Výsledky vyhledávání - "Pharmacology."

Glucagon-Like Peptide 1 and Its Analogs Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight Autor Anderberg, Rozita H, Richard, Jennifer E, Eerola, Kim, López-Ferreras, Lorena, Banke, Elin, Hansson, Caroline, Nissbrandt, Hans, Berqquist, Filip, Gribble, Fiona M, Reimann, Frank, Wernstedt Asterholm, Ingrid, Lamy, Christophe M, Skibicka, Karolina P

“…Glucagon-like peptide 1 (GLP-1) and serotonin play critical roles in energy balance regulation. Both systems are exploited clinically as antiobesity…”
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Comparative Pharmacodynamics and Pharmacokinetics of Oral Direct Thrombin and Factor Xa Inhibitors in Development Autor Eriksson, Bengt I., Quinlan, Daniel J., Weitz, Jeffrey I.

“…For the past five decades, there has been little progress in the development of oral anticoagulants, with the choices being limited to the vitamin K…”
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Targeting apoptosis pathways by natural compounds in cancer: Marine compounds as lead structures and chemical tools for cancer therapy Autor von Schwarzenberg, Karin, Vollmar, Angelika M.

“…Natural compounds derived from marine organisms have shown a wide variety of anti-tumor effects and a lot of attention has been drawn to further development of…”
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Important Flavonoids and Their Role as a Therapeutic Agent Autor Ullah, Asad, Munir, Sidra, Badshah, Syed Lal, Khan, Noreen, Ghani, Lubna, Poulson, Benjamin Gabriel, Emwas, Abdul-Hamid, Jaremko, Mariusz

“…Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and leaves, with potential applications in medicinal chemistry. Flavonoids…”
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Antiviral Drugs for Viruses Other Than Human Immunodeficiency Virus Autor Razonable, Raymund R.

“…Most viral diseases, with the exception of those caused by human immunodeficiency virus, are self-limited illnesses that do not require specific antiviral…”
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Presynaptic α4β2 nicotinic acetylcholine receptors increase glutamate release and serotonin neuron excitability in the dorsal raphe nucleus Autor Garduño, Julieta, Galindo-Charles, Luis, Jiménez-Rodríguez, Javier, Galarraga, Elvira, Tapia, Dagoberto, Mihailescu, Stefan, Hernandez-Lopez, Salvador

“…Several behavioral effects of nicotine are mediated by changes in serotonin (5-HT) release in brain areas that receive serotonergic afferents from the dorsal…”
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Effects of Microplate Type and Broth Additives on Microdilution MIC Susceptibility Assays Autor Kavanagh, Angela, Ramu, Soumya, Gong, Yujing, Cooper, Matthew A, Blaskovich, Mark A T

“…The determination of antibiotic potency against bacterial strains by assessment of their minimum inhibitory concentration normally uses a standardized broth…”
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Systematic review and meta-analysis of in vitro efficacy of antibiotic combination therapy against carbapenem-resistant Gram-negative bacilli Autor Scudeller, Luigia, Righi, Elda, Chiamenti, Margherita, Bragantini, Damiano, Menchinelli, Giulia, Cattaneo, Paolo, Giske, Christian G., Lodise, Thomas, Sanguinetti, Maurizio, Piddock, Laura J.V., Franceschi, François, Ellis, Sally, Carrara, Elena, Savoldi, Alessia, Tacconelli, Evelina

“…•In vitro models may inform on the efficacy of antibiotic regimens against carbapenem-resistant Gram-negative bacilli.•High or moderate synergism was shown for…”
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Onion (Allium cepa L.) peels: A review on bioactive compounds and biomedical activities Autor Kumar, Manoj, Barbhai, Mrunal D., Hasan, Muzaffar, Punia, Sneh, Dhumal, Sangram, Radha, Rais, Nadeem, Chandran, Deepak, Pandiselvam, R., Kothakota, Anjineyulu, Tomar, Maharishi, Satankar, Varsha, Senapathy, Marisennayya, Anitha, T., Dey, Abhijit, Sayed, Ali A.S., Gadallah, Farouk M., Amarowicz, Ryszard, Mekhemar, Mohamed

“…Huge quantities of byproducts/wastes generated in onion processing are usually discarded, but they are excellent sources of bioactive compounds and…”
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Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants Autor Tikhonov, Denis B, Zhorov, Boris S

“…Local anesthetics, antiarrhythmics, and anticonvulsants include both charged and electroneutral compounds that block voltage-gated sodium channels. Prior…”
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Performance of a broth microdilution assay for routine minimum inhibitory concentration determination of 14 anti-tuberculous drugs against the Mycobacterium tuberculosis complex based on the EUCAST reference protocol Autor Mansjö, Mikael, Espinosa-Gongora, Carmen, Samanci, Ishak, Groenheit, Ramona, Werngren, Jim

“…This comparative study aimed at qualifying a broth microdilution (BMD) assay for phenotypic drug susceptibility testing (pDST) of complex (MTBC) strains for…”
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The contribution of α4β2 and non-α4β2 nicotinic acetylcholine receptors to the discriminative stimulus effects of nicotine and varenicline in mice Autor de Moura, Fernando B., McMahon, Lance R.

“…Rationale The extent to which non-α4β2 versus α4β2* nAChRs contribute to the behavioral effects of varenicline and other nAChR agonists is unclear. Objectives…”
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Development of a reliable automated screening system to identify small molecules and biologics that promote human β-cell regeneration Autor Aamodt, Kristie I, Aramandla, Radhika, Brown, Judy J, Fiaschi-Taesch, Nathalie, Wang, Peng, Stewart, Andrew F, Brissova, Marcela, Powers, Alvin C

“…Numerous compounds stimulate rodent β-cell proliferation; however, translating these findings to human β-cells remains a challenge. To examine human β-cell…”
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Antioxidant dietary approach in treatment of fatty liver: New insights and updates Autor Ferramosca, Alessandra, Di Giacomo, Mariangela, Zara, Vincenzo

“…Non-alcoholic fatty liver disease (NAFLD) is a common clinicopathological condition, encompassing a range of conditions caused by lipid deposition within liver…”
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Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala Autor Di, Shi, Itoga, Christy A, Fisher, Marc O, Solomonow, Jonathan, Roltsch, Emily A, Gilpin, Nicholas W, Tasker, Jeffrey G

“…Stress and glucocorticoids stimulate the rapid mobilization of endocannabinoids in the basolateral amygdala (BLA). Cannabinoid receptors in the BLA contribute…”
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JAK selectivity and the implications for clinical inhibition of pharmacodynamic cytokine signalling by filgotinib, upadacitinib, tofacitinib and baricitinib Autor Traves, Paqui G, Murray, Bernard, Campigotto, Federico, Galien, René, Meng, Amy, Di Paolo, Julie A

“…ObjectiveJanus kinase inhibitors (JAKinibs) are efficacious in rheumatoid arthritis (RA) with variable reported rates of adverse events, potentially related to…”
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Novel therapies for metastatic castrate-resistant prostate cancer Autor Dayyani, Farshid, Gallick, Gary E, Logothetis, Christopher J, Corn, Paul G

“…Recent advances in tumor biology have made remarkable achievements in the development of therapy for metastatic castrate-resistant prostate cancer. These…”
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Genomic Characterization of Antimicrobial-Resistant Salmonella enterica in Duck, Chicken, and Pig Farms and Retail Markets in Eastern China Autor Tang, Biao, Elbediwi, Mohammed, Nambiar, Reshma B., Yang, Hua, Lin, Jiahui, Yue, Min

“…Public health is a significant concern in China, and the foodborne pathogen Salmonella , which is spread via the animal-borne food chain, plays an important…”
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Kaempferol-induces vasorelaxation via endothelium-independent pathways in rat isolated pulmonary artery Autor Mahobiya, Archana, Singh, Thakur Uttam, Rungsung, Soya, Kumar, Tarun, Chandrasekaran, Gokul, Parida, Subhashree, Kumar, Dinesh

“…Kaempferol, a flavonoid, is the essential part of human diet. Flavonoids have different pharmacological activities like cardioprotective, anti-inflammatory and…”
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Advance on the Flavonoid C-glycosides and Health Benefits Autor Xiao, Jianbo, Capanoglu, Esra, Jassbi, Amir Reza, Miron, Anca

“…The dietary flavonoids, especially their glycosides, are the most vital phytochemicals in diets and are of great general interest due to their diverse…”
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