Výsledky vyhľadávania - "Ramadan, Kristijan"

The role of ubiquitin-dependent segregase p97 (VCP or Cdc48) in chromatin dynamics after DNA double strand breaks Autor Torrecilla, Ignacio, Oehler, Judith, Ramadan, Kristijan

“…DNA double strand breaks (DSBs) are the most cytotoxic DNA lesions and, if not repaired, lead to chromosomal rearrangement, genomic instability and cell death…”
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DNA–protein crosslink proteases in genome stability Autor Ruggiano, Annamaria, Ramadan, Kristijan

“…Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are common and bulky DNA lesions that interfere with DNA replication, repair,…”
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The NUCKS1-SKP2-p21/p27 axis controls S phase entry Autor Hume, Samuel, Grou, Claudia P., Lascaux, Pauline, D’Angiolella, Vincenzo, Legrand, Arnaud J., Ramadan, Kristijan, Dianov, Grigory L.

“…Efficient entry into S phase of the cell cycle is necessary for embryonic development and tissue homoeostasis. However, unscheduled S phase entry triggers DNA…”
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p97/VCP- and Lys48-linked polyubiquitination form a new signaling pathway in DNA damage response Autor Ramadan, Kristijan

“…RNF8/RNF168-dependent Lys63-linked polyubiquitination at sites of DNA double-strand breaks (DSBs) was originally regarded as the sole ubiquitin-signaling…”
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The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin Autor Krastev, Dragomir B., Li, Shudong, Sun, Yilun, Wicks, Andrew J., Hoslett, Gwendoline, Weekes, Daniel, Badder, Luned M., Knight, Eleanor G., Marlow, Rebecca, Pardo, Mercedes Calvo, Yu, Lu, Talele, Tanaji T., Bartek, Jiri, Choudhary, Jyoti S., Pommier, Yves, Pettitt, Stephen J., Tutt, Andrew N. J., Ramadan, Kristijan, Lord, Christopher J.

“…Poly (ADP-ribose) polymerase (PARP) inhibitors elicit antitumour activity in homologous recombination-defective cancers by trapping PARP1 in a chromatin-bound…”
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TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts Autor Fielden, John, Wiseman, Katherine, Torrecilla, Ignacio, Li, Shudong, Hume, Samuel, Chiang, Shih-Chieh, Ruggiano, Annamaria, Narayan Singh, Abhay, Freire, Raimundo, Hassanieh, Sylvana, Domingo, Enric, Vendrell, Iolanda, Fischer, Roman, Kessler, Benedikt M., Maughan, Timothy S., El-Khamisy, Sherif F., Ramadan, Kristijan

“…Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. TOP1 is also a major driver of endogenous…”
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Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair Autor Vaz, Bruno, Popovic, Marta, Newman, Joseph A, Fielden, John, Aitkenhead, Hazel, Halder, Swagata, Singh, Abhay Narayan, Vendrell, Iolanda, Fischer, Roman, Torrecilla, Ignacio, Drobnitzky, Neele, Freire, Raimundo, Amor, David J, Lockhart, Paul J, Kessler, Benedikt M, McKenna, Gillies W, Gileadi, Opher, Ramadan, Kristijan

“…The cytotoxicity of DNA-protein crosslinks (DPCs) is largely ascribed to their ability to block the progression of DNA replication. DPCs frequently occur in…”
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Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review Autor Bolland, Hannah, Ma, Tiffany S, Ramlee, Syafiq, Ramadan, Kristijan, Hammond, Ester M

“…Hypoxia is a feature of most solid tumours and predicts for poor prognosis. In radiobiological hypoxia (<0.1% O2) cells become up to three times more resistant…”
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The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability Autor Ruggiano, Annamaria, Vaz, Bruno, Kilgas, Susan, Popović, Marta, Rodriguez-Berriguete, Gonzalo, Singh, Abhay N., Higgins, Geoff S., Kiltie, Anne E., Ramadan, Kristijan

“…DNA-protein crosslinks (DPCs) are a specific type of DNA lesion in which proteins are covalently attached to DNA. Unrepaired DPCs lead to genomic instability,…”
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Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress Autor Herbert, Katharine J, Puliyadi, Rathi, Prevo, Remko, Rodriguez-Berriguete, Gonzalo, Ryan, Anderson, Ramadan, Kristijan, Higgins, Geoff S

“…T-LAK-originated protein kinase (TOPK) overexpression is a feature of multiple cancers, yet is absent from most phenotypically normal tissues. As such, TOPK…”
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SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells Autor Na, Juri, Newman, Joseph A., Then, Chee Kin, Syed, Junetha, Vendrell, Iolanda, Torrecilla, Ignacio, Ellermann, Sophie, Ramadan, Kristijan, Fischer, Roman, Kiltie, Anne E.

“…The human MRE11/RAD50/NBS1 (MRN) complex plays a crucial role in sensing and repairing DNA DSB. MRE11 possesses dual 3′−5′ exonuclease and endonuclease…”
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SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication Autor Halder, Swagata, Torrecilla, Ignacio, Burkhalter, Martin D., Popović, Marta, Fielden, John, Vaz, Bruno, Oehler, Judith, Pilger, Domenic, Lessel, Davor, Wiseman, Katherine, Singh, Abhay Narayan, Vendrell, Iolanda, Fischer, Roman, Philipp, Melanie, Ramadan, Kristijan

“…The SPRTN metalloprotease is essential for DNA-protein crosslink (DPC) repair and DNA replication in vertebrate cells. Cells deficient in SPRTN protease…”
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Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin Autor Ramadan, Kristijan, Bruderer, Roland, Spiga, Fabio M., Popp, Oliver, Baur, Tina, Gotta, Monica, Meyer, Hemmo H.

“…During division of metazoan cells, the nucleus disassembles to allow chromosome segregation, and then reforms in each daughter cell. Reformation of the nucleus…”
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A three-in-one-bullet for oesophageal cancer: replication fork collapse, spindle attachment failure and enhanced radiosensitivity generated by a ruthenium( ii ) metallo-intercalator Autor Gill, Martin R., Jarman, Paul J., Halder, Swagata, Walker, Michael G., Saeed, Hiwa K., Thomas, Jim A., Smythe, Carl, Ramadan, Kristijan, Vallis, Katherine A.

“…Substitutionally inert ruthenium( ii ) polypyridyl complexes have been developed as DNA intercalating agents yet cellular DNA damage responses to this binding…”
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Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression Autor Franz, André, Pirson, Paul A., Pilger, Domenic, Halder, Swagata, Achuthankutty, Divya, Kashkar, Hamid, Ramadan, Kristijan, Hoppe, Thorsten

“…The coordinated activity of DNA replication factors is a highly dynamic process that involves ubiquitin-dependent regulation. In this context, the…”
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Editorial: Ubiquitin and Ubiquitin-Relative SUMO in DNA Damage Response Autor Ramadan, Kristijan, Dikic, Ivan

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Immunofluorescence microscopy-based detection of ssDNA foci by BrdU in mammalian cells Autor Kilgas, Susan, Kiltie, Anne E., Ramadan, Kristijan

“…DNA end resection converts broken ends of double-stranded DNA (dsDNA) to 3′-single-stranded DNA (3′-ssDNA). The extent of resection regulates DNA double-strand…”
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Ubiquitin and Ubiquitin-Relative SUMO in DNA Damage Response Autor Kristijan Ramadan, Ivan Dikic

“…DNA damage response (DDR) is a term that includes a variety of highly sophisticated mechanisms that cells have evolved in safeguarding the genome from the…”
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Erratum: Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression Autor Franz, André, Pirson, Paul A., Pilger, Domenic, Halder, Swagata, Achuthankutty, Divya, Kashkar, Hamid, Ramadan, Kristijan, Hoppe, Thorsten

“…Nature Communications 7: Article number: 10612 (2016); Published: 4 February 2016; Updated: 17 May 2016. This Article contains errors in the labelling of Fig…”
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Inhibitors of the ATPase p97/VCP: From basic research to clinical applications Autor Kilgas, Susan, Ramadan, Kristijan

“…Protein homeostasis deficiencies underlie various cancers and neurodegenerative diseases. The ubiquitin-proteasome system (UPS) and autophagy are responsible…”
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