Suchergebnisse - "Perks, Claire M"

Association between genetically proxied PCSK9 inhibition and prostate cancer risk: A Mendelian randomisation study von Fang, Si, Yarmolinsky, James, Gill, Dipender, Bull, Caroline J., Perks, Claire M., Davey Smith, George, Gaunt, Tom R., Richardson, Tom G.

“… Prostate cancer (PrCa) is the second most prevalent malignancy in men worldwide. Observational studies have linked the use of low-density lipoprotein …”
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Caffeine and Caffeic Acid Inhibit Growth and Modify Estrogen Receptor and Insulin-like Growth Factor I Receptor Levels in Human Breast Cancer von Rosendahl, Ann H, Perks, Claire M, Zeng, Li, Markkula, Andrea, Simonsson, Maria, Rose, Carsten, Ingvar, Christian, Holly, Jeff M P, Jernström, Helena

“… Epidemiologic studies indicate that dietary factors, such as coffee, may influence breast cancer and modulate hormone receptor status. The purpose of this …”
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Editorial: Insights in cancer endocrinology: 2022 von Perks, Claire M., Belfiore, Antonino

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Editorial: The Role of the IGF/Insulin-IGFBP Axis in Normal Physiology and Disease von Takahashi, Shin-Ichiro, Perks, Claire M.

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The Neglected Insulin: IGF-II, a Metabolic Regulator with Implications for Diabetes, Obesity, and Cancer von Holly, Jeff M. P., Biernacka, Kalina, Perks, Claire M.

“… When originally discovered, one of the initial observations was that, when all of the insulin peptide was depleted from serum, the vast majority of the insulin …”
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Obesity, Diabetes and COVID-19: An Infectious Disease Spreading From the East Collides With the Consequences of an Unhealthy Western Lifestyle von Holly, Jeff M. P., Biernacka, Kalina, Maskell, Nick, Perks, Claire M.

“… The pandemic of COVID-19, caused by the coronavirus, SARS-CoV-2, has had a global impact not seen for an infectious disease for over a century. This acute …”
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Editorial: insights in cancer endocrinology 2021 von Perks, Claire M., Belfiore, Antonino

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CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer von Uzor, Simon, Porazinski, Sean R., Li, Ling, Clark, Bethany, Ajiro, Masahiko, Iida, Kei, Hagiwara, Masatoshi, Alqasem, Abdullah A., Perks, Claire M., Wilson, Ian D., Oltean, Sebastian, Ladomery, Michael R.

“… Dysregulation of alternative splicing is a feature of cancer, both in aetiology and progression. It occurs because of mutations in splice sites or sites that …”
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Evaluating circulating tumour cell enrichment techniques to establish an appropriate method for clinical application in glioblastomas von Barber, Hannah R., Perks, Claire M., Kurian, Kathreena M.

“… Brain tumours reduce life expectancy for an average of 20 years per patient, the highest of any cancer. A third of brain tumour patients visit their GP at …”
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Editorial: Women in endocrinology 2021 von Perks, Claire M., Radovick, Sally, Samaras, Katherine

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Glioma Stem-Like Cells and Metabolism: Potential for Novel Therapeutic Strategies von Harland, Abigail, Liu, Xia, Ghirardello, Mattia, Galan, M. Carmen, Perks, Claire M., Kurian, Kathreena M.

“… Glioma stem-like cells (GSCs) were first described as a population which may in part be resistant to traditional chemotherapeutic therapies and responsible for …”
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Investigation of the Interplay between Circulating Lipids and IGF-I and Relevance to Breast Cancer Risk: An Observational and Mendelian Randomization Study von Tan, Vanessa Y, Bull, Caroline J, Biernacka, Kalina M, Teumer, Alexander, Richardson, Tom G, Sanderson, Eleanor, Corbin, Laura J, Dudding, Tom, Qi, Qibin, Kaplan, Robert C, Rotter, Jerome I, Friedrich, Nele, Völker, Uwe, Mayerle, Julia, Perks, Claire M, Holly, Jeff M P, Timpson, Nicholas J

“… Circulating lipids and insulin-like growth factor 1 (IGF-I) have been reliably associated with breast cancer. Observational studies suggest an interplay …”
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Insulin‐like growth factor binding protein‐2 and glucose‐regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH‐wildtype glioblastoma patients von Harland, Abigail J., Perks, Claire M., White, Paul, Kurian, Kathreena M., Barber, Hannah R.

“… Background The overall survival of IDH‐wildtype glioblastoma patients is poor despite best available treatments. There is an urgent need for new biomarkers to …”
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Mini Review: Opposing Pathologies in Cancer and Alzheimer's Disease: Does the PI3K/Akt Pathway Provide Clues? von Barker, Rachel M., Holly, Jeff M. P., Biernacka, Kalina M., Allen-Birt, Shelley J., Perks, Claire M.

“… This minireview is a brief overview examining the roles of insulin-like growth factors (IGFs) and the PI3K/Akt pathway in two apparently unconnected diseases: …”
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Systemic Metabolism, Its Regulators, and Cancer: Past Mistakes and Future Potential von Holly, Jeff M. P., Biernacka, Kalina, Perks, Claire M.

“… There has been a resurgence of interest in cancer metabolism; primarily in the resetting of metabolism within malignant cells. Metabolism within cells has …”
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Effects of Physiological Levels of the Green Tea Extract Epigallocatechin-3-Gallate on Breast Cancer Cells von Zeng, Li, Holly, Jeff M. P., Perks, Claire M.

“… Physiological concentrations of the green tea extract epigallocatechin-3-gallate (EGCG) caused growth inhibition in estrogen receptor α (ERα)-positive MCF7 …”
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Mini-Review: Current Bladder Cancer Treatment—The Need for Improvement von Gill, Emily, Perks, Claire M.

“… Bladder cancer is the tenth most common cancer and is a significant burden on health care services worldwide, as it is one of the most costly cancers to treat …”
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A Role for ER-Beta in the Effects of Low-Density Lipoprotein Cholesterol and 27-Hydroxycholesterol on Breast Cancer Progression: Involvement of the IGF Signalling Pathway? von Mashat, Reham M., Zielinska, Hanna A., Holly, Jeff M. P., Perks, Claire M.

“… Cholesterol—in particular, high levels of low-density lipoprotein (LDL) and its metabolite, 27-hydroxycholesterol (27-OHC)—is correlated with increases in the …”
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Case report: Molecular characterisation of adipose-tissue derived cells from a patient with ROHHAD syndrome von Biernacka, Kalina M., Giri, Dinesh, Hawton, Katherine, Segers, Francisca, Perks, Claire M., Hamilton-Shield, Julian P.

“… There have been over 100 cases of Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) syndrome reported, …”
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Hormonal mechanisms underlying the relationship between obesity and breast cancer von Perks, Claire M, Holly, Jeff M P

“… Given the worldwide epidemic of obesity, it is inevitably an increasingly common comorbidity for women who develop breast cancer; therefore, it is critical to …”
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