Suchergebnisse - "Pirovano, Giacomo"

TOPKi-NBD: a fluorescent small molecule for tumor imaging von Pirovano, Giacomo, Roberts, Sheryl, Reiner, Thomas

“… Purpose OTS514 is a highly specific inhibitor targeting lymphokine-activated killer T cell-originated protein kinase (TOPK). A fluorescently labeled TOPK …”
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The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia von Ashton, Thomas M., Fokas, Emmanouil, Kunz-Schughart, Leoni A., Folkes, Lisa K., Anbalagan, Selvakumar, Huether, Melanie, Kelly, Catherine J., Pirovano, Giacomo, Buffa, Francesca M., Hammond, Ester M., Stratford, Michael, Muschel, Ruth J., Higgins, Geoff S., McKenna, William Gillies

“… Tumour hypoxia renders cancer cells resistant to cancer therapy, resulting in markedly worse clinical outcomes. To find clinical candidate compounds that …”
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Targeted Brain Tumor Radiotherapy Using an Auger Emitter von Pirovano, Giacomo, Jannetti, Stephen A, Carter, Lukas M, Sadique, Ahmad, Kossatz, Susanne, Guru, Navjot, Demétrio De Souza França, Paula, Maeda, Masatomo, Zeglis, Brian M, Lewis, Jason S, Humm, John L, Reiner, Thomas

“… Glioblastoma multiforme is a highly aggressive form of brain cancer whose location, tendency to infiltrate healthy surrounding tissue, and heterogeneity …”
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Use of the γ-H2AX Assay to Investigate DNA Repair Dynamics Following Multiple Radiation Exposures von Mariotti, Luca G., Pirovano, Giacomo, Savage, Kienan I., Ghita, Mihaela, Ottolenghi, Andrea, Prise, Kevin M., Schettino, Giuseppe

“… Radiation therapy is one of the most common and effective strategies used to treat cancer. The irradiation is usually performed with a fractionated scheme, …”
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A role for human homologous recombination factors in suppressing microhomology-mediated end joining von Ahrabi, Sara, Sarkar, Sovan, Pfister, Sophia X., Pirovano, Giacomo, Higgins, Geoff S., Porter, Andrew C.G., Humphrey, Timothy C.

“… DNA double-strand breaks (DSBs) are toxic lesions, which if improperly repaired can result in cell death or genomic instability. DSB repair is usually …”
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CDK1 inhibition sensitizes normal cells to DNA damage in a cell cycle dependent manner von Prevo, Remko, Pirovano, Giacomo, Puliyadi, Rathi, Herbert, Katharine J., Rodriguez-Berriguete, Gonzalo, O'Docherty, Alice, Greaves, William, McKenna, W. Gillies, Higgins, Geoff S.

“… Cyclin-dependent kinase 1 (CDK1) orchestrates the transition from the G2 phase into mitosis and as cancer cells often display enhanced CDK1 activity, it has …”
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Validation of the use of a fluorescent PARP1 inhibitor for the detection of oral, oropharyngeal and oesophageal epithelial cancers von Kossatz, Susanne, Pirovano, Giacomo, Demétrio De Souza França, Paula, Strome, Arianna L., Sunny, Sumsum P., Zanoni, Daniella Karassawa, Mauguen, Audrey, Carney, Brandon, Brand, Christian, Shah, Veer, Ramanajinappa, Ravindra D., Hedne, Naveen, Birur, Praveen, Sihag, Smita, Ghossein, Ronald A., Gönen, Mithat, Strome, Marshall, Suresh, Amritha, Molena, Daniela, Ganly, Ian, Kuriakose, Moni A., Patel, Snehal G., Reiner, Thomas

“… For oral, oropharyngeal and oesophageal cancer, the early detection of tumours and of residual tumour after surgery are prognostic factors of recurrence rates …”
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Fluorescence labeling of a NaV1.7-targeted peptide for near-infrared nerve visualization von Gonzales, Junior, Pirovano, Giacomo, Chow, Chun Yuen, de Souza Franca, Paula Demetrio, Carter, Lukas M., Klint, Julie K., Guru, Navjot, Lewis, Jason S., King, Glenn F., Reiner, Thomas

“… Background Accidental peripheral nerve injury during surgical intervention results in a broad spectrum of potentially debilitating side effects. Tissue …”
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The anti-malarial drug atovaquone potentiates platinum-mediated cancer cell death by increasing oxidative stress von Coates, James T. T., Rodriguez-Berriguete, Gonzalo, Puliyadi, Rathi, Ashton, Thomas, Prevo, Remko, Wing, Archie, Granata, Giovanna, Pirovano, Giacomo, McKenna, Gillies W., Higgins, Geoff S.

“… Platinum chemotherapies are highly effective cytotoxic agents but often induce resistance when used as monotherapies. Combinatorial strategies limit this risk …”
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[18F]PARPi Imaging Is Not Affected by HPV Status In Vitro von Guru, Navjot, Demétrio De Souza França, Paula, Pirovano, Giacomo, Huang, Cien, Patel, Snehal G., Reiner, Thomas

“… Background. Human papillomavirus- (HPV-) associated oropharyngeal squamous cell carcinomas (OPSCCs) are clinically and pathologically distinct from …”
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Optical Imaging Modalities: Principles and Applications in Preclinical Research and Clinical Settings von Pirovano, Giacomo, Roberts, Sheryl, Kossatz, Susanne, Reiner, Thomas

“… With the ability to noninvasively image and monitor molecular processes within tumors, molecular imaging represents a fundamental tool for cancer scientists …”
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Auger: The future of precision medicine von Pirovano, Giacomo, Wilson, Thomas C., Reiner, Thomas

“… First reported by Lise Meitner in 1922 and independently by Pierre Auger in 1923, the Auger effect has been explored as a potential source for targeted …”
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T-LAK cell-originated protein kinase (TOPK): an emerging target for cancer-specific therapeutics von Herbert, Katharine J., Ashton, Thomas M., Prevo, Remko, Pirovano, Giacomo, Higgins, Geoff S.

“… ‘Targeted’ or ‘biological’ cancer treatments rely on differential gene expression between normal tissue and cancer, and genetic changes that render tumour …”
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PARP-Targeted Auger Therapy in p53 Mutant Colon Cancer Xenograft Mouse Models von Wilson, Thomas, Pirovano, Giacomo, Xiao, Gu, Samuels, Zachary, Roberts, Sheryl, Viray, Tara, Guru, Navjot, Zanzonico, Pat, Gollub, Marc, Pillarsetty, Naga Vara Kishore, Reiner, Thomas, Bargonetti, Jill

“… Despite Auger electrons being highly appealing due to their short-range and high linear energy transfer to surrounding tissues, the progress in the field has …”
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Improved radiosynthesis of 123I-MAPi, an auger theranostic agent von Wilson, Thomas C., Jannetti, Stephen A., Guru, Navjot, Pillarsetty, Nagavarakishore, Reiner, Thomas, Pirovano, Giacomo

“… 123 I-MAPi, a novel PARP1-targeted Auger radiotherapeutic has shown promising results in pre-clinical glioma model. Currently, 123 I-MAPi is synthesized using …”
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Improved radiosynthesis of 123 I-MAPi, an auger theranostic agent von Wilson, Thomas C., Jannetti, Stephen A., Guru, Navjot, Pillarsetty, Nagavarakishore, Reiner, Thomas, Pirovano, Giacomo

“… I-MAPi, a novel PARP1-targeted Auger radiotherapeutic has shown promising results in pre-clinical glioma model. Currently, I-MAPi is synthesized using …”
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Today’s Research, Tomorrow’s Practice – White Paper from the Translation of New Therapy (TNT) Radiotheranostics Kick-off Pre-meeting of the Annual World Molecular Imaging Conference 2024 von Krebs, Simone, Baird, Lisa, Pirovano, Giacomo, Yamaguchi, Aiko, Coll, Ryan P., Lee, Jason T., Carroll, Laurence S., Pomper, Martin G., Manning, H. Charles

“… Theranostics, a concept combining "therapy" and "diagnostics", is poised to enter an exponential growth phase. By using specific diagnostic markers to guide …”
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An 89Zr-HDL PET Tracer Monitors Response to a CSF1R Inhibitor von Mason, Christian A, Kossatz, Susanne, Carter, Lukas M, Pirovano, Giacomo, Brand, Christian, Guru, Navjot, Pérez-Medina, Carlos, Lewis, Jason S, Mulder, Willem J M, Reiner, Thomas

“… The immune function within the tumor microenvironment has become a prominent therapeutic target, with tumor-associated macrophages (TAMs) playing a critical …”
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Fluorescence Imaging of Peripheral Nerves by a Nav1.7-Targeted Inhibitor Cystine Knot Peptide von Gonzales, Junior, Demetrio de Souza Franca, Paula, Jiang, Yan, Pirovano, Giacomo, Kossatz, Susanne, Guru, Navjot, Yarilin, Dimitry, Agwa, Akello J, Schroeder, Christina I, Patel, Snehal G, Ganly, Ian, King, Glenn F, Reiner, Thomas

“… Twenty million Americans suffer from peripheral nerve injury caused by trauma and medical disorders, resulting in a broad spectrum of potentially debilitating …”
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18FPARPi Imaging Is Not Affected by HPV Status In Vitro von Guru, Navjot, Demétrio De Souza França, Paula, Pirovano, Giacomo, Huang, Cien, Patel, Snehal G, Reiner, Thomas

“… Human papillomavirus- (HPV-) associated oropharyngeal squamous cell carcinomas (OPSCCs) are clinically and pathologically distinct from HPV-negative tumors …”
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