Suchergebnisse - "Randomized Controlled Trials as Topic - methods"

Treatment Trials in Young Patients with Chronic Obstructive Pulmonary Disease and Pre-Chronic Obstructive Pulmonary Disease Patients: Time to Move Forward von Martinez, Fernando J, Agusti, Alvar, Celli, Bartolome R, Han, MeiLan K, Allinson, James P, Bhatt, Surya P, Calverley, Peter, Chotirmall, Sanjay H, Chowdhury, Badrul, Darken, Patrick, Da Silva, Carla A, Donaldson, Gavin, Dorinsky, Paul, Dransfield, Mark, Faner, Rosa, Halpin, David M, Jones, Paul, Krishnan, Jerry A, Locantore, Nicholas, Martinez, Fernando D, Mullerova, Hana, Price, David, Rabe, Klaus F, Reisner, Colin, Singh, Dave, Vestbo, Jørgen, Vogelmeier, Claus F, Wise, Robert A, Tal-Singer, Ruth, Wedzicha, Jadwiga A

“… To advance these concepts, we propose therapeutic trials in two major groups of subjects: "young" individuals with COPD and those with pre-COPD …”
Weitere Angaben

Patient engagement in research: a systematic review von Domecq, Juan Pablo, Prutsky, Gabriela, Elraiyah, Tarig, Wang, Zhen, Nabhan, Mohammed, Shippee, Nathan, Brito, Juan Pablo, Boehmer, Kasey, Hasan, Rim, Firwana, Belal, Erwin, Patricia, Eton, David, Sloan, Jeff, Montori, Victor, Asi, Noor, Abu Dabrh, Abd Moain, Murad, Mohammad Hassan

“… Background A compelling ethical rationale supports patient engagement in healthcare research. It is also assumed that patient engagement will lead to research …”
Volltext

Factorial experiments: efficient tools for evaluation of intervention components von Collins, Linda M, Dziak, John J, Kugler, Kari C, Trail, Jessica B

“… An understanding of the individual and combined effects of a set of intervention components is important for moving the science of preventive medicine …”
Volltext

Cost-Effectiveness Analysis Alongside Clinical Trials II—An ISPOR Good Research Practices Task Force Report von Ramsey, Scott D., Willke, Richard J., Glick, Henry, Reed, Shelby D., Augustovski, Federico, Jonsson, Bengt, Briggs, Andrew, Sullivan, Sean D.

“… Clinical trials evaluating medicines, medical devices, and procedures now commonly assess the economic value of these interventions. The growing number of …”
Volltext

Influence of trial sample size on treatment effect estimates: meta-epidemiological study von Dechartres, Agnes, Trinquart, Ludovic, Boutron, Isabelle, Ravaud, Philippe

“… ) assessing therapeutic interventions with binary outcomes, published in the 10 leading journals of each medical subject category of the Journal Citation Reports or in the Cochrane Database of Systematic …”
Volltext

Effects of physical activity and exercise on the cognitive function of patients with Alzheimer disease: a meta-analysis von Jia, Rui-xia, Liang, Jing-hong, Xu, Yong, Wang, Ying-quan

“… Background Alzheimer’s disease (AD), as the most common cause of dementia, brings huge economic burden for patients and social health care systems, which …”
Volltext

Randomized comparison of the clinical outcome of single versus multiple arterial grafts: the ROMA trial-rationale and study protocol von Gaudino, Mario, Alexander, John H, Bakaeen, Faisal G, Ballman, Karla, Barili, Fabio, Calafiore, Antonio Maria, Davierwala, Piroze, Goldman, Steven, Kappetein, Peter, Lorusso, Roberto, Mylotte, Darren, Pagano, Domenico, Ruel, Marc, Schwann, Thomas, Suma, Hisayoshi, Taggart, David P, Tranbaugh, Robert F, Fremes, Stephen

“… The ROMA trial is a prospective, unblinded, randomized event-driven multicentre trial comprising at least 4300 subjects …”
Weitere Angaben

Sample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation study von Teare, M Dawn, Dimairo, Munyaradzi, Shephard, Neil, Hayman, Alex, Whitehead, Amy, Walters, Stephen J

“… Background External pilot or feasibility studies can be used to estimate key unknown parameters to inform the design of the definitive randomised controlled …”
Volltext

Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology von Kozek-Langenecker, Sibylle A, Afshari, Arash, Albaladejo, Pierre, Santullano, Cesar Aldecoa Alvarez, De Robertis, Edoardo, Filipescu, Daniela C, Fries, Dietmar, Görlinger, Klaus, Haas, Thorsten, Imberger, Georgina, Jacob, Matthias, Lancé, Marcus, Llau, Juan, Mallett, Sue, Meier, Jens, Rahe-Meyer, Niels, Samama, Charles Marc, Smith, Andrew, Solomon, Cristina, Van der Linden, Philippe, Wikkelsø, Anne Juul, Wouters, Patrick, Wyffels, Piet

“… The purpose of these guidelines is to provide an overview of current knowledge on the subject with an assessment of the quality of the evidence in order to allow anaesthetists throughout Europe …”
Weitere Angaben

Chinese herbal medicine for Alzheimer’s disease: Clinical evidence and possible mechanism of neurogenesis von Yang, Wen-ting, Zheng, Xia-wei, Chen, Shuang, Shan, Chun-shuo, Xu, Qing-qing, Zhu, Jia-Zhen, Bao, Xiao-Yi, Lin, Yan, Zheng, Guo-qing, Wang, Yan

“… ) and reviewed its possible mechanisms of neurogenesis according to animal-based researches. Twenty eligible studies with 1767 subjects were identified in eight database searches from inception to February 2017 …”
Volltext

Aspirin for Primary Prevention of Cardiovascular Events von Abdelaziz, Hesham K, Saad, Marwan, Pothineni, Naga Venkata K, Megaly, Michael, Potluri, Rahul, Saleh, Mohammed, Kon, David Lai Chin, Roberts, David H, Bhatt, Deepak L, Aronow, Herbert D, Abbott, J Dawn, Mehta, Jawahar L

“… The efficacy and safety of aspirin for primary prevention of cardiovascular disease (CVD) remain debatable. The purpose of this study was to examine the …”
Weitere Angaben

Cerebral near-infrared spectroscopy monitoring and neurologic outcomes in adult cardiac surgery patients: a systematic review von Zheng, Fei, Sheinberg, Rosanne, Yee, May-Sann, Ono, Masa, Zheng, Yueyging, Hogue, Charles W

“… Near-infrared spectroscopy is used during cardiac surgery to monitor the adequacy of cerebral perfusion. In this systematic review, we evaluated available data …”
Weitere Angaben

Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database von Watkins, Paul B., Lewis, James H., Kaplowitz, Neil, Alpers, David H., Blais, Jaime D., Smotzer, Dan M., Krasa, Holly, Ouyang, John, Torres, Vicente E., Czerwiec, Frank S., Zimmer, Christopher A.

“… Introduction Subjects with autosomal dominant polycystic kidney disease (ADPKD) who were taking tolvaptan experienced aminotransferase elevations more frequently than those on placebo in the TEMPO 3:4 …”
Volltext

Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression von Sublette, M Elizabeth, Ellis, Steven P, Geant, Amy L, Mann, J John

“… Randomized trials of omega-3 polyunsaturated fatty acid (PUFA) treatment for depression have differed in outcome. Recent meta-analyses ascribe discrepancies to …”
Weitere Angaben

Research participation effects: a skeleton in the methodological cupboard von McCambridge, Jim, Kypri, Kypros, Elbourne, Diana

“… There have been concerns about impacts of various aspects of taking part in research studies for a century. The concerns have not, however, been sufficiently …”
Volltext

Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study von Corona, Giovanni, Rastrelli, Giulia, Monami, Matteo, Guay, André, Buvat, Jaques, Sforza, Alessandra, Forti, Gianni, Mannucci, Edoardo, Maggi, Mario

“… ) improves CV parameters in subjects with known CV diseases (CVDs). Meta-analysis. An extensive Medline search was performed using the following words 'testosterone, CVD, and males …”
Weitere Angaben

Changing Landscape of Randomized Clinical Trials in Stroke: Explaining Contemporary Trial Designs and Methods von Reeves, Mathew J, Gall, Seana, Li, Linxin

“… obtaining human subjects approval, identifying clinical sites, training trial personnel, and enrolling …”
Weitere Angaben

Motivational Interviewing Improves Medication Adherence: a Systematic Review and Meta-analysis von Palacio, Ana, Garay, Desiree, Langer, Benjamin, Taylor, Janielle, Wood, Barbara A., Tamariz, Leonardo

“… Data Synthesis The main outcome was medication adherence defined as any subjective or objective measure reported as the proportion of subjects with adequate adherence or mean adherence and standard deviation …”
Volltext

Application of artificial intelligence to analyze data from randomized controlled trials: An example from DECAAF II von Mekhael, Mario, Feng, Han, Akoum, Nazem, Sohns, Christian, Sommer, Philipp, Mahnkopf, Christian, Kholmovski, Eugene, Bax, Jeroen J, Sanders, Prashanthan, McGann, Christopher, Marchlinski, Francis, Mansour, Moussa, Hindricks, Gerhard, Wilber, David, Calkins, Hugh, Jais, Pierre, Younes, Hadi, Assaf, Ala, Noujaim, Charbel, Lim, Chanho, Huang, Chao, Pandey, Amitabh, Wazni, Oussama, Marrouche, Nassir

“… applications, identifying subgroups that may be superior when subject to one of the treatments over the other …”
Weitere Angaben

Perineural Versus Intravenous Dexamethasone as an Adjuvant for Peripheral Nerve Blocks: A Systematic Review and Meta-Analysis von Chong, Matthew Alan, Berbenetz, Nicolas Matthew, Lin, Cheng, Singh, Sudha

“… Eleven RCTs met the inclusion criteria with a total of 1076 subjects. Perineural dexamethasone prolonged the duration of analgesia by 3.77 hours (95 …”
Volltext