Suchergebnisse - "Pogorelyy, Mikhail V."

Detecting T cell receptors involved in immune responses from single repertoire snapshots von Pogorelyy, Mikhail V., Minervina, Anastasia A., Shugay, Mikhail, Chudakov, Dmitriy M., Lebedev, Yuri B., Mora, Thierry, Walczak, Aleksandra M.

“… Hypervariable T cell receptors (TCRs) play a key role in adaptive immunity, recognizing a vast diversity of pathogen-derived antigens. Our ability to extract …”
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A Framework for Annotation of Antigen Specificities in High-Throughput T-Cell Repertoire Sequencing Studies von Pogorelyy, Mikhail V., Shugay, Mikhail

“… Recently developed molecular methods allow large-scale profiling of T-cell receptor (TCR) sequences that encode for antigen specificity and immunological …”
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VDJtools: Unifying Post-analysis of T Cell Receptor Repertoires von Shugay, Mikhail, Bagaev, Dmitriy V., Turchaninova, Maria A., Bolotin, Dmitriy A., Britanova, Olga V., Putintseva, Ekaterina V., Pogorelyy, Mikhail V., Nazarov, Vadim I., Zvyagin, Ivan V., Kirgizova, Vitalina I., Kirgizov, Kirill I., Skorobogatova, Elena V., Chudakov, Dmitriy M.

“… Despite the growing number of immune repertoire sequencing studies, the field still lacks software for analysis and comprehension of this high-dimensional …”
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Learning predictive signatures of HLA type from T-cell repertoires von Ruiz Ortega, María, Pogorelyy, Mikhail V., Minervina, Anastasia A., Thomas, Paul G., Mora, Thierry, Walczak, Aleksandra M.

“… T cells recognize a wide range of pathogens using surface receptors that interact directly with peptides presented on major histocompatibility complexes (MHC) …”
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Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection von Minervina, Anastasia A, Komech, Ekaterina A, Titov, Aleksei, Bensouda Koraichi, Meriem, Rosati, Elisa, Mamedov, Ilgar Z, Franke, Andre, Efimov, Grigory A, Chudakov, Dmitriy M, Mora, Thierry, Walczak, Aleksandra M, Lebedev, Yuri B, Pogorelyy, Mikhail V

“… COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. T cells play a key role in the adaptive antiviral immune response by killing infected cells …”
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Immune fingerprinting through repertoire similarity von Dupic, Thomas, Bensouda Koraichi, Meriem, Minervina, Anastasia A., Pogorelyy, Mikhail V., Mora, Thierry, Walczak, Aleksandra M.

“… Immune repertoires provide a unique fingerprint reflecting the immune history of individuals, with potential applications in precision medicine. However, the …”
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Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires von Pogorelyy, Mikhail V., Elhanati, Yuval, Marcou, Quentin, Sycheva, Anastasiia L., Komech, Ekaterina A., Nazarov, Vadim I., Britanova, Olga V., Chudakov, Dmitriy M., Mamedov, Ilgar Z., Lebedev, Yury B., Mora, Thierry, Walczak, Aleksandra M.

“… The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent …”
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The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging von Egorov, Evgeny S., Kasatskaya, Sofya A., Zubov, Vasiliy N., Izraelson, Mark, Nakonechnaya, Tatiana O., Staroverov, Dmitriy B., Angius, Andrea, Cucca, Francesco, Mamedov, Ilgar Z., Rosati, Elisa, Franke, Andre, Shugay, Mikhail, Pogorelyy, Mikhail V., Chudakov, Dmitriy M., Britanova, Olga V.

“… Human aging is associated with a profound loss of thymus productivity, yet naïve T lymphocytes still maintain their numbers by division in the periphery for …”
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Primary and secondary anti-viral response captured by the dynamics and phenotype of individual T cell clones von Minervina, Anastasia A, Pogorelyy, Mikhail V, Komech, Ekaterina A, Karnaukhov, Vadim K, Bacher, Petra, Rosati, Elisa, Franke, Andre, Chudakov, Dmitriy M, Mamedov, Ilgar Z, Lebedev, Yuri B, Mora, Thierry, Walczak, Aleksandra M

“… The diverse repertoire of T-cell receptors (TCR) plays a key role in the adaptive immune response to infections. Using TCR alpha and beta repertoire sequencing …”
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Distinctive properties of identical twins' TCR repertoires revealed by high-throughput sequencing von Zvyagin, Ivan V, Pogorelyy, Mikhail V, Ivanova, Marina E, Komech, Ekaterina A, Shugay, Mikhail, Bolotin, Dmitry A, Shelenkov, Andrey A, Kurnosov, Alexey A, Staroverov, Dmitriy B, Chudakov, Dmitriy M, Lebedev, Yuri B, Mamedov, Ilgar Z

“… Adaptive immunity in humans is provided by hypervariable Ig-like molecules on the surface of B and T cells. The final set of these molecules in each organism …”
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Method for identification of condition-associated public antigen receptor sequences von Pogorelyy, Mikhail V, Minervina, Anastasia A, Chudakov, Dmitriy M, Mamedov, Ilgar Z, Lebedev, Yuri B, Mora, Thierry, Walczak, Aleksandra M

“… Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin …”
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Inactivated tick-borne encephalitis vaccine elicits several overlapping waves of T cell response von Sycheva, Anastasiia L., Komech, Ekaterina A., Pogorelyy, Mikhail V., Minervina, Anastasia A., Urazbakhtin, Shamil Z., Salnikova, Maria A., Vorovitch, Mikhail F., Kopantzev, Eugene P., Zvyagin, Ivan V., Komkov, Alexander Y., Mamedov, Ilgar Z., Lebedev, Yuri B.

“… The development and implementation of vaccines have been growing exponentially, remaining one of the major successes of healthcare over the last century …”
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Exploring the pre-immune landscape of antigen-specific T cells von Pogorelyy, Mikhail V., Fedorova, Alla D., McLaren, James E., Ladell, Kristin, Bagaev, Dmitri V., Eliseev, Alexey V., Mikelov, Artem I., Koneva, Anna E., Zvyagin, Ivan V., Price, David A., Chudakov, Dmitry M., Shugay, Mikhail

“… Background Adaptive immune responses to newly encountered pathogens depend on the mobilization of antigen-specific clonotypes from a vastly diverse pool of …”
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The Evidence for Increased L1 Activity in the Site of Human Adult Brain Neurogenesis von Kurnosov, Alexey A., Ustyugova, Svetlana V., Nazarov, Vadim I., Minervina, Anastasia A., Komkov, Alexander Yu, Shugay, Mikhail, Pogorelyy, Mikhail V., Khodosevich, Konstantin V., Mamedov, Ilgar Z., Lebedev, Yuri B.

“… Retroelement activity is a common source of polymorphisms in human genome. The mechanism whereby retroelements contribute to the intraindividual genetic …”
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Huge Overlap of Individual TCR Beta Repertoires von Shugay, Mikhail, Bolotin, Dmitriy A., Putintseva, Ekaterina V., Pogorelyy, Mikhail V., Mamedov, Ilgar Z., Chudakov, Dmitriy M.

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Robust SARS-CoV-2 T cell responses with common TCRαβ motifs toward COVID-19 vaccines in patients with hematological malignancy impacting B cells von Nguyen, Thi H.O., Rowntree, Louise C., Allen, Lilith F., Chua, Brendon Y., Kedzierski, Lukasz, Lim, Chhay, Lasica, Masa, Tennakoon, G. Surekha, Saunders, Natalie R., Crane, Megan, Chee, Lynette, Seymour, John F., Anderson, Mary Ann, Whitechurch, Ashley, Clemens, E. Bridie, Zhang, Wuji, Chang, So Young, Habel, Jennifer R., Jia, Xiaoxiao, McQuilten, Hayley A., Minervina, Anastasia A., Pogorelyy, Mikhail V., Chaurasia, Priyanka, Petersen, Jan, Menon, Tejas, Hensen, Luca, Neil, Jessica A., Mordant, Francesca L., Tan, Hyon-Xhi, Cabug, Aira F., Wheatley, Adam K., Kent, Stephen J., Subbarao, Kanta, Karapanagiotidis, Theo, Huang, Han, Vo, Lynn K., Cain, Natalie L., Nicholson, Suellen, Krammer, Florian, Gibney, Grace, James, Fiona, Trevillyan, Janine M., Trubiano, Jason A., Mitchell, Jeni, Christensen, Britt, Bond, Katherine A., Williamson, Deborah A., Rossjohn, Jamie, Crawford, Jeremy Chase, Thomas, Paul G., Thursky, Karin A., Slavin, Monica A., Tam, Constantine S., Teh, Benjamin W., Kedzierska, Katherine

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VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2 von Goncharov, Mikhail, Bagaev, Dmitry, Shcherbinin, Dmitrii, Zvyagin, Ivan, Bolotin, Dmitry, Thomas, Paul G., Minervina, Anastasia A., Pogorelyy, Mikhail V., Ladell, Kristin, McLaren, James E., Price, David A., Nguyen, Thi H. O., Rowntree, Louise C., Clemens, E. Bridie, Kedzierska, Katherine, Dolton, Garry, Rius, Cristina Rafael, Sewell, Andrew, Samir, Jerome, Luciani, Fabio, Zornikova, Ksenia V., Khmelevskaya, Alexandra A., Sheetikov, Saveliy A., Efimov, Grigory A., Chudakov, Dmitry, Shugay, Mikhail

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Mother and Child T Cell Receptor Repertoires: Deep Profiling Study von Putintseva, Ekaterina V., Britanova, Olga V., Staroverov, Dmitriy B., Merzlyak, Ekaterina M., Turchaninova, Maria A., Shugay, Mikhail, Bolotin, Dmitriy A., Pogorelyy, Mikhail V., Mamedov, Ilgar Z., Bobrynina, Vlasta, Maschan, Mikhail, Lebedev, Yuri B., Chudakov, Dmitriy M.

“… The relationship between maternal and child immunity has been actively studied in the context of complications during pregnancy, autoimmune diseases, and …”
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tcR: an R package for T cell receptor repertoire advanced data analysis von Nazarov, Vadim I., Pogorelyy, Mikhail V., Komech, Ekaterina A., Zvyagin, Ivan V., Bolotin, Dmitry A., Shugay, Mikhail, Chudakov, Dmitry M., Lebedev, Yury B., Mamedov, Ilgar Z.

“… Background The Immunoglobulins (IG) and the T cell receptors (TR) play the key role in antigen recognition during the adaptive immune response. Recent progress …”
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Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins von Pogorelyy, Mikhail V, Minervina, Anastasia A, Touzel, Maximilian Puelma, Sycheva, Anastasiia L, Komech, Ekaterina A, Kovalenko, Elena I, Karganova, Galina G, Egorov, Evgeniy S, Komkov, Alexander Yu, Chudakov, Dmitriy M, Mamedov, Ilgar Z, Mora, Thierry, Walczak, Aleksandra M, Lebedev, Yuri B

“… T cell receptor (TCR) repertoire data contain information about infections that could be used in disease diagnostics and vaccine development, but extracting …”
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