Výsledky vyhľadávania - "Ramiro, Almudena R"

Aging-Associated miR-217 Aggravates Atherosclerosis and Promotes Cardiovascular Dysfunction Autor de Yébenes, Virginia G, Briones, Ana M, Martos-Folgado, Inmaculada, Mur, Sonia M, Oller, Jorge, Bilal, Faiz, González-Amor, María, Méndez-Barbero, Nerea, Silla-Castro, Juan Carlos, Were, Felipe, Jiménez-Borreguero, Luis J, Sánchez-Cabo, Fátima, Bueno, Héctor, Salaices, Mercedes, Redondo, Juan Miguel, Ramiro, Almudena R

“…microRNAs are master regulators of gene expression with essential roles in virtually all biological processes. miR-217 has been associated with aging and…”
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A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets Autor Álvarez-Prado, Ángel F, Pérez-Durán, Pablo, Pérez-García, Arantxa, Benguria, Alberto, Torroja, Carlos, de Yébenes, Virginia G, Ramiro, Almudena R

“…Activation-induced deaminase (AID) initiates antibody diversification in germinal center (GC) B cells through the deamination of cytosines on immunoglobulin…”
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Estrogen directly activates AID transcription and function Autor Pauklin, Siim, Sernández, Isora V, Bachmann, Gudrun, Ramiro, Almudena R, Petersen-Mahrt, Svend K

“…The immunological targets of estrogen at the molecular, humoral, and cellular level have been well documented, as has estrogen's role in establishing a gender…”
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Activation-induced deaminase expression defines mature B cell lymphoma in the mouse Autor Gómez-Escolar, Carmen, Marina-Zárate, Ester, Ramiro, Almudena R.

“…Germinal centers (GCs) are the sites of secondary antibody diversification and underlie the mechanism of action of many vaccination strategies…”
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MicroRNAs prevent the generation of autoreactive antibodies Autor Belver, Laura, de Yébenes, Virginia G, Ramiro, Almudena R

“…MicroRNAs have been shown to be critical for a number of aspects of immune system regulation and function. Here, we have examined the role of microRNAs in…”
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MicroRNA control of lymphocyte differentiation and function Autor Belver, Laura, Papavasiliou, F Nina, Ramiro, Almudena R

“…► miRNAs negatively regulate gene expression at a post-transcriptional level. ► Different aspects of lymphocyte development and function are controlled by…”
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miR-181b negatively regulates activation-induced cytidine deaminase in B cells Autor de Yébenes, Virginia G, Belver, Laura, Pisano, David G, González, Susana, Villasante, Aranzazu, Croce, Carlo, He, Lin, Ramiro, Almudena R

“…Activated B cells reshape their primary antibody repertoire after antigen encounter by two molecular mechanisms: somatic hypermutation (SHM) and class switch…”
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The balance between conventional and unconventional T follicular helper cells influences autoreactive B cell responses Autor He, Chenfei, Wang, Shan, Moreews, Marion, Pei, Shengduo, Chen, Guangchun, Li, Quan-Zhen, Del Monte Monge, Alberto, Ramiro, Almudena R., Cai, Curtis, Gaya, Mauro, Barral, Patricia, Buggert, Marcus, Batista, Facundo D., Karlsson, Mikael C.I.

“…Invariant natural killer T (iNKT) cells are activated by glycolipids presented on CD1d. When iNKT cells interact with and activate B cells, they can…”
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Regulation of B-cell development and function by microRNAs Autor de Yébenes, Virginia G, Bartolomé-Izquierdo, Nahikari, Ramiro, Almudena R.

“…Summary MicroRNAs (miRNAs) have emerged as a new class of gene expression regulators whose functions influence a myriad of biological processes, from…”
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Immunoglobulin A/PIGR axis as potential mediators of human abdominal aortic aneurysms revealed by topologically resolved proteomics Autor Cerro-Pardo, Isabel, Núñez, Estefanía, Picatoste, Belén, Márquez-Gálvez, Cristina, Ortega-Villanueva, Lucía, Raposo-Gutiérrez, Irene, Lindholt, Jes S., Blanco-Colio, Luis Miguel, Ramiro, Almudena R., Vázquez, Jesús, Martín-Ventura, José Luis

“…Background Abdominal aortic aneurysm (AAA) is an asymptomatic chronic disease of the aorta and its evolution is unpredictable. Despite the existence of several…”
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Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID Autor Rodríguez-Hernández, Guillermo, Opitz, Friederike V., Delgado, Pilar, Walter, Carolin, Álvarez-Prado, Ángel F., González-Herrero, Inés, Auer, Franziska, Fischer, Ute, Janssen, Stefan, Bartenhagen, Christoph, Raboso-Gallego, Javier, Casado-García, Ana, Orfao, Alberto, Blanco, Oscar, Alonso-López, Diego, Rivas, Javier De Las, Tena-Dávila, Sara González de, Müschen, Markus, Dugas, Martin, Criado, Francisco Javier García, Cenador, María Begoña García, Vicente-Dueñas, Carolina, Hauer, Julia, Ramiro, Almudena R., Sanchez-Garcia, Isidro, Borkhardt, Arndt

“…The prerequisite to prevent childhood B-cell acute lymphoblastic leukemia (B-ALL) is to decipher its etiology. The current model suggests that infection…”
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miR-28-based combination therapy impairs aggressive B cell lymphoma growth by rewiring DNA replication Autor Fuertes, Teresa, Álvarez-Corrales, Emigdio, Gómez-Escolar, Carmen, Ubieto-Capella, Patricia, Serrano-Navarro, Álvaro, de Molina, Antonio, Méndez, Juan, Ramiro, Almudena R., de Yébenes, Virginia G.

“…Diffuse large B cell lymphoma (DLBCL) is the most common aggressive B cell lymphoma and accounts for nearly 40% of cases of B cell non-Hodgkin lymphoma. DLBCL…”
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A new role for circulating T follicular helper cells in humoral response to anti-PD-1 therapy Autor Sánchez-Alonso, Santiago, Setti-Jerez, Giulia, Arroyo, Montserrat, Hernández, Tathiana, Martos, Mª Inmaculada, Sánchez-Torres, Jose Miguel, Colomer, Ramon, Ramiro, Almudena R, Alfranca, Arantzazu

“…BackgroundLung cancer is one of the most frequent malignancies in humans and is a major cause of death. A number of therapies aimed at reinforcing antitumor…”
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CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation Autor Pérez-García, Arantxa, Marina-Zárate, Ester, Álvarez-Prado, Ángel F., Ligos, Jose M., Galjart, Niels, Ramiro, Almudena R.

“…In germinal centres (GC) mature B cells undergo intense proliferation and immunoglobulin gene modification before they differentiate into memory B cells or…”
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AID is required for c-myc/IgH chromosome translocations in vivo Autor Ramiro, Almudena R, Jankovic, Mila, Eisenreich, Thomas, Difilippantonio, Simone, Chen-Kiang, Selina, Muramatsu, Masamichi, Honjo, Tasuku, Nussenzweig, André, Nussenzweig, Michel C

“…Chromosome translocations between c-myc and immunoglobulin (Ig) are associated with Burkitt's lymphoma in humans and with pristane- and IL6-induced…”
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Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand Autor Ramiro, Almudena R., Stavropoulos, Pete, Jankovic, Mila, Nussenzweig, Michel C.

“…Somatic hypermutation and class switch recombination are DNA modification reactions that alter the genes encoding antibodies in B lymphocytes. Both of these…”
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Role of genomic instability and p53 in AID-induced c-myc–Igh translocations Autor Ramiro, Almudena R., Jankovic, Mila, Callen, Elsa, Difilippantonio, Simone, Chen, Hua-Tang, McBride, Kevin M., Eisenreich, Thomas R., Chen, Junjie, Dickins, Ross A., Lowe, Scott W., Nussenzweig, Andre, Nussenzweig, Michel C.

“…Chromosomal translocations involving the immunoglobulin switch region are a hallmark feature of B-cell malignancies 1 . However, little is known about the…”
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CCCTC-Binding Factor Locks Premature IgH Germline Transcription and Restrains Class Switch Recombination Autor Marina-Zárate, Ester, Pérez-García, Arantxa, Ramiro, Almudena R.

“…In response to antigenic stimulation B cells undergo class switch recombination (CSR) at the immunoglobulin heavy chain (IgH) to replace the primary IgM/IgD…”
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Low-affinity CTCF binding drives transcriptional regulation whereas high-affinity binding encompasses architectural functions Autor Marina-Zárate, Ester, Rodríguez-Ronchel, Ana, Gómez, Manuel J., Sánchez-Cabo, Fátima, Ramiro, Almudena R.

“…CTCF is a DNA-binding protein which plays critical roles in chromatin structure organization and transcriptional regulation; however, little is known about the…”
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Assessing the impact of an antigen-specific antibody response on atherosclerosis development in mice Autor Del Monte-Monge, Alberto, Martos-Folgado, Inmaculada, Rodríguez-Ronchel, Ana, Ramiro, Almudena R.

“…The antibody immune response plays a critical role in atherosclerosis. Here, we present a protocol for assessing the impact of an antigen-specific germinal…”
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