Suchergebnisse - "Prevo, Remko"

Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress von Herbert, Katharine J, Puliyadi, Rathi, Prevo, Remko, Rodriguez-Berriguete, Gonzalo, Ryan, Anderson, Ramadan, Kristijan, Higgins, Geoff S

“… T-LAK-originated protein kinase (TOPK) overexpression is a feature of multiple cancers, yet is absent from most phenotypically normal tissues. As such, TOPK …”
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CDK1 inhibition sensitizes normal cells to DNA damage in a cell cycle dependent manner von Prevo, Remko, Pirovano, Giacomo, Puliyadi, Rathi, Herbert, Katharine J., Rodriguez-Berriguete, Gonzalo, O'Docherty, Alice, Greaves, William, McKenna, W. Gillies, Higgins, Geoff S.

“… Cyclin-dependent kinase 1 (CDK1) orchestrates the transition from the G2 phase into mitosis and as cancer cells often display enhanced CDK1 activity, it has …”
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The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy von Prevo, Remko, Fokas, Emmanouil, Reaper, Philip M., Charlton, Peter A., Pollard, John R., McKenna, W. Gillies, Muschel, Ruth J., Brunner, Thomas B.

“… DNA damaging agents such as radiotherapy and gemcitabine are frequently used for the treatment of pancreatic cancer. However, these treatments typically …”
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Antitumour effect of the mitochondrial complex III inhibitor Atovaquone in combination with anti-PD-L1 therapy in mouse cancer models von Rodriguez-Berriguete, Gonzalo, Puliyadi, Rathi, Machado, Nicole, Barberis, Alessandro, Prevo, Remko, McLaughlin, Martin, Buffa, Francesca M., Harrington, Kevin J., Higgins, Geoff S.

“… Immune checkpoint blockade (ICB) provides effective and durable responses for several tumour types by unleashing an immune response directed against cancer …”
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Inflammation-induced uptake and degradation of the lymphatic endothelial hyaluronan receptor LYVE-1 von Johnson, Louise A, Prevo, Remko, Clasper, Steven, Jackson, David G

“… The hyaluronan receptor LYVE-1 is selectively expressed in the endothelium of lymphatic capillaries, where it has been proposed to function in hyaluronan …”
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A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown von Higgins, Geoff S, Prevo, Remko, Lee, Yin-Fai, Helleday, Thomas, Muschel, Ruth J, Taylor, Steve, Yoshimura, Michio, Hickson, Ian D, Bernhard, Eric J, McKenna, W Gillies

“… The effectiveness of radiotherapy treatment could be significantly improved if tumor cells could be rendered more sensitive to ionizing radiation (IR) without …”
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The anti-malarial drug atovaquone potentiates platinum-mediated cancer cell death by increasing oxidative stress von Coates, James T. T., Rodriguez-Berriguete, Gonzalo, Puliyadi, Rathi, Ashton, Thomas, Prevo, Remko, Wing, Archie, Granata, Giovanna, Pirovano, Giacomo, McKenna, Gillies W., Higgins, Geoff S.

“… Platinum chemotherapies are highly effective cytotoxic agents but often induce resistance when used as monotherapies. Combinatorial strategies limit this risk …”
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NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity von Fokas, Emmanouil, Yoshimura, Michio, Prevo, Remko, Higgins, Geoff, Hackl, Wolfgang, Maira, Sauveur-Michel, Bernhard, Eric J, McKenna, WGillies, Muschel, Ruth J

“… Background The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is activated in tumor cells and promotes tumor cell survival after radiation-induced DNA …”
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Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1 von Gale, Nicholas W, Prevo, Remko, Espinosa, Jorge, Ferguson, David J, Dominguez, Melissa G, Yancopoulos, George D, Thurston, Gavin, Jackson, David G

“… The hyaluronan receptor LYVE-1 is expressed abundantly on the surfaces of lymphatic vessels and lymph node sinus endothelial cells from early development, …”
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Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis von Skobe, Mihaela, Hawighorst, Thomas, Jackson, David G., Prevo, Remko, Janes, Lauren, Velasco, Paula, Riccardi, Lucia, Alitalo, Kari, Claffey, Kevin, Detmar, Michael

“… Metastasis of breast cancer occurs primarily through the lymphatic system, and the extent of lymph node involvement is a key prognostic factor for the disease …”
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Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine inhibitor PI-103 enhances tumor radiosensitivity von Prevo, Remko, Deutsch, Eric, Sampson, Oliver, Diplexcito, Julie, Cengel, Keith, Harper, Jane, O'Neill, Peter, McKenna, W Gillies, Patel, Sonal, Bernhard, Eric J

“… Cell signaling initiated at the epidermal growth factor receptor (EGFR), RAS oncoproteins, or PI3K contributes to a common pathway that promotes tumor survival …”
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Overexpression of POLQ confers a poor prognosis in early breast cancer patients von Higgins, Geoff S, Harris, Adrian L, Prevo, Remko, Helleday, Thomas, McKenna, W Gillies, Buffa, Francesca M

“… Depletion of POLQ (DNA polymerase theta) has recently been shown to render tumour cells more sensitive to radiotherapy whilst having little or no effect on …”
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VEGF-D promotes the metastatic spread of tumor cells via the lymphatics von Stacker, Steven A., Caesar, Carol, Baldwin, Megan E., Thornton, Gillian E., Williams, Richard A., Prevo, Remko, Jackson, David G., Nishikawa, Shin-ichi, Kubo, Hajime, Achen, Marc G.

“… Metastasis to local lymph nodes via the lymphatic vessels is a common step in the spread of solid tumors. To investigate the molecular mechanisms underlying …”
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Mouse LYVE-1 is an endocytic receptor for hyaluronan in lymphatic endothelium von Prevo, R, Banerji, S, Ferguson, D J, Clasper, S, Jackson, D G

“… The glycosaminoglycan hyaluronan is a key substrate for cell migration in tissues during inflammation, wound healing, and neoplasia. Unlike other matrix …”
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LYVE-1, the lymphatic system and tumor lymphangiogenesis von Jackson, David G, Prevo, Remko, Clasper, Steven, Banerji, Suneale

“… Previous research into hyaluronan (HA) has focused on the role of this abundant tissue glycosaminoglycan in promoting cell migration through interactions with …”
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Depletion of signal recognition particle 72kDa increases radiosensitivity von Prevo, Remko, Tiwana, Gaganpreet S., Maughan, Timothy S., Buffa, Francesca M., McKenna, W. Gillies, Higgins, Geoff S.

“… The identification of genetic determinants that underpin tumor radioresistance can help the development of targeted radiosensitizers or aid personalization of …”
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Automated 96-well format high throughput colony formation assay for siRNA library screen von Hatch, Stephanie B., Prevo, Remko, Chan, Tiffany, Millar, Val, Cornelissen, Bart, Higgins, Geoff, Ebner, Daniel

“… The colony formation assay is the gold-standard technique to assess cell viability after treatment with cytotoxic reagents, ionizing radiation, and cytotoxic …”
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Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen von Tiwana, Gaganpreet S, Prevo, Remko, Buffa, Francesca M, Yu, Sheng, Ebner, Daniel V, Howarth, Alison, Folkes, Lisa K, Budwal, Balam, Chu, Kwun-Ye, Durrant, Lisa, Muschel, Ruth J, McKenna, W Gillies, Higgins, Geoff S

“… Colony formation is the gold standard assay for determining reproductive cell death after radiation treatment, since effects on proliferation often do not …”
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Absence of lymphangiogenesis and intratumoural lymph vessels in human metastatic breast cancer von Williams, Cory SM, Leek, Russell D, Robson, Alistair M, Banerji, Suneale, Prevo, Remko, Harris, Adrian L, Jackson, David G

“… Early metastasis to lymph nodes is a frequent complication in human breast cancer. However, the extent to which this depends on lymphangiogenesis or on …”
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Rapid plasma membrane-endosomal trafficking of the lymph node sinus and high endothelial venule scavenger receptor/homing receptor stabilin-1 (FEEL-1/CLEVER-1) von Prevo, Remko, Banerji, Suneale, Ni, Jian, Jackson, David G

“… The sinusoidal endothelia of liver, spleen, and lymph node are major sites for uptake and recycling of waste macromolecules through promiscuous binding to a …”
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