Search Results - "R-loops"

A hypothetical model of trans-acting R-loops-mediated promoter-enhancer interactions by Alu elements by Bai, Xue, Li, Feifei, Zhang, Zhihua

“…) may directly contact their targeted promoters by forming trans-acting R-loops at those Alu sequences…”
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TERRA R-LOOPS ARE INCREASED IN ACUTE MYELOID LEUKEMIA by Catto, LFB, Zanelatto, LC, Donaires, FS, Carvalho, VS, Santana, BA, Pinto, AL, Fantacini, DMC, Traina, F, Rego, EM, Calado, RT

“… TERRA binds to subtelomeric and telomeric regions, forming R-loops, structures composed of DNA-RNA hybrids and displaced single-stranded DNA…”
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p53 mediated regulation of LINE1 retrotransposition derived R-loops by Paul, Pratyashaa, Kumar, Arun, De, Astik Kumar, Parida, Ankita Subhadarsani, Bhadke, Gauri, Khatua, Satyajeet, Pattanayak, Fizalin, Tiwari, Bhavana

“… In this study, we demonstrate that p53 silences both L1mRNA-gDNA (cis L1 R-loops) and L1mRNA-cDNA hybrids (trans L1 R-loops…”
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Evidences for functional trans-acting eRNA-promoter R-loops at Alu sequences by Bai, Xue, Li, Feifei, Zhang, Zhihua

“… After rejecting the alternative DNA:DNA and DNA:RNA triplex models, we proposed that enhancer-associated RNAs, or eRNAs, may directly contact their targeted promoters by forming trans-acting R-loops at those Alu sequences…”
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The SUMOylated METTL8 Induces R-loop and Tumorigenesis via m3C by Zhang, Li-Hong, Zhang, Xue-Yun, Hu, Tao, Chen, Xin-Yun, Li, Jing-Jia, Raida, Manfred, Sun, Ning, Luo, Yan, Gao, Xiang

“…R-loops, three-stranded DNA-DNA:RNA hybrid structures, are best known for their deleterious effects on genome stability…”
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The integrated stress response induces R-loops and hinders replication fork progression by Josephine Ann Mun Yee Choo, Schloesser, Denise, Manzini, Valentina, Magerhans, Anna, Dobbelstein, Matthias

“… Mechanistically, the translational shutdown blocks histone synthesis, promoting the formation of DNA:RNA hybrids (R-loops) which interfere with DNA replication…”
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Telomeric repeat-containing RNA is dysregulated in acute myeloid leukemia by Catto, Luiz Fernando B., Zanelatto, Leonardo C., Donaires, Flavia S., de Carvalho, Vinicius S., Santana, Bárbara A., Pinto, André L., Fantacini, Daianne, de Souza, Lucas Eduardo B., Fonseca, Natasha P., Telho, Bruno S., Ayrosa Madeira, Maria Isabel, Barbosa Pagnano, Katia Borgia, Firmato, Ana Beatriz, Fagundes, Evandro Maranhão, Higashi, Marcia, Nunes, Elenaide Coutinho, Traina, Fabiola, Lobo de F. Pontes, Lorena, Rego, Eduardo M., Calado, Rodrigo T.

“…), regardless of their telomere lengths.•TERRA is dysregulated in a subset of AML characterized by higher R-loop formation and low TERT and RNAseH2 expression. [Display omitted] TERRA…”
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Personalized Perturbation Profiles Reveal Concordance between Autism Blood Transcriptome Datasets by Laird, Jason, Maertens, Alexandra

“… that are perturbed in ASD subjects. We find the resultant perturbed gene pools to include the following unnamed genes…”
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HELME R LOOPS IN BOLD 'TALES' by Gaydos, Steven

“…Best-known for his work on some of the past two decades' most audacious and powerful music videos and commercials, Romanek has accrued multiple Grammy Awards…”
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SPLITTING LOOPS AND NECKLACES: VARIANTS OF THE SQUARE PEG PROBLEM by ASLAM, JAI, CHEN, SHUJIAN, FRICK, FLORIAN, SALOFF-COSTE, SAM, SETIABRATA, LINUS, THOMAS, HUGH

“…$ pieces that can be rearranged by translations to form $r$ loops of equal length. We relate our results to fair divisions of necklaces in the sense of Alon and to Tverberg-type results. This provides a new approach and a common framework to obtain inscribability results for the class of all continuous curves…”
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The problem of hypernegative supercoiling and R-loop formation in transcription by Drolet, Marc, Broccoli, Sonia, Rallu, Fabien, Hraiky, Chadi, Fortin, Charles, Massé, Eric, Baaklini, Imad

“…DNA supercoiling and topoisomerases have long been known to affect transcription initiation. In many studies, topA mutants were used to perturb chromosomal…”
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Towards a Mechanistic Understanding of R-Loop Regulation and Function at Telomeres by Pires, Vanessa Borges

“…RNA-DNA hybrids are generated during transcription, DNA replication and DNA repair, due to base pairing of RNA with DNA. They are crucial intermediates in…”
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The RNA Processing Factor Y14 Participates in DNA Damage Response and Repair by Chuang, Tzu-Wei, Lu, Chia-Chen, Su, Chun-Hao, Wu, Pei-Yu, Easwvaran, Sarasvathi, Lee, Chi-Chieh, Kuo, Hung-Che, Hung, Kuan-Yang, Lee, Kuo-Ming, Tsai, Ching-Yen, Tarn, Woan-Yuh

“… Y14 depletion differentially affected the expression of DNA damage response (DDR) factors and induced R-loops, both of which threaten genomic stability…”
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Developing a disease-specific accessible transcriptional signature as a biomarker for ataxia with oculomotor apraxia type 2 by Ngo, Kathie J., Wong, Darice Y., Huang, Alden Y., Lee, Hane, Nelson, Stanley F., Fogel, Brent L.

“… SETX encodes a ubiquitous DNA/RNA helicase crucial for resolving R-loops and maintaining genome stability…”
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R loop

“…the structure formed when an RNA of complementary sequence stably base pairs with one of the DNA strands of double‐stranded…”
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Mapping the Genomic Distribution Of Rna: Dna Hybrids by Bocek, Michael Joseph

“… These resolution mechanisms maintain a constant turnover of R-loops in a cell, making them dynamic structures whose levels are subject to change within di…”
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New roles for RAD52 in DNA repair by Xue, Chaoyou, Greene, Eric C.

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The Influence of CG sites on dynamic DNA sequence mutagenesis in the genomic evolution of mammalian lifespan by Smith, Steven S

“… This pool is distinguished from those studied previously by the presence of one or more CG sites, suggesting that they are subject to structural suppression DNA methylation in mammals…”
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Targeting evolution to inhibit antibiotic resistance by Merrikh, Houra, Kohli, Rahul M.

“… that are less subject to existing resistance mechanisms, history shows that this strategy by itself is unlikely…”
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Mitotic block and epigenetic repression underlie neurodevelopmental defects and neurobehavioral deficits in congenital heart disease by Gabriel, George C., Yagi, Hisato, Tan, Tuantuan, Bais, Abha, Glennon, Benjamin J., Stapleton, Margaret C., Huang, Lihua, Reynolds, William T., Shaffer, Marla G., Ganapathiraju, Madhavi, Simon, Dennis, Panigrahy, Ashok, Wu, Yijen L., Lo, Cecilia W.

“…Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease associated with microcephaly and poor neurodevelopmental outcomes. Here we show…”
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