Search Results - "RNA Interference"

Pharmacology of Antisense Drugs by Bennett, C Frank, Baker, Brenda F, Pham, Nguyen, Swayze, Eric, Geary, Richard S

“…Recent studies have led to a greater appreciation of the diverse roles RNAs play in maintaining normal cellular function and how they contribute to disease…”
Get more information

RNA interference technology in crop protection against arthropod pests, pathogens and nematodes by Zotti, Moises, dos Santos, Ericmar Avila, Cagliari, Deise, Christiaens, Olivier, Taning, Clauvis Nji Tizi, Smagghe, Guy

“…Scientists have made significant progress in understanding and unraveling several aspects of double‐stranded RNA (dsRNA)‐mediated gene silencing during the…”
Get full text

A journey into the world of small RNAs in the arbuscular mycorrhizal symbiosis by Ledford, William Conrad, Silvestri, Alessandro, Fiorilli, Valentina, Roth, Ronelle, Rubio‐Somoza, Ignacio, Lanfranco, Luisa

“…Summary Arbuscular mycorrhizal (AM) symbiosis is a mutualistic interaction between fungi and most land plants that is underpinned by a bidirectional exchange…”
Get full text

RNA interference by feeding in vitro–synthesized double‐stranded RNA to planarians: Methodology and dynamics by Rouhana, Labib, Weiss, Jennifer A., Forsthoefel, David J., Lee, Hayoung, King, Ryan S., Inoue, Takeshi, Shibata, Norito, Agata, Kiyokazu, Newmark, Phillip A.

“…Background The ability to assess gene function is essential for understanding biological processes. Currently, RNA interference (RNAi) is the only technique…”
Get full text

involvement of clathrin‐mediated endocytosis and two Sid‐1‐like transmembrane proteins in double‐stranded RNA uptake in the Colorado potato beetle midgut by Cappelle, K., de Oliveira, C. F. R., Van Eynde, B., Christiaens, O., Smagghe, G.

“…RNA interference (RNAi) is a powerful tool in entomology and shows promise as a crop protection strategy, but variability in its efficiency across different…”
Get full text

Small RNA-based antimicrobial immunity by Guo, Zhongxin, Li, Yang, Ding, Shou-Wei

“…Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the…”
Get full text

viral silencing suppressors: Tools forged to fine-tune host-pathogen coexistence by Csorba, Tibor, Kontra, Levente, Burgyán, József

“…RNA silencing is a homology-dependent gene inactivation mechanism that regulates a wide range of biological processes including antiviral defense. To deal with…”
Get full text

Therapeutic targeting of microRNAs: current status and future challenges by Li, Zhonghan, Rana, Tariq M.

“…Key Points MicroRNAs (miRNAs) have important roles in many aspects of human diseases, and their targeted inhibition may have substantial therapeutic impact…”
Get full text

A fungal sRNA silences a host plant transcription factor to promote arbuscular mycorrhizal symbiosis by Silvestri, Alessandro, Ledford, William Conrad, Fiorilli, Valentina, Votta, Cristina, Scerna, Alessia, Tucconi, Jacopo, Mocchetti, Antonio, Grasso, Gianluca, Balestrini, Raffaella, Jin, Hailing, Rubio‐Somoza, Ignacio, Lanfranco, Luisa

“…Summary Cross‐kingdom RNA interference (ckRNAi) is a mechanism of interspecies communication where small RNAs (sRNAs) are transported from one organism to…”
Get full text

Developing RNAi pesticides in the post genomic era: A review by Duanmu, Haonan, Guo, Fangyuan, Liu, Ying, He, Kang

“…RNA interference (RNAi) has emerged as a promising platform for next-generation pesticides, offering high target specificity and environmental safety. In the…”
Get full text

Abstract 2359 Investigation of cytocompatibility and cellular internalization of novel, enzyme-cleavable peptides by Xia, Ruxi, Alatise, Kharimat, Alexander-Bryant, Angela

Get full text

Small RNAs - Big Players in Plant-Microbe Interactions by Huang, Chien-Yu, Wang, Huan, Hu, Po, Hamby, Rachael, Jin, Hailing

“…Eukaryotic small RNAs (sRNAs) are short non-coding regulatory molecules that induce RNA interference (RNAi). During microbial infection, host RNAi machinery is…”
Get more information

Mechanisms, Applications, and Challenges of Insect RNA Interference by Zhu, Kun Yan, Palli, Subba Reddy

“…The RNA interference (RNAi) triggered by short/small interfering RNA (siRNA) was discovered in nematodes and found to function in most living organisms. RNAi…”
Get more information

RNA interference (RNAi)-based plasmonic nanomaterials for cancer diagnosis and therapy by Yoon, Jinho, Shin, Minkyu, Lee, Ji-Young, Lee, Sang-Nam, Choi, Jin-Ha, Choi, Jeong-Woo

“…RNA interference (RNAi) is being extensively investigated as a potential therapeutic strategy for cancer treatment. However, RNAi-based therapeutics have not…”
Get full text

Chemistry, structure and function of approved oligonucleotide therapeutics by Egli, Martin, Manoharan, Muthiah

“…Abstract Eighteen nucleic acid therapeutics have been approved for treatment of various diseases in the last 25 years. Their modes of action include antisense…”
Get full text

miRDB: an online database for prediction of functional microRNA targets by Chen, Yuhao, Wang, Xiaowei

“…Abstract MicroRNAs (miRNAs) are small noncoding RNAs that act as master regulators in many biological processes. miRNAs function mainly by downregulating the…”
Get full text

Next-Generation Lipids in RNA Interference Therapeutics by Rietwyk, Stephanie, Peer, Dan

“…RNA is emerging as a potential therapeutic modality for the treatment of incurable diseases. Despite intense research, the advent to clinical utility remains…”
Get full text

Spray-Induced Gene Silencing: a Powerful Innovative Strategy for Crop Protection by Wang, Ming, Jin, Hailing

“…Plant pathogens cause serious crop losses worldwide. Recent new studies demonstrate that spraying double-stranded RNAs (dsRNAs) and small RNAs (sRNAs) that…”
Get full text

The roles of microRNAs in epigenetic regulation by Yao, Qian, Chen, Yuqi, Zhou, Xiang

“…MicroRNAs (miRNAs) are small noncoding RNAs, approximately 18–25 nucleotides in length, now recognized as one of the major regulatory gene families in…”
Get full text

RNAi-mediated silencing of hepatic Alas1 effectively prevents and treats the induced acute attacks in acute intermittent porphyria mice by Yasuda, Makiko, Gan, Lin, Chen, Brenden, Kadirvel, Senkottuvelan, Yu, Chunli, Phillips, John D, New, Maria I, Liebow, Abigail, Fitzgerald, Kevin, Querbes, William, Desnick, Robert J

“…The acute hepatic porphyrias are inherited disorders of heme biosynthesis characterized by life-threatening acute neurovisceral attacks. Factors that induce…”
Get more information