Suchergebnisse - "Randomized Controlled Trials as Topic methods"

The PRECIS-2 tool: designing trials that are fit for purpose von Loudon, Kirsty, Treweek, Shaun, Sullivan, Frank, Donnan, Peter, Thorpe, Kevin E, Zwarenstein, Merrick

“… PRECIS is a tool to help trialists make design decisions consistent with the intended purpose of their trial. This paper gives guidance on how to use an …”
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Laparoscopic Versus Open Pancreaticoduodenectomy: A Systematic Review and Meta-analysis of Randomized Controlled Trials von Nickel, Felix, Haney, Caelán Max, Kowalewski, Karl Friedrich, Probst, Pascal, Limen, Eldridge Frederick, Kalkum, Eva, Diener, Marcus K, Strobel, Oliver, Müller-Stich, Beat Peter, Hackert, Thilo

“… To compare perioperative outcomes of laparoscopic pancreaticoduodenectomy (LPD) to open pancreaticoduodenectomy (OPD) using evidence from randomized controlled …”
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Reporting of Factorial Randomized Trials: Extension of the CONSORT 2010 Statement von Kahan, Brennan C, Hall, Sophie S, Beller, Elaine M, Birchenall, Megan, Chan, An-Wen, Elbourne, Diana, Little, Paul, Fletcher, John, Golub, Robert M, Goulao, Beatriz, Hopewell, Sally, Islam, Nazrul, Zwarenstein, Merrick, Juszczak, Edmund, Montgomery, Alan A

“… Transparent reporting of randomized trials is essential to facilitate critical appraisal and interpretation of results. Factorial trials, in which 2 or more …”
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A tutorial on sample size calculation for multiple-period cluster randomized parallel, cross-over and stepped-wedge trials using the Shiny CRT Calculator von Hemming, Karla, Kasza, Jessica, Hooper, Richard, Forbes, Andrew, Taljaard, Monica

“… Abstract It has long been recognized that sample size calculations for cluster randomized trials require consideration of the correlation between multiple …”
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Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI extension von Liu, Xiaoxuan, Cruz Rivera, Samantha, Moher, David, Calvert, Melanie J., Denniston, Alastair K.

“… The CONSORT 2010 statement provides minimum guidelines for reporting randomized trials. Its widespread use has been instrumental in ensuring transparency in …”
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Emulating Randomized Clinical Trials With Nonrandomized Real-World Evidence Studies: First Results From the RCT DUPLICATE Initiative von Franklin, Jessica M, Patorno, Elisabetta, Desai, Rishi J, Glynn, Robert J, Martin, David, Quinto, Kenneth, Pawar, Ajinkya, Bessette, Lily G, Lee, Hemin, Garry, Elizabeth M, Gautam, Nileesa, Schneeweiss, Sebastian

“… Regulators are evaluating the use of noninterventional real-world evidence (RWE) studies to assess the effectiveness of medical products. The RCT DUPLICATE …”
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Nature as a Trialist?: Deconstructing the Analogy Between Mendelian Randomization and Randomized Trials von Swanson, Sonja A, Tiemeier, Henning, Ikram, M Arfan, Hernán, Miguel A

“… Mendelian randomization (MR) studies are often described as naturally occurring randomized trials in which genetic factors are randomly assigned by nature …”
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Randomization in Clinical Trials: Permuted Blocks and Stratification von Broglio, Kristine

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Pragmatic Trials von Ford, Ian, Norrie, John

“… In pragmatic trials, participants are broadly representative of people who will receive a treatment or diagnostic strategy, and the outcomes affect day-to-day …”
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CINeMA: An approach for assessing confidence in the results of a network meta-analysis von Nikolakopoulou, Adriani, Higgins, Julian P. T., Papakonstantinou, Theodoros, Chaimani, Anna, Del Giovane, Cinzia, Egger, Matthias, Salanti, Georgia

“… The evaluation of the credibility of results from a meta-analysis has become an important part of the evidence synthesis process. We present a methodological …”
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Acupuncture for Chronic Pain: Update of an Individual Patient Data Meta-Analysis von Vickers, Andrew J, Vertosick, Emily A, Lewith, George, MacPherson, Hugh, Foster, Nadine E, Sherman, Karen J, Irnich, Dominik, Witt, Claudia M, Linde, Klaus

“… Despite wide use in clinical practice, acupuncture remains a controversial treatment for chronic pain. Our objective was to update an individual patient data …”
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Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis von Cipriani, Andrea, Furukawa, Toshi A, Salanti, Georgia, Chaimani, Anna, Atkinson, Lauren Z, Ogawa, Yusuke, Leucht, Stefan, Ruhe, Henricus G, Turner, Erick H, Higgins, Julian P T, Egger, Matthias, Takeshima, Nozomi, Hayasaka, Yu, Imai, Hissei, Shinohara, Kiyomi, Tajika, Aran, Ioannidis, John P A, Geddes, John R

“… Major depressive disorder is one of the most common, burdensome, and costly psychiatric disorders worldwide in adults. Pharmacological and non-pharmacological …”
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Confidence intervals for policy evaluation in adaptive experiments von Hadad, Vitor, Hirshberg, David A, Zhan, Ruohan, Wager, Stefan, Athey, Susan

“… Adaptive experimental designs can dramatically improve efficiency in randomized trials. But with adaptively collected data, common estimators based on sample …”
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Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS) von Lefaucheur, Jean-Pascal, Antal, Andrea, Ayache, Samar S., Benninger, David H., Brunelin, Jérôme, Cogiamanian, Filippo, Cotelli, Maria, De Ridder, Dirk, Ferrucci, Roberta, Langguth, Berthold, Marangolo, Paola, Mylius, Veit, Nitsche, Michael A., Padberg, Frank, Palm, Ulrich, Poulet, Emmanuel, Priori, Alberto, Rossi, Simone, Schecklmann, Martin, Vanneste, Sven, Ziemann, Ulf, Garcia-Larrea, Luis, Paulus, Walter

“… •A group of European experts reviewed current evidence for therapeutic efficacy of tDCS.•Level B evidence (probable efficacy) was found for fibromyalgia, …”
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Intention to treat and per protocol analysis in clinical trials von Tripepi, Giovanni, Chesnaye, Nicholas C., Dekker, Friedo W., Zoccali, Carmine, Jager, Kitty J.

“… In clinical epidemiology, experimental studies usually take the form of randomized controlled clinical trials (RCTs). The data analysis of an RCT can be …”
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The stepped wedge cluster randomised trial: rationale, design, analysis, and reporting von Hemming, K, Haines, T P, Chilton, P J, Girling, A J, Lilford, R J

“… [...]it may be the case that a key stakeholder (such as hospital manager or government minister) thinks that there is already sufficient evidence of …”
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Aptamers as Therapeutics von Nimjee, Shahid M, White, Rebekah R, Becker, Richard C, Sullenger, Bruce A

“… Aptamers are single-stranded nucleic acid molecules that bind to and inhibit proteins and are commonly produced by systematic evolution of ligands by …”
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Current and future directions of deep brain stimulation for neurological and psychiatric disorders von Lee, Darrin J, Lozano, Christopher S, Dallapiazza, Robert F, Lozano, Andres M

“… Deep brain stimulation (DBS) has evolved considerably over the past 4 decades. Although it has primarily been used to treat movement disorders such as …”
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Randomized Controlled Trials von Zabor, Emily C, Kaizer, Alexander M, Hobbs, Brian P

“… Randomized controlled trials (RCTs) are considered the highest level of evidence to establish causal associations in clinical research. There are many RCT …”
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Experimental and quasi-experimental designs in implementation research von Miller, Christopher J., Smith, Shawna N., Pugatch, Marianne

“… •Many implementation science questions can be addressed by experimental designs (e.g., randomized controlled trials [RCTs]).•Implementation trials differ in …”
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