse transcriptases (RTs) corresponding to azidothymidine…”
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