Výsledky vyhledávání - "Raffield, Laura M."

Development and Validation of Machine Learning-Based Race-Specific Models to Predict 10-Year Risk of Heart Failure: A Multicohort Analysis Autor Segar, Matthew W, Jaeger, Byron C, Patel, Kershaw V, Nambi, Vijay, Ndumele, Chiadi E, Correa, Adolfo, Butler, Javed, Chandra, Alvin, Ayers, Colby, Rao, Shreya, Lewis, Alana A, Raffield, Laura M, Rodriguez, Carlos J, Michos, Erin D, Ballantyne, Christie M, Hall, Michael E, Mentz, Robert J, de Lemos, James A, Pandey, Ambarish

“…Heart failure (HF) risk and the underlying risk factors vary by race. Traditional models for HF risk prediction treat race as a covariate in risk prediction…”
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DNAmFitAge: biological age indicator incorporating physical fitness Autor McGreevy, Kristen M, Radak, Zsolt, Torma, Ferenc, Jokai, Matyas, Lu, Ake T, Belsky, Daniel W, Binder, Alexandra, Marioni, Riccardo E, Ferrucci, Luigi, Pośpiech, Ewelina, Branicki, Wojciech, Ossowski, Andrzej, Sitek, Aneta, Spólnicka, Magdalena, Raffield, Laura M, Reiner, Alex P, Cox, Simon, Kobor, Michael, Corcoran, David L, Horvath, Steve

“…Physical fitness is a well-known correlate of health and the aging process and DNA methylation (DNAm) data can capture aging via epigenetic clocks. However,…”
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Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-differential effects via GAUDI Autor Sun, Quan, Rowland, Bryce T., Chen, Jiawen, Mikhaylova, Anna V., Avery, Christy, Peters, Ulrike, Lundin, Jessica, Matise, Tara, Buyske, Steve, Tao, Ran, Mathias, Rasika A., Reiner, Alexander P., Auer, Paul L., Cox, Nancy J., Kooperberg, Charles, Thornton, Timothy A., Raffield, Laura M., Li, Yun

“…Polygenic risk scores (PRS) have shown successes in clinics, but most PRS methods focus only on participants with distinct primary continental ancestry without…”
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Super interactive promoters provide insight into cell type-specific regulatory networks in blood lineage cell types Autor Wen, Jia, Lagler, Taylor M., Sun, Quan, Yang, Yuchen, Chen, Jiawen, Harigaya, Yuriko, Sankaran, Vijay G., Hu, Ming, Reiner, Alexander P., Raffield, Laura M., Li, Yun

“…Existing studies of chromatin conformation have primarily focused on potential enhancers interacting with gene promoters. By contrast, the interactivity of…”
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Canonical correlation analysis for multi-omics: Application to cross-cohort analysis Autor Jiang, Min-Zhi, Aguet, François, Ardlie, Kristin, Chen, Jiawen, Cornell, Elaine, Cruz, Dan, Durda, Peter, Gabriel, Stacey B., Gerszten, Robert E., Guo, Xiuqing, Johnson, Craig W., Kasela, Silva, Lange, Leslie A., Lappalainen, Tuuli, Liu, Yongmei, Reiner, Alex P., Smith, Josh, Sofer, Tamar, Taylor, Kent D., Tracy, Russell P., VanDenBerg, David J., Wilson, James G., Rich, Stephen S., Rotter, Jerome I., Love, Michael I., Raffield, Laura M., Li, Yun

“…Integrative approaches that simultaneously model multi-omics data have gained increasing popularity because they provide holistic system biology views of…”
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Methylation profile of individuals with sickle cell trait Autor Vasconcelos, Ana Gabriela, Johnson, Mari, Cai, Yanwei, Hsu, Li, Franceschini, Nora, Auer, Paul L., Kooperberg, Charles, Raffield, Laura M., Reiner, Alex P.

“…Sickle cell trait (SCT) is due to heterozygosity for the β-globin sickle cell mutation. SCT recently has been associated with increased risk of various adverse…”
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Protein quantitative trait locus analysis in African American and non-Hispanic White individuals Autor Cai, Yanwei, Johnson, Mari, Haessler, Jeffrey, Molstad, Aaron J., Hwang, Shih-Jen, Joehanes, Roby, Murabito, Joanne M., Tahir, Usman A., Franceschini, Nora, Gerszten, Robert E., Sun, Wei, Levy, Daniel, Raffield, Laura M., Kooperberg, Charles, Hsu, Li, Reiner, Alexander P.

“…Background Substantial efforts have been dedicated to exploring the link between genetic regulation and the proteome, informing studies of complex trait…”
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Common genetic risk variants identified in the SPARK cohort support DDHD2 as a candidate risk gene for autism Autor Matoba, Nana, Liang, Dan, Sun, Huaigu, Aygün, Nil, McAfee, Jessica C., Davis, Jessica E., Raffield, Laura M., Qian, Huijun, Piven, Joseph, Li, Yun, Kosuri, Sriam, Won, Hyejung, Stein, Jason L.

“…Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder. Large genetically informative cohorts of individuals with ASD have led to the…”
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Integrating whole genome and transcriptome sequencing to characterize the genetic architecture of isoform variation Autor Liu, Chunyu, Joehanes, Roby, Ma, Jiantao, Xie, Jiuyong, Yang, Jian, Wang, Mengyao, Huan, Tianxiao, Hwang, Shih-Jen, Wen, Jia, Sun, Quan, Demirkale, Cumhur Y., Heard-Costa, Nancy L., Orchard, Peter, Carson, April P., Haessler, Jeffrey W., Raffield, Laura M., Reiner, Alex P., Franceschini, Nora, Auer, Paul L., Kooperberg, Charles, Li, Yun, O’Connor, George, Murabito, Joanne M., Munson, Peter, Levy, Daniel

“…We present a whole-blood isoform ratio QTL (irQTL) resource by analyzing genome-wide isoform-to-gene expression ratios using sequencing data. In Framingham…”
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Interferon gamma-induced protein 10 (IP-10) and cardiovascular disease in African Americans Autor Leavitt, Colton, Zakai, Neil A., Auer, Paul, Cushman, Mary, Lange, Ethan M., Levitan, Emily B., Olson, Nels, Thornton, Timothy A., Tracy, Russell P., Wilson, James G., Lange, Leslie A., Reiner, Alex P., Raffield, Laura M.

“…Biomarkers of chronic inflammation (such as C-reactive protein) have long been associated with cardiovascular disease and mortality; however, biomarkers…”
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Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation Autor Kirmani, Sara, Huan, Tianxiao, Van Amburg, Joseph C., Joehanes, Roby, Uddin, Md Mesbah, Nguyen, Ngoc Quynh H., Yu, Bing, Brody, Jennifer A., Fornage, Myriam, Bressler, Jan, Sotoodehnia, Nona, Ong, David A., Puddu, Fabio, Floyd, James S., Ballantyne, Christie M., Psaty, Bruce M., Raffield, Laura M., Natarajan, Pradeep, Conneely, Karen N., Weinstock, Joshua S., Carson, April P., Lange, Leslie A., Ferrier, Kendra, Heard-Costa, Nancy L., Murabito, Joanne, Bick, Alexander G., Levy, Daniel

“…With age, hematopoietic stem cells can acquire somatic mutations in leukemogenic genes that confer a proliferative advantage in a phenomenon termed CHIP. How…”
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Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: the Framingham Heart Study Autor Keshawarz, Amena, Bui, Helena, Joehanes, Roby, Ma, Jiantao, Liu, Chunyu, Huan, Tianxiao, Hwang, Shih-Jen, Tejada, Brandon, Sooda, Meera, Courchesne, Paul, Munson, Peter J., Demirkale, Cumhur Y., Yao, Chen, Heard-Costa, Nancy L., Pitsillides, Achilleas N., Lin, Honghuang, Liu, Ching-Ti, Wang, Yuxuan, Peloso, Gina M., Lundin, Jessica, Haessler, Jeffrey, Du, Zhaohui, Cho, Michael, Hersh, Craig P., Castaldi, Peter, Raffield, Laura M., Wen, Jia, Li, Yun, Reiner, Alexander P., Feolo, Mike, Sharopova, Nataliya, Vasan, Ramachandran S., DeMeo, Dawn L., Carson, April P., Kooperberg, Charles, Levy, Daniel

“…Expression quantitative trait methylation (eQTM) analysis identifies DNA CpG sites at which methylation is associated with gene expression. The present study…”
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Genetic underpinnings of regional adiposity distribution in African Americans: Assessments from the Jackson Heart Study Autor Anwar, Mohammad Y., Raffield, Laura M., Lange, Leslie A., Correa, Adolfo, Taylor, Kira C.

“…Background African ancestry individuals with comparable overall anthropometric measures to Europeans have lower abdominal adiposity. To explore the genetic…”
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Circulating Soluble CD163, Associations With Cardiovascular Outcomes and Mortality, and Identification of Genetic Variants in Older Individuals: The Cardiovascular Health Study Autor Durda, Peter, Raffield, Laura M., Lange, Ethan M., Olson, Nels C., Jenny, Nancy Swords, Cushman, Mary, Deichgraeber, Pia, Grarup, Niels, Jonsson, Anna, Hansen, Torben, Mychaleckyj, Josyf C., Psaty, Bruce M., Reiner, Alex P., Tracy, Russell P., Lange, Leslie A.

“…Background Monocytes/macrophages participate in cardiovascular disease. CD163 (cluster of differentiation 163) is a monocyte/macrophage receptor, and the shed…”
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Common α-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease Autor Raffield, Laura M., Ulirsch, Jacob C., Naik, Rakhi P., Lessard, Samuel, Handsaker, Robert E., Jain, Deepti, Kang, Hyun M., Pankratz, Nathan, Auer, Paul L., Bao, Erik L., Smith, Joshua D., Lange, Leslie A., Lange, Ethan M., Li, Yun, Thornton, Timothy A., Young, Bessie A., Abecasis, Goncalo R., Laurie, Cathy C., Nickerson, Deborah A., McCarroll, Steven A., Correa, Adolfo, Wilson, James G., Lettre, Guillaume, Sankaran, Vijay G., Reiner, Alex P.

“…Co-inheritance of α-thalassemia has a significant protective effect on the severity of complications of sickle cell disease (SCD), including stroke. However,…”
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A multi-ethnic polygenic risk score for chronic kidney disease is associated with increased risk of hypertension in African American individuals Autor Kakar, Aastha, Litkowski, Elizabeth M., Scadden, Ashley W., Anwar, Mohammad Y., Konigsberg, Iain R., Stanislawski, Maggie A., DuPre, Natalie C., Mitra, Riten, Baumgartner, Richard, Raffield, Laura M., Lange, Ethan M., Lange, Leslie A., Taylor, Kira C.

“…Background Hypertension (HT) and chronic kidney diseases (CKD) are complex conditions having both genetic and environmental contributions, disproportionately…”
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Ancestry-specific associations identified in genome-wide combined-phenotype study of red blood cell traits emphasize benefits of diversity in genomics Autor Hodonsky, Chani J., Baldassari, Antoine R., Bien, Stephanie A., Raffield, Laura M., Highland, Heather M., Sitlani, Colleen M., Wojcik, Genevieve L., Tao, Ran, Graff, Marielisa, Tang, Weihong, Thyagarajan, Bharat, Buyske, Steve, Fornage, Myriam, Hindorff, Lucia A., Li, Yun, Lin, Danyu, Reiner, Alex P., North, Kari E., Loos, Ruth J. F., Kooperberg, Charles, Avery, Christy L.

“…Background Quantitative red blood cell (RBC) traits are highly polygenic clinically relevant traits, with approximately 500 reported GWAS loci. The majority of…”
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Characterization of the phenotypic consequences of the Duffy-null genotype Autor Hysong, Micah R., Shuey, Megan M., Huffman, Jennifer E., Auer, Paul, Reiner, Alexander, Raffield, Laura M.

“…•rs2814778-CC is only reproducibly associated with changes in white blood cell count and not with any disease outcomes.•Race is not an accurate predictor of…”
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Systemic Lupus Erythematosus and Vitamin D Deficiency Are Associated with Shorter Telomere Length among African Americans: A Case-Control Study Autor Hoffecker, Brett M., Raffield, Laura M., Kamen, Diane L., Nowling, Tamara K.

“…Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease that disproportionately affects African American females. The causes of SLE are…”
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Obesity Duration, Severity, and Distribution Trajectories and Cardiovascular Disease Risk in the Atherosclerosis Risk in Communities Study Autor Raffield, Laura M., Howard, Annie Green, Graff, Misa, Lin, Dan‐Yu, Cheng, Susan, Demerath, Ellen, Ndumele, Chiadi, Palta, Priya, Rebholz, Casey M., Seidelmann, Sara, Yu, Bing, Gordon‐Larsen, Penny, North, Kari E., Avery, Christy L.

“…Background Research examining the role of obesity in cardiovascular disease (CVD) often fails to adequately consider heterogeneity in obesity severity,…”
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