Search Results - "Proteasome Endopeptidase Complex - metabolism"

Ubiquitin signaling and the proteasome drive human DNA–protein crosslink repair by Essawy, Maram, Chesner, Lisa, Alshareef, Duha, Ji, Shaofei, Tretyakova, Natalia, Campbell, Colin

“…Abstract DNA–protein crosslinks (DPCs) are large cytotoxic DNA lesions that form following exposure to chemotherapeutic drugs and environmental chemicals…”
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Ubiquitin-independent proteasomal degradation driven by C-degron pathways by Makaros, Yaara, Raiff, Anat, Timms, Richard T, Wagh, Ajay R, Gueta, Mor Israel, Bekturova, Aizat, Guez-Haddad, Julia, Brodsky, Sagie, Opatowsky, Yarden, Glickman, Michael H, Elledge, Stephen J, Koren, Itay

“… Stability profiling of a genome-wide collection of human open reading frames identified 69 full-length proteins subject to UbInPD…”
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The role of protein clearance mechanisms in organismal ageing and age-related diseases by Vilchez, David, Saez, Isabel, Dillin, Andrew

“…Proteins are subject to continuous and complex quality-control mechanisms, which ensure integrity of the proteome. Vilchez et al…”
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Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.) by Gandhi, Anita K, Kang, Jian, Havens, Courtney G, Conklin, Thomas, Ning, Yuhong, Wu, Lei, Ito, Takumi, Ando, Hideki, Waldman, Michelle F, Thakurta, Anjan, Klippel, Anke, Handa, Hiroshi, Daniel, Thomas O, Schafer, Peter H, Chopra, Rajesh

“…Cereblon (CRBN), the molecular target of lenalidomide and pomalidomide, is a substrate receptor of the cullin ring E3 ubiquitin ligase complex, CRL4(CRBN) . T…”
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Ubiquitin-dependent chloroplast-associated protein degradation in plants by Ling, Qihua, Broad, William, Trösch, Raphael, Töpel, Mats, Demiral Sert, Tijen, Lymperopoulos, Panagiotis, Baldwin, Amy, Jarvis, R Paul

“…Chloroplasts contain thousands of nucleus-encoded proteins that are imported from the cytosol by translocases in the chloroplast envelope membranes…”
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Mechanisms of productive folding and endoplasmic reticulum-associated degradation of glycoproteins and non-glycoproteins by Ninagawa, Satoshi, George, Ginto, Mori, Kazutoshi

“…The quality of proteins destined for the secretory pathway is ensured by two distinct mechanisms in the endoplasmic reticulum (ER): productive folding of newly…”
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Ubiquitin–proteasome pathway and cellular responses to oxidative stress by Shang, Fu, Taylor, Allen

“…The ubiquitin–proteasome pathway (UPP) is the primary cytosolic proteolytic machinery for the selective degradation of various forms of damaged proteins. Thus,…”
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Regulation and Functions of the ER-Associated Nrf1 Transcription Factor by Ruvkun, Gary, Lehrbach, Nicolas

“…) machinery and is subject to rapid proteasomal degradation. When proteasome function is impaired, Nrf1 escapes degradation and undergoes proteolytic cleavage and deglycosylation…”
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The roles of intrinsically disordered proteins in neurodegeneration by Utami, Kagistia Hana, Morimoto, Satoru, Mitsukura, Yasue, Okano, Hideyuki

“…Neurodegenerative diseases such as Amyotrophic Lateral Sclerosis, Alzheimer's disease, Parkinson's disease, and Huntington's disease share a common…”
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Synaptic proteins associated with cognitive performance and neuropathology in older humans revealed by multiplexed fractionated proteomics by Carlyle, Becky C., Kandigian, Savannah E., Kreuzer, Johannes, Das, Sudeshna, Trombetta, Bianca A., Kuo, Yikai, Bennett, David A., Schneider, Julie A., Petyuk, Vladislav A., Kitchen, Robert R., Morris, Robert, Nairn, Angus C., Hyman, Bradley T., Haas, Wilhelm, Arnold, Steven E.

“…•Proteomics linked 123 proteins to AD pathology and cognitive performance•Proteins involved in glucose metabolism are altered in cognitive impairment•Frail…”
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Ubiquitin-like modification dependent proteasomal degradation and disease therapy by Wang, Tiantian, Jiang, Jie, Zhang, Xue, Ke, Xisong, Qu, Yi

“…Many proteins have been identified subject to ubiquitin (Ub)-independent proteasome degradation (UbIPD…”
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Diversity of degradation signals in the ubiquitin–proteasome system by Ravid, Tommer, Hochstrasser, Mark

“…Key Points Substrate proteins that are destined for elimination are initially attached to polymers of the highly conserved ubiquitin protein. This covalent…”
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Diaphragm Muscle Fiber Weakness and Ubiquitin–Proteasome Activation in Critically Ill Patients by Hooijman, Pleuni E., Beishuizen, Albertus, Witt, Christian C., de Waard, Monique C., Girbes, Armand R. J., Spoelstra-de Man, Angelique M. E., Niessen, Hans W. M., Manders, Emmy, van Hees, Hieronymus W. H., van den Brom, Charissa E., Silderhuis, Vera, Lawlor, Michael W., Labeit, Siegfried, Stienen, Ger J. M., Hartemink, Koen J., Paul, Marinus A., Heunks, Leo M. A., Ottenheijm, Coen A. C.

“…The clinical significance of diaphragm weakness in critically ill patients is evident: it prolongs ventilator dependency, and increases morbidity and duration…”
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Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1 by Lehrbach, Nicolas J, Ruvkun, Gary

“… Mammalian Nrf1 is also ER-associated and subject to proteolytic…”
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The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation by Weissman, Allan M., Shabek, Nitzan, Ciechanover, Aaron

“…) are largely responsible for conferring substrate specificity to the ubiquitin–proteasome system (UPS). An increasing number of these ligases are being shown to be subject to self-ubiquitylation…”
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PSMD11 loss-of-function variants correlate with a neurobehavioral phenotype, obesity, and increased interferon response by Deb, Wallid, Rosenfelt, Cory, Vignard, Virginie, Papendorf, Jonas Johannes, Möller, Sophie, Wendlandt, Martin, Studencka-Turski, Maja, Cogné, Benjamin, Besnard, Thomas, Ruffier, Léa, Toutain, Bérénice, Poirier, Léa, Cuinat, Silvestre, Kritzer, Amy, Crunk, Amy, diMonda, Janette, Vengoechea, Jaime, Mercier, Sandra, Kleinendorst, Lotte, van Haelst, Mieke M, Zuurbier, Linda, Sulem, Telma, Katrínardóttir, Hildigunnur, Friðriksdóttir, Rún, Sulem, Patrick, Stefansson, Kari, Jonsdottir, Berglind, Zeidler, Shimriet, Sinnema, Margje, Stegmann, Alexander P A, Naveh, Natali, Skraban, Cara M, Gray, Christopher, Murrell, Jill R, Isikay, Sedat, Pehlivan, Davut, Calame, Daniel G, Posey, Jennifer E, Nizon, Mathilde, McWalter, Kirsty, Lupski, James R, Isidor, Bertrand, Bolduc, François V, Bézieau, Stéphane, Krüger, Elke, Küry, Sébastien, Ebstein, Frédéric

“…Primary proteasomopathies have recently emerged as a new class of rare early-onset neurodevelopmental disorders (NDDs) caused by pathogenic variants in the…”
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The chemical biology of ubiquitin by Burslem, George M.

“…This mini-review will cover the various chemical biology approaches employed to prepare and modulate ubiquitin chains and the ubiquitin-proteasome system…”
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The complexity of recognition of ubiquitinated substrates by the 26S proteasome by Ciechanover, Aaron, Stanhill, Ariel

“…The Ubiquitin Proteasome System (UPS) was discovered in two steps. Initially, APF-1 (ATP-dependent proteolytic Factor 1) later identified as ubiquitin (Ub), a…”
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An ankylosing spondylitis risk variant alters osteoclast differentiation by Wu, Fangyi, Han, Xuling, Liu, Jing, Zhang, Zhenghua, Yan, Kexiang, Wang, Beilan, Yang, Lin, Zou, Hejian, Yang, Chengde, Huang, Wei, Jin, Li, Wang, Jiucun, Qian, Feng, Niu, Zhenmin

“… HLA-B27-positive subjects comprised 90.0% of patients. A nonsynonymous SNP rs12717 in proteasome gene PSMB1 significantly associated…”
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Ethylene-Induced Stabilization of ETHYLENE INSENSITIVE3 and EIN3-LIKE1 Is Mediated by Proteasomal Degradation of EIN3 Binding F-Box 1 and 2 That Requires EIN2 in Arabidopsis by An, Fengying, Zhao, Qiong, Ji, Yusi, Li, Wenyang, Jiang, Zhiqiang, Yu, Xiangchun, Zhang, Chen, Han, Ying, He, Wenrong, Liu, Yidong, Zhang, Shuqun, Ecker, Joseph R., Guo, Hongwei

“…Plant responses to ethylene are mediated by regulation of EBF1/2-dependent degradation of the ETHYLENE INSENSITIVE3 (EIN3) transcription factor. Here, we…”
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