Suchergebnisse - "Piehowski, Paul D"

Nanodroplet processing platform for deep and quantitative proteome profiling of 10–100 mammalian cells von Zhu, Ying, Piehowski, Paul D., Zhao, Rui, Chen, Jing, Shen, Yufeng, Moore, Ronald J., Shukla, Anil K., Petyuk, Vladislav A., Campbell-Thompson, Martha, Mathews, Clayton E., Smith, Richard D., Qian, Wei-Jun, Kelly, Ryan T.

“… Nanoscale or single-cell technologies are critical for biomedical applications. However, current mass spectrometry (MS)-based proteomic approaches require …”
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Automated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-μm spatial resolution von Piehowski, Paul D., Zhu, Ying, Bramer, Lisa M., Stratton, Kelly G., Zhao, Rui, Orton, Daniel J., Moore, Ronald J., Yuan, Jia, Mitchell, Hugh D., Gao, Yuqian, Webb-Robertson, Bobbie-Jo M., Dey, Sudhansu K., Kelly, Ryan T., Burnum-Johnson, Kristin E.

“… Biological tissues exhibit complex spatial heterogeneity that directs the functions of multicellular organisms. Quantifying protein expression is essential for …”
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Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia von Yu, Lei, Petyuk, Vladislav A., Gaiteri, Chris, Mostafavi, Sara, Young‐Pearse, Tracy, Shah, Raj C., Buchman, Aron S., Schneider, Julie A., Piehowski, Paul D., Sontag, Ryan L., Fillmore, Thomas L., Shi, Tujin, Smith, Richard D., Jager, Philip L., Bennett, David A.

“… Objective Previous gene expression analysis identified a network of coexpressed genes that is associated with β‐amyloid neuropathology and cognitive decline in …”
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A unique deubiquitinase that deconjugates phosphoribosyl-linked protein ubiquitination von Qiu, Jiazhang, Yu, Kaiwen, Fei, Xiaowen, Liu, Yao, Nakayasu, Ernesto S, Piehowski, Paul D, Shaw, Jared B, Puvar, Kedar, Das, Chittaranjan, Liu, Xiaoyun, Luo, Zhao-Qing

“… Ubiquitination regulates many aspects of host immunity and thus is a common target for infectious agents. Recent studies have revealed that members of the SidE …”
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High-resolution ultrahigh-pressure long column reversed-phase liquid chromatography for top-down proteomics von Shen, Yufeng, Tolić, Nikola, Piehowski, Paul D., Shukla, Anil K., Kim, Sangtae, Zhao, Rui, Qu, Yi, Robinson, Errol, Smith, Richard D., Paša-Tolić, Ljiljana

“… •Column length was found as an important factor for top-down proteomic RPLC separation.•Long (≥1m) columns can provide peak capacities of >400 for resolving …”
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Subnanogram proteomics: Impact of LC column selection, MS instrumentation and data analysis strategy on proteome coverage for trace samples von Zhu, Ying, Zhao, Rui, Piehowski, Paul D., Moore, Ronald J., Lim, Sujung, Orphan, Victoria J., Paša-Tolić, Ljiljana, Qian, Wei-Jun, Smith, Richard D., Kelly, Ryan T.

“… [Display omitted] •In-depth proteome analysis was achieved for low- and subnanogram biological samples.•NanoLC with 30-μm-i.d. column and Orbitrap Fusion Lumos …”
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Advanced multi-modal mass spectrometry imaging reveals functional differences of placental villous compartments at microscale resolution von Veličković, Marija, Kadam, Leena, Kim, Joonhoon, Zemaitis, Kevin J., Veličković, Dušan, Gao, Yuqian, Wu, Ruonan, Fillmore, Thomas L., Orton, Daniel, Williams, Sarah M., Monroe, Matthew E., Moore, Ronald J., Piehowski, Paul D., Bramer, Lisa M., Myatt, Leslie, Burnum-Johnson, Kristin E.

“… The placenta is a complex and heterogeneous organ that links the mother and fetus, playing a crucial role in nourishing and protecting the fetus throughout …”
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Correction: Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region von Jarlsberg, Leah G., Kedia, Komal, Wendler, Jason, Wright, Aaron T., Piehowski, Paul D., Gritsenko, Marina A., Shi, Tujin, Lewinsohn, David M., Sigal, George B., Weiner, Marc H., Smith, Richard D., Keane, Joseph, Jacobs, Jon M., Nahid, Payam

“… [This corrects the article DOI: 10.1371/journal.pone.0250586.] …”
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efam: an expanded, metaproteome-supported HMM profile database of viral protein families von Zayed, Ahmed A, Lücking, Dominik, Mohssen, Mohamed, Cronin, Dylan, Bolduc, Ben, Gregory, Ann C, Hargreaves, Katherine R, Piehowski, Paul D, White III, Richard A, Huang, Eric L, Adkins, Joshua N, Roux, Simon, Moraru, Cristina, Sullivan, Matthew B

“… Abstract Motivation Viruses infect, reprogram and kill microbes, leading to profound ecosystem consequences, from elemental cycling in oceans and soils to …”
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Integrated lipidomic and proteomic profiling reveals metabolic network disruption by SARS-CoV-2 variants von Farley, Scotland E., Kyle, Jennifer E., Jahn, Helene, Bramer, Lisa M., Piehowski, Paul D., Shepmoes, Athena A., Kaiser, Brooke LD, Williams, Sarai M., Eder, Josie G., Schultz, Carsten, Tafesse, Fikadu G.

“… The rapid evolution of SARS-CoV-2 has produced myriad viral strains with increasing transmissibility and capacity for immune evasion. While effective …”
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An Integrative Analysis of Tumor Proteomic and Phosphoproteomic Profiles to Examine the Relationships Between Kinase Activity and Phosphorylation von Arshad, Osama A, Danna, Vincent, Petyuk, Vladislav A, Piehowski, Paul D, Liu, Tao, Rodland, Karin D, McDermott, Jason E

“… Phosphorylation of proteins is a key way cells regulate function, both at the individual protein level and at the level of signaling pathways. Kinases are …”
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Automated Nanoflow Two-Dimensional Reversed-Phase Liquid Chromatography System Enables In-Depth Proteome and Phosphoproteome Profiling of Nanoscale Samples von Dou, Maowei, Tsai, Chia-Feng, Piehowski, Paul D, Wang, Yang, Fillmore, Thomas L, Zhao, Rui, Moore, Ronald J, Zhang, Pengfei, Qian, Wei-Jun, Smith, Richard D, Liu, Tao, Kelly, Ryan T, Shi, Tujin, Zhu, Ying

“… Two-dimensional reversed-phase capillary liquid chromatography (2D RPLC) separations have enabled comprehensive proteome profiling of biological systems …”
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Robust collection and processing for label-free single voxel proteomics von Kitata, Reta Birhanu, Velickovic, Marija, Xu, Zhangyang, Zhao, Rui, Scholten, David, Chu, Rosalie K., Orton, Daniel J., Chrisler, William B., Zhang, Tong, Mathews, Jeremy V., Bumgarner, Benjamin M., Gursel, Demirkan B., Moore, Ronald J., Piehowski, Paul D., Liu, Tao, Smith, Richard D., Liu, Huiping, Wasserfall, Clive H., Tsai, Chia-Feng, Shi, Tujin

“… With advanced mass spectrometry (MS)-based proteomics, genome-scale proteome coverage can be achieved from bulk tissues. However, such bulk measurement lacks …”
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CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance von Ma, Shaolin, Mangala, Lingegowda S., Hu, Wen, Bayaktar, Emine, Yokoi, Akira, Hu, Wei, Pradeep, Sunila, Lee, Sanghoon, Piehowski, Paul D., Villar-Prados, Alejandro, Wu, Sherry Y., McGuire, Michael H., Lara, Olivia D., Rodriguez-Aguayo, Cristian, LaFargue, Christopher J., Jennings, Nicholas B., Rodland, Karin D., Liu, Tao, Kundra, Vikas, Ram, Prahlad T., Ramakrishnan, Sundaram, Lopez-Berestein, Gabriel, Coleman, Robert L., Sood, Anil K.

“… Despite wide use of anti-vascular endothelial growth factor (VEGF) therapy for many solid cancers, most individuals become resistant to this therapy, leading …”
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Accurate Identification of Deamidation and Citrullination from Global Shotgun Proteomics Data Using a Dual-Search Delta Score Strategy von Wang, Xi, Swensen, Adam C, Zhang, Tong, Piehowski, Paul D, Gaffrey, Matthew J, Monroe, Matthew E, Zhu, Ying, Dong, Hailiang, Qian, Wei-Jun

“… Proteins with deamidated/citrullinated amino acids play critical roles in the pathogenesis of many human diseases; however, identifying these modifications in …”
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Determining protein polarization proteome-wide using physical dissection of individual Stentor coeruleus cells von Lin, Athena, Piehowski, Paul D, Tsai, Chia-Feng, Makushok, Tatyana, Yi, Lian, Diaz, Ulises, Yan, Connie, Summers, Diana, Sood, Pranidhi, Smith, Richard D, Liu, Tao, Marshall, Wallace F

“… Cellular components are non-randomly arranged with respect to the shape and polarity of the whole cell. Patterning within cells can extend down to the level of …”
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Oncogenic NTRK3 mutations exhibit differential sensitivity to tropomyosin receptor kinase inhibitors in patients with acute myeloid leukemia von Joshi, Sunil K, Huang, Ariane, Pittsenbarger, Janét, Shinde, Ujwal, Posso, Camilo, Piehowski, Paul D, Gosline, Sara J C, Press, Richard D, Gritsenko, Marina A, Hutchinson, Chelsea, Weitz, Karl K, Watanabe-Smith, Kevin, Long, Nicola, Rodland, Karin D, Tyner, Jeffrey W, Druker, Brian J, Tognon, Cristina E

“… Not available.Not available …”
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Spatially-Resolved Proteomics: Rapid Quantitative Analysis of Laser Capture Microdissected Alveolar Tissue Samples von Clair, Geremy, Piehowski, Paul D., Nicola, Teodora, Kitzmiller, Joseph A., Huang, Eric L., Zink, Erika M., Sontag, Ryan L., Orton, Daniel J., Moore, Ronald J., Carson, James P., Smith, Richard D., Whitsett, Jeffrey A., Corley, Richard A., Ambalavanan, Namasivayam, Ansong, Charles

“… Laser capture microdissection (LCM)-enabled region-specific tissue analyses are critical to better understand complex multicellular processes. However, current …”
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Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region von Jarsberg, Leah G., Kedia, Komal, Wendler, Jason, Wright, Aaron T., Piehowski, Paul D., Gritsenko, Marina A., Shi, Tujin, Lewinsohn, David M., Sigal, George B., Weiner, Marc H., Smith, Richard D., Keane, Joseph, Jacobs, Jon M., Nahid, Payam

“… Contemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus non-African regions, …”
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SNaPP: Simplified Nanoproteomics Platform for Reproducible Global Proteomic Analysis of Nanogram Protein Quantities von Huang, Eric L, Piehowski, Paul D, Orton, Daniel J, Moore, Ronald J, Qian, Wei-Jun, Casey, Cameron P, Sun, Xiaofei, Dey, Sudhansu K, Burnum-Johnson, Kristin E, Smith, Richard D

“… Global proteomic analyses of complex protein samples in nanogram quantities require a fastidious approach to achieve in-depth protein coverage and quantitative …”
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