Search Results - "Protein Interaction Domains and Motifs - physiology"

Nucleic acid chaperone activity associated with the arginine-rich domain of human hepatitis B virus core protein by Chu, Tien-Hua, Liou, An-Ting, Su, Pei-Yi, Wu, Huey-Nan, Shih, Chiaho

“…Hepatitis B virus (HBV) DNA replication occurs within the HBV icosahedral core particles. HBV core protein (HBc) contains an arginine-rich domain (ARD) at its…”
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A systematic screen for protein–lipid interactions in Saccharomyces cerevisiae by Gallego, Oriol, Betts, Matthew J, Gvozdenovic‐Jeremic, Jelena, Maeda, Kenji, Matetzki, Christian, Aguilar‐Gurrieri, Carmen, Beltran‐Alvarez, Pedro, Bonn, Stefan, Fernández‐Tornero, Carlos, Jensen, Lars Juhl, Kuhn, Michael, Trott, Jamie, Rybin, Vladimir, Müller, Christoph W, Bork, Peer, Kaksonen, Marko, Russell, Robert B, Gavin, Anne‐Claude

“…Protein–metabolite networks are central to biological systems, but are incompletely understood. Here, we report a screen to catalog protein–lipid interactions…”
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A novel point mutation in the DNA-binding domain (DBD) of the human glucocorticoid receptor causes primary generalized glucocorticoid resistance by disrupting the hydrophobic structure of its DBD by Roberts, Michael L, Kino, Tomoshige, Nicolaides, Nicolas C, Hurt, Darrell E, Katsantoni, Eleni, Sertedaki, Amalia, Komianou, Filadelfia, Kassiou, Korina, Chrousos, George P, Charmandari, Evangelia

“… Most affected subjects present with clinical manifestations of mineralocorticoid and androgen excess…”
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Conformational dynamics of CYP3A4 demonstrate the important role of Arg212 coupled with the opening of ingress, egress and solvent channels to dehydrogenation of 4-hydroxy-tamoxifen by Shahrokh, Kiumars, Cheatham, Thomas E., Yost, Garold S.

“…Structure-based methods for P450 substrates are commonly used during drug development to identify sites of metabolism. However, docking studies using available…”
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Differential protein–protein interactions of full length human FasL and FasL fragments generated by proteolysis by Lettau, Marcus, Voss, Matthias, Ebsen, Henriette, Kabelitz, Dieter, Janssen, Ottmar

“…Fas ligand (FasL) is a death factor of the tumor necrosis factor superfamily. Like other members of this family of type II transmembrane proteins, FasL is subject to ectodomain shedding by a disintegrin and metalloproteinases (ADAMs…”
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Down syndrome candidate region-1 protein interacts with Tollip and positively modulates interleukin-1 receptor-mediated signaling by Lee, Jae Youn, Lee, Hyun Jung, Lee, Eun Jung, Jang, Sung Hee, Kim, Hyeyoung, Yoon, Joo-Heon, Chung, Kwang Chul

“…The Down syndrome candidate region-1 gene ( DSCR1, also known as RCAN1) is situated close to the Down Syndrome Critical Region (DSCR), which contains genes…”
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Interaction of heparin and heparin-derived oligosaccharides with synthetic peptide analogues of the heparin-binding domain of heparin/heparan sulfate-interacting protein by Wang, Jing, Rabenstein, Dallas L.

“…Although protamine is effective as an antidote of heparin, there is a need to replace protamine due to its side effects. HIP peptide has been reported to…”
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