Search Results - "Proceedings of the National Academy of Sciences - PNAS"

Catalytic amino acid production from biomass-derived intermediates by Deng, Weiping, Wang, Yunzhu, Zhang, Sui, Gupta, Krishna M, Hülsey, Max J, Asakura, Hiroyuki, Liu, Lingmei, Han, Yu, Karp, Eric M, Beckham, Gregg T, Dyson, Paul J, Jiang, Jianwen, Tanaka, Tsunehiro, Wang, Ye, Yan, Ning

“…Amino acids are the building blocks for protein biosynthesis and find use in myriad industrial applications including in food for humans, in animal feed, and…”
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Field-induced superconducting phase of FeSe in the BCS-BEC cross-over by Kasahara, Shigeru, Watashige, Tatsuya, Hanaguri, Tetsuo, Kohsaka, Yuhki, Yamashita, Takuya, Shimoyama, Yusuke, Mizukami, Yuta, Endo, Ryota, Ikeda, Hiroaki, Aoyama, Kazushi, Terashima, Taichi, Uji, Shinya, Wolf, Thomas, von Löhneysen, Hilbert, Shibauchi, Takasada, Matsuda, Yuji

“…Fermi systems in the cross-over regime between weakly coupled Bardeen-Cooper-Schrieffer (BCS) and strongly coupled Bose-Einstein-condensate (BEC) limits are…”
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Designing toughness and strength for soft materials by Zhao, Xuanhe

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Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells by Mahgoub, Mohamed, Yasunaga, Jun-Ichirou, Iwami, Shingo, Nakaoka, Shinji, Koizumi, Yoshiki, Shimura, Kazuya, Matsuoka, Masao

“…Viruses causing chronic infection artfully manipulate infected cells to enable viral persistence in vivo under the pressure of immunity. Human T-cell leukemia…”
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A carlactonoic acid methyltransferase that contributes to the inhibition of shoot branching in Arabidopsis by Mashiguchi, Kiyoshi, Seto, Yoshiya, Onozuka, Yuta, Suzuki, Sarina, Takemoto, Kiyoko, Wang, Yanting, Dong, Lemeng, Asami, Kei, Noda, Ryota, Kisugi, Takaya, Kitaoka, Naoki, Akiyama, Kohki, Bouwmeester, Harro, Yamaguchi, Shinjiro

“…SignificanceStrigolactones (SLs) are a group of apocarotenoid hormones, which regulates shoot branching and other diverse developmental processes in plants…”
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Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation by Mikami, Norihisa, Kawakami, Ryoji, Chen, Kelvin Y, Sugimoto, Atsushi, Ohkura, Naganari, Sakaguchi, Shimon

“…Foxp3-expressing regulatory T cells (Tregs) can be generated in vitro by antigenic stimulation of conventional T cells (Tconvs) in the presence of TGF-β and…”
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Nitrate is an important nitrogen source for Arctic tundra plants by Liu, Xue-Yan, Koba, Keisuke, Koyama, Lina A, Hobbie, Sarah E, Weiss, Marissa S, Inagaki, Yoshiyuki, Shaver, Gaius R, Giblin, Anne E, Hobara, Satoru, Nadelhoffer, Knute J, Sommerkorn, Martin, Rastetter, Edward B, Kling, George W, Laundre, James A, Yano, Yuriko, Makabe, Akiko, Yano, Midori, Liu, Cong-Qiang

“…Plant nitrogen (N) use is a key component of the N cycle in terrestrial ecosystems. The supply of N to plants affects community species composition and…”
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Country-level gender inequality is associated with structural differences in the brains of women and men by Zugman, André, Alliende, Luz María, Medel, Vicente, Bethlehem, Richard A I, Seidlitz, Jakob, Ringlein, Grace, Arango, Celso, Arnatkevičiūtė, Aurina, Asmal, Laila, Bellgrove, Mark, Benegal, Vivek, Bernardo, Miquel, Billeke, Pablo, Bosch-Bayard, Jorge, Bressan, Rodrigo, Busatto, Geraldo F, Castro, Mariana N, Chaim-Avancini, Tiffany, Compte, Albert, Costanzi, Monise, Czepielewski, Leticia, Dazzan, Paola, de la Fuente-Sandoval, Camilo, Di Forti, Marta, Díaz-Caneja, Covadonga M, María Díaz-Zuluaga, Ana, Du Plessis, Stefan, Duran, Fabio L S, Fittipaldi, Sol, Fornito, Alex, Freimer, Nelson B, Gadelha, Ary, Gama, Clarissa S, Garani, Ranjini, Garcia-Rizo, Clemente, Gonzalez Campo, Cecilia, Gonzalez-Valderrama, Alfonso, Guinjoan, Salvador, Holla, Bharath, Ibañez, Agustín, Ivanovic, Daniza, Jackowski, Andrea, Leon-Ortiz, Pablo, Lochner, Christine, López-Jaramillo, Carlos, Luckhoff, Hilmar, Massuda, Raffael, McGuire, Philip, Miyata, Jun, Mizrahi, Romina, Murray, Robin, Ozerdem, Aysegul, Pan, Pedro M, Parellada, Mara, Phahladira, Lebogan, Ramirez-Mahaluf, Juan P, Reckziegel, Ramiro, Reis Marques, Tiago, Reyes-Madrigal, Francisco, Roos, Annerine, Rosa, Pedro, Salum, Giovanni, Scheffler, Freda, Schumann, Gunter, Serpa, Mauricio, Stein, Dan J, Tepper, Angeles, Tiego, Jeggan, Ueno, Tsukasa, Undurraga, Juan, Undurraga, Eduardo A, Valdes-Sosa, Pedro, Valli, Isabel, Villarreal, Mirta, Winton-Brown, Toby T, Yalin, Nefize, Zamorano, Francisco, Zanetti, Marcus V, Winkler, Anderson M, Pine, Daniel S, Evans-Lacko, Sara, Crossley, Nicolas A

“…Gender inequality across the world has been associated with a higher risk to mental health problems and lower academic achievement in women compared to men. We…”
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Aging-associated and CD4 T-cell-dependent ectopic CXCL13 activation predisposes to anti-PD-1 therapy-induced adverse events by Tsukamoto, Hirotake, Komohara, Yoshihiro, Tomita, Yusuke, Miura, Yuji, Motoshima, Takanobu, Imamura, Kosuke, Kimura, Toshiki, Ikeda, Tokunori, Fujiwara, Yukio, Yano, Hiromu, Kamba, Tomomi, Sakagami, Takuro, Oshiumi, Hiroyuki

“…Clinical success of immune-checkpoint blockade (ICB) cancer immunotherapy is compromised by increased risk of immune-related adverse events (irAEs). However,…”
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CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch by Narasimamurthy, Rajesh, Hunt, Sabrina R, Lu, Yining, Fustin, Jean-Michel, Okamura, Hitoshi, Partch, Carrie L, Forger, Daniel B, Kim, Jae Kyoung, Virshup, David M

“…Multisite phosphorylation of the PERIOD 2 (PER2) protein is the key step that determines the period of the mammalian circadian clock. Previous studies…”
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LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention by Fukata, Yuko, Chen, Xiumin, Chiken, Satomi, Hirano, Yoko, Yamagata, Atsushi, Inahashi, Hiroki, Sanbo, Makoto, Sano, Hiromi, Goto, Teppei, Hirabayashi, Masumi, Kornau, Hans-Christian, Prüss, Harald, Nambu, Atsushi, Fukai, Shuya, Nicoll, Roger A, Fukata, Masaki

“…Physiological functioning and homeostasis of the brain rely on finely tuned synaptic transmission, which involves nanoscale alignment between presynaptic…”
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Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model by Zhang, Baihao, Chikuma, Shunsuke, Hori, Shohei, Fagarasan, Sidonia, Honjo, Tasuku

“…PD-1 (programmed-death 1), an immune-inhibitory receptor required for immune self-tolerance whose deficiency causes autoimmunity with variable severity and…”
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Early 20th-century Arctic warming intensified by Pacific and Atlantic multidecadal variability by Tokinaga, Hiroki, Xie, Shang-Ping, Mukougawa, Hitoshi

“…With amplified warming and record sea ice loss, the Arctic is the canary of global warming. The historical Arctic warming is poorly understood, limiting our…”
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Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock by Uehara, Takahiro N, Mizutani, Yoshiyuki, Kuwata, Keiko, Hirota, Tsuyoshi, Sato, Ayato, Mizoi, Junya, Takao, Saori, Matsuo, Hiromi, Suzuki, Takamasa, Ito, Shogo, Saito, Ami N, Nishiwaki-Ohkawa, Taeko, Yamaguchi-Shinozaki, Kazuko, Yoshimura, Takashi, Kay, Steve A, Itami, Kenichiro, Kinoshita, Toshinori, Yamaguchi, Junichiro, Nakamichi, Norihito

“…The circadian clock provides organisms with the ability to adapt to daily and seasonal cycles. Eukaryotic clocks mostly rely on lineage-specific…”
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A genetically linked pair of NLR immune receptors shows contrasting patterns of evolution by Shimizu, Motoki, Hirabuchi, Akiko, Sugihara, Yu, Abe, Akira, Takeda, Takumi, Kobayashi, Michie, Hiraka, Yukie, Kanzaki, Eiko, Oikawa, Kaori, Saitoh, Hiromasa, Langner, Thorsten, Banfield, Mark J, Kamoun, Sophien, Terauchi, Ryohei

“…Throughout their evolution, plant nucleotide-binding leucine-rich-repeat receptors (NLRs) have acquired widely divergent unconventional integrated domains that…”
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Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility by Kameda, Masahiro, Teruya, Takayuki, Yanagida, Mitsuhiro, Kondoh, Hiroshi

“…As human society ages globally, age-related disorders are becoming increasingly common. Due to decreasing physiological reserves and increasing organ system…”
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A blast fungus zinc-finger fold effector binds to a hydrophobic pocket in host Exo70 proteins to modulate immune recognition in rice by De la Concepcion, Juan Carlos, Fujisaki, Koki, Bentham, Adam R, Cruz Mireles, Neftaly, Sanchez de Medina Hernandez, Victor, Shimizu, Motoki, Lawson, David M, Kamoun, Sophien, Terauchi, Ryohei, Banfield, Mark J

“…Exocytosis plays an important role in plant-microbe interactions, in both pathogenesis and symbiosis. Exo70 proteins are integral components of the exocyst, an…”
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Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway by Nakano-Kobayashi, Akiko, Canela, Andres, Yoshihara, Toru, Hagiwara, Masatoshi

“…Neuroinflammation is a common feature of neurodegenerative disorders such as Alzheimer's disease (AD). Neuroinflammation is induced by dysregulated glial…”
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ALS mutations in the TIA-1 prion-like domain trigger highly condensed pathogenic structures by Sekiyama, Naotaka, Takaba, Kiyofumi, Maki-Yonekura, Saori, Akagi, Ken-Ichi, Ohtani, Yasuko, Imamura, Kayo, Terakawa, Tsuyoshi, Yamashita, Keitaro, Inaoka, Daigo, Yonekura, Koji, Kodama, Takashi S, Tochio, Hidehito

“…T cell intracellular antigen-1 (TIA-1) plays a central role in stress granule (SG) formation by self-assembly via the prion-like domain (PLD). In the TIA-1…”
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Geometric trade-off between contractile force and viscous drag determines the actomyosin-based motility of a cell-sized droplet by Sakamoto, Ryota, Izri, Ziane, Shimamoto, Yuta, Miyazaki, Makito, Maeda, Yusuke T

“…Cell migration in confined environments is fundamental for diverse biological processes from cancer invasion to leukocyte trafficking. The cell body is…”
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