Výsledky vyhľadávania - "Ragoussis, Jiannis"

Genotyping technologies for genetic research Autor Ragoussis, Jiannis

“…The past few years have seen enormous advances in genotyping technology, including chips that accommodate in excess of 1 million SNP assays. In addition, the…”
Zistit podrobnosti o prístupe

Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons Autor Nagy, Corina, Maitra, Malosree, Tanti, Arnaud, Suderman, Matthew, Théroux, Jean-Francois, Davoli, Maria Antonietta, Perlman, Kelly, Yerko, Volodymyr, Wang, Yu Chang, Tripathy, Shreejoy J, Pavlidis, Paul, Mechawar, Naguib, Ragoussis, Jiannis, Turecki, Gustavo

“…Major depressive disorder (MDD) has an enormous impact on global disease burden, affecting millions of people worldwide and ranking as a leading cause of…”
Získať plný text

Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy Autor Couturier, Charles P., Ayyadhury, Shamini, Le, Phuong U., Nadaf, Javad, Monlong, Jean, Riva, Gabriele, Allache, Redouane, Baig, Salma, Yan, Xiaohua, Bourgey, Mathieu, Lee, Changseok, Wang, Yu Chang David, Wee Yong, V., Guiot, Marie-Christine, Najafabadi, Hamed, Misic, Bratislav, Antel, Jack, Bourque, Guillaume, Ragoussis, Jiannis, Petrecca, Kevin

“…Cancer stem cells are critical for cancer initiation, development, and treatment resistance. Our understanding of these processes, and how they relate to…”
Získať plný text

Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain Autor Tansley, Shannon, Uttam, Sonali, Ureña Guzmán, Alba, Yaqubi, Moein, Pacis, Alain, Parisien, Marc, Deamond, Haley, Wong, Calvin, Rabau, Oded, Brown, Nicole, Haglund, Lisbet, Ouellet, Jean, Santaguida, Carlo, Ribeiro-da-Silva, Alfredo, Tahmasebi, Soroush, Prager-Khoutorsky, Masha, Ragoussis, Jiannis, Zhang, Ji, Salter, Michael W., Diatchenko, Luda, Healy, Luke M., Mogil, Jeffrey S., Khoutorsky, Arkady

“…Activation of microglia in the spinal cord following peripheral nerve injury is critical for the development of long-lasting pain hypersensitivity. However, it…”
Získať plný text

Model-based analysis of sample index hopping reveals its widespread artifacts in multiplexed single-cell RNA-sequencing Autor Farouni, Rick, Djambazian, Haig, Ferri, Lorenzo E., Ragoussis, Jiannis, Najafabadi, Hamed S.

“…Index hopping is the main cause of incorrect sample assignment of sequencing reads in multiplexed pooled libraries. We introduce a statistical model for…”
Získať plný text

A coordinated progression of progenitor cell states initiates urinary tract development Autor Sanchez-Ferras, Oraly, Pacis, Alain, Sotiropoulou, Maria, Zhang, Yuhong, Wang, Yu Chang, Bourgey, Mathieu, Bourque, Guillaume, Ragoussis, Jiannis, Bouchard, Maxime

“…The kidney and upper urinary tract develop through reciprocal interactions between the ureteric bud and the surrounding mesenchyme. Ureteric bud branching…”
Získať plný text

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq Autor Schödel, Johannes, Oikonomopoulos, Spyros, Ragoussis, Jiannis, Pugh, Christopher W, Ratcliffe, Peter J, Mole, David R

“…Hypoxia-inducible factor (HIF) regulates the major transcriptional cascade central to the response of all mammalian cells to alterations in oxygen tension…”
Zistit podrobnosti o prístupe

Benchmarking of the Oxford Nanopore MinION sequencing for quantitative and qualitative assessment of cDNA populations Autor Oikonomopoulos, Spyros, Wang, Yu Chang, Djambazian, Haig, Badescu, Dunarel, Ragoussis, Jiannis

“…To assess the performance of the Oxford Nanopore Technologies MinION sequencing platform, cDNAs from the External RNA Controls Consortium (ERCC) RNA Spike-In…”
Získať plný text

Methodologies for Transcript Profiling Using Long-Read Technologies Autor Oikonomopoulos, Spyros, Bayega, Anthony, Fahiminiya, Somayyeh, Djambazian, Haig, Berube, Pierre, Ragoussis, Jiannis

“…RNA sequencing using next-generation sequencing technologies (NGS) is currently the standard approach for gene expression profiling, particularly for…”
Získať plný text

A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers Autor De Santa, Francesca, Barozzi, Iros, Mietton, Flore, Ghisletti, Serena, Polletti, Sara, Tusi, Betsabeh Khoramian, Muller, Heiko, Ragoussis, Jiannis, Wei, Chia-Lin, Natoli, Gioacchino

“…Mammalian genomes are pervasively transcribed outside mapped protein-coding genes. One class of extragenic transcription products is represented by long…”
Získať plný text

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization Autor Korpal, Manav, Ell, Brian J, Buffa, Francesca M, Ibrahim, Toni, Blanco, Mario A, Celià-Terrassa, Toni, Mercatali, Laura, Khan, Zia, Goodarzi, Hani, Hua, Yuling, Wei, Yong, Hu, Guohong, Garcia, Benjamin A, Ragoussis, Jiannis, Amadori, Dino, Harris, Adrian L, Kang, Yibin

“…The miR200 family regulates EMT through E-cadherin modulation and has been proposed to contribute to metastasis thusly. This report identifies a promoting role…”
Získať plný text

Direct reprogramming of fibroblasts into endothelial cells capable of angiogenesis and reendothelialization in tissue-engineered vessels Autor Margariti, Andriana, Winkler, Bernhard, Karamariti, Eirini, Zampetaki, Anna, Tsai, Tsung-neng, Baban, Dilair, Ragoussis, Jiannis, Huang, Yi, Han, Jing-Dong J, Zeng, Lingfang, Hu, Yanhua, Xu, Qingbo

“…The generation of induced pluripotent stem (iPS) cells is an important tool for regenerative medicine. However, the main restriction is the risk of tumor…”
Zistit podrobnosti o prístupe

microRNA-associated progression pathways and potential therapeutic targets identified by integrated mRNA and microRNA expression profiling in breast cancer Autor Buffa, Francesca M, Camps, Carme, Winchester, Laura, Snell, Cameron E, Gee, Harriet E, Sheldon, Helen, Taylor, Marian, Harris, Adrian L, Ragoussis, Jiannis

“…microRNA expression profiling plays an emerging role in cancer classification and identification of therapeutic strategies. In this study, we have evaluated…”
Zistit podrobnosti o prístupe

Nanopore long-read RNA-seq and absolute quantification delineate transcription dynamics in early embryo development of an insect pest Autor Bayega, Anthony, Oikonomopoulos, Spyros, Gregoriou, Maria-Eleni, Tsoumani, Konstantina T., Giakountis, Antonis, Wang, Yu Chang, Mathiopoulos, Kostas D., Ragoussis, Jiannis

“…The olive fruit fly, Bactrocera oleae , is the most important pest for the olive fruit but lacks adequate transcriptomic characterization that could aid in…”
Získať plný text

Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages Autor Ghisletti, Serena, Barozzi, Iros, Mietton, Flore, Polletti, Sara, De Santa, Francesca, Venturini, Elisa, Gregory, Lorna, Lonie, Lorne, Chew, Adeline, Wei, Chia-Lin, Ragoussis, Jiannis, Natoli, Gioacchino

“…Enhancers determine tissue-specific gene expression programs. Enhancers are marked by high histone H3 lysine 4 mono-methylation (H3K4me1) and by the…”
Zistit podrobnosti o prístupe

Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer Autor Yang, Jun, AlTahan, Alaa, Jones, Dylan T, Buffa, Francesca M, Bridges, Esther, Interiano, Rodrigo B, Qu, Chunxu, Vogt, Nathan, Li, Ji-Liang, Baban, Dilair, Ragoussis, Jiannis, Nicholson, Robert, Davidoff, Andrew M, Harris, Adrian L

“…A majority of breast cancers are driven by estrogen via estrogen receptor-α (ERα). Our previous studies indicate that hypoxia-inducible factor 1α (HIF-1α)…”
Zistit podrobnosti o prístupe

hsa-miR-210 Is induced by hypoxia and is an independent prognostic factor in breast cancer Autor Camps, Carme, Buffa, Francesca M, Colella, Stefano, Moore, John, Sotiriou, Christos, Sheldon, Helen, Harris, Adrian L, Gleadle, Jonathan M, Ragoussis, Jiannis

“…MicroRNA (miRNA) expression alterations have been described in cancer. Many cancers are characterized by areas of hypoxia, enhanced hypoxia-inducible factor…”
Zistit podrobnosti o prístupe

Improved Nanopore full-length cDNA sequencing by PCR-suppression Autor Bayega, Anthony, Oikonomopoulos, Spyros, Wang, Yu Chang, Ragoussis, Jiannis

“…Full-length transcript sequencing remains a main goal of RNA sequencing. However, even the application of long-read sequencing technologies such as Oxford…”
Získať plný text

Global long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides Autor Zhou, Yi, Lutz, Pierre-Eric, Wang, Yu Chang, Ragoussis, Jiannis, Turecki, Gustavo

“…Long non-coding RNAs (lncRNAs) are an emerging class of regulatory RNA that may be implicated in psychiatric disorders. Here we performed RNA-sequencing in the…”
Získať plný text

A novel role for Friend of GATA1 (FOG-1) in regulating cholesterol transport in murine erythropoiesis Autor Roussis, Ioannis-Marios, Pearton, David J., Niazi, Umar, Tsaknakis, Grigorios, Papadopoulos, Giorgio L., Cook, Riley, Saqi, Mansoor, Ragoussis, Jiannis, Strouboulis, John

“…Friend of GATA1 (FOG-1) is an essential transcriptional co-factor of the master erythroid transcription factor GATA1. The knockout of the Zfpm1 gene, coding…”
Získať plný text