Search Results - "Pharoah, Paul D P"

Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study by Ali, H. Raza, Chlon, Leon, Pharoah, Paul D. P., Markowetz, Florian, Caldas, Carlos

“…Immune infiltration of breast tumours is associated with clinical outcome. However, past work has not accounted for the diversity of functionally distinct cell…”
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Polygenic risk-tailored screening for prostate cancer: A benefit–harm and cost-effectiveness modelling study by Callender, Tom, Emberton, Mark, Morris, Steve, Eeles, Ros, Kote-Jarai, Zsofia, Pharoah, Paul D. P., Pashayan, Nora

“…The United States Preventive Services Task Force supports individualised decision-making for prostate-specific antigen (PSA)-based screening in men aged 55-69…”
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Breast cancer risk factors and their effects on survival: a Mendelian randomisation study by Escala-Garcia, Maria, Morra, Anna, Canisius, Sander, Chang-Claude, Jenny, Kar, Siddhartha, Zheng, Wei, Bojesen, Stig E., Easton, Doug, Pharoah, Paul D. P., Schmidt, Marjanka K.

“…Background Observational studies have investigated the association of risk factors with breast cancer prognosis. However, the results have been conflicting and…”
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An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation by Candido dos Reis, Francisco J., Wishart, Gordon C., Dicks, Ed M., Greenberg, David, Rashbass, Jem, Schmidt, Marjanka K., van den Broek, Alexandra J., Ellis, Ian O., Green, Andrew, Rakha, Emad, Maishman, Tom, Eccles, Diana M., Pharoah, Paul D. P.

“…Background PREDICT is a breast cancer prognostic and treatment benefit model implemented online. The overall fit of the model has been good in multiple…”
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Association between tumour infiltrating lymphocytes, histotype and clinical outcome in epithelial ovarian cancer by James, Fiona R., Jiminez-Linan, Mercedes, Alsop, Jennifer, Mack, Marie, Song, Honglin, Brenton, James D., Pharoah, Paul D. P., Ali, H. Raza

“…Background There is evidence that some ovarian tumours evoke an immune response, which can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate…”
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Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer by Pharoah, Paul D.P, Antoniou, Antonis C, Easton, Douglas F, Ponder, Bruce A.J

“…This article reviews the genetic susceptibility to breast cancer, with emphasis on genomewide association studies that have uncovered six single-nucleotide…”
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PREDICT breast v4.0: an update to the PREDICT breast prognostic model by Pharoah, Paul D. P., Hsiao, Yi-Wen, Wishart, Gordon C., Peng, Pei-Chen

“…Objective The PREDICT breast prognostic and treatment benefit model has undergone several revisions since its release. The latest version (v3.1) was developed…”
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Genomic risk prediction of coronary artery disease in women with breast cancer: a prospective cohort study by Liou, Lathan, Kaptoge, Stephen, Dennis, Joe, Shah, Mitul, Tyrer, Jonathan, Inouye, Michael, Easton, Douglas F., Pharoah, Paul D. P.

“…Background Advancements in cancer therapeutics have resulted in increases in cancer-related survival; however, there is a growing clinical dilemma. The current…”
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Risk factors for the incidence of breast cancer: do they affect survival from the disease? by Barnett, Gillian C, Shah, Mitul, Redman, Karen, Easton, Douglas F, Ponder, Bruce A J, Pharoah, Paul D P

“…Risk factors that influence the incidence of breast cancer may also affect survival after diagnosis. Data from 4,560 women with invasive breast cancer who had…”
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Association studies for finding cancer-susceptibility genetic variants by Pharoah, Paul D. P., Dunning, Alison M., Ponder, Bruce A. J., Easton, Douglas F.

“…Key Points The polygenic model for cancer susceptibility indicates that much of the inherited risk of cancer is due to multiple risk alleles, each with a low…”
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Meta-analysis confirms BCL2 is an independent prognostic marker in breast cancer by Callagy, Grace M, Webber, Mark J, Pharoah, Paul DP, Caldas, Carlos

“…Background A number of protein markers have been investigated as prognostic adjuncts in breast cancer but their translation into clinical practice has been…”
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Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Screening for Breast Cancer: A Life-Table Model by Pashayan, Nora, Morris, Steve, Gilbert, Fiona J, Pharoah, Paul D P

“…The age-based or "one-size-fits-all" breast screening approach does not take into account the individual variation in risk. Mammography screening reduces death…”
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The importance of using public data to validate reported associations by Chenevix-Trench, Georgia, Beesley, Jonathan, Pharoah, Paul D. P., Berchuck, Andrew

“…About the Authors: Georgia Chenevix-Trench Roles Conceptualization, Writing – original draft * E-mail: georgiaT@qimr.edu.au Affiliation: Queensland Institute…”
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Association between Common Variation in 120 Candidate Genes and Breast Cancer Risk by Pharoah, Paul D. P, Tyrer, Jonathan, Dunning, Alison M, Easton, Douglas F, Ponder, Bruce A. J

“…Association studies in candidate genes have been widely used to search for common low penetrance susceptibility alleles, but few definite associations have…”
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Multiple loci with different cancer specificities within the 8q24 gene desert by Ghoussaini, Maya, Song, Honglin, Koessler, Thibaud, Al Olama, Ali Amin, Kote-Jarai, Zsofia, Driver, Kristy E, Pooley, Karen A, Ramus, Susan J, Kjaer, Susanne Krüger, Hogdall, Estrid, DiCioccio, Richard A, Whittemore, Alice S, Gayther, Simon A, Giles, Graham G, Guy, Michelle, Edwards, Stephen M, Morrison, Jonathan, Donovan, Jenny L, Hamdy, Freddie C, Dearnaley, David P, Ardern-Jones, Audrey T, Hall, Amanda L, O'Brien, Lynne T, Gehr-Swain, Beatrice N, Wilkinson, Rosemary A, Brown, Paul M, Hopper, John L, Neal, David E, Pharoah, Paul D P, Ponder, Bruce A J, Eeles, Rosalind A, Easton, Douglas F, Dunning, Alison M

“…Recent studies based on genome-wide association, linkage, and admixture scan analysis have reported associations of various genetic variants in 8q24 with…”
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Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study by Barnett, Gillian C, Coles, Charlotte E, Elliott, Rebecca M, Baynes, Caroline, Luccarini, Craig, Conroy, Don, Wilkinson, Jennifer S, Tyrer, Jonathan, Misra, Vivek, Platte, Radka, Gulliford, Sarah L, Sydes, Matthew R, Hall, Emma, Bentzen, Søren M, Dearnaley, David P, Burnet, Neil G, Pharoah, Paul DP, Dunning, Alison M, West, Catharine ML

“…Several studies have reported associations between radiation toxicity and single nucleotide polymorphisms (SNPs) in candidate genes. Few associations have been…”
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Polygenic scores in cancer by Yang, Xin, Kar, Siddhartha, Antoniou, Antonis C, Pharoah, Paul D P

“…Since the publication of the first genome-wide association study for cancer in 2007, thousands of common alleles that are associated with the risk of cancer…”
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Ovarian cancer risk associated with inherited inflammation-related variants by White, Kristin L, Schildkraut, Joellen M, Palmieri, Rachel T, Iversen, Jr, Edwin S, Berchuck, Andrew, Vierkant, Robert A, Rider, David N, Charbonneau, Bridget, Cicek, Mine S, Sutphen, Rebecca, Birrer, Michael J, Pharoah, Paul P D, Song, Honglin, Tyrer, Jonathan, Gayther, Simon A, Ramus, Susan J, Wentzensen, Nicolas, Yang, Hannah P, Garcia-Closas, Montserrat, Phelan, Catherine M, Cunningham, Julie M, Fridley, Brooke L, Sellers, Thomas A, Goode, Ellen L

“…The importance of inflammation pathways to the development of many human cancers prompted us to examine the associations between single-nucleotide…”
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Cost-effectiveness of Population-Based BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2 Mutation Testing in Unselected General Population Women by Manchanda, Ranjit, Patel, Shreeya, Gordeev, Vladimir S, Antoniou, Antonis C, Smith, Shantel, Lee, Andrew, Hopper, John L, MacInnis, Robert J, Turnbull, Clare, Ramus, Susan J, Gayther, Simon A, Pharoah, Paul D P, Menon, Usha, Jacobs, Ian, Legood, Rosa

“…The cost-effectiveness of population-based panel testing for high- and moderate-penetrance ovarian cancer (OC)/breast cancer (BC) gene mutations is unknown. We…”
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The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case-Control Study by Dorling, Leila, Kar, Siddhartha, Michailidou, Kyriaki, Hiller, Louise, Vallier, Anne-Laure, Ingle, Susan, Hardy, Richard, Bowden, Sarah J., Dunn, Janet A., Twelves, Chris, Poole, Christopher J., Caldas, Carlos, Earl, Helena M., Pharoah, Paul D. P., Abraham, Jean E.

“…Ninety-four common genetic variants are confirmed to be associated with breast cancer. This study tested the hypothesis that breast cancer susceptibility…”
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