Suchergebnisse - "Peck, Barrie"

Lipid desaturation – the next step in targeting lipogenesis in cancer? von Peck, Barrie, Schulze, Almut

“… Metabolic reprogramming is a central feature of transformed cells. Cancer metabolism is now fully back in the focus of cancer research, as the interactions …”
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Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development von Baenke, Franziska, Peck, Barrie, Miess, Heike, Schulze, Almut

“… An increased rate of lipid synthesis in cancerous tissues has long been recognised as an important aspect of the rewired metabolism of transformed cells …”
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Lipid Metabolism at the Nexus of Diet and Tumor Microenvironment von Peck, Barrie, Schulze, Almut

“… Obesity is a leading contributing factor to cancer development worldwide. Epidemiological evidence suggests that diet affects cancer risk and also …”
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The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma von Miess, Heike, Dankworth, Beatrice, Gouw, Arvin M., Rosenfeldt, Mathias, Schmitz, Werner, Jiang, Ming, Saunders, Becky, Howell, Michael, Downward, Julian, Felsher, Dean W., Peck, Barrie, Schulze, Almut

“… Metabolic reprogramming is a prominent feature of clear cell renal cell carcinoma (ccRCC). Here we investigated metabolic dependencies in a panel of ccRCC cell …”
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Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress von Schug, Zachary T, Peck, Barrie, Jones, Dylan T, Zhang, Qifeng, Grosskurth, Shaun, Alam, Israt S, Goodwin, Louise M, Smethurst, Elizabeth, Mason, Susan, Blyth, Karen, McGarry, Lynn, James, Daniel, Shanks, Emma, Kalna, Gabriela, Saunders, Rebecca E, Jiang, Ming, Howell, Michael, Lassailly, Francois, Thin, May Zaw, Spencer-Dene, Bradley, Stamp, Gordon, van den Broek, Niels J F, Mackay, Gillian, Bulusu, Vinay, Kamphorst, Jurre J, Tardito, Saverio, Strachan, David, Harris, Adrian L, Aboagye, Eric O, Critchlow, Susan E, Wakelam, Michael J O, Schulze, Almut, Gottlieb, Eyal

“… A functional genomics study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted …”
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Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation von Bensaad, Karim, Favaro, Elena, Lewis, Caroline A., Peck, Barrie, Lord, Simon, Collins, Jennifer M., Pinnick, Katherine E., Wigfield, Simon, Buffa, Francesca M., Li, Ji-Liang, Zhang, Qifeng, Wakelam, Michael J.O., Karpe, Fredrik, Schulze, Almut, Harris, Adrian L.

“… An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) …”
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SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2 von Peck, Barrie, Chen, Chun-Yuan, Ho, Ka-Kei, Di Fruscia, Paolo, Myatt, Stephen S, Coombes, R Charles, Fuchter, Matthew J, Hsiao, Chwan-Deng, Lam, Eric W-F

“… SIRT proteins play an important role in the survival and drug resistance of tumor cells, especially during chemotherapy. In this study, we investigated the …”
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Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments von Peck, Barrie, Schug, Zachary T., Zhang, Qifeng, Dankworth, Beatrice, Jones, Dylan T., Smethurst, Elizabeth, Patel, Rachana, Mason, Susan, Jiang, Ming, Saunders, Rebecca, Howell, Michael, Mitter, Richard, Spencer-Dene, Bradley, Stamp, Gordon, McGarry, Lynn, James, Daniel, Shanks, Emma, Aboagye, Eric O., Critchlow, Susan E., Leung, Hing Y., Harris, Adrian L., Wakelam, Michael J. O., Gottlieb, Eyal, Schulze, Almut

“… Background Enhanced macromolecule biosynthesis is integral to growth and proliferation of cancer cells. Lipid biosynthesis has been predicted to be an …”
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FOXM1 confers acquired cisplatin resistance in breast cancer cells von Kwok, Jimmy M-M, Peck, Barrie, Monteiro, Lara J, Schwenen, Helma D C, Millour, Julie, Coombes, R Charles, Myatt, Stephen S, Lam, Eric W-F

“… The transcription factor Forkhead box M1 (FOXM1) is a key regulator of cell proliferation and is overexpressed in many forms of primary cancers, leading to …”
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Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth von Griffiths, Beatrice, Lewis, Caroline A, Bensaad, Karim, Ros, Susana, Zhang, Qifeng, Ferber, Emma C, Konisti, Sofia, Peck, Barrie, Miess, Heike, East, Philip, Wakelam, Michael, Harris, Adrian L, Schulze, Almut

“… Background Regulation of lipid metabolism via activation of sterol regulatory element binding proteins (SREBPs) has emerged as an important function of the …”
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Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer von McGovern, Ursula B, Francis, Richard E, Peck, Barrie, Guest, Stephanie K, Wang, Jun, Myatt, Stephen S, Krol, Janna, Kwok, Jimmy M-M, Polychronis, Andreas, Coombes, R Charles, Lam, Eric W-F

“… Gefitinib (Iressa) is a specific and effective epidermal growth factor receptor inhibitor. An understanding of the downstream cellular targets of gefitinib …”
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TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression von Gibson, Shayin V., Tomas Bort, Elena, Rodríguez-Fernández, Lucía, Allen, Michael D., Gomm, Jennifer J., Goulding, Iain, auf dem Keller, Ulrich, Agnoletto, Andrea, Brisken, Cathrin, Peck, Barrie, Cameron, Angus J., Marshall, John F., Jones, J. Louise, Carter, Edward P., Grose, Richard P.

“… Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Virtually all women with DCIS are treated, despite evidence suggesting …”
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Cholesteryl esters: fueling the fury of prostate cancer von Peck, Barrie, Schulze, Almut

“… Tumors display distinct metabolic programs, and altered lipid metabolism is emerging as an important process in cancer. In this issue, Yue et al. (2014) report …”
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SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response von Bland, Philip, Saville, Harry, Wai, Patty T., Curnow, Lucinda, Muirhead, Gareth, Nieminuszczy, Jadwiga, Ravindran, Nivedita, John, Marie Beatrix, Hedayat, Somaieh, Barker, Holly E., Wright, James, Yu, Lu, Mavrommati, Ioanna, Read, Abigail, Peck, Barrie, Allen, Mark, Gazinska, Patrycja, Pemberton, Helen N., Gulati, Aditi, Nash, Sarah, Noor, Farzana, Guppy, Naomi, Roxanis, Ioannis, Pratt, Guy, Oldreive, Ceri, Stankovic, Tatjana, Barlow, Samantha, Kalirai, Helen, Coupland, Sarah E., Broderick, Ronan, Alsafadi, Samar, Houy, Alexandre, Stern, Marc-Henri, Pettit, Stephen, Choudhary, Jyoti S., Haider, Syed, Niedzwiedz, Wojciech, Lord, Christopher J., Natrajan, Rachael

“… SF3B1 hotspot mutations are associated with a poor prognosis in several tumor types and lead to global disruption of canonical splicing. Through synthetic …”
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CREBBP histone acetyltransferase domain mutations predict response to mTOR inhibition in relapsed/refractory follicular lymphoma von Kumar, Emil Arjun, Korfi, Koorosh, Bewicke‐Copley, Findlay, Close, Karina, Heward, James, Witzig, Thomas, Leukam, Michael, Ansell, Stephen, Scott, Jessica, Clear, Andrew, Efeyan, Alejo, Green, Michael, Siebert, Reiner, Peck, Barrie, Calaminici, Maria, Wang, Jun, Smith, Sonali, Novak, Anne, Fitzgibbon, Jude, Okosun, Jessica

“… Summary Despite the clinical and molecular heterogeneity of follicular lymphoma (FL), there remains a lack of biomarker‐directed therapeutic approaches in …”
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A micronutrient with major effects on cancer cell viability von Kapara, Anastasia, Vannini, Alessandro, Peck, Barrie

“… Selenium is a micronutrient essential for the generation of selenoproteins, which function predominantly by detoxifying cellular reactive oxygen species. In …”
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Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model von Maguire, Sarah L, Peck, Barrie, Wai, Patty T, Campbell, James, Barker, Holly, Gulati, Aditi, Daley, Frances, Vyse, Simon, Huang, Paul, Lord, Christopher J, Farnie, Gillian, Brennan, Keith, Natrajan, Rachael

“… The initiation and progression of breast cancer from the transformation of the normal epithelium to ductal carcinoma in situ (DCIS) and invasive disease is a …”
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Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation von Dembitz, Vilma, Lawson, Hannah, Burt, Richard, Natani, Sirisha, Philippe, Céline, James, Sophie C., Atkinson, Samantha, Durko, Jozef, Wang, Lydia M., Campos, Joana, Magee, Aoife M. S., Woodley, Keith, Austin, Michael J., Rio-Machin, Ana, Casado, Pedro, Bewicke-Copley, Findlay, Rodriguez Blanco, Giovanny, Pereira-Martins, Diego, Oudejans, Lieve, Boet, Emeline, von Kriegsheim, Alex, Schwaller, Juerg, Finch, Andrew J., Patel, Bela, Sarry, Jean-Emmanuel, Tamburini, Jerome, Schuringa, Jan Jacob, Hazlehurst, Lori, Copland III, John A., Yuneva, Mariia, Peck, Barrie, Cutillas, Pedro, Fitzgibbon, Jude, Rouault-Pierre, Kevin, Kranc, Kamil, Gallipoli, Paolo

“… Identification of specific and therapeutically actionable vulnerabilities, ideally present across multiple mutational backgrounds, is needed to improve acute …”
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A role for the cancer-associated miR-106b~25 cluster in neuronal stem cells von Peck, Barrie, Schulze, Almut

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Antagonism between FOXO and MYC Regulates Cellular Powerhouse von Peck, Barrie, Ferber, Emma C., Schulze, Almut

“… Alterations in cellular metabolism are a key feature of the transformed phenotype. Enhanced macromolecule synthesis is a prerequisite for rapid proliferation …”
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