Výsledky vyhľadávania - "Qu, Chunxu"

The genomic landscape of pediatric acute lymphoblastic leukemia Autor Brady, Samuel W., Roberts, Kathryn G., Gu, Zhaohui, Shi, Lei, Pounds, Stanley, Pei, Deqing, Cheng, Cheng, Dai, Yunfeng, Devidas, Meenakshi, Qu, Chunxu, Hill, Ashley N., Payne-Turner, Debbie, Ma, Xiaotu, Iacobucci, Ilaria, Baviskar, Pradyuamna, Wei, Lei, Arunachalam, Sasi, Hagiwara, Kohei, Liu, Yanling, Flasch, Diane A., Liu, Yu, Parker, Matthew, Chen, Xiaolong, Elsayed, Abdelrahman H., Pathak, Omkar, Li, Yongjin, Fan, Yiping, Michael, J. Robert, Rusch, Michael, Wilkinson, Mark R., Foy, Scott, Hedges, Dale J., Newman, Scott, Zhou, Xin, Wang, Jian, Reilly, Colleen, Sioson, Edgar, Rice, Stephen V., Pastor Loyola, Victor, Wu, Gang, Rampersaud, Evadnie, Reshmi, Shalini C., Gastier-Foster, Julie, Guidry Auvil, Jaime M., Gesuwan, Patee, Smith, Malcolm A., Winick, Naomi, Carroll, Andrew J., Heerema, Nyla A., Harvey, Richard C., Willman, Cheryl L., Larsen, Eric, Raetz, Elizabeth A., Borowitz, Michael J., Wood, Brent L., Carroll, William L., Zweidler-McKay, Patrick A., Rabin, Karen R., Mattano, Leonard A., Maloney, Kelly W., Winter, Stuart S., Burke, Michael J., Salzer, Wanda, Dunsmore, Kimberly P., Angiolillo, Anne L., Crews, Kristine R., Downing, James R., Jeha, Sima, Pui, Ching-Hon, Evans, William E., Yang, Jun J., Relling, Mary V., Gerhard, Daniela S., Loh, Mignon L., Hunger, Stephen P., Zhang, Jinghui, Mullighan, Charles G.

“…Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using whole-genome, exome and transcriptome sequencing of 2,754 childhood…”
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RCE-GAN: A Rebar Clutter Elimination Network to Improve Tunnel Lining Void Detection from GPR Images Autor Wang, Yuanzheng, Qin, Hui, Tang, Yu, Zhang, Donghao, Yang, Donghui, Qu, Chunxu, Geng, Tiesuo

“…Ground penetrating radar (GPR) is one of the most recommended tools for routine inspection of tunnel linings. However, the rebars in the reinforced concrete…”
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Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas Autor GANG WU, BRONISCER, Alberto, JUNYUAN ZHANG, GAJJAR, Amar, DYER, Michael A, MULLIGHAN, Charles G, GILBERTSON, Richard J, MARDIS, Elaine R, WILSON, Richard K, DOWNING, James R, ELLISON, David W, JINGHUI ZHANG, MCEACHRON, Troy A, BAKER, Suzanne J, LU, Charles, PAUGH, Barbara S, BECKSFORT, Jared, CHUNXU QU, LI DING, HUETHER, Robert, PARKER, Matthew

“…Suzanne Baker and colleagues sequenced the whole genomes of seven pediatric brainstem glioblastomas and matched normal tissue. They found that 78% of diffuse…”
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Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia Autor Almeida, Afonso R. M., Neto, João L., Cachucho, Ana, Euzébio, Mayara, Meng, Xiangyu, Kim, Rathana, Fernandes, Marta B., Raposo, Beatriz, Oliveira, Mariana L., Ribeiro, Daniel, Fragoso, Rita, Zenatti, Priscila P., Soares, Tiago, de Matos, Mafalda R., Corrêa, Juliana Ronchi, Duque, Mafalda, Roberts, Kathryn G., Gu, Zhaohui, Qu, Chunxu, Pereira, Clara, Pyne, Susan, Pyne, Nigel J., Barreto, Vasco M., Bernard-Pierrot, Isabelle, Clappier, Emannuelle, Mullighan, Charles G., Grosso, Ana R., Yunes, J. Andrés, Barata, João T.

“…Interleukin-7 receptor α (encoded by IL7R ) is essential for lymphoid development. Whether acute lymphoblastic leukemia (ALL)-related IL7R gain-of-function…”
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Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation Autor Chandra, Bappaditya, Michmerhuizen, Nicole L, Shirnekhi, Hazheen K, Tripathi, Swarnendu, Pioso, Brittany J, Baggett, David W, Mitrea, Diana M, Iacobucci, Ilaria, White, Michael R, Chen, Jingjing, Park, Cheon-Gil, Wu, Huiyun, Pounds, Stanley, Medyukhina, Anna, Khairy, Khaled, Gao, Qingsong, Qu, Chunxu, Abdelhamed, Sherif, Gorman, Scott D, Bawa, Simranjot, Maslanka, Carolyn, Kinger, Swati, Dogra, Priyanka, Ferrolino, Mylene C, Di Giacomo, Danika, Mecucci, Cristina, Klco, Jeffery M, Mullighan, Charles G, Kriwacki, Richard W

“…NUP98 fusion oncoproteins (FO) are drivers in pediatric leukemias and many transform hematopoietic cells. Most NUP98 FOs harbor an intrinsically disordered…”
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Deregulation of DUX4 and ERG in acute lymphoblastic leukemia Autor Zhang, Jinghui, McCastlain, Kelly, Yoshihara, Hiroki, Xu, Beisi, Chang, Yunchao, Churchman, Michelle L, Wu, Gang, Li, Yongjin, Wei, Lei, Iacobucci, Ilaria, Liu, Yu, Qu, Chunxu, Wen, Ji, Edmonson, Michael, Payne-Turner, Debbie, Kaufmann, Kerstin B, Takayanagi, Shin-ichiro, Wienholds, Erno, Waanders, Esmé, Ntziachristos, Panagiotis, Bakogianni, Sofia, Wang, Jingjing, Aifantis, Iannis, Roberts, Kathryn G, Ma, Jing, Song, Guangchun, Easton, John, Mulder, Heather L, Chen, Xiang, Newman, Scott, Ma, Xiaotu, Rusch, Michael, Gupta, Pankaj, Boggs, Kristy, Vadodaria, Bhavin, Dalton, James, Liu, Yanling, Valentine, Marcus L, Ding, Li, Lu, Charles, Fulton, Robert S, Fulton, Lucinda, Tabib, Yashodhan, Ochoa, Kerri, Devidas, Meenakshi, Pei, Deqing, Cheng, Cheng, Yang, Jun, Evans, William E, Relling, Mary V, Pui, Ching-Hon, Jeha, Sima, Harvey, Richard C, Chen, I-Ming L, Willman, Cheryl L, Marcucci, Guido, Bloomfield, Clara D, Kohlschmidt, Jessica, Mrózek, Krzysztof, Paietta, Elisabeth, Tallman, Martin S, Stock, Wendy, Foster, Matthew C, Racevskis, Janis, Rowe, Jacob M, Luger, Selina, Kornblau, Steven M, Shurtleff, Sheila A, Raimondi, Susana C, Mardis, Elaine R, Wilson, Richard K, Dick, John E, Hunger, Stephen P, Loh, Mignon L, Downing, James R, Mullighan, Charles G

“…Charles Mullighan, Jinghui Zhang and colleagues characterize a subtype of B-progenitor acute lymphoblastic leukemia with deregulated DUX4 and ERG . They find…”
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Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression Autor Larson, Jon D, Kasper, Lawryn H, Paugh, Barbara S, Jin, Hongjian, Wu, Gang, Kwon, Chang-Hyuk, Fan, Yiping, Shaw, Timothy I, Silveira, André B, Qu, Chunxu, Xu, Raymond, Zhu, Xiaoyan, Zhang, Junyuan, Russell, Helen R, Peters, Jennifer L, Finkelstein, David, Xu, Beisi, Lin, Tong, Tinkle, Christopher L, Patay, Zoltan, Onar-Thomas, Arzu, Pounds, Stanley B, McKinnon, Peter J, Ellison, David W, Zhang, Jinghui, Baker, Suzanne J

“…Diffuse intrinsic pontine gliomas (DIPGs) are incurable childhood brainstem tumors with frequent histone H3 K27M mutations and recurrent alterations in PDGFRA…”
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Subset simulation-based reliability analysis of the corroding natural gas pipeline Autor Yu, Weichao, Huang, Weihe, Wen, Kai, Zhang, Jie, Liu, Hongfei, Wang, Kun, Gong, Jing, Qu, Chunxu

“…•Subset simulation is applied to evaluate the reliability of corroding pipeline.•The competitiveness of failure modes and correlation of defects are…”
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Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia Autor Montefiori, Lindsey E, Bendig, Sonja, Gu, Zhaohui, Chen, Xiaolong, Pölönen, Petri, Ma, Xiaotu, Murison, Alex, Zeng, Andy, Garcia-Prat, Laura, Dickerson, Kirsten, Iacobucci, Ilaria, Abdelhamed, Sherif, Hiltenbrand, Ryan, Mead, Paul E, Mehr, Cyrus M, Xu, Beisi, Cheng, Zhongshan, Chang, Ti-Cheng, Westover, Tamara, Ma, Jing, Stengel, Anna, Kimura, Shunsuke, Qu, Chunxu, Valentine, Marcus B, Rashkovan, Marissa, Luger, Selina, Litzow, Mark R, Rowe, Jacob M, den Boer, Monique L, Wang, Victoria, Yin, Jun, Kornblau, Steven M, Hunger, Stephen P, Loh, Mignon L, Pui, Ching-Hon, Yang, Wenjian, Crews, Kristine R, Roberts, Kathryn G, Yang, Jun J, Relling, Mary V, Evans, William E, Stock, Wendy, Paietta, Elisabeth M, Ferrando, Adolfo A, Zhang, Jinghui, Kern, Wolfgang, Haferlach, Torsten, Wu, Gang, Dick, John E, Klco, Jeffery M, Haferlach, Claudia, Mullighan, Charles G

“…Lineage-ambiguous leukemias are high-risk malignancies of poorly understood genetic basis. Here, we describe a distinct subgroup of acute leukemia with…”
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Molecular classification improves risk assessment in adult BCR-ABL1-negative B-ALL Autor Paietta, Elisabeth, Roberts, Kathryn G, Wang, Victoria, Gu, Zhaohui, Buck, Georgina A N, Pei, Deqing, Cheng, Cheng, Levine, Ross L, Abdel-Wahab, Omar, Cheng, Zhongshan, Wu, Gang, Qu, Chunxu, Shi, Lei, Pounds, Stanley, Willman, Cheryl L, Harvey, Richard, Racevskis, Janis, Barinka, Jan, Zhang, Yanming, Dewald, Gordon W, Ketterling, Rhett P, Alejos, David, Lazarus, Hillard M, Luger, Selina M, Foroni, Letizia, Patel, Bela, Fielding, Adele K, Melnick, Ari, Marks, David I, Moorman, Anthony V, Wiernik, Peter H, Rowe, Jacob M, Tallman, Martin S, Goldstone, Anthony H, Mullighan, Charles G, Litzow, Mark R

“…Genomic classification has improved risk assignment of pediatric, but not adult B-lineage acute lymphoblastic leukemia (B-ALL). The international…”
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Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia Autor Churchman, Michelle L, Qian, Maoxiang, Te Kronnie, Geertruy, Zhang, Ranran, Yang, Wenjian, Zhang, Hui, Lana, Tobia, Tedrick, Paige, Baskin, Rebekah, Verbist, Katherine, Peters, Jennifer L, Devidas, Meenakshi, Larsen, Eric, Moore, Ian M, Gu, Zhaohui, Qu, Chunxu, Yoshihara, Hiroki, Porter, Shaina N, Pruett-Miller, Shondra M, Wu, Gang, Raetz, Elizabeth, Martin, Paul L, Bowman, W Paul, Winick, Naomi, Mardis, Elaine, Fulton, Robert, Stanulla, Martin, Evans, William E, Relling, Mary V, Pui, Ching-Hon, Hunger, Stephen P, Loh, Mignon L, Handgretinger, Rupert, Nichols, Kim E, Yang, Jun J, Mullighan, Charles G

“…Somatic genetic alterations of IKZF1, which encodes the lymphoid transcription factor IKAROS, are common in high-risk B-progenitor acute lymphoblastic leukemia…”
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The genomic landscape of core-binding factor acute myeloid leukemias Autor Faber, Zachary J, Chen, Xiang, Gedman, Amanda Larson, Boggs, Kristy, Cheng, Jinjun, Ma, Jing, Radtke, Ina, Chao, Jyh-Rong, Walsh, Michael P, Song, Guangchun, Andersson, Anna K, Dang, Jinjun, Dong, Li, Liu, Yu, Huether, Robert, Cai, Zhongling, Mulder, Heather, Wu, Gang, Edmonson, Michael, Rusch, Michael, Qu, Chunxu, Li, Yongjin, Vadodaria, Bhavin, Wang, Jianmin, Hedlund, Erin, Cao, Xueyuan, Yergeau, Donald, Nakitandwe, Joy, Pounds, Stanley B, Shurtleff, Sheila, Fulton, Robert S, Fulton, Lucinda L, Easton, John, Parganas, Evan, Pui, Ching-Hon, Rubnitz, Jeffrey E, Ding, Li, Mardis, Elaine R, Wilson, Richard K, Gruber, Tanja A, Mullighan, Charles G, Schlenk, Richard F, Paschka, Peter, Döhner, Konstanze, Döhner, Hartmut, Bullinger, Lars, Zhang, Jinghui, Klco, Jeffery M, Downing, James R

“…Lars Bullinger, Jinghui Zhang, Jeffery Klco, James Downing and colleagues report a detailed genomic analysis of pediatric and adult core-binding factor acute…”
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Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma Autor Chen, Xiang, Bahrami, Armita, Pappo, Alberto, Easton, John, Dalton, James, Hedlund, Erin, Ellison, David, Shurtleff, Sheila, Wu, Gang, Wei, Lei, Parker, Matthew, Rusch, Michael, Nagahawatte, Panduka, Wu, Jianrong, Mao, Shenghua, Boggs, Kristy, Mulder, Heather, Yergeau, Donald, Lu, Charles, Ding, Li, Edmonson, Michael, Qu, Chunxu, Wang, Jianmin, Li, Yongjin, Navid, Fariba, Daw, Najat C., Mardis, Elaine R., Wilson, Richard K., Downing, James R., Zhang, Jinghui, Dyer, Michael A.

“…Pediatric osteosarcoma is characterized by multiple somatic chromosomal lesions, including structural variations (SVs) and copy number alterations (CNAs). To…”
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Genomic subtyping and therapeutic targeting of acute erythroleukemia Autor Iacobucci, Ilaria, Wen, Ji, Meggendorfer, Manja, Choi, John K., Shi, Lei, Pounds, Stanley B., Carmichael, Catherine L., Masih, Katherine E., Morris, Sarah M., Lindsley, R. Coleman, Janke, Laura J., Alexander, Thomas B., Song, Guangchun, Qu, Chunxu, Li, Yongjin, Payne-Turner, Debbie, Tomizawa, Daisuke, Kiyokawa, Nobutaka, Valentine, Marcus, Valentine, Virginia, Basso, Giuseppe, Locatelli, Franco, Enemark, Eric J., Kham, Shirley K. Y., Yeoh, Allen E. J., Ma, Xiaotu, Zhou, Xin, Sioson, Edgar, Rusch, Michael, Ries, Rhonda E., Stieglitz, Elliot, Hunger, Stephen P., Wei, Andrew H., To, L Bik, Lewis, Ian D., D’Andrea, Richard J., Kile, Benjamin T., Brown, Anna L., Scott, Hamish S., Hahn, Christopher N., Marlton, Paula, Pei, Deqing, Cheng, Cheng, Loh, Mignon L., Ebert, Benjamin L., Meshinchi, Soheil, Haferlach, Torsten, Mullighan, Charles G.

“…Acute erythroid leukemia (AEL) is a high-risk leukemia of poorly understood genetic basis, with controversy regarding diagnosis in the spectrum of…”
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Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia Autor Chang, Yunchao, Min, Jaeki, Jarusiewicz, Jamie A, Actis, Marisa, Yu-Chen Bradford, Shanshan, Mayasundari, Anand, Yang, Lei, Chepyala, Divyabharathi, Alcock, Lisa J, Roberts, Kathryn G, Nithianantham, Stanley, Maxwell, Dylan, Rowland, Lauren, Larsen, Randolph, Seth, Aman, Goto, Hiroaki, Imamura, Toshihiko, Akahane, Koshi, Hansen, Baranda S, Pruett-Miller, Shondra M, Paietta, Elisabeth M, Litzow, Mark R, Qu, Chunxu, Yang, Jun J, Fischer, Marcus, Rankovic, Zoran, Mullighan, Charles G

“…CRLF2-rearranged (CRLF2r) acute lymphoblastic leukemia (ALL) accounts for more than half of Philadelphia chromosome-like (Ph-like) ALL and is associated with a…”
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A mouse model of the most aggressive subgroup of human medulloblastoma Autor Kawauchi, Daisuke, Robinson, Giles, Uziel, Tamar, Gibson, Paul, Rehg, Jerold, Gao, Cuilan, Finkelstein, David, Qu, Chunxu, Pounds, Stanley, Ellison, David W, Gilbertson, Richard J, Roussel, Martine F

“…Medulloblastomas that display a large cell/anaplastic morphology and overexpress the cellular c-MYC gene are highly aggressive and carry a very poor prognosis…”
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Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer Autor Yang, Jun, AlTahan, Alaa, Jones, Dylan T, Buffa, Francesca M, Bridges, Esther, Interiano, Rodrigo B, Qu, Chunxu, Vogt, Nathan, Li, Ji-Liang, Baban, Dilair, Ragoussis, Jiannis, Nicholson, Robert, Davidoff, Andrew M, Harris, Adrian L

“…A majority of breast cancers are driven by estrogen via estrogen receptor-α (ERα). Our previous studies indicate that hypoxia-inducible factor 1α (HIF-1α)…”
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Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease Autor Paugh, Barbara S, Qu, Chunxu, Jones, Chris, Liu, Zhaoli, Adamowicz-Brice, Martyna, Zhang, Junyuan, Bax, Dorine A, Coyle, Beth, Barrow, Jennifer, Hargrave, Darren, Lowe, James, Gajjar, Amar, Zhao, Wei, Broniscer, Alberto, Ellison, David W, Grundy, Richard G, Baker, Suzanne J

“…To define copy number alterations and gene expression signatures underlying pediatric high-grade glioma (HGG). We conducted a high-resolution analysis of…”
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Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia Autor Churchman, Michelle L, Low, Jonathan, Qu, Chunxu, Paietta, Elisabeth M, Kasper, Lawryn H, Chang, Yunchao, Payne-Turner, Debbie, Althoff, Mark J, Song, Guangchun, Chen, Shann-Ching, Ma, Jing, Rusch, Michael, McGoldrick, Dan, Edmonson, Michael, Gupta, Pankaj, Wang, Yong-Dong, Caufield, William, Freeman, Burgess, Li, Lie, Panetta, John C, Baker, Sharyn, Yang, Yung-Li, Roberts, Kathryn G, McCastlain, Kelly, Iacobucci, Ilaria, Peters, Jennifer L, Centonze, Victoria E, Notta, Faiyaz, Dobson, Stephanie M, Zandi, Sasan, Dick, John E, Janke, Laura, Peng, Junmin, Kodali, Kiran, Pagala, Vishwajeeth, Min, Jaeki, Mayasundari, Anand, Williams, Richard T, Willman, Cheryl L, Rowe, Jacob, Luger, Selina, Dickins, Ross A, Guy, R Kiplin, Chen, Taosheng, Mullighan, Charles G

“…Alterations of IKZF1, encoding the lymphoid transcription factor IKAROS, are a hallmark of high-risk acute lymphoblastic leukemia (ALL), however the role of…”
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Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas Autor Paugh, Barbara S, Zhu, Xiaoyan, Qu, Chunxu, Endersby, Raelene, Diaz, Alexander K, Zhang, Junyuan, Bax, Dorine A, Carvalho, Diana, Reis, Rui M, Onar-Thomas, Arzu, Broniscer, Alberto, Wetmore, Cynthia, Zhang, Jinghui, Jones, Chris, Ellison, David W, Baker, Suzanne J

“…The outcome for children with high-grade gliomas (HGG) remains dismal, with a 2-year survival rate of only 10% to 30%. Diffuse intrinsic pontine glioma (DIPG)…”
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