Výsledky vyhľadávania - "Pradeep, Sunila"

MYC Targeted Long Noncoding RNA DANCR Promotes Cancer in Part by Reducing p21 Levels Autor Lu, Yunqi, Hu, Zhongyi, Mangala, Lingegowda S, Stine, Zachary E, Hu, Xiaowen, Jiang, Dahai, Xiang, Yan, Zhang, Youyou, Pradeep, Sunila, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, DeMarzo, Angelo M, Sood, Anil K, Zhang, Lin, Dang, Chi V

“…The MYC oncogene broadly promotes transcription mediated by all nuclear RNA polymerases, thereby acting as a positive modifier of global gene expression. Here,…”
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From Gut to Hormones: Unraveling the Role of Gut Microbiota in (Phyto)Estrogen Modulation in Health and Disease Autor Kumari, Nikki, Kumari, Rashmi, Dua, Ankita, Singh, Mona, Kumar, Roushan, Singh, Poonam, Duyar‐Ayerdi, Susan, Pradeep, Sunila, Ojesina, Akinyemi I., Kumar, Roshan

“…The human gut microbiota regulates estrogen metabolism through the “estrobolome,” the collection of bacterial genes that encode enzymes like β‐glucuronidases…”
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Macrophages Facilitate Resistance to Anti-VEGF Therapy by Altered VEGFR Expression Autor Dalton, Heather J, Pradeep, Sunila, McGuire, Michael, Hailemichael, Yared, Ma, Shaolin, Lyons, Yasmin, Armaiz-Pena, Guillermo N, Previs, Rebecca A, Hansen, Jean Marie, Rupaimoole, Rajesha, Gonzalez-Villasana, Vianey, Cho, Min Soon, Wu, Sherry Y, Mangala, Lingegowda S, Jennings, Nicholas B, Hu, Wei, Langley, Robert, Mu, Hong, Andreeff, Michael, Bar-Eli, Menashe, Overwijk, Willem, Ram, Prahlad, Lopez-Berestein, Gabriel, Coleman, Robert L, Sood, Anil K

“…VEGF-targeted therapies have modest efficacy in cancer patients, but acquired resistance is common. The mechanisms underlying such resistance are poorly…”
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Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth Autor Yang, Lifeng, Achreja, Abhinav, Yeung, Tsz-Lun, Mangala, Lingegowda S, Jiang, Dahai, Han, Cecil, Baddour, Joelle, Marini, Juan C, Ni, Joseph, Nakahara, Ryuichi, Wahlig, Stephen, Chiba, Lisa, Kim, Sun Hye, Morse, Joshua, Pradeep, Sunila, Nagaraja, Archana Sidalaghatta, Haemmerle, Monika, Kyunghee, Noh, Derichsweiler, Mathew, Plackemeier, Thomas, Mercado-Uribe, Imelda, Lopez-Berestein, Gabriel, Moss, Tyler, Ram, Prahlad T, Liu, Jinsong, Lu, Xiongbin, Mok, Samuel C, Sood, Anil K, Nagrath, Deepak

“…Reactive stromal cells are an integral part of tumor microenvironment (TME) and interact with cancer cells to regulate their growth. Although targeting stromal…”
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Role of Platelet-Derived Tgfβ1 in the Progression of Ovarian Cancer Autor Hu, Qianghua, Hisamatsu, Takeshi, Haemmerle, Monika, Cho, Min Soon, Pradeep, Sunila, Rupaimoole, Rajesha, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Wong, Stephen T C, Sood, Anil K, Afshar-Kharghan, Vahid

“…Transforming growth factor β1 (Tgfβ1) plays an important role in cancer. Most of Tgfβ1 in plasma is from platelets; thus, we studied whether platelet Tgfβ1 has…”
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FABP4 as a key determinant of metastatic potential of ovarian cancer Autor Gharpure, Kshipra M., Pradeep, Sunila, Sans, Marta, Rupaimoole, Rajesha, Ivan, Cristina, Wu, Sherry Y., Bayraktar, Emine, Nagaraja, Archana S., Mangala, Lingegowda S., Zhang, Xinna, Haemmerle, Monika, Hu, Wei, Rodriguez-Aguayo, Cristian, McGuire, Michael, Mak, Celia Sze Ling, Chen, Xiuhui, Tran, Michelle A., Villar-Prados, Alejandro, Pena, Guillermo Armaiz, Kondetimmanahalli, Ragini, Nini, Ryan, Koppula, Pranavi, Ram, Prahlad, Liu, Jinsong, Lopez-Berestein, Gabriel, Baggerly, Keith, S. Eberlin, Livia, Sood, Anil K.

“…The standard treatment for high-grade serous ovarian cancer is primary debulking surgery followed by chemotherapy. The extent of metastasis and invasive…”
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Platelets reduce anoikis and promote metastasis by activating YAP1 signaling Autor Haemmerle, Monika, Taylor, Morgan L., Gutschner, Tony, Pradeep, Sunila, Cho, Min Soon, Sheng, Jianting, Lyons, Yasmin M., Nagaraja, Archana S., Dood, Robert L., Wen, Yunfei, Mangala, Lingegowda S., Hansen, Jean M., Rupaimoole, Rajesha, Gharpure, Kshipra M., Rodriguez-Aguayo, Cristian, Yim, Sun Young, Lee, Ju-Seog, Ivan, Cristina, Hu, Wei, Lopez-Berestein, Gabriel, Wong, Stephen T., Karlan, Beth Y., Levine, Douglas A., Liu, Jinsong, Afshar-Kharghan, Vahid, Sood, Anil K.

“…Thrombocytosis is present in more than 30% of patients with solid malignancies and correlates with worsened patient survival. Tumor cell interaction with…”
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Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth Autor Geethadevi, Anjali, Nair, Ajay, Parashar, Deepak, Ku, Zhiqiang, Xiong, Wei, Deng, Hui, Li, Yongsheng, George, Jasmine, McAllister, Donna M, Sun, Yunguang, Kadamberi, Ishaque P, Gupta, Prachi, Dwinell, Michael B, Bradley, William H, Rader, Janet S, Rui, Hallgeir, Schwabe, Robert F, Zhang, Ningyan, Pradeep, Sunila, An, Zhiqiang, Chaluvally-Raghavan, Pradeep

“…Although patients with advanced ovarian cancer may respond initially to treatment, disease relapse is common, and nearly 50% of patients do not survive beyond…”
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The hidden role of paxillin: localization to nucleus promotes tumor angiogenesis Autor Noh, Kyunghee, Bach, Duc-Hiep, Choi, Hyun-Jin, Kim, Mark S., Wu, Sherry Y., Pradeep, Sunila, Ivan, Cristina, Cho, Min-Soon, Bayraktar, Emine, Rodriguez-Aguayo, Cristian, Dasari, Santosh K., Stur, Elaine, Mangala, Lingegowda S., Lopez-Berestein, Gabriel, Sood, Anil K.

“…Paxillin (PXN), a key component of the focal adhesion complex, has been associated with cancer progression, but the underlying mechanisms are poorly…”
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ERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis Autor Chen, Changliang, Gupta, Prachi, Parashar, Deepak, Nair, Gopakumar G, George, Jasmine, Geethadevi, Anjali, Wang, Wei, Tsaih, Shirng-Wern, Bradley, William, Ramchandran, Ramani, Rader, Janet S, Chaluvally-Raghavan, Pradeep, Pradeep, Sunila

“…High-grade serous carcinoma, accounts for up to 70% of all ovarian cases. Furin, a proprotein convertase, is highly expressed in high-grade serous carcinoma of…”
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Metabolic Reprogramming in Tumor-Associated Macrophages in the Ovarian Tumor Microenvironment Autor Kumar, Sudhir, Mittal, Sonam, Gupta, Prachi, Singh, Mona, Chaluvally-Raghavan, Pradeep, Pradeep, Sunila

“…The interaction between tumor cells and macrophages in the tumor microenvironment plays an essential role in metabolic changes in macrophages and reprograms…”
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A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis Autor Masiero, Massimo, Simões, Filipa Costa, Han, Hee Dong, Snell, Cameron, Peterkin, Tessa, Bridges, Esther, Mangala, Lingegowda S, Wu, Sherry Yen-Yao, Pradeep, Sunila, Li, Demin, Han, Cheng, Dalton, Heather, Lopez-Berestein, Gabriel, Tuynman, Jurriaan B, Mortensen, Neil, Li, Ji-Liang, Patient, Roger, Sood, Anil K, Banham, Alison H, Harris, Adrian L, Buffa, Francesca M

“…Limited clinical benefits derived from anti-VEGF therapy have driven the identification of new targets involved in tumor angiogenesis. Here, we report an…”
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Overcoming adaptive resistance to anti-VEGF therapy by targeting CD5L Autor LaFargue, Christopher J., Amero, Paola, Noh, Kyunghee, Mangala, Lingegowda S., Wen, Yunfei, Bayraktar, Emine, Umamaheswaran, Sujanitha, Stur, Elaine, Dasari, Santosh K., Ivan, Cristina, Pradeep, Sunila, Yoo, Wonbeak, Lu, Chunhua, Jennings, Nicholas B., Vathipadiekal, Vinod, Hu, Wei, Chelariu-Raicu, Anca, Ku, Zhiqiang, Deng, Hui, Xiong, Wei, Choi, Hyun-Jin, Hu, Min, Kiyama, Takae, Mao, Chai-An, Ali-Fehmi, Rouba, Birrer, Michael J., Liu, Jinsong, Zhang, Ningyan, Lopez-Berestein, Gabriel, de Franciscis, Vittorio, An, Zhiqiang, Sood, Anil K.

“…Antiangiogenic treatment targeting the vascular endothelial growth factor (VEGF) pathway is a powerful tool to combat tumor growth and progression; however,…”
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Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer Autor Kang, Yu, Hu, Wei, Ivan, Cristina, Dalton, Heather J, Miyake, Takahito, Pecot, Chad V, Zand, Behrouz, Liu, Tao, Huang, Jie, Jennings, Nicholas B, Rupaimoole, Rajesha, Taylor, Morgan, Pradeep, Sunila, Wu, Sherry Y, Lu, Chunhua, Wen, Yunfei, Huang, Jianfei, Liu, Jinsong, Sood, Anil K

“…We previously found focal adhesion kinase (FAK) inhibition sensitizes ovarian cancer to taxanes; however, the mechanisms are not well understood. We…”
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RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site Autor George, Jasmine, Li, Yongsheng, Kadamberi, Ishaque P., Parashar, Deepak, Tsaih, Shirng-Wern, Gupta, Prachi, Geethadevi, Anjali, Chen, Changliang, Ghosh, Chandrima, Sun, Yunguang, Mittal, Sonam, Ramchandran, Ramani, Rui, Hallgeir, Lopez-Berestein, Gabriel, Rodriguez-Aguayo, Cristian, Leone, Gustavo, Rader, Janet S., Sood, Anil K., Dey, Madhusudan, Pradeep, Sunila, Chaluvally-Raghavan, Pradeep

“…Fragile X-related protein-1 (FXR1) gene is highly amplified in patients with ovarian cancer, and this amplification is associated with increased expression of…”
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Peritoneal Spread of Ovarian Cancer Harbors Therapeutic Vulnerabilities Regulated by FOXM1 and EGFR/ERBB2 Signaling Autor Parashar, Deepak, Nair, Bindu, Geethadevi, Anjali, George, Jasmine, Nair, Ajay, Tsaih, Shirng-Wern, Kadamberi, Ishaque P, Gopinadhan Nair, Gopa Kumar, Lu, Yiling, Ramchandran, Ramani, Uyar, Denise S, Rader, Janet S, Ram, Prahlad T, Mills, Gordon B, Pradeep, Sunila, Chaluvally-Raghavan, Pradeep

“…Peritoneal spread is the primary mechanism of metastasis of ovarian cancer, and survival of ovarian cancer cells in the peritoneal cavity as nonadherent…”
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Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression Autor Rupaimoole, Rajesha, Wu, Sherry Y., Pradeep, Sunila, Ivan, Cristina, Pecot, Chad V., Gharpure, Kshipra M., Nagaraja, Archana S., Armaiz-Pena, Guillermo N., McGuire, Michael, Zand, Behrouz, Dalton, Heather J., Filant, Justyna, Miller, Justin Bottsford, Lu, Chunhua, Sadaoui, Nouara C., Mangala, Lingegowda S., Taylor, Morgan, van den Beucken, Twan, Koch, Elizabeth, Rodriguez-Aguayo, Cristian, Huang, Li, Bar-Eli, Menashe, Wouters, Bradly G., Radovich, Milan, Ivan, Mircea, Calin, George A., Zhang, Wei, Lopez-Berestein, Gabriel, Sood, Anil K.

“…Cancer-related deregulation of miRNA biogenesis has been suggested, but the underlying mechanisms remain elusive. Here we report a previously unrecognized…”
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Targeting c-MYC in Platinum-Resistant Ovarian Cancer Autor Reyes-González, Jeyshka M, Armaiz-Peña, Guillermo N, Mangala, Lingegowda S, Valiyeva, Fatma, Ivan, Cristina, Pradeep, Sunila, Echevarría-Vargas, Ileabett M, Rivera-Reyes, Adrian, Sood, Anil K, Vivas-Mejía, Pablo E

“…The purpose of this study was to investigate the molecular and therapeutic effects of siRNA-mediated c-MYC silencing in cisplatin-resistant ovarian cancer…”
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Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction Autor Allen, Julie K, Armaiz-Pena, Guillermo N, Nagaraja, Archana S, Sadaoui, Nouara C, Ortiz, Tatiana, Dood, Robert, Ozcan, Merve, Herder, Danielle M, Haemmerle, Monika, Gharpure, Kshipra M, Rupaimoole, Rajesha, Previs, Rebecca A, Wu, Sherry Y, Pradeep, Sunila, Xu, Xiaoyun, Han, Hee Dong, Zand, Behrouz, Dalton, Heather J, Taylor, Morgan, Hu, Wei, Bottsford-Miller, Justin, Moreno-Smith, Myrthala, Kang, Yu, Mangala, Lingegowda S, Rodriguez-Aguayo, Cristian, Sehgal, Vasudha, Spaeth, Erika L, Ram, Prahlad T, Wong, Stephen T C, Marini, Frank C, Lopez-Berestein, Gabriel, Cole, Steve W, Lutgendorf, Susan K, De Biasi, Mariella, Sood, Anil K

“…Mounting clinical and preclinical evidence supports a key role for sustained adrenergic signaling in the tumor microenvironment as a driver of tumor growth and…”
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Autocrine Effects of Tumor-Derived Complement Autor Cho, Min Soon, Vasquez, Hernan G., Rupaimoole, Rajesha, Pradeep, Sunila, Wu, Sherry, Zand, Behrouz, Han, Hee-Dong, Rodriguez-Aguayo, Cristian, Bottsford-Miller, Justin, Huang, Jie, Miyake, Takahito, Choi, Hyun-Jin, Dalton, Heather J., Ivan, Cristina, Baggerly, Keith, Lopez-Berestein, Gabriel, Sood, Anil K., Afshar-Kharghan, Vahid

“…We describe a role for the complement system in enhancing cancer growth. Cancer cells secrete complement proteins that stimulate tumor growth upon activation…”
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