Výsledky vyhledávání - "Polymorphism, Single Nucleotide genetics"

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression Autor Claringbould, Annique, Westra, Harm-Jan, Bonder, Marc Jan, Deelen, Patrick, Kirsten, Holger, Saha, Ashis, Yazar, Seyhan, Brugge, Harm, Oelen, Roy, de Vries, Dylan H., van der Wijst, Monique G. P., Kasela, Silva, Pervjakova, Natalia, Alves, Isabel, Favé, Marie-Julie, Agbessi, Mawussé, Christiansen, Mark W., Jansen, Rick, Seppälä, Ilkka, Tong, Lin, Teumer, Alexander, Schramm, Katharina, Hemani, Gibran, Verlouw, Joost, Yaghootkar, Hanieh, Sönmez Flitman, Reyhan, Brown, Andrew, Kukushkina, Viktorija, Kalnapenkis, Anette, Rüeger, Sina, Porcu, Eleonora, Kettunen, Johannes, Lee, Bernett, Zhang, Futao, Qi, Ting, Arindrarto, Wibowo, Beutner, Frank, Dmitrieva, Julia, Elansary, Mahmoud, Fairfax, Benjamin P., Georges, Michel, Heijmans, Bastiaan T., Hewitt, Alex W., Kähönen, Mika, Kim, Yungil, Knight, Julian C., Kovacs, Peter, Krohn, Knut, Li, Shuang, Loeffler, Markus, Marigorta, Urko M., Mei, Hailang, Momozawa, Yukihide, Müller-Nurasyid, Martina, Nauck, Matthias, Nivard, Michel G., Penninx, Brenda W. J. H., Pritchard, Jonathan K., Raitakari, Olli T., Rotzschke, Olaf, Slagboom, Eline P., Stehouwer, Coen D. A., Stumvoll, Michael, Sullivan, Patrick, ’t Hoen, Peter A. C., Thiery, Joachim, Tönjes, Anke, van Dongen, Jenny, van Iterson, Maarten, Veldink, Jan H., Völker, Uwe, Warmerdam, Robert, Wijmenga, Cisca, Swertz, Morris, Andiappan, Anand, Montgomery, Grant W., Ripatti, Samuli, Perola, Markus, Kutalik, Zoltan, Dermitzakis, Emmanouil, Bergmann, Sven, van Meurs, Joyce, Prokisch, Holger, Ahsan, Habibul, Pierce, Brandon L., Lehtimäki, Terho, Psaty, Bruce M., Gharib, Sina A., Awadalla, Philip, Milani, Lili, Ouwehand, Willem H., Downes, Kate, Stegle, Oliver, Battle, Alexis, Visscher, Peter M., Yang, Jian, Powell, Joseph, Gibson, Greg, Esko, Tõnu, Franke, Lude

“…Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms on the transcriptome. To investigate the genetics of gene…”
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Mapping genomic loci implicates genes and synaptic biology in schizophrenia Autor Trubetskoy, Vassily, Qi, Ting, Bryois, Julien, Chen, Chia-Yen, Magnusson, Sigurdur, Kim, Minsoo, Adams, Mark, Agartz, Ingrid, Agerbo, Esben, Athanasiu, Lavinia, Bacanu, Silviu A., Calkins, Monica E., Carr, Vaughan J., Consoli, Angèle, Costas, Javier, Davis, Kenneth L., Degenhardt, Franziska, Dickerson, Faith, Frustaci, Alessandra, Giegling, Ina, Goldstein, Jacqueline I., González Peñas, Javier, Hayward, Caroline, Howrigan, Daniel P., Ikeda, Masashi, Kam-Thong, Tony, Kamatani, Yoichiro, Khrunin, Andrey, Kim, Sung-Wan, Klovins, Janis, Kubo, Michiaki, Lazzeroni, Laura C., Lehrer, Douglas S., Li, Miaoxin, Liu, Chih-Min, Loughland, Carmel M., Mallet, Jacques, Mattheisen, Manuel, McCarley, Robert W., Meier, Sandra, Milani, Lili, Milanova, Vihra, Morley, Christopher P., Muntané, Gerard, Murphy, Kieran C., Olincy, Ann, Papadimitriou, George N., Parellada, Mara, Paunio, Tiina, Pellegrino, Renata, Radant, Allen D., Saker-Delye, Safaa, Sanjuan, Julio, Savitz, Adam, Seidman, Larry J., Sim, Kang, Stain, Helen J., Streit, Fabian, Strengman, Eric, Ta, Thi Minh Tam, Terao, Chikashi, Toncheva, Draga, Veijola, Juha, Waddington, John, Walter, Henrik, Webb, Bradley T., Wu, Jing Qin, Xu, Zhida, Ayub, Muhammad, Bertolino, Alessandro, Buccola, Nancy G., Byerley, William F., Hwu, Hai-Gwo, McCarroll, Steven A., Neil, Amanda L., Smoller, Jordan W., Vilella, Elisabet, Xu, Shuhua, Braff, David, Buxbaum, Joseph D., Cichon, Sven, Ehrenreich, Hannelore, Escott-Price, Valentina, Esko, Tõnu, Iwata, Nakao, Kirov, George, Lee, Jimmy, Li, Qingqin S., Malhotra, Anil K., Malhotra, Dheeraj, McQuillin, Andrew, Morgan, Vera A., Nöthen, Markus M., Saka, Meram C., Sanders, Alan R., Serretti, Alessandro, van Os, Jim, Yu, Xin, Neale, Benjamin M., Ripke, Stephan

“…Schizophrenia has a heritability of 60–80% 1 , much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up…”
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The Polygenic and Monogenic Basis of Blood Traits and Diseases Autor Vuckovic, Dragana, Bao, Erik L, Akbari, Parsa, Lareau, Caleb A, Mousas, Abdou, Jiang, Tao, Chen, Ming-Huei, Raffield, Laura M, Tardaguila, Manuel, Huffman, Jennifer E, Ritchie, Scott C, Megy, Karyn, Ponstingl, Hannes, Penkett, Christopher J, Albers, Patrick K, Wigdor, Emilie M, Sakaue, Saori, Moscati, Arden, Manansala, Regina, Lo, Ken Sin, Qian, Huijun, Akiyama, Masato, Bartz, Traci M, Ben-Shlomo, Yoav, Beswick, Andrew, Bork-Jensen, Jette, Bottinger, Erwin P, Brody, Jennifer A, van Rooij, Frank J A, Chitrala, Kumaraswamy N, Wilson, Peter W F, Choquet, Hélène, Danesh, John, Di Angelantonio, Emanuele, Dimou, Niki, Ding, Jingzhong, Elliott, Paul, Esko, Tõnu, Evans, Michele K, Felix, Stephan B, Floyd, James S, Broer, Linda, Grarup, Niels, Guo, Michael H, Guo, Qi, Greinacher, Andreas, Haessler, Jeff, Hansen, Torben, Howson, Joanna M M, Huang, Wei, Jorgenson, Eric, Kacprowski, Tim, Kähönen, Mika, Kamatani, Yoichiro, Kanai, Masahiro, Karthikeyan, Savita, Koskeridis, Fotios, Lange, Leslie A, Lehtimäki, Terho, Linneberg, Allan, Liu, Yongmei, Lyytikäinen, Leo-Pekka, Manichaikul, Ani, Matsuda, Koichi, Mohlke, Karen L, Mononen, Nina, Murakami, Yoshinori, Nadkarni, Girish N, Nikus, Kjell, Pankratz, Nathan, Pedersen, Oluf, Preuss, Michael, Psaty, Bruce M, Raitakari, Olli T, Rich, Stephen S, Rodriguez, Benjamin A T, Rosen, Jonathan D, Rotter, Jerome I, Schubert, Petra, Spracklen, Cassandra N, Surendran, Praveen, Tang, Hua, Tardif, Jean-Claude, Ghanbari, Mohsen, Völker, Uwe, Völzke, Henry, Watkins, Nicholas A, Weiss, Stefan, Cai, Na, Kundu, Kousik, Watt, Stephen B, Walter, Klaudia, Zonderman, Alan B, Cho, Kelly, Li, Yun, Loos, Ruth J F, Knight, Julian C, Georges, Michel, Stegle, Oliver, Evangelou, Evangelos

“…Blood cells play essential roles in human health, underpinning physiological processes such as immunity, oxygen transport, and clotting, which when perturbed…”
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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation Autor Kitajima, Hidetoshi, Kim, Young Jin, Horikoshi, Momoko, Moon, Sanghoon, Robertson, Neil R., Nano, Jana, Lamri, Amel, Nakatochi, Masahiro, Graff, Mariaelisa, Yao, Jie, Bielak, Lawrence F., Hai, Yang, Schmidt, Ellen M., Nousome, Darryl, Trompet, Stella, Ahmad, Meraj, Noordam, Raymond, Lim, Victor J. Y., Joo, Yoonjung Yoonie, Prins, Bram Peter, Chen, Guanjie, Jensen, Richard A., Kabagambe, Edmond K., Xiang, Anny H., Flanagan, Jack, Adair, Linda S., Akiyama, Masato, Bertoni, Alain, Chee, Miao-Li, Chen, Shyh-Huei, Chen, Yuan-Tsong, Das, Swapan K., de Silva, H. Janaka, Eckardt, Kai-Uwe, Evans, Daniel S., Evans, Michele K., Franco, Oscar H., Fuchsberger, Christian, Genter, Pauline, Goodarzi, Mark O., Gordon-Larsen, Penny, Gorkin, David, Guo, Yu, Howard, Annie-Green, Hung, Yi-Jen, Hwang, Mi Yeong, Ingelsson, Martin, Jonas, Jost B., Jørgensen, Torben, Kamatani, Yoichiro, Kasturiratne, Anuradhani, Katsuya, Tomohiro, Keaton, Jacob M., Kho, Abel N., Khor, Chiea-Chuen, Läll, Kristi, Li-Gao, Ruifang, Liu, Jianjun, Luan, Jian’an, Luo, Xi, Lyssenko, Valeriya, Metspalu, Andres, Morris, Andrew D., Nalls, Michael A., Ntalla, Ioanna, Sattar, Naveed, Shi, Jinxiu, Shriner, Daniel, Stilp, Adrienne M., Takahashi, Atsushi, Taylor, Kent D., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Varma, Rohit, Yamamoto, Ken, Yoon, Kyungheon, Yusuf, Salim, Zheng, Wei, Cho, Yoon Shin, Lind, Lars, Province, Michael A., Zonderman, Alan B., Becker, Diane M., Yokota, Mitsuhiro, Chen, Yii-Der Ida, Ma, Ronald C. W., Chandak, Giriraj R., Sale, Michèle M., Shu, Xiao-Ou, Jukema, J. Wouter, McKean-Cowdin, Roberta, Kooner, Jaspal S., North, Kari E., Florez, Jose C., Maeda, Shiro, Stefansson, Kari, Mohlke, Karen L., Gloyn, Anna L., Below, Jennifer E., Rotter, Jerome I.

“…We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055…”
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Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information Autor Maihofer, Adam X., Daskalakis, Nikolaos P., Denckla, Christy A., Ketema, Elizabeth, Morey, Rajendra A., Torres, Katy, Aiello, Allison E., Almli, Lynn M., Austin, S. Bryn, Borglum, Anders D., Babić, Dragan, Beckham, Jean C., Bisson, Jonathan I., Boks, Marco P., Bryant, Richard A., Bustamante, Angela C., Caldas-de-Almeida, José M., Chen, Chia-Yen, Dale, Anders M., Deckert, Jürgen, Delahanty, Douglas L., Domschke, Katharina, Džubur Kulenović, Alma, Erbes, Christopher R., Farrer, Lindsay A., Flory, Janine D., Forbes, David, Franz, Carol E., Gautam, Aarti, Gelaye, Bizu, Geuze, Elbert, Gillespie, Charles F., Goçi, Aferdita, Guffanti, Guia, Hauser, Michael A., Heath, Andrew C., Hemmings, Sian M.J., Hougaard, David Michael, Jett, Marti, Qin, Xue-Jun, Karstoft, Karen-Inge, Kaufman, Milissa L., Kessler, Ronald C., Koen, Nastassja, Kranzler, Henry R., Kremen, William S., Lawford, Bruce R., Liberzon, Israel, Lori, Adriana, Lugonja, Božo, Luykx, Jurjen J., Marmar, Charles, Martin, Nicholas G., Maurer, Douglas, Mavissakalian, Matig R., McFarlane, Alexander, McLean, Samuel A., Mellor, Rebecca, Michopoulos, Vasiliki, Milberg, William, Morris, Charles Phillip, Nelson, Elliot C., Nordentoft, Merete, Norman, Sonya B., O’Donnell, Meaghan, Peterson, Alan L., Pietrzak, Robert H., Roberts, Andrea L., Rothbaum, Barbara O., Rung, Ariane, Sanchez, Sixto E., Schijven, Dick, Seedat, Soraya, Seng, Julia S., Sheerin, Christina M., Silove, Derrick, Smith, Alicia K., Smoller, Jordan W., Sponheim, Scott R., Stein, Dan J., Teicher, Martin H., Thompson, Wesley K., van den Heuvel, Leigh Luella, Van Hooff, Miranda, Vinkers, Christiaan H., Wang, Yunpeng, Wang, Zhewu, Williams, Michelle A., Winternitz, Sherry, Wolf, Christiane, Wolf, Erika J., Young, Ross McD, Zhao, Hongyu, Zoellner, Lori A., Provost, Allison C., Sebat, Jonathan, Shaffer, Richard A., Koenen, Karestan C., Stein, Murray B., Nievergelt, Caroline M.

“…Posttraumatic stress disorder (PTSD) is heritable and a potential consequence of exposure to traumatic stress. Evidence suggests that a quantitative approach…”
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The power of genetic diversity in genome-wide association studies of lipids Autor Ramdas, Shweta, Vedantam, Sailaja, Locke, Adam E., Narita, Akira, Choudhury, Ananyo, Trivedi, Bhavi, Zhu, Xiang, Gudbjartsson, Daniel F., Lingren, Todd, Haessler, Jeffrey, Giulianini, Franco, Bradford, Yuki, Zhao, Wei, Weir, David R., Schmidt, Ellen M., Luan, Jian’an, Yoon, Kyungheon, Medina-Gomez, Carolina, Willemsen, Gonneke, Haworth, Simon, Warren, Helen R., Sabater-Lleal, Maria, Noordam, Raymond, Fiorillo, Edoardo, Wielscher, Matthias, Munz, Matthias, Zeng, Lingyao, Kurbasic, Azra, Daw, E. Warwick, Christensen, Henry, Verweij, Niek, Iha, Hiroyuki, Wong, Andrew, Yousri, Noha A., Arbeeva, Liubov, Li, Xiaohui, Takeuchi, Fumihiko, Spracklen, Cassandra N., Sung, Yun Ju, Hung, Yi-Jen, Chen, Shufeng, Meidtner, Karina, Bielak, Lawrence F., Lin, Maoxuan, Cade, Brian E., Lyytikäinen, Leo-Pekka, Nikus, Kjell, Cuellar-Partida, Gabriel, Obura, Morgan O., Highland, Heather M., Kawaguchi, Takahisa, Nalls, Mike A., Braund, Peter S., Giardoglou, Tota, de Kleijn, Dominique, Rallidis, Loukianos S., Hewitt, Alex W., Ohlsson, Claes, Mellström, Dan, Homuth, Georg, Chen, Y. Eugene, Bandinelli, Stefania, Kato, Norihiro, De Jager, Philip L., Mamakou, Vasiliki, Caulfield, Mark J., Kaprio, Jaakko, Bechayda, Sonny Augustin, den Hollander, Anneke I., Wilson, James G., Nelson, Amanda E., Cruz, Miguel, Lettre, Guillaume, Loos, Ruth J. F., Psaty, Bruce M., Brandslund, Ivan, Christensen, Kaare, Loeffler, Markus, Khera, Amit V., Jarvelin, Marjo-Riitta, Kutalik, Zoltan, Wong, Tien-Yin, Peters, Annette, Gieger, Christian, Langenberg, Claudia, Morrison, Alanna C., North, Kari E., Holmes, Michael V., Justice, Anne E., Kooperberg, Charles, Wei, Wei-Qi, Åsvold, Bjørn Olav, Kamatani, Yoichiro, Thorsteinsdottir, Unnur, Chang, Kyong-Mi, Tamiya, Gen, Mohlke, Karen L., Boehnke, Michael, Natarajan, Pradeep, Brown, Christopher D.

“…Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and…”
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Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries Autor Liu, Zhanju, Liu, Ruize, Gao, Han, Jung, Seulgi, Gao, Xiang, Sun, Ruicong, Liu, Xiaoming, Kim, Yongjae, Lee, Ho-Su, Kawai, Yosuke, Nagasaki, Masao, Umeno, Junji, Tokunaga, Katsushi, Kinouchi, Yoshitaka, Masamune, Atsushi, Shi, Wenzhao, Shen, Chengguo, Guo, Zhenglin, Yuan, Kai, Zhu, Shu, Li, Dalin, Liu, Jianjun, Ge, Tian, Cho, Judy, Daly, Mark J., McGovern, Dermot P. B., Ye, Byong Duk, Song, Kyuyoung, Kakuta, Yoichi, Li, Mingsong, Huang, Hailiang

“…Inflammatory bowel diseases (IBDs) are chronic disorders of the gastrointestinal tract with the following two subtypes: Crohn’s disease (CD) and ulcerative…”
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New genetic loci link adipose and insulin biology to body fat distribution Autor Ferreira, Teresa, Locke, Adam E., Justice, Anne E., Wu, Joseph M. W., Buchkovich, Martin L., Heard-Costa, Nancy L., Drong, Alexander W., Gustafsson, Stefan, Fall, Tove, Scherag, André, Absher, Devin, Ehret, Georg B., Kleber, Marcus E., Peters, Marjolein J., Albrecht, Eva, Bellis, Claire, Böhringer, Stefan, Böttcher, Yvonne, Clarke, Robert, Eklund, Niina, Erdos, Michael R., Estrada, Karol, Eury, Elodie, Friedrich, Nele, Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S., Hallmans, Goran, Hassinen, Maija, Hunt, Steven C., Koenig, Wolfgang, Kratzer, Wolfgang, Lindström, Jaana, Merger, Sigrun, Mihailov, Evelin, Mills, Rebecca, Moayyeri, Alireza, Müller-Nurasyid, Martina, Nalls, Michael A., Narisu, Narisu, Nolte, Ilja M., Sanna, Serena, Seufferlein, Thomas, Wennauer, Roman, Choi, Murim, Karpe, Fredrik, Keildson, Sarah, Kiryluk, Krzysztof, Lifton, Richard P., Ma, Baoshan, Nicholson, George, Schadt, Eric E., Scott, Robert A., Westra, Harm-Jan, Beilby, John, Bergman, Richard N., Brown, Morris J., Campbell, Harry, Danesh, John, de Geus, Eco J. C., Ferrannini, Ele, Ferrières, Jean, Haiman, Christopher A., Johansen, Berit, Jousilahti, Pekka, Keinanen-Kiukaanniemi, Sirkka M., Kooperberg, Charles, Kumari, Meena, Matise, Tara C., Möhlenkamp, Stefan, Nelis, Mari, Ong, Ken K., Palmer, Lyle J., Ritchie, Marylyn D., Salomaa, Veikko, Samani, Nilesh J., Saramies, Jouko, Sarzynski, Mark A., Schwarz, Peter E. H., Strauch, Konstantin, Boehm, Bernhard O., Chambers, John C., Grabe, Hans-Jörgen, Hamsten, Anders, Kivimaki, Mika, März, Winfried, Pedersen, Nancy L., Pérusse, Louis, Power, Chris, Rauramaa, Rainer, Rivadeneira, Fernando, Thorsteinsdottir, Unnur, Stumvoll, Michael, Watkins, Hugh, Wichmann, H-Erich, Hunter, David J., Qi, Lu, Speliotes, Elizabeth K., Fox, Caroline S., Barroso, Inês

“…Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our…”
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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals Autor Ntalla, Ioanna, Karthikeyan, Savita, Mifsud, Borbala, Kraja, Aldi T., Cartwright, James H., Hellwege, Jacklyn N., Giri, Ayush, Tragante, Vinicius, Prins, Bram P., Cabrera, Claudia P., Eales, James M., Akbarov, Artur, Bielak, Lawrence F., Brody, Jennifer A., Drenos, Fotios, Nielsen, Sune Fallgaard, Faul, Jessica D., Franceschini, Nora, Gao, He, Giulianini, Franco, Hwang, Shih-Jen, Kanoni, Stavroula, Lindström, Jaana, Luan, Jian’an, Mahajan, Anubha, Malerba, Giovanni, Perola, Markus, Richard, Melissa, Richardson, Tom G., Sepúlveda, Nuno, Thériault, Sébastien, Trompet, Stella, Varga, Tibor V., Velez Edwards, Digna R., Veronesi, Giovanni, Weiss, Stefan, Willems, Sara M., Young, Robin, Zhang, Weihua, Zhao, Wei, Evangelou, Evangelos, Aeschbacher, Stefanie, Asllanaj, Eralda, Mutsert, Renée de, Dörr, Marcus, Gaziano, J. Michael, Have, Christian T., Kajantie, Eero, Kamat, Mihir, Karpe, Fredrik, Koistinen, Heikki A., Moitry, Marie, Peters, James, Rossouw, Jacques, Sever, Peter S., Sigurdsson, Emil L., Skaaby, Tea, Sun, Yan V., Trabetti, Elisabetta, Vaartjes, Ilonca, Buring, Julie E., Chowdhury, Rajiv, Correa, Adolfo, Deary, Ian J., Deloukas, Panos, Ferrières, Jean, Fornage, Myriam, Gaunt, Tom R., Harris, Tamara B., Järvelin, Marjo-Riitta, Kooperberg, Charles, Launer, Lenore J., Majumder, Abdulla al Shafi, Laakso, Markku, Melander, Olle, Mohlke, Karen L., Orho-Melander, Marju, Palmas, Walter, Polasek, Ozren, Province, Michael A., Rolandsson, Olov, Rosendaal, Frits R., Rotter, Jerome I., Samani, Nilesh J., Soranzo, Nicole, Spector, Timothy D., Starr, John M., van der Harst, Pim, van der Meer, Peter, Verweij, Niek, Virtamo, Jarmo, Wareham, Nicholas J., Langenberg, Claudia, Liu, Chunyu, Manning, Alisa K., Morrison, Alanna C., O’Donnell, Christopher J., Saleheen, Danish, Boerwinkle, Eric, Chasman, Daniel I.

“…Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million…”
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Genetic studies of body mass index yield new insights for obesity biology Autor Croteau-Chonka, Damien C., Wood, Andrew R., Absher, Devin, Bragg-Gresham, Jennifer L., Buyske, Steven, Feitosa, Mary F., Mangino, Massimo, Mateo Leach, Irene, Palmer, Cameron D., Pasko, Dorota, Ju Sung, Yun, Teumer, Alexander, van der Laan, Sander W., Ärnlöv, Johan, Berne, Christian, Bonnycastle, Lori L., Bruinenberg, Marcel, Ida Chen, Yii-Der, de Craen, Anton J. M., Delgado, Graciela, Fraser, Ross M., Grönberg, Henrik, Gusto, Gaëlle, Hassinen, Maija, Jeff, Janina M., Kinnunen, Leena, Kratzer, Wolfgang, Lee, Nanette R., Lichtner, Peter, Lind, Lars, Sin Lo, Ken, Lorbeer, Roberto, Mahajan, Anubha, Milani, Lili, Monda, Keri L., Nolte, Ilja M., Pilz, Stefan, Rettig, Rainer, Ripke, Stephan, Sanna, Serena, Schumacher, Fredrick R., Scott, William R., Smolonska, Joanna, Stirrups, Kathleen, Stringham, Heather M., Uh, Hae-Won, Vandenput, Liesbeth, Warren, Helen R., Brennan, Eoin P., Drong, Alexander W., Min, Josine L., Okada, Yukinori, Takahashi, Atsushi, Tanaka, Toshihiro, Westra, Harm-Jan, Campbell, Harry, den Ruijter, Hester M., Erbel, Raimund, Farrall, Martin, Franco, Oscar H., Gejman, Pablo V., Gieger, Christian, Gottesman, Omri, Hingorani, Aroon D., Hyppönen, Elina, Jarvelin, Marjo-Riitta, Jöckel, Karl-Heinz, Johansen, Berit, Kooperberg, Charles, Langenberg, Claudia, Postma, Dirkje S., Price, Jackie F., Rao, D. C., Rioux, John D., Schunkert, Heribert, Shuldiner, Alan R., Strauch, Konstantin, Tremblay, Angelo, Adair, Linda S., de Bakker, Paul I. W., Ferrucci, Luigi, Hveem, Kristian, März, Winfried, Munroe, Patricia B., Njølstad, Inger, Palmer, Colin N. A., Pedersen, Nancy L., Pérusse, Louis, Saaristo, Timo E., Saleheen, Danish, Sattar, Naveed, Eline Slagboom, P., Tuomilehto, Jaakko, Deloukas, Panos, Stefansson, Kari, van Duijn, Cornelia M., Willer, Cristen J., Ingelsson, Erik, Hirschhorn, Joel N., Loos, Ruth J. F.

“…Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and…”
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Evolutionary history of human colitis-associated colorectal cancer Autor Baker, Ann-Marie, Cross, William, Curtius, Kit, Al Bakir, Ibrahim, Choi, Chang-Ho Ryan, Davis, Hayley Louise, Temko, Daniel, Biswas, Sujata, Martinez, Pierre, Williams, Marc J, Lindsay, James O, Feakins, Roger, Vega, Roser, Hayes, Stephen J, Tomlinson, Ian P M, McDonald, Stuart A C, Moorghen, Morgan, Silver, Andrew, East, James E, Wright, Nicholas A, Wang, Lai Mun, Rodriguez-Justo, Manuel, Jansen, Marnix, Hart, Ailsa L, Leedham, Simon J, Graham, Trevor A

“…ObjectiveIBD confers an increased lifetime risk of developing colorectal cancer (CRC), and colitis-associated CRC (CA-CRC) is molecularly distinct from…”
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webTWAS: a resource for disease candidate susceptibility genes identified by transcriptome-wide association study Autor Cao, Chen, Wang, Jianhua, Kwok, Devin, Cui, Feifei, Zhang, Zilong, Zhao, Da, Li, Mulin Jun, Zou, Quan

“…Abstract The development of transcriptome-wide association studies (TWAS) has enabled researchers to better identify and interpret causal genes in many…”
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Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations Autor Chen, Ming-Huei, Raffield, Laura M, Mousas, Abdou, Sakaue, Saori, Huffman, Jennifer E, Moscati, Arden, Trivedi, Bhavi, Jiang, Tao, Akbari, Parsa, Vuckovic, Dragana, Bao, Erik L, Zhong, Xue, Manansala, Regina, Laplante, Véronique, Chen, Minhui, Lo, Ken Sin, Qian, Huijun, Lareau, Caleb A, Beaudoin, Mélissa, Hunt, Karen A, Akiyama, Masato, Bartz, Traci M, Ben-Shlomo, Yoav, Beswick, Andrew, Bork-Jensen, Jette, Bottinger, Erwin P, Brody, Jennifer A, van Rooij, Frank J A, Chitrala, Kumaraswamynaidu, Cho, Kelly, Choquet, Hélène, Correa, Adolfo, Danesh, John, Di Angelantonio, Emanuele, Dimou, Niki, Ding, Jingzhong, Elliott, Paul, Esko, Tõnu, Evans, Michele K, Floyd, James S, Broer, Linda, Grarup, Niels, Guo, Michael H, Greinacher, Andreas, Haessler, Jeff, Hansen, Torben, Howson, Joanna M M, Huang, Qin Qin, Huang, Wei, Jorgenson, Eric, Kacprowski, Tim, Kähönen, Mika, Kamatani, Yoichiro, Kanai, Masahiro, Karthikeyan, Savita, Koskeridis, Fotis, Lange, Leslie A, Lehtimäki, Terho, Lerch, Markus M, Linneberg, Allan, Liu, Yongmei, Lyytikäinen, Leo-Pekka, Manichaikul, Ani, Martin, Hilary C, Matsuda, Koichi, Mohlke, Karen L, Mononen, Nina, Murakami, Yoshinori, Nadkarni, Girish N, Nauck, Matthias, Nikus, Kjell, Ouwehand, Willem H, Pankratz, Nathan, Pedersen, Oluf, Preuss, Michael, Psaty, Bruce M, Raitakari, Olli T, Roberts, David J, Rich, Stephen S, Rodriguez, Benjamin A T, Rosen, Jonathan D, Rotter, Jerome I, Schubert, Petra, Spracklen, Cassandra N, Surendran, Praveen, Tang, Hua, Tardif, Jean-Claude, Trembath, Richard C, Ghanbari, Mohsen, Völker, Uwe, Völzke, Henry, Watkins, Nicholas A, Zonderman, Alan B, Wilson, Peter W F, Li, Yun, Butterworth, Adam S, Gauchat, Jean-François, Chiang, Charleston W K, Li, Bingshan, Loos, Ruth J F

“…Most loci identified by GWASs have been found in populations of European ancestry (EUR). In trans-ethnic meta-analyses for 15 hematological traits in 746,667…”
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The Missing Diversity in Human Genetic Studies Autor Sirugo, Giorgio, Williams, Scott M, Tishkoff, Sarah A

“…The majority of studies of genetic association with disease have been performed in Europeans. This European bias has important implications for risk prediction…”
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Evaluating the potential role of pleiotropy in Mendelian randomization studies Autor Hemani, Gibran, Bowden, Jack, Davey Smith, George

“…Abstract Pleiotropy, the phenomenon of a single genetic variant influencing multiple traits, is likely widespread in the human genome. If pleiotropy arises…”
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Identification of common variants associated with human hippocampal and intracranial volumes Autor Vasquez, Alejandro Arias, Toro, Roberto, Bartecek, Richard, Bergmann, Ørjan, Bernard, Manon, Chakravarty, M Mallar, Grimm, Oliver, Homuth, Georg, Lopez, Lorna M, Hansell, Narelle K, Kim, Sungeun, Laje, Gonzalo, Lee, Phil H, Liu, Xinmin, Loth, Eva, Lourdusamy, Anbarasu, Mattingsdal, Morten, Mohnke, Sebastian, Maniega, Susana Muñoz, O'Brien, Carol, Pütz, Benno, Rasmussen, Jerod, Risacher, Shannon L, Rose, Emma J, Ryten, Mina, Sprooten, Emma, Teumer, Alexander, Trabzuni, Daniah, Turner, Jessica, van Eijk, Kristel, van Erp, Theo G M, van Tol, Marie-Jose, Wolf, Christiane, Aleman, Andre, Alhusaini, Saud, Binder, Elisabeth B, Brohawn, David G, Cantor, Rita M, Czisch, Michael, de Almeida, Marcio A A, Delanty, Norman, Dyer, Thomas D, Erk, Susanne, Fox, Peter T, Freimer, Nelson B, Hagler, Donald J, Hoogman, Martine, Johnson, Matthew P, Kasperaviciute, Dalia, Kent, Jack W, Kochunov, Peter, Lancaster, Jack L, Liewald, David C, Matarin, Mar, Mattheisen, Manuel, Moses, Eric K, Mühleisen, Thomas W, Nöthen, Markus M, Puls, Ralf, Reinvang, Ivar, Savitz, Jonathan, Schnack, Hugo G, Seiferth, Nina, Valdés Hernández, Maria C, Van Haren, Neeltje E M, Veltman, Joris A, Völzke, Henry, Westlye, Lars T, Whelan, Christopher D, Cavalleri, Gianpiero L, Dale, Anders M, Drevets, Wayne C, Heinz, Andreas, Le Hellard, Stephanie, Macciardi, Fabio, Montgomery, Grant W, Starr, John M, Gudnason, Vilmundur, Tzourio, Christophe, Vernooij, Meike W, Launer, Lenore J, Andreassen, Ole A, Bastin, Mark E, Blangero, John, Brunner, Han G, Buckner, Randy L, Coppola, Giovanni, de Zubicaray, Greig I, Fernández, Guillén, Glahn, David C, Hardy, John, Kahn, René S, McIntosh, Andrew M, Nichols, Thomas E, Ophoff, Roel A, Pausova, Zdenka, Potkin, Steven G, Smoller, Jordan W, Martin, Nicholas G, Thompson, Paul M

“…Paul Thompson and colleagues report a genome-wide association study for hippocampal, intracranial and total brain volume. They identify a locus at 12q24…”
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Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry Autor Pulit, Sara L, Stoneman, Charli, Morris, Andrew P, Wood, Andrew R, Glastonbury, Craig A, Tyrrell, Jessica, Yengo, Loïc, Ferreira, Teresa, Marouli, Eirini, Ji, Yingjie, Yang, Jian, Jones, Samuel, Beaumont, Robin, Croteau-Chonka, Damien C, Winkler, Thomas W, Hattersley, Andrew T, Loos, Ruth J F, Hirschhorn, Joel N, Visscher, Peter M, Frayling, Timothy M, Yaghootkar, Hanieh, Lindgren, Cecilia M

“…Abstract More than one in three adults worldwide is either overweight or obese. Epidemiological studies indicate that the location and distribution of excess…”
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Potential drug targets for multiple sclerosis identified through Mendelian randomization analysis Autor Lin, Jianfeng, Zhou, Jiawei, Xu, Yan

“…Abstract Multiple sclerosis is a complex autoimmune disease, and several therapies for multiple sclerosis have been developed and widely used. However,…”
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Leveraging Polygenic Functional Enrichment to Improve GWAS Power Autor Kichaev, Gleb, Bhatia, Gaurav, Loh, Po-Ru, Gazal, Steven, Burch, Kathryn, Freund, Malika K, Schoech, Armin, Pasaniuc, Bogdan, Price, Alkes L

“…Functional genomics data has the potential to increase GWAS power by identifying SNPs that have a higher prior probability of association. Here, we introduce a…”
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Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances Autor Timmers, Paul RHJ, Mounier, Ninon, Lall, Kristi, Fischer, Krista, Ning, Zheng, Feng, Xiao, Bretherick, Andrew D, Clark, David W, Agbessi, M, Ahsan, H, Alves, I, Andiappan, A, Awadalla, P, Battle, A, Bonder, MJ, Boomsma, D, Christiansen, M, Claringbould, A, Deelen, P, van Dongen, J, Esko, T, Favé, M, Franke, L, Frayling, T, Gharib, SA, Gibson, G, Hemani, G, Jansen, R, Kalnapenkis, A, Kasela, S, Kettunen, J, Kim, Y, Kirsten, H, Kovacs, P, Krohn, K, Kronberg-Guzman, J, Kukushkina, V, Kutalik, Z, Kähönen, M, Lee, B, Lehtimäki, T, Loeffler, M, Marigorta, U, Metspalu, A, van Meurs, J, Milani, L, Müller-Nurasyid, M, Nauck, M, Nivard, M, Penninx, B, Perola, M, Pervjakova, N, Pierce, B, Powell, J, Prokisch, H, Psaty, BM, Raitakari, O, Ring, S, Ripatti, S, Rotzschke, O, Ruëger, S, Saha, A, Scholz, M, Schramm, K, Seppälä, I, Stumvoll, M, Sullivan, P, Teumer, A, Thiery, J, Tong, L, Tönjes, A, Verlouw, J, Visscher, PM, Võsa, U, Völker, U, Yaghootkar, H, Yang, J, Zeng, B, Zhang, F, Shen, Xia, Esko, Tõnu, Kutalik, Zoltán, Wilson, James F, Joshi, Peter K

“…We use a genome-wide association of 1 million parental lifespans of genotyped subjects and data on mortality risk factors to validate previously unreplicated…”
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