Suchergebnisse - "Raaben, Matthijs"

Viral escape from endosomes and host detection at a glance von Staring, Jacqueline, Raaben, Matthijs, Brummelkamp, Thijn R

“… In order to replicate, most pathogens need to enter their target cells. Many viruses enter the host cell through an endocytic pathway and hijack endosomes for …”
Weitere Angaben

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1 von Carette, Jan E., Raaben, Matthijs, Wong, Anthony C., Herbert, Andrew S., Obernosterer, Gregor, Mulherkar, Nirupama, Kuehne, Ana I., Kranzusch, Philip J., Griffin, April M., Ruthel, Gordon, Cin, Paola Dal, Dye, John M., Whelan, Sean P., Chandran, Kartik, Brummelkamp, Thijn R.

Volltext

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy von Logtenberg, Meike E W, Jansen, J H Marco, Raaben, Matthijs, Toebes, Mireille, Franke, Katka, Brandsma, Arianne M, Matlung, Hanke L, Fauster, Astrid, Gomez-Eerland, Raquel, Bakker, Noor A M, van der Schot, Simone, Marijt, Koen A, Verdoes, Martijn, Haanen, John B A G, van den Berg, Joost H, Neefjes, Jacques, van den Berg, Timo K, Brummelkamp, Thijn R, Leusen, Jeanette H W, Scheeren, Ferenc A, Schumacher, Ton N

“… Cancer cells can evade immune surveillance through the expression of inhibitory ligands that bind their cognate receptors on immune effector cells. Expression …”
Volltext

Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism von Loregger, Anke, Raaben, Matthijs, Nieuwenhuis, Joppe, Tan, Josephine M. E., Jae, Lucas T., van den Hengel, Lisa G., Hendrix, Sebastian, van den Berg, Marlene, Scheij, Saskia, Song, Ji-Ying, Huijbers, Ivo J., Kroese, Lona J., Ottenhoff, Roelof, van Weeghel, Michel, van de Sluis, Bart, Brummelkamp, Thijn, Zelcer, Noam

“… The sterol-regulatory element binding proteins (SREBP) are central transcriptional regulators of lipid metabolism. Using haploid genetic screens we identify …”
Volltext

The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses von Jongsma, Marlieke L M, de Waard, Antonius A, Raaben, Matthijs, Zhang, Tao, Cabukusta, Birol, Platzer, René, Blomen, Vincent A, Xagara, Anastasia, Verkerk, Tamara, Bliss, Sophie, Kong, Xiangrui, Gerke, Carolin, Janssen, Lennert, Stickel, Elmer, Holst, Stephanie, Plomp, Rosina, Mulder, Arend, Ferrone, Soldano, Claas, Frans H J, Heemskerk, Mirjam H M, Griffioen, Marieke, Halenius, Anne, Overkleeft, Hermen, Huppa, Johannes B, Wuhrer, Manfred, Brummelkamp, Thijn R, Neefjes, Jacques, Spaapen, Robbert M

“… HLA class I (HLA-I) glycoproteins drive immune responses by presenting antigens to cognate CD8 T cells. This process is often hijacked by tumors and pathogens …”
Weitere Angaben

KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses von Staring, Jacqueline, van den Hengel, Lisa G, Raaben, Matthijs, Blomen, Vincent A, Carette, Jan E, Brummelkamp, Thijn R

“… Human type A Enteroviruses (EV-As) cause diseases ranging from hand-foot-and-mouth disease to poliomyelitis-like disease. Although cellular receptors are …”
Weitere Angaben

Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry von Jae, Lucas T, Raaben, Matthijs, Riemersma, Moniek, van Beusekom, Ellen, Blomen, Vincent A, Velds, Arno, Kerkhoven, Ron M, Carette, Jan E, Topaloglu, Haluk, Meinecke, Peter, Wessels, Marja W, Lefeber, Dirk J, Whelan, Sean P, van Bokhoven, Hans, Brummelkamp, Thijn R

“… Glycosylated α-dystroglycan (α-DG) serves as cellular entry receptor for multiple pathogens, and defects in its glycosylation cause hereditary Walker-Warburg …”
Weitere Angaben

NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry von Raaben, Matthijs, Jae, Lucas T, Herbert, Andrew S, Kuehne, Ana I, Stubbs, Sarah H, Chou, Yi-Ying, Blomen, Vincent A, Kirchhausen, Tomas, Dye, John M, Brummelkamp, Thijn R, Whelan, Sean P

“… Arenaviruses cause fatal hemorrhagic disease in humans. Old World arenavirus glycoproteins (GPs) mainly engage α-dystroglycan as a cell-surface receptor, while …”
Weitere Angaben

The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway von Mulherkar, Nirupama, Raaben, Matthijs, de la Torre, Juan Carlos, Whelan, Sean P., Chandran, Kartik

“… Ebola virus (EBOV) has been reported to enter cultured cell lines via a dynamin-2-independent macropinocytic pathway or clathrin-mediated endocytosis. The …”
Volltext

Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis von Loregger, Anke, Raaben, Matthijs, Tan, Josephine, Scheij, Saskia, Moeton, Martina, van den Berg, Marlene, Gelberg-Etel, Hila, Stickel, Elmer, Roitelman, Joseph, Brummelkamp, Thijn, Zelcer, Noam

“… The cellular demand for cholesterol requires control of its biosynthesis by the mevalonate pathway. Regulation of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A …”
Weitere Angaben

Reconstruction of the cell entry pathway of an extinct virus von Robinson-McCarthy, Lindsey R., McCarthy, Kevin R., Raaben, Matthijs, Piccinotti, Silvia, Nieuwenhuis, Joppe, Stubbs, Sarah H., Bakkers, Mark J. G., Whelan, Sean P. J.

“… Endogenous retroviruses (ERVs), remnants of ancient germline infections, comprise 8% of the human genome. The most recently integrated includes human ERV-K …”
Volltext

The ubiquitin-proteasome system plays an important role during various stages of the coronavirus infection cycle von Raaben, Matthijs, Posthuma, Clara C, Verheije, Monique H, te Lintelo, Eddie G, Kikkert, Marjolein, Drijfhout, Jan W, Snijder, Eric J, Rottier, Peter J M, de Haan, Cornelis A M

“… The ubiquitin-proteasome system (UPS) is a key player in regulating the intracellular sorting and degradation of proteins. In this study we investigated the …”
Weitere Angaben

CD200 Receptor Controls Sex-Specific TLR7 Responses to Viral Infection von Karnam, Guruswamy, Rygiel, Tomasz P., Raaben, Matthijs, Grinwis, Guy C. M., Coenjaerts, Frank E., Ressing, Maaike E., Rottier, Peter J. M., de Haan, Cornelis A. M., Meyaard, Linde

“… Immunological checkpoints, such as the inhibitory CD200 receptor (CD200R), play a dual role in balancing the immune system during microbial infection. On the …”
Volltext

Mouse Hepatitis Coronavirus RNA Replication Depends on GBF1-Mediated ARF1 Activation von Verheije, Monique H., Raaben, Matthijs, Mari, Muriel, te Lintelo, Eddie G., Reggiori, Fulvio, van Kuppeveld, Frank J. M., Rottier, Peter J. M., de Haan, Cornelis A. M.

“… Coronaviruses induce in infected cells the formation of double membrane vesicles, which are the sites of RNA replication. Not much is known about the formation …”
Volltext

Intermediate filaments enable pathogen docking to trigger type 3 effector translocation von Russo, Brian C., Stamm, Luisa M., Raaben, Matthijs, Kim, Caleb M., Kahoud, Emily, Robinson, Lindsey R., Bose, Sayantan, Queiroz, Ana L., Herrera, Bobby Brooke, Baxt, Leigh A., Mor-Vaknin, Nirit, Fu, Yang, Molina, Gabriel, Markovitz, David M., Whelan, Sean P., Goldberg, Marcia B.

“… Type 3 secretion systems (T3SSs) of bacterial pathogens translocate bacterial effector proteins that mediate disease into the eukaryotic cytosol. Effectors …”
Volltext

Mouse hepatitis coronavirus replication induces host translational shutoff and mRNA decay, with concomitant formation of stress granules and processing bodies von Raaben, Matthijs, Groot Koerkamp, Marian J. A., Rottier, Peter J. M., De Haan, Cornelis A. M.

“… Summary Many viruses, including coronaviruses, induce host translational shutoff, while maintaining synthesis of their own gene products. In this study we …”
Volltext

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles von Ndungo, Esther, Herbert, Andrew S., Raaben, Matthijs, Obernosterer, Gregor, Biswas, Rohan, Miller, Emily Happy, Wirchnianski, Ariel S., Carette, Jan E., Brummelkamp, Thijn R., Whelan, Sean P., Dye, John M., Chandran, Kartik

“… Identifying cellular factors that determine susceptibility to infection can help us understand how Ebola virus is transmitted. We asked if the EBOV receptor …”
Volltext

The proteasome inhibitor Velcade enhances rather than reduces disease in mouse hepatitis coronavirus-infected mice von Raaben, Matthijs, Grinwis, Guy C M, Rottier, Peter J M, de Haan, Cornelis A M

“… Many viruses, including coronaviruses (CoVs), depend on a functional cellular proteasome for efficient infection in vitro. Hence, the proteasome inhibitor …”
Weitere Angaben

Cooperative involvement of the S1 and S2 subunits of the murine coronavirus spike protein in receptor binding and extended host range von de Haan, Cornelis A M, Te Lintelo, Eddie, Li, Zhen, Raaben, Matthijs, Wurdinger, Tom, Bosch, Berend Jan, Rottier, Peter J M

“… To study the process of spike (S)-receptor interaction during coronavirus entry, we evaluated the contributions of mutations in different regions of the murine …”
Weitere Angaben

Type I interferon receptor-independent and -dependent host transcriptional responses to mouse hepatitis coronavirus infection in vivo von Raaben, Matthijs, Groot Koerkamp, Marian JA, Rottier, Peter JM, de Haan, Cornelis AM

“… Background The role of type I IFNs in protecting against coronavirus (CoV) infections is not fully understood. While CoVs are poor inducers of type I IFNs in …”
Volltext