Suchergebnisse - "Penengo, Lorenza"

Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity von Vujanovic, Marko, Krietsch, Jana, Raso, Maria Chiara, Terraneo, Nastassja, Zellweger, Ralph, Schmid, Jonas A, Taglialatela, Angelo, Huang, Jen-Wei, Holland, Cory L, Zwicky, Katharina, Herrador, Raquel, Jacobs, Heinz, Cortez, David, Ciccia, Alberto, Penengo, Lorenza, Lopes, Massimo

“… DNA damage tolerance during eukaryotic replication is orchestrated by PCNA ubiquitination. While monoubiquitination activates mutagenic translesion synthesis, …”
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RNF168 Promotes Noncanonical K27 Ubiquitination to Signal DNA Damage von Gatti, Marco, Pinato, Sabrina, Maiolica, Alessio, Rocchio, Francesca, Prato, Maria Giulia, Aebersold, Ruedi, Penengo, Lorenza

“… Ubiquitination regulates numerous cellular processes by generating a versatile communication system based on eight structurally and functionally different …”
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A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase von Gatti, Marco, Pinato, Sabrina, Maspero, Elena, Soffientini, Paolo, Polo, Simona, Penengo, Lorenza

“… Ubiquitination of histones plays a critical role in the regulation of several processes within the nucleus, including maintenance of genome stability and …”
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Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15 von Moro, Ramona N., Biswas, Uddipta, Kharat, Suhas S., Duzanic, Filip D., Das, Prosun, Stavrou, Maria, Raso, Maria C., Freire, Raimundo, Chaudhuri, Arnab Ray, Sharan, Shyam K., Penengo, Lorenza

“… DNA replication and repair defects or genotoxic treatments trigger interferon (IFN)-mediated inflammatory responses. However, whether and how IFN signaling in …”
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A Novel BRCA1-Associated Protein-1 Isoform Affects Response of Mesothelioma Cells to Drugs Impairing BRCA1-Mediated DNA Repair von Parrotta, Rossella, Okonska, Agata, Ronner, Manuel, Weder, Walter, Stahel, Rolf, Penengo, Lorenza, Felley-Bosco, Emanuela

“… BRCA1 associated protein1 (BAP1) is a tumor suppressor involved in multiple cellular processes such as transcriptional regulation, chromatin modification by …”
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ASH1L histone methyltransferase regulates the handoff between damage recognition factors in global-genome nucleotide excision repair von Balbo Pogliano, Chiara, Gatti, Marco, Rüthemann, Peter, Garajovà, Zuzana, Penengo, Lorenza, Naegeli, Hanspeter

“… Global-genome nucleotide excision repair (GG-NER) prevents ultraviolet (UV) light-induced skin cancer by removing mutagenic cyclobutane pyrimidine dimers …”
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Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is a tumoural cytokine released from melanoma von Grolla, Ambra A., Torretta, Simone, Gnemmi, Ilaria, Amoruso, Angela, Orsomando, Giuseppe, Gatti, Marco, Caldarelli, Antonio, Lim, Dmitry, Penengo, Lorenza, Brunelleschi, Sandra, Genazzani, Armando A., Travelli, Cristina

“… Summary High plasma levels of nicotinamide phosphoribosyltransferase (NAMPT), traditionally considered an intracellular enzyme with a key role in NAD …”
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UMI, a Novel RNF168 Ubiquitin Binding Domain Involved in the DNA Damage Signaling Pathway von Pinato, Sabrina, Gatti, Marco, Scandiuzzi, Cristina, Confalonieri, Stefano, Penengo, Lorenza

“… Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley …”
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Pramel7 mediates ground-state pluripotency through proteasomal–epigenetic combined pathways von Graf, Urs, Casanova, Elisa A., Wyck, Sarah, Dalcher, Damian, Gatti, Marco, Vollenweider, Eva, Okoniewski, Michal J., Weber, Fabienne A., Patel, Sameera S., Schmid, Marc W., Li, Jiwen, Sharif, Jafar, Wanner, Guido A., Koseki, Haruhiko, Wong, Jiemin, Pelczar, Pawel, Penengo, Lorenza, Santoro, Raffaella, Cinelli, Paolo

“… Naive pluripotency is established in preimplantation epiblast. Embryonic stem cells (ESCs) represent the immortalization of naive pluripotency. 2i culture has …”
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Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability von Mattiroli, Francesca, Penengo, Lorenza

“… Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin plays a central role in these mechanisms. The ever-growing complexity …”
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Human papillomavirus type 16 E6 and E7 oncoproteins interact with the nuclear p53-binding protein 1 in an in vitro reconstructed 3D epithelium: new insights for the virus-induced DNA damage response von Squarzanti, Diletta Francesca, Sorrentino, Rita, Landini, Manuela Miriam, Chiesa, Andrea, Pinato, Sabrina, Rocchio, Francesca, Mattii, Martina, Penengo, Lorenza, Azzimonti, Barbara

“… Background Despite vaccination and screening measures, anogenital cancer, mainly promoted by HPV16 oncoproteins, still represents the fourth tumor and the …”
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Modulation of the chromatin phosphoproteome by the Haspin protein kinase von Maiolica, Alessio, de Medina-Redondo, Maria, Schoof, Erwin M, Chaikuad, Apirat, Villa, Fabrizio, Gatti, Marco, Jeganathan, Siva, Lou, Hua Jane, Novy, Karel, Hauri, Simon, Toprak, Umut H, Herzog, Franz, Meraldi, Patrick, Penengo, Lorenza, Turk, Benjamin E, Knapp, Stefan, Linding, Rune, Aebersold, Ruedi

“… Recent discoveries have highlighted the importance of Haspin kinase activity for the correct positioning of the kinase Aurora B at the centromere. Haspin …”
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The ubiquitination code: a signalling problem von Woelk, Tanja, Sigismund, Sara, Penengo, Lorenza, Polo, Simona

“… Ubiquitin is a highly versatile post-translational modification that controls virtually all types of cellular events. Over the past ten years we have learned …”
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SV40 replication in human mesothelial cells induces HGF/Met receptor activation: a model for viral-related carcinogenesis of human malignant mesothelioma von Cacciotti, P, Libener, R, Betta, P, Martini, F, Porta, C, Procopio, A, Strizzi, L, Penengo, L, Tognon, M, Mutti, L, Gaudino, G

“… Recent studies suggested that simian virus 40 (SV40) may cause malignant mesothelioma, although the pathogenic mechanism is unclear. We found that in …”
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Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling von Germano, Serena, Barberis, Davide, Santoro, Massimo M, Penengo, Lorenza, Citri, Ami, Yarden, Yosef, Gaudino, Giovanni

“… Ron, the tyrosine kinase receptor for macrophage-stimulating protein is responsible for proliferation and migration of cells from different tissues. Ron can …”
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c-Cbl is a critical modulator of the Ron tyrosine kinase receptor von Penengo, Lorenza, Rubin, Chanan, Yarden, Yosef, Gaudino, Giovanni

“… Ron, the receptor tyrosine kinase (RTK) for the macrophage stimulating protein (MSP), activates multiple signaling pathways by recruiting several positive …”
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The interferon response at the intersection of genome integrity and innate immunity von Duzanic, Filip D., Penengo, Lorenza

“… In recent years, numerous reports indicated that, besides pathogen infections, DNA replication stress and defective DNA repair can trigger the innate immune …”
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Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the ron receptor von Santoro, Massimo Mattia, Penengo, Lorenza, Minetto, Marta, Orecchia, Sara, Cilli, Michele, Gaudino, Giovanni

“… Ron (the receptor for Macrophage Stimulating Protein) has never been implicated before in human malignancies or in cell transformation. In this report we show …”
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Interferon-stimulated gene 15 accelerates replication fork progression inducing chromosomal breakage von Raso, Maria Chiara, Djoric, Nikola, Walser, Franziska, Hess, Sandra, Schmid, Fabian Marc, Burger, Sibylle, Knobeloch, Klaus-Peter, Penengo, Lorenza

“… DNA replication is highly regulated by the ubiquitin system, which plays key roles upon stress. The ubiquitin-like modifier ISG15 (interferon-stimulated gene …”
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Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response von Walser, Franziska, Mulder, Monique P C, Bragantini, Benoît, Burger, Sibylle, Gubser, Tatiana, Gatti, Marco, Botuyan, Maria Victoria, Villa, Alessandra, Altmeyer, Matthias, Neri, Dario, Ovaa, Huib, Mer, Georges, Penengo, Lorenza

“… The ubiquitin system regulates the DNA damage response (DDR) by modifying histone H2A at Lys15 (H2AK15ub) and triggering downstream signaling events. Here, we …”
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