Suchergebnisse - "Polygenic inheritance"

Family Clustering of Autoimmune Vitiligo Results Principally from Polygenic Inheritance of Common Risk Alleles von Roberts, Genevieve H L, Paul, Subrata, Yorgov, Daniel, Santorico, Stephanie A, Spritz, Richard A

“… Vitiligo is an autoimmune disease that results in patches of depigmented skin and hair. Previous genome-wide association studies (GWASs) of vitiligo have …”
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Towards Precision Medicine for Hypertension: A Review of Genomic, Epigenomic, and Microbiomic Effects on Blood Pressure in Experimental Rat Models and Humans von Padmanabhan, Sandosh, Joe, Bina

“… Compelling evidence for the inherited nature of essential hypertension has led to extensive research in rats and humans. Rats have served as the primary model …”
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Polygenic Inheritance von Miquel Porta

“… The transmission of a phenotypic Trait whose expression depends on the effect of multiple genes …”
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Accelerating Medicines Partnership: Parkinson's Disease. Genetic Resource von Iwaki, Hirotaka, Leonard, Hampton L., Makarious, Mary B., Bookman, Matt, Landin, Barry, Vismer, David, Casey, Bradford, Gibbs, J. Raphael, Hernandez, Dena G., Blauwendraat, Cornelis, Vitale, Daniel, Song, Yeajin, Kumar, Dinesh, Dalgard, Clifton L., Sadeghi, Mahdiar, Dong, Xianjun, Misquitta, Leonie, Scholz, Sonja W., Scherzer, Clemens R., Nalls, Mike A., Biswas, Shameek, Singleton, Andrew B.

“… Background Whole‐genome sequencing data are available from several large studies across a variety of diseases and traits. However, massive storage and …”
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Investigating asthma heterogeneity through shared and distinct genetics: Insights from genome-wide cross-trait analysis von Zhu, Zhaozhong, Hasegawa, Kohei, Camargo, Carlos A., Liang, Liming

“… Investigating the shared genetic effects enables better understanding of the mechanisms of phenotypic correlations and is less subject to confounding by environmental factors …”
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Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals von Marnetto, Davide, Pärna, Katri, Läll, Kristi, Molinaro, Ludovica, Montinaro, Francesco, Haller, Toomas, Metspalu, Mait, Mägi, Reedik, Fischer, Krista, Pagani, Luca

“… Polygenic Scores (PSs) describe the genetic component of an individual’s quantitative phenotype or their susceptibility to diseases with a genetic basis …”
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Polygenic Profile of Elite Strength Athletes von Moreland, Ethan, Borisov, Oleg V, Semenova, Ekaterina A, Larin, Andrey K, Andryushchenko, Oleg N, Andryushchenko, Liliya B, Generozov, Edward V, Williams, Alun G, Ahmetov, Ildus I

“… Moreland, E, Borisov, OV, Semenova, EA, Larin, AK, Andryushchenko, ON, Andryushchenko, LB, Generozov, EV, Williams, AG, and Ahmetov, II. Polygenic profile of …”
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Interpreting population- and family-based genome-wide association studies in the presence of confounding von Veller, Carl, Coop, Graham M.

“… : the causal effects on an individual’s phenotype of the alleles that they carry. However, estimates of direct effects can be subject to genetic and environmental confounding and can also absorb the “indirect …”
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Genetics of dispersal von Saastamoinen, Marjo, Bocedi, Greta, Cote, Julien, Legrand, Delphine, Guillaume, Frédéric, Wheat, Christopher W., Fronhofer, Emanuel A., Garcia, Cristina, Henry, Roslyn, Husby, Arild, Baguette, Michel, Bonte, Dries, Coulon, Aurélie, Kokko, Hanna, Matthysen, Erik, Niitepõld, Kristjan, Nonaka, Etsuko, Stevens, Virginie M., Travis, Justin M. J., Donohue, Kathleen, Bullock, James M., del Mar Delgado, Maria

“… It is subject to evolutionary change, which begs the question, what is the genetic basis of this potentially complex trait …”
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Polygenic risk for schizophrenia and schizotypal traits in non-clinical subjects von Nenadić, Igor, Meller, Tina, Schmitt, Simon, Stein, Frederike, Brosch, Katharina, Mosebach, Johannes, Ettinger, Ulrich, Grant, Phillip, Meinert, Susanne, Opel, Nils, Lemke, Hannah, Fingas, Stella, Förster, Katharina, Hahn, Tim, Jansen, Andreas, Andlauer, Till F. M., Forstner, Andreas J., Heilmann-Heimbach, Stefanie, Hall, Alisha S. M., Awasthi, Swapnil, Ripke, Stephan, Witt, Stephanie H., Rietschel, Marcella, Müller-Myhsok, Bertram, Nöthen, Markus M., Dannlowski, Udo, Krug, Axel, Streit, Fabian, Kircher, Tilo

“… ) for schizophrenia in a sample of 623 psychiatrically healthy, non-clinical subjects from the FOR2107 multi-centre study and a second sample of 1133 blood donors …”
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Mendelian and polygenic inheritance of intelligence: A common set of causal genes? Using next-generation sequencing to examine the effects of 168 intellectual disability genes on normal-range intelligence von Franić, Sanja, Dolan, Conor V., Broxholme, John, Hu, Hao, Zemojtel, Tomasz, Davies, Garreth E., Nelson, Kelly A., Ehli, Erik A., Pool, René, Hottenga, Jouke-Jan, Ropers, H.-Hilger, Boomsma, Dorret I.

“… This is largely ascribed to the high polygenicity of intelligence, i.e., to its being subject to the effects of a large number of genes of individually small effect …”
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The contribution of common and rare genetic variants to variation in metabolic traits in 288,137 East Asians von Kim, Young Jin, Moon, Sanghoon, Hwang, Mi Yeong, Han, Sohee, Jang, Hye-Mi, Kong, Jinhwa, Shin, Dong Mun, Yoon, Kyungheon, Kim, Sung Min, Lee, Jong-Eun, Mahajan, Anubha, Park, Hyun-Young, McCarthy, Mark I., Cho, Yoon Shin, Kim, Bong-Jo

“… ) in 125,872 Korean subjects genotyped with the Korea Biobank Array. Following meta-analysis with GWAS from Biobank Japan identify 144 novel signals (MAF ≥ 1%), of which 57.0 …”
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Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits von Thareja, Gaurav, Al-Sarraj, Yasser, Belkadi, Aziz, Almotawa, Maryam, Suhre, Karsten, Albagha, Omar M. E.

“… We report a genome-wide association study with 45 clinically relevant traits from the population of Qatar using a whole genome sequencing approach in a discovery set of 6218 individuals and replication in 7768 subjects …”
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The genetics of human personality von Sanchez‐Roige, S., Gray, J. C., MacKillop, J., Chen, C.‐H., Palmer, A. A.

“… Genome‐wide association studies hits (log10 transformed) discovered as a function of sample size and personality trait. Personality traits are the relatively …”
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Air pollution interacts with genetic risk to influence cortical networks implicated in depression von Li, Zhi, Yan, Hao, Zhang, Xiao, Shah, Shefali, Yang, Guang, Chen, Qiang, Han, Shizhong, Zhang, Dai, Weinberger, Daniel R, Yue, Weihua, Tan, Hao Yang

“… However, the neural bases of these associations have been unclear. Here, in healthy human subjects exposed to relatively high air pollution and controlling for socio …”
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The impact of COVID-19 on a college freshman sample reveals genetic and nongenetic forms of susceptibility and resilience to stress von Turner, Cortney A, Khalil, Huzefa, Murphy-Weinberg, Virginia, Hagenauer, Megan H, Gates, Linda, Tang, Yu, Weinberg, Lauren, Grysko, Robert, Floran-Garduno, Leonor, Dokas, Thomas, Samaniego, Catherine, Zhao, Zhuo, Fang, Yu, Sen, Srijan, Lopez, Juan F, Watson, Jr, Stanley J, Akil, Huda

“… Subjects were genotyped, and a polygenic risk score for depression (MDD-PRS) was calculated. Daily physical activity and sleep were captured …”
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Temperature-driven gene expression evolution in natural and laboratory populations highlights the crucial role of correlated fitness effects for polygenic adaptation von Thorhölludottir, Dagny A V, Nolte, Viola, Schlötterer, Christian

“… The influence of pleiotropy on adaptive responses is a highly controversial topic, with limited empirical evidence available. Recognizing the pivotal role of …”
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Challenging the utility of polygenic scores for social science: Environmental confounding, downward causation, and unknown biology von Burt, Callie H.

“… The sociogenomics revolution is upon us, we are told. Whether revolutionary or not, sociogenomics is poised to flourish given the ease of incorporating …”
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Elucidating pathways to pediatric obesity: a study evaluating obesity polygenic risk scores related to appetitive traits in children von Renier, Timothy J., Yeum, Dabin, Emond, Jennifer A., Lansigan, Reina K., Ballarino, Grace A., Carlson, Delaina D., Loos, Ruth J. F., Gilbert-Diamond, Diane

“… Obesity polygenic risk scores (PRS) explain substantial variation in body mass index (BMI), yet associations between PRSs and appetitive traits in children …”
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A path integral approach for allele frequency dynamics under polygenic selection von Anderson, Nathan W, Kirk, Lloyd, Schraiber, Joshua G, Ragsdale, Aaron P

“… Many phenotypic traits have a polygenic genetic basis, making it challenging to learn their genetic architectures and predict individual phenotypes. One …”
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