Suchergebnisse - "Rando, Thomas A"

Stem cells and healthy aging von Goodell, Margaret A, Rando, Thomas A

“… Research into stem cells and aging aims to understand how stem cells maintain tissue health, what mechanisms ultimately lead to decline in stem cell function …”
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Cells, scaffolds, and bioactive factors: Engineering strategies for improving regeneration following volumetric muscle loss von Eugenis, Ioannis, Wu, Di, Rando, Thomas A.

“… Severe traumatic skeletal muscle injuries, such as volumetric muscle loss (VML), result in the obliteration of large amounts of skeletal muscle and lead to …”
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Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock von Rando, Thomas A, Chang, Howard Y

“… The underlying cause of aging remains one of the central mysteries of biology. Recent studies in several different systems suggest that not only may the rate …”
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Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation von Tang, Ann H, Rando, Thomas A

“… The exit of a stem cell out of quiescence into an activated state is characterized by major metabolic changes associated with increased biosynthesis of …”
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Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration von Heredia, Jose E, Mukundan, Lata, Chen, Francis M, Mueller, Alisa A, Deo, Rahul C, Locksley, Richard M, Rando, Thomas A, Chawla, Ajay

“… In vertebrates, activation of innate immunity is an early response to injury, implicating it in the regenerative process. However, the mechanisms by which …”
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Manifestations and mechanisms of stem cell aging von Liu, Ling, Rando, Thomas A

“… Adult stem cells exist in most mammalian organs and tissues and are indispensable for normal tissue homeostasis and repair. In most tissues, there is an …”
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Tissue-specific stem cells: lessons from the skeletal muscle satellite cell von Brack, Andrew S, Rando, Thomas A

“… In 1961, the satellite cell was first identified when electron microscopic examination of skeletal muscle demonstrated a cell wedged between the plasma …”
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Chronic inflammation in the etiology of disease across the life span von Furman, David, Campisi, Judith, Verdin, Eric, Carrera-Bastos, Pedro, Targ, Sasha, Franceschi, Claudio, Ferrucci, Luigi, Gilroy, Derek W, Fasano, Alessio, Miller, Gary W, Miller, Andrew H, Mantovani, Alberto, Weyand, Cornelia M, Barzilai, Nir, Goronzy, Jorg J, Rando, Thomas A, Effros, Rita B, Lucia, Alejandro, Kleinstreuer, Nicole, Slavich, George M

“… Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain …”
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Isolation of skeletal muscle stem cells by fluorescence-activated cell sorting von Liu, Ling, Cheung, Tom H, Charville, Gregory W, Rando, Thomas A

“… In this protocol, limb muscles are physically and enzymatically dissociated to maximally release resident mononucleated cells. Pure populations of either …”
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Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells von Sarkar, Tapash Jay, Quarta, Marco, Mukherjee, Shravani, Colville, Alex, Paine, Patrick, Doan, Linda, Tran, Christopher M., Chu, Constance R., Horvath, Steve, Qi, Lei S., Bhutani, Nidhi, Rando, Thomas A., Sebastiano, Vittorio

“… Aging is characterized by a gradual loss of function occurring at the molecular, cellular, tissue and organismal levels. At the chromatin level, aging …”
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Exercise plasma boosts memory and dampens brain inflammation via clusterin von De Miguel, Zurine, Khoury, Nathalie, Betley, Michael J., Lehallier, Benoit, Willoughby, Drew, Olsson, Niclas, Yang, Andrew C., Hahn, Oliver, Lu, Nannan, Vest, Ryan T., Bonanno, Liana N., Yerra, Lakshmi, Zhang, Lichao, Saw, Nay Lui, Fairchild, J. Kaci, Lee, Davis, Zhang, Hui, McAlpine, Patrick L., Contrepois, Kévin, Shamloo, Mehrdad, Elias, Joshua E., Rando, Thomas A., Wyss-Coray, Tony

“… Physical exercise is generally beneficial to all aspects of human and animal health, slowing cognitive ageing and neurodegeneration 1 . The cognitive benefits …”
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Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging von Liu, Ling, Cheung, Tom H., Charville, Gregory W., Hurgo, Bernadette Marie Ceniza, Leavitt, Tripp, Shih, Johnathan, Brunet, Anne, Rando, Thomas A.

“… The ability to maintain quiescence is critical for the long-term maintenance of a functional stem cell pool. To date, the epigenetic and transcriptional …”
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Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging von Leeman, Dena S, Hebestreit, Katja, Ruetz, Tyson, Webb, Ashley E, McKay, Andrew, Pollina, Elizabeth A, Dulken, Ben W, Zhao, Xiaoai, Yeo, Robin W, Ho, Theodore T, Mahmoudi, Salah, Devarajan, Keerthana, Passegué, Emmanuelle, Rando, Thomas A, Frydman, Judith, Brunet, Anne

“… In the adult brain, the neural stem cell (NSC) pool comprises quiescent and activated populations with distinct roles. Transcriptomic analysis revealed that …”
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Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss von Quarta, Marco, Cromie, Melinda, Chacon, Robert, Blonigan, Justin, Garcia, Victor, Akimenko, Igor, Hamer, Mark, Paine, Patrick, Stok, Merel, Shrager, Joseph B., Rando, Thomas A.

“… Volumetric muscle loss (VML) is associated with loss of skeletal muscle function, and current treatments show limited efficacy. Here we show that bioconstructs …”
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Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches von Conboy, Irina M., Rando, Thomas A.

“… Aging is unmistakable and undeniable in mammals. Interestingly, mice develop cataracts, muscle atrophy, osteoporosis, obesity, diabetes and cognitive deficits …”
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Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle von Wosczyna, Michael N., Konishi, Colin T., Perez Carbajal, Edgar E., Wang, Theodore T., Walsh, Rachel A., Gan, Qiang, Wagner, Mark W., Rando, Thomas A.

“… The necessity of mesenchymal stromal cells, called fibroadipogenic progenitors (FAPs), in skeletal muscle regeneration and maintenance remains unestablished …”
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H3K4me3 breadth is linked to cell identity and transcriptional consistency von Benayoun, Bérénice A, Pollina, Elizabeth A, Ucar, Duygu, Mahmoudi, Salah, Karra, Kalpana, Wong, Edith D, Devarajan, Keerthana, Daugherty, Aaron C, Kundaje, Anshul B, Mancini, Elena, Hitz, Benjamin C, Gupta, Rakhi, Rando, Thomas A, Baker, Julie C, Snyder, Michael P, Cherry, J Michael, Brunet, Anne

“… Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to mark the transcription start sites of active genes. Here, we show that …”
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Translational strategies and challenges in regenerative medicine von Dimmeler, Stefanie, Ding, Sheng, Rando, Thomas A, Trounson, Alan

“… Our understanding of stem cell biology is increasing, but the translation of this knowledge into regenerative medicine therapies for aged or diseased tissues …”
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Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity von Conboy, Michael J., Conboy, Irina M., Rando, Thomas A.

“… Summary Pairing two animals in parabiosis to test for systemic or circulatory factors from one animal affecting the other animal has been used in scientific …”
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Electrical stimulation of human neural stem cells via conductive polymer nerve guides enhances peripheral nerve recovery von Song, Shang, McConnell, Kelly W., Amores, Danielle, Levinson, Alexa, Vogel, Hannes, Quarta, Marco, Rando, Thomas A., George, Paul M.

“… Severe peripheral nerve injuries often result in permanent loss of function of the affected limb. Current treatments are limited by their efficacy in …”
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