Suchergebnisse - "Paronis, Carol A"

Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans von Lutz, Joshua A., Sulima, Agnieszka, Gutman, Eugene S., Bow, Eric W., Luo, Dan, Kaska, Sophia, Prisinzano, Thomas E., Paronis, Carol A., Bergman, Jack, Imler, Gregory H., Kerr, Andrew T., Jacobson, Arthur E., Rice, Kenner C.

“… All possible diastereomeric C9-hydroxymethyl-, hydroxyethyl-, and hydroxypropyl-substituted 5-phenylmorphans were synthesized to explore the three-dimensional …”
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Concurrent Assessment of the Antinociceptive and Behaviorally Disruptive Effects of Opioids in Squirrel Monkeys von Withey, Sarah L, Paronis, Carol A, Bergman, Jack

“… Although the clinical application of opioids for pain management is often hindered by undesired behavioral impairment, preclinical assays of antinociception …”
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A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists von Chambers, Dana R., Sulima, Agnieszka, Luo, Dan, Prisinzano, Thomas E., Goldberg, Alexander, Xie, Bing, Shi, Lei, Paronis, Carol A., Bergman, Jack, Nassehi, Nima, Selley, Dana E., Imler, Gregory H., Jacobson, Arthur E., Rice, Kenner C.

“… Four sets of diastereomeric C9-alkenyl 5-phenylmorphans, varying in the length of the C9-alkenyl chain, were designed to examine the effect of these spatially …”
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Smoking, stress, and negative affect: correlation, causation, and context across stages of smoking von Kassel, Jon D, Stroud, Laura R, Paronis, Carol A

“… This transdisciplinary review of the literature addresses the questions, Do stress and negative affect (NA) promote smoking? and Does smoking genuinely relieve …”
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Altered sleep during spontaneous cannabinoid withdrawal in male mice von Missig, Galen, Mehta, Niyati, Robbins, James O, Good, Cameron H, Iliopoulos-Tsoutsouvas, Christos, Makriyannis, Alex, Nikas, Spyros P, Bergman, Jack, Carlezon, Jr, William A, Paronis, Carol A

“… Cessation of cannabinoid use in humans often leads to a withdrawal state that includes sleep disruption. Despite important health implications, little is known …”
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The Intriguing Effects of Substituents in the N-Phenethyl Moiety of Norhydromorphone: A Bifunctional Opioid from a Set of “Tail Wags Dog” Experiments von Wang, Meining, Irvin, Thomas C., Herdman, Christine A., Hanna, Ramsey D., Hassan, Sergio A., Lee, Yong-Sok, Kaska, Sophia, Crowley, Rachel Saylor, Prisinzano, Thomas E., Withey, Sarah L., Paronis, Carol A., Bergman, Jack, Inan, Saadet, Geller, Ellen B., Adler, Martin W., Kopajtic, Theresa A., Katz, Jonathan L., Chadderdon, Aaron M., Traynor, John R., Jacobson, Arthur E., Rice, Kenner C.

“… (−)-N-Phenethyl analogs of optically pure N-norhydromorphone were synthesized and pharmacologically evaluated in several in vitro assays (opioid receptor …”
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Buprenorphine and opioid antagonism, tolerance, and naltrexone-precipitated withdrawal von Paronis, Carol A, Bergman, Jack

“… The dual antagonist effects of the mixed-action μ-opioid partial agonist/κ-opioid antagonist buprenorphine have not been previously compared in behavioral …”
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The Effects of Chronic Naltrexone on Reinstatement of Opioid-Induced Drug-Seeking Behavior and Antinociception von Withey, Sarah L, Bergman, Jack, Paronis, Carol A

“… Opioid addiction is a chronic relapsing disorder in which drug-seeking behavior during abstinence can be provoked by exposure to a -opioid receptor (MOR) …”
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Xanomeline treatment attenuates cocaine self-administration in rats and nonhuman primates von Marsh, Samuel A., Heslep, Nicholas, Paronis, Carol A., Bergman, Jack, Negus, S. Stevens, Banks, Matthew L.

“… The lack of an FDA-approved pharmacotherapy to combat cocaine use disorder (CUD) is an ongoing and urgent public health challenge. Emerging evidence suggests …”
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Probing the Carboxyester Side Chain in Controlled Deactivation (−)‑Δ8‑Tetrahydrocannabinols von Nikas, Spyros P, Sharma, Rishi, Paronis, Carol A, Kulkarni, Shashank, Thakur, Ganesh A, Hurst, Dow, Wood, JodiAnne T, Gifford, Roger S, Rajarshi, Girija, Liu, Yingpeng, Raghav, Jimit Girish, Guo, Jason Jianxin, Järbe, Torbjörn U.C, Reggio, Patricia H, Bergman, Jack, Makriyannis, Alexandros

“… We recently reported on a controlled deactivation/detoxification approach for obtaining cannabinoids with improved druggability. Our design incorporates a …”
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Effects of inhaled low-concentration xenon gas on naltrexone-precipitated withdrawal symptoms in morphine-dependent mice von Kaufman, Marc J., Meloni, Edward G., Qrareya, Alaa N., Paronis, Carol A., Bogin, Vlad

“… Opioid withdrawal symptoms (OWS) are highly aversive and prompt unprescribed opioid use, which increases morbidity, mortality, and, among individuals being …”
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Behavioral Effects of Opioid Full and Partial Agonists During Chronic Buprenorphine Treatment von Withey, Sarah L, Spealman, Roger D, Bergman, Jack, Paronis, Carol A

“… Buprenorphine, a partial agonist at the -opioid receptor, is commonly prescribed for the management of opioid addiction. Notwithstanding buprenorphine's …”
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Δ(9)-Tetrahydrocannabinol acts as a partial agonist/antagonist in mice von Paronis, Carol A, Nikas, Spyros P, Shukla, Vidyanand G, Makriyannis, Alexandros

“… Δ-Tetrahydrocannabinol (THC) has been characterized as a partial agonist at cannabinoid CB1 receptors in vitro; however, it often produces the same maximum …”
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Reinforcing effects of synthetic cathinones in rhesus monkeys: Dose-response and behavioral economic analyses von de Moura, Fernando B., Sherwood, Alexander, Prisinzano, Thomas E., Paronis, Carol A., Bergman, Jack, Kohut, Stephen J.

“… The abuse of synthetic cathinones (“bath salts”) with psychomotor stimulant and/or entactogenic properties emerged as a public health concern when they were …”
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Improved cyclobutyl nabilone analogs as potent CB1 receptor agonists von Papanastasiou, Ioannis P., Georgiadis, Markos-Orestis, Iliopoulos-Tsoutsouvas, Christos, Paronis, Carol A., Brust, Christina A., Tran, Ngan K., Ji, Lipin, Ma, Xiaoyu, Wood, JodiAnne T., Zvonok, Nikolai, Tong, Fei, Bohn, Laura M., Nikas, Spyros P., Makriyannis, Alexandros

“… In earlier work, we explored the SAR for the C3 side chain pharmacophore in the hexahydrocannabinol template represented by the drug nabilone, which resulted …”
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Cannabinoid-induced lower lip retraction in rats von Chopda, Girish R., Nikas, Spyros P., Sharma, Rishi, Kulkarni, Shashank, Makriyannis, Alexandros, Paronis, Carol A.

“… Rationale Lower lip retraction (LLR) in rats has been described as a distinctive effect of 5-HT 1A agonists. In the course of evaluating behavioral effects of …”
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Discriminative-Stimulus Effects of Synthetic Cathinones in Squirrel Monkeys von Wakeford, Alison G P, Sherwood, Alexander M, Prisinzano, Thomas E, Bergman, Jack, Kohut, Stephen J, Paronis, Carol A

“… Abstract Background Synthetic cathinones display overlapping behavioral effects with psychostimulants (e.g., methamphetamine [MA]) and/or entactogens (e.g., …”
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Modification by dopaminergic drugs of choice behavior under concurrent schedules of intravenous saline and food delivery in monkeys von Gasior, Maciej, Paronis, Carol A, Bergman, Jack

“… The allocation of "choice" behavior provides a measure that may be useful in developing experimental models of clinical relapse. In the present experiments, …”
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Long-Lasting In Vivo Effects of the Cannabinoid CB1 Antagonist AM6538 von Paronis, Carol A, Chopda, Girish R, Vemuri, Kiran, Zakarian, Ani S, Makriyannis, Alexandros, Bergman, Jack

“… AM6538 is a cannabinoid antagonist that binds CB1 receptors expressed in HEK-293 cells in a wash-resistant manner. The effects of AM6538 in live animals has …”
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Effects of cocaine under concurrent fixed ratio schedules of food and IV drug availability: a novel choice procedure in monkeys von Paronis, Carol A., Gasior, Maciej, Bergman, Jack

“… The relative reinforcing strength of cocaine can be characterized by the distribution of operant behavior during the availability of other reinforcing stimuli …”
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