Suchergebnisse - "Rajkowska, Grazyna"

Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue von Rajkowska, Grazyna, Stockmeier, Craig A

“… The present paper reviews astrocyte pathology in major depressive disorder (MDD) and proposes that reductions in astrocytes and related markers are key …”
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Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes von Setiawan, Elaine, Wilson, Alan A, Mizrahi, Romina, Rusjan, Pablo M, Miler, Laura, Rajkowska, Grazyna, Suridjan, Ivonne, Kennedy, James L, Rekkas, P Vivien, Houle, Sylvain, Meyer, Jeffrey H

“… The neuroinflammatory hypothesis of major depressive disorder is supported by several main findings. First, in humans and animals, activation of the immune …”
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Decreased expression of synapse-related genes and loss of synapses in major depressive disorder von Kang, Hyo Jung, Voleti, Bhavya, Hajszan, Tibor, Rajkowska, Grazyna, Stockmeier, Craig A, Licznerski, Pawel, Lepack, Ashley, Majik, Mahesh S, Jeong, Lak Shin, Banasr, Mounira, Son, Hyeon, Duman, Ronald S

“… Ronald Duman and colleagues report that synapse number is reduced in subjects with major depressive disorder. This is associated with decreased expression of …”
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Coverage of Blood Vessels by Astrocytic Endfeet Is Reduced in Major Depressive Disorder von Rajkowska, Grazyna, Hughes, Jonathan, Stockmeier, Craig A., Javier Miguel-Hidalgo, Jose, Maciag, Dorota

“… Depression and cerebrovascular disease influence each other, according to clinical studies. Despite this evidence, no studies have investigated the …”
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Astrocyte pathology in the ventral prefrontal white matter in depression von Rajkowska, Grazyna, Legutko, Beata, Moulana, Mohadetheh, Syed, Maryam, Romero, Damian G., Stockmeier, Craig A., Miguel-Hidalgo, Jose Javier

“… Astrocyte functions in white matter are less well understood than in gray matter. Our recent study of white matter in ventral prefrontal cortex (vPFC) revealed …”
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Reduced length of nodes of Ranvier and altered proteoglycan immunoreactivity in prefrontal white matter in major depressive disorder and chronically stressed rats von Miguel-Hidalgo, José Javier, Hearn, Erik, Moulana, Mohadetheh, Saleem, Khunsa, Clark, Austin, Holmes, Maggie, Wadhwa, Kashish, Kelly, Isabella, Stockmeier, Craig Allen, Rajkowska, Grazyna

“… Major depressive disorder (MDD) and chronic unpredictable stress (CUS) in animals feature comparable cellular and molecular disturbances that involve neurons …”
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Reduced Density of Calbindin Immunoreactive GABAergic Neurons in the Occipital Cortex in Major Depression: Relevance to Neuroimaging Studies von Maciag, Dorota, Hughes, Jonathan, O'Dwyer, Gillian, Pride, Yilianys, Stockmeier, Craig A., Sanacora, Gerard, Rajkowska, Grazyna

“… Several lines of evidence suggest dysfunction of the γ-aminobutyric acid (GABA)ergic system in major depressive disorder. Neuroimaging studies report reduced …”
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Cell pathology in bipolar disorder von Rajkowska, Grazyna

“… Objectives: The objective of this paper is to review findings of morphometric postmortem studies conducted on tissues from subjects with bipolar disorder (BPD) …”
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Layer III pyramidal cells in the prefrontal cortex reveal morphological changes in subjects with depression, schizophrenia, and suicide von Larsen, Nick Y., Vihrs, Ninna, Møller, Jesper, Sporring, Jon, Tan, Xueke, Li, Xixia, Ji, Gang, Rajkowska, Grazyna, Sun, Fei, Nyengaard, Jens R.

“… Brodmann Area 46 (BA46) has long been regarded as a hotspot of disease pathology in individuals with schizophrenia (SCH) and major depressive disorder (MDD) …”
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Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder von Rajkowska, Grazyna, Halaris, Angelos, Selemon, Lynn D

“… Background: Bipolar disorder (BPD) is a mental illness in which depression and mania typically alternate, and both phases can present with psychotic features …”
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Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats von Wang, Shaoxun, Lv, Wenshan, Zhang, Huawei, Liu, Yedan, Li, Longyang, Jefferson, Joshua R., Guo, Ya, Li, Man, Gao, Wenjun, Fang, Xing, Paul, Ian A., Rajkowska, Grazyna, Shaffery, James P., Mosley, Thomas H., Hu, Xinlin, Liu, Ruen, Wang, Yangang, Yu, Hongwei, Roman, Richard J., Fan, Fan

“… Diabetes mellitus (DM) is a leading risk factor for aging-related dementia; however, the underlying mechanisms are not well understood. The present study, …”
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Cellular changes in the postmortem hippocampus in major depression von Stockmeier, Craig A., Mahajan, Gouri J., Konick, Lisa C., Overholser, James C., Jurjus, George J., Meltzer, Herbert Y., Uylings, Harry B.M., Friedman, Lee, Rajkowska, Grazyna

“… Imaging studies report that hippocampal volume is decreased in major depressive disorder (MDD). A cellular basis for reduced hippocampal volume in MDD has not …”
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Transcriptome Analysis of Post-Mortem Brain Tissue Reveals Up-Regulation of the Complement Cascade in a Subgroup of Schizophrenia Patients von Lindholm Carlström, Eva, Niazi, Adnan, Etemadikhah, Mitra, Halvardson, Jonatan, Enroth, Stefan, Stockmeier, Craig A., Rajkowska, Grazyna, Nilsson, Bo, Feuk, Lars

“… Schizophrenia is a genetically complex neuropsychiatric disorder with largely unresolved mechanisms of pathology. Identification of genes and pathways …”
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Cellular 3D-reconstruction and analysis in the human cerebral cortex using automatic serial sections von Larsen, Nick Y., Li, Xixia, Tan, Xueke, Ji, Gang, Lin, Jing, Rajkowska, Grazyna, Møller, Jesper, Vihrs, Ninna, Sporring, Jon, Sun, Fei, Nyengaard, Jens R.

“… Techniques involving three-dimensional (3D) tissue structure reconstruction and analysis provide a better understanding of changes in molecules and function …”
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Chronic Unpredictable Stress Reduces Immunostaining for Connexins 43 and 30 and Myelin Basic Protein in the Rat Prelimbic and Orbitofrontal Cortices von Miguel-Hidalgo, José Javier, Moulana, Mohadetheh, Deloach, Preston Hardin, Rajkowska, Grazyna

“… Background Astrocytes and oligodendrocytes are pathologically altered in dorsolateral prefrontal and orbitofrontal cortices in major depressive disorder. In …”
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The Reduction of R1, a Novel Repressor Protein for Monoamine Oxidase A, in Major Depressive Disorder von Johnson, Shakevia, Stockmeier, Craig A, Meyer, Jeffrey H, Austin, Mark C, Albert, Paul R, Wang, Junming, May, Warren L, Rajkowska, Grazyna, Overholser, James C, Jurjus, George, Dieter, Lesa, Johnson, Chandra, Sittman, Donald B, Ou, Xiao-Ming

“… The novel transcriptional repressor protein, R1 (JPO2/CDCA7L/RAM2), inhibits monoamine oxidase A (MAO A) gene expression and influences cell proliferation and …”
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Age-Dependent Reductions in the Level of Glial Fibrillary Acidic Protein in the Prefrontal Cortex in Major Depression von Si, Xiaohong, Miguel-Hidalgo, Jose Javier, O'Dwyer, Gillian, Stockmeier, Craig A, Rajkowska, Grazyna

“… The density of glial cells is reduced in certain layers of the dorsolateral prefrontal cortex in major depressive disorder (MDD). Moreover, there are …”
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Enhancement of Hippocampal Neurogenesis by Lithium von Chen, Guang, Rajkowska, Grazyna, Du, Fu, Seraji‐Bozorgzad, Navid, Manji, Husseini K.

“… : Increasing evidence suggests that mood disorders are associated with a reduction in regional CNS volume and neuronal and glial cell atrophy or loss. Lithium, …”
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Prominent Reduction in Pyramidal Neurons Density in the Orbitofrontal Cortex of Elderly Depressed Patients von Rajkowska, Grazyna, Miguel-Hidalgo, Jose Javier, Dubey, Priti, Stockmeier, Craig A., Krishnan, K. Ranga Rama

“… Elderly depressed patients have more vascular hyperintensities in frontal white matter and basal ganglia than elderly control subjects. Cell pathology that …”
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Gene expression profiling in postmortem prefrontal cortex of major depressive disorder von Kang, Hyo Jung, Adams, David H, Simen, Arthur, Simen, Birgitte B, Rajkowska, Grazyna, Stockmeier, Craig A, Overholser, James C, Meltzer, Herbert Y, Jurjus, George J, Konick, Lisa C, Newton, Samuel S, Duman, Ronald S

“… Investigations of the molecular mechanisms underlying major depressive disorder (MDD) have been hampered by the complexity of brain tissue and sensitivity of …”
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