Search Results - "Prostatic Neoplasms - metabolism"

99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen: pharmacokinetics and biodistribution studies in healthy subjects and patients with metastatic prostate cancer by Vallabhajosula, Shankar, Nikolopoulou, Anastasia, Babich, John W, Osborne, Joseph R, Tagawa, Scott T, Lipai, Irina, Solnes, Lilja, Maresca, Kevin P, Armor, Thomas, Joyal, John L, Crummet, Robert, Stubbs, James B, Goldsmith, Stanley J

“… This study reports the first, to our knowledge, human data in men with metastatic PCa and in healthy male subjects…”
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Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming by Mishra, Rajeev, Haldar, Subhash, Placencio, Veronica, Madhav, Anisha, Rohena-Rivera, Krizia, Agarwal, Priyanka, Duong, Frank, Angara, Bryan, Tripathi, Manisha, Liu, Zhenqiu, Gottlieb, Roberta A., Wagner, Shawn, Posadas, Edwin M., Bhowmick, Neil A.

“…Prostate cancer is an androgen-dependent disease subject to interactions between the tumor epithelium and its microenvironment…”
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The Rise of PSMA Ligands for Diagnosis and Therapy of Prostate Cancer by Afshar-Oromieh, Ali, Babich, John W, Kratochwil, Clemens, Giesel, Frederik L, Eisenhut, Michael, Kopka, Klaus, Haberkorn, Uwe

“… Ga-PSMA-11 is currently the subject of multicenter…”
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Clinical validation of an epigenetic assay to predict negative histopathological results in repeat prostate biopsies by Partin, Alan W, Van Neste, Leander, Klein, Eric A, Marks, Leonard S, Gee, Jason R, Troyer, Dean A, Rieger-Christ, Kimberly, Jones, J Stephen, Magi-Galluzzi, Cristina, Mangold, Leslie A, Trock, Bruce J, Lance, Raymond S, Bigley, Joseph W, Van Criekinge, Wim, Epstein, Jonathan I

“… We evaluated the archived, cancer negative prostate biopsy core tissue samples of 350 subjects from a total of 5 urological centers in the United States…”
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Comprehensive evaluation of methods for small extracellular vesicles separation from human plasma, urine and cell culture medium by Dong, Liang, Zieren, Richard C., Horie, Kengo, Kim, Chi‐Ju, Mallick, Emily, Jing, Yuezhou, Feng, Mingxiao, Kuczler, Morgan D., Green, Jordan, Amend, Sarah R., Witwer, Kenneth W., de Reijke, Theo M., Cho, Yoon‐Kyoung, Pienta, Kenneth J., Xue, Wei

“…One of the challenges that restricts the evolving extracellular vesicle (EV) research field is the lack of a consensus method for EV separation. This may also…”
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Systematic identification of regions where DNA methylation is correlated with transcription refines regulatory logic in normal and tumour tissues by Heery, Richard, Schaefer, Martin H

“…Abstract DNA methylation at gene promoters is generally considered to be associated with transcriptional repression in vertebrates. However, lack of a clear…”
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Molecular events in neuroendocrine prostate cancer development by Wang, Yong, Wang, Yu, Ci, Xinpei, Choi, Stephen Y C, Crea, Francesco, Lin, Dong, Wang, Yuzhuo

“…; the disease predominantly develops from adenocarcinoma in response to drug-induced androgen receptor signalling inhibition, although the mechanisms behind this transdifferentiation are a subject of debate…”
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Identification of a biomarker panel for improvement of prostate cancer diagnosis by volatile metabolic profiling of urine by Lima, Ana Rita, Pinto, Joana, Azevedo, Ana Isabel, Barros-Silva, Daniela, Jerónimo, Carmen, Henrique, Rui, de Lourdes Bastos, Maria, Guedes de Pinho, Paula, Carvalho, Márcia

“… Results Results showed that PCa patients ( n  = 40) can be differentiated from cancer-free subjects ( n  = 42…”
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Ultra-high-frequency radio-frequency acoustic molecular imaging with saline nanodroplets in living subjects by Chen, Yun-Sheng, Zhao, Yang, Beinat, Corinne, Zlitni, Aimen, Hsu, En-Chi, Chen, Dong-Hua, Achterberg, Friso, Wang, Hanwei, Stoyanova, Tanya, Dionne, Jennifer, Gambhir, Sanjiv Sam

“…Molecular imaging is a crucial technique in clinical diagnostics but it relies on radioactive tracers or strong magnetic fields that are unsuitable for many…”
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Dietary Fructose Promotes Prostate Cancer Growth by Carreño, Daniela V, Corro, Néstor B, Cerda-Infante, Javier F, Echeverría, Carolina E, Asencio-Barría, Catalina A, Torres-Estay, Verónica A, Mayorga-Weber, Gonzalo A, Rojas, Pablo A, Véliz, Loreto P, Cisternas, Pedro A, Montecinos, Viviana P, San Francisco, Ignacio F, Varas-Godoy, Manuel A, Sotomayor, Paula C, Castro, Maite A, Nualart, Francisco J, Inestrosa, Nibaldo C, Godoy, Alejandro S

“…Clinical localization of primary tumors and sites of metastasis by PET is based on the enhanced cellular uptake of 2-deoxy-2-[ F]-fluoro-D-glucose (FDG). In…”
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Ferroptosis induction, androgen biosynthesis disruption and prostate cancer suppression by androgen and vitamin D combination by Park, Bobae, Khadka, Subash, Ahn, Jungmi, Vaquiz, Jacqueline, Igbekoyi, Okunola, Song, Chung S., Chatterjee, Bandana

“…Prostate cancer regression by hormonal vitamin D3(calcitriol) is clinically untenable despite its well-documented anticancer effects in experimental models,…”
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Blood platelets contain tumor-derived RNA biomarkers by Nilsson, R Jonas A, Balaj, Leonora, Hulleman, Esther, van Rijn, Sjoerd, Pegtel, D Michiel, Walraven, Maudy, Widmark, Anders, Gerritsen, Winald R, Verheul, Henk M, Vandertop, W Peter, Noske, David P, Skog, Johan, Würdinger, Thomas

“… In addition, gene-expression profiling revealed a distinct RNA signature in platelets from glioma patients compared with normal control subjects…”
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Evaluation of prostate cancer antigen 3 for detecting prostate cancer: a systematic review and meta-analysis by Cui, Yong, Cao, Wenzhou, Li, Quan, Shen, Hua, Liu, Chao, Deng, Junpeng, Xu, Jiangfeng, Shao, Qiang

“… A total of 46 clinical trials including 12,295 subjects were included in this meta-analysis…”
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Characterization and Prediction of Organic Anion Transporting Polypeptide 1B Activity in Prostate Cancer Patients on Abiraterone Acetate Using Endogenous Biomarker Coproporphyrin I by Wang, Ziteng, Luk, Kylie Hoi Yan, Cheong, Eleanor Jing Yi, Tham, Sin Mun, Periaswami, Revathi, Toh, Poh Choo, Wang, Ziting, Wu, Qing Hui, Tsang, Woon Chau, Kesavan, Arshvin, Wong, Alvin Seng Cheong, Wong, Patrick Thomas, Lim, Felicia, Chiong, Edmund, Chan, Eric Chun Yong

“…Organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 are important hepatic transporters. We previously identified OATP1B3 being critically implicated…”
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Clinical utility of an epigenetic assay to detect occult prostate cancer in histopathologically negative biopsies: results of the MATLOC study by Stewart, Grant D, Van Neste, Leander, Delvenne, Philippe, Delrée, Paul, Delga, Agnès, McNeill, S Alan, O'Donnell, Marie, Clark, James, Van Criekinge, Wim, Bigley, Joseph, Harrison, David J

“… The MATLOC study blindly tested archived prostate biopsy needle core tissue samples of 498 subjects from the United Kingdom and Belgium with histopathologically negative prostate biopsies, followed by positive (cases) or negative (controls…”
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Urinary-exosomal miR-2909: A novel pathognomonic trait of prostate cancer severity by Wani, S., Kaul, D., Mavuduru, R.S., Kakkar, N., Bhatia, A.

“…•Urinary exosomal-miR-2909 recruitment distinguishes Prostate from Bladder cancer.•Urinary exosomal-miR2909 level correlates with the severity of Prostate…”
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CircBIRC6 affects prostate cancer progression by regulating miR-574-5p and DNAJB1 by Zhao, Bin, Yang, Jinye, Ran, Fengming, Shi, Yuanlong, Yang, Libo, Duan, Yuanpeng, Shi, Zhiyu, Li, Xin, Zhang, Jianpeng, Li, Zhiyao, Wang, Jiansong

“…) is routinely tested, it has disadvantages, such as poor prognostic ability. Therefore, finding more PCa markers and therapeutic targets remains a subject of study…”
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Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay by Park, Jung Wook, Lee, John K, Phillips, John W, Huang, Patrick, Cheng, Donghui, Huang, Jiaoti, Witte, Owen N

“…The cell of origin for prostate cancer remains a subject of debate. Genetically engineered mouse models have demonstrated that both basal and luminal cells can serve as cells of origin for prostate cancer…”
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Selective neutralization of IL-12 p40 monomer induces death in prostate cancer cells via IL-12-IFN-γ by Kundu, Madhuchhanda, Roy, Avik, Pahan, Kalipada

“… Similarly, the serum level of p40 was much greater in patients with prostate cancer than in healthy control subjects…”
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Drugging the undruggable: activity-based protein profiling offers opportunities for targeting the KLK activome by Lee, Kristi Y., Chau, Cindy H., Price, Douglas K., Figg, William D.

“…) was subject to ABPP to elucidate enzymatic activities in the presence…”
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