Suchergebnisse - "Pilzecker, Bas"

Mutating for Good: DNA Damage Responses During Somatic Hypermutation von Pilzecker, Bas, Jacobs, Heinz

“… Somatic hypermutation (SHM) of immunoglobulin ( ) genes plays a key role in antibody mediated immunity. SHM in B cells provides the molecular basis for …”
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DNA damage tolerance in hematopoietic stem and progenitor cells in mice von Pilzecker, Bas, Buoninfante, Olimpia Alessandra, van den Berk, Paul, Lancini, Cesare, Song, Ji-Ying, Citterio, Elisabetta, Jacobs, Heinz

“… DNA damage tolerance (DDT) enables bypassing of DNA lesions during replication, thereby preventing fork stalling, replication stress, and secondary DNA damage …”
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Molecular dependencies and genomic consequences of a global DNA damage tolerance defect von de Groot, Daniel, Spanjaard, Aldo, Shah, Ronak, Kreft, Maaike, Morris, Ben, Lieftink, Cor, Catsman, Joyce J. I., Ormel, Shirley, Ayidah, Matilda, Pilzecker, Bas, Buoninfante, Olimpia Alessandra, van den Berk, Paul C. M., Beijersbergen, Roderick L., Jacobs, Heinz

“… Background DNA damage tolerance (DDT) enables replication to continue in the presence of fork stalling lesions. In mammalian cells, DDT is regulated by two …”
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Tandem Substitutions in Somatic Hypermutation von Sepúlveda-Yáñez, Julieta H., Alvarez Saravia, Diego, Pilzecker, Bas, van Schouwenburg, Pauline A., van den Burg, Mirjam, Veelken, Hendrik, Navarrete, Marcelo A., Jacobs, Heinz, Koning, Marvyn T.

“… Upon antigen recognition, activation-induced cytosine deaminase initiates affinity maturation of the B-cell receptor by somatic hypermutation (SHM) through …”
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The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity von Will Castro, Luiza S. E. P., Pieters, Wietske, Alemdehy, Mir Farshid, Aslam, Muhammad A., Buoninfante, Olimpia Alessandra, Raaijmakers, Jonne A., Pilzecker, Bas, van den Berk, Paul C. M., te Riele, Hein, Medema, René H., Pedrosa, Rozangela C., Jacobs, Heinz

“… The antihelmintic drug ABZ and its metabolites belong to the chemical family of benzimidazoles (BZM) that act as potent tubulin polymerization inhibitors, …”
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DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy von Pilzecker, Bas, Buoninfante, Olimpia Alessandra, Jacobs, Heinz

“… Abstract The DNA damage response network guards the stability of the genome from a plethora of exogenous and endogenous insults. An essential feature of the …”
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CD4 + T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness von Ahrends, Tomasz, Spanjaard, Aldo, Pilzecker, Bas, Bąbała, Nikolina, Bovens, Astrid, Xiao, Yanling, Jacobs, Heinz, Borst, Jannie

“… CD4 T cells optimize the cytotoxic T cell (CTL) response in magnitude and quality, by unknown molecular mechanisms. We here present the transcriptomic changes …”
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Mammalian life depends on two distinct pathways of DNA damage tolerance von Buoninfante, Olimpia Alessandra, Pilzecker, Bas, Spanjaard, Aldo, de Groot, Daniël, Prekovic, Stefan, Song, Ji-Ying, Lieftink, Cor, Ayidah, Matilda, Pritchard, Colin E J, Vivié, Judith, Mcgrath, Kathleen E, Huijbers, Ivo J, Philipsen, Sjaak, von Lindern, Marieke, Zwart, Wilbert, Beijersbergen, Roderick L, Palis, James, van den Berk, Paul C M, Jacobs, Heinz

“… DNA damage threatens genomic integrity and instigates stem cell failure. To bypass genotoxic lesions during replication, cells employ DNA damage tolerance …”
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PrimPol prevents APOBEC/AID family mediated DNA mutagenesis von Pilzecker, Bas, Buoninfante, Olimpia Alessandra, Pritchard, Colin, Blomberg, Olga S., Huijbers, Ivo J., van den Berk, Paul C.M., Jacobs, Heinz

“… PrimPol is a DNA damage tolerant polymerase displaying both translesion synthesis (TLS) and (re)-priming properties. This led us to study the consequences of a …”
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A C57BL/6J Fancg-KO Mouse Model Generated by CRISPR/Cas9 Partially Captures the Human Phenotype von Shah, Ronak, van den Berk, Paul C. M., Pritchard, Colin E. J., Song, Ji-Ying, Kreft, Maaike, Pilzecker, Bas, Jacobs, Heinz

“… Fanconi anemia (FA) develops due to a mutation in one of the FANC genes that are involved in the repair of interstrand crosslinks (ICLs). FANCG, a member of …”
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Dictating Phenotype, Function, and Fate of Human T Cells with Co‐Stimulatory Antibodies Presented by Filamentous Immune Cell Mimics von Schluck, Marjolein, Eggermont, Loek J., Weiden, Jorieke, Popelier, Carlijn, Weiss, Lea, Pilzecker, Bas, Kolder, Sigrid, Heinemans, Anne, Rodriguez Mogeda, Carla, Verdoes, Martijn, Figdor, Carl G., Hammink, Roel

“… T cells require a co‐stimulatory signal in addition to T‐cell receptor (TCR) stimulation to achieve full activation. While most studies focus on the …”
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Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system von Buoninfante, Olimpia Alessandra, Pilzecker, Bas, Aslam, Muhammad Assad, Zavrakidis, Ioannis, van der Wiel, Rianne, van de Ven, Marieke, van den Berk, Paul C M, Jacobs, Heinz

“… DNA damage tolerance (DDT) enables replication to continue in the presence of a damaged template and constitutes a key step in DNA interstrand crosslink …”
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Dual role of proliferating cell nuclear antigen monoubiquitination in facilitating Fanconi anemia-mediated interstrand crosslink repair von Shah, Ronak, Aslam, Muhammad Assad, Spanjaard, Aldo, de Groot, Daniel, Zürcher, Lisa M, Altelaar, Maarten, Hoekman, Liesbeth, Pritchard, Colin E J, Pilzecker, Bas, van den Berk, Paul C M, Jacobs, Heinz

“… Abstract The Fanconi anemia (FA) repair pathway governs repair of highly genotoxic DNA interstrand crosslinks (ICLs) and relies on translesion synthesis (TLS) …”
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Molecular dependencies and genomic consequences of a global DNA damage tolerance defect von Groot, Daniel De, Spanjaard, Aldo, Shah, Ronak, Kreft, Maaike, Morris, Ben, Cor Lieftink Sr, Joyce Ji Catsman, Ormel, Shirley, Ayidah, Matilda, Pilzecker, Bas, Buoninfante, Olimpia Alessandra, Paul Cm Van Denberk, Beijersbergen, Roderick L, Jacobs, Heinz

“… DNA damage tolerance (DDT) enables replication to continue in the presence of fork stalling lesions. To determine the molecular and genomic impact of a global …”
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DNA polymerase β prevents AID-instigated mutagenic non-canonical mismatch DNA repair von Mahnoush Bahjat, Stratigopoulou, Maria, Pilzecker, Bas, Van Dam, Tijmen P, Mobach, Simon, Bende, Richard J, Carel Jm Van Noesel, Jacobs, Heinz E, Guikema, Jeroen E

“… In B cells, the error-prone repair of activation-induced cytidine deaminase (AID)-induced lesions in immunoglobulin variable genes cause somatic hypermutation …”
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