Suchergebnisse - "Park, Stephen D E"

A Complete Mitochondrial Genome Sequence from a Mesolithic Wild Aurochs (Bos primigenius) von Edwards, Ceiridwen J., Magee, David A., Park, Stephen D. E., McGettigan, Paul A., Lohan, Amanda J., Murphy, Alison, Finlay, Emma K., Shapiro, Beth, Chamberlain, Andrew T., Richards, Martin B., Bradley, Daniel G., Loftus, Brendan J., MacHugh, David E.

“… The derivation of domestic cattle from the extinct wild aurochs (Bos primigenius) has been well-documented by archaeological and genetic studies. Genetic …”
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Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis von Magee, David A., Taraktsoglou, Maria, Killick, Kate E., Nalpas, Nicolas C., Browne, John A., Park, Stephen D. E., Conlon, Kevin M., Lynn, David J., Hokamp, Karsten, Gordon, Stephen V., Gormley, Eamonn, MacHugh, David E.

“… Mycobacterium bovis, the causative agent of bovine tuberculosis, is a major cause of mortality in global cattle populations. Macrophages are among the first …”
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Genome sequencing of the extinct Eurasian wild aurochs, Bos primigenius, illuminates the phylogeography and evolution of cattle von Park, Stephen D E, Magee, David A., McGettigan, Paul A., Teasdale, Matthew D., Edwards, Ceiridwen J., Lohan, Amanda J., Murphy, Alison, Braud, Martin, Donoghue, Mark T., Liu, Yuan, Chamberlain, Andrew T., Rue-Albrecht, Kévin, Schroeder, Steven, Spillane, Charles, Tai, Shuaishuai, Bradley, Daniel G., Sonstegard, Tad S., Loftus, Brendan J., MacHugh, David E.

“… Background Domestication of the now-extinct wild aurochs, Bos primigenius , gave rise to the two major domestic extant cattle taxa, B. taurus and B. indicus  …”
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Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes von Killick, Kate E, Browne, John A, Park, Stephen DE, Magee, David A, Martin, Irene, Meade, Kieran G, Gordon, Stephen V, Gormley, Eamonn, O'Farrelly, Cliona, Hokamp, Karsten, MacHugh, David E

“… Background Mycobacterium bovis is the causative agent of bovine tuberculosis (BTB), a pathological infection with significant economic impact. Recent studies …”
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Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility von O'Gorman, Grace M, Park, Stephen DE, Hill, Emmeline W, Meade, Kieran G, Coussens, Paul M, Agaba, Morris, Naessens, Jan, Kemp, Stephen J, MacHugh, David E

“… Background African animal trypanosomiasis (AAT) caused by tsetse fly-transmitted protozoa of the genus Trypanosoma is a major constraint on livestock and …”
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The application of transcriptomic data in the authentication of beef derived from contrasting production systems von Sweeney, Torres, Lejeune, Alex, Moloney, Aidan P., Monahan, Frank J., Gettigan, Paul Mc, Downey, Gerard, Park, Stephen D. E., Ryan, Marion T.

“… Background Differences between cattle production systems can influence the nutritional and sensory characteristics of beef, in particular its fatty acid (FA) …”
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Genomic Characterisation of the Indigenous Irish Kerry Cattle Breed von Browett, Sam, McHugo, Gillian, Richardson, Ian W., Magee, David A., Park, Stephen D. E., Fahey, Alan G., Kearney, John F., Correia, Carolina N., Randhawa, Imtiaz A. S., MacHugh, David E.

“… Kerry cattle are an endangered landrace heritage breed of cultural importance to Ireland. In the present study we have used genome-wide SNP array data to …”
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RNA-seq Transcriptional Profiling of Peripheral Blood Leukocytes from Cattle Infected with Mycobacterium bovis von McLoughlin, Kirsten E., Nalpas, Nicolas C., Rue-Albrecht, Kévin, Browne, John A., Magee, David A., Killick, Kate E., Park, Stephen D. E., Hokamp, Karsten, Meade, Kieran G., O’Farrelly, Cliona, Gormley, Eamonn, Gordon, Stephen V., MacHugh, David E.

“… Bovine tuberculosis, caused by infection with Mycobacterium bovis, is a major endemic disease affecting cattle populations worldwide, despite the …”
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Pan-genomic analysis of bovine monocyte-derived macrophage gene expression in response to in vitro infection with Mycobacterium avium subspecies paratuberculosis von MacHugh, David E, Taraktsoglou, Maria, Killick, Kate E, Nalpas, Nicolas C, Browne, John A, DE Park, Stephen, Hokamp, Karsten, Gormley, Eamonn, Magee, David A

“… Mycobacterium avium subspecies paratuberculosis is the causative agent of Johne’s disease, an intestinal disease of ruminants with major economic consequences …”
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A Population Genomics Analysis of the Native Irish Galway Sheep Breed von McHugo, Gillian P., Browett, Sam, Randhawa, Imtiaz A. S., Howard, Dawn J., Mullen, Michael P., Richardson, Ian W., Park, Stephen D. E., Magee, David A., Scraggs, Erik, Dover, Michael J., Correia, Carolina N., Hanrahan, James P., MacHugh, David E.

“… The Galway sheep population is the only native Irish sheep breed and this livestock genetic resource is currently categorised as 'at-risk'. In the present …”
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Bioinformatic discovery of novel bioactive peptides von Edwards, Richard J, Moran, Niamh, Devocelle, Marc, Kiernan, Aoife, Meade, Gerardene, Signac, William, Foy, Martina, Park, Stephen D E, Dunne, Eimear, Kenny, Dermot, Shields, Denis C

“… Short synthetic oligopeptides based on regions of human proteins that encompass functional motifs are versatile reagents for understanding protein signaling …”
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Whole-transcriptome, high-throughput RNA sequence analysis of the bovine macrophage response to Mycobacterium bovis infection in vitro von Nalpas, Nicolas C, Park, Stephen DE, Magee, David A, Taraktsoglou, Maria, Browne, John A, Conlon, Kevin M, Rue-Albrecht, Kévin, Killick, Kate E, Hokamp, Karsten, Lohan, Amanda J, Loftus, Brendan J, Gormley, Eamonn, Gordon, Stephen V, MacHugh, David E

“… Background Mycobacterium bovis , the causative agent of bovine tuberculosis, is an intracellular pathogen that can persist inside host macrophages during …”
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Key Hub and Bottleneck Genes Differentiate the Macrophage Response to Virulent and Attenuated Mycobacterium bovis von Killick, Kate E., Magee, David A., Park, Stephen D. E., Taraktsoglou, Maria, Browne, John A., Conlon, Kevin M., Nalpas, Nicolas C., Gormley, Eamonn, Gordon, Stephen V., MacHugh, David E., Hokamp, Karsten

“… Mycobacterium bovis is an intracellular pathogen that causes tuberculosis in cattle. Following infection, the pathogen resides and persists inside host …”
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Domestication of cattle: Two or three events? von Pitt, Daniel, Sevane, Natalia, Nicolazzi, Ezequiel L., MacHugh, David E., Park, Stephen D. E., Colli, Licia, Martinez, Rodrigo, Bruford, Michael W., Orozco‐terWengel, Pablo

“… Cattle have been invaluable for the transition of human society from nomadic hunter‐gatherers to sedentary farming communities throughout much of Europe, Asia …”
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Transcriptional adaptations following exercise in Thoroughbred horse skeletal muscle highlights molecular mechanisms that lead to muscle hypertrophy von McGivney, Beatrice A, Eivers, Suzanne S, MacHugh, David E, MacLeod, James N, O'Gorman, Grace M, Park, Stephen DE, Katz, Lisa M, Hill, Emmeline W

“… Background Selection for exercise-adapted phenotypes in the Thoroughbred racehorse has provided a valuable model system to understand molecular responses to …”
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Transmission ratio distortion at the growth hormone gene (GH1) in bovine preimplantation embryos: An in vitro culture-induced phenomenon? von Murphy, Angela M., Meade, Kieran G., Hayes, Patricia A., Park, Stephen D.E., Evans, Alex C.O., Lonergan, Patrick, MacHugh, David E.

“… The growth hormone gene (GH1) and its polypeptide product (GH) have a crucial role in reproduction, embryogenesis and general development. A polymorphism …”
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Genome-Wide microRNA Binding Site Variation between Extinct Wild Aurochs and Modern Cattle Identifies Candidate microRNA-Regulated Domestication Genes von Braud, Martin, Magee, David A., Park, Stephen D. E., Sonstegard, Tad S., Waters, Sinead M., MacHugh, David E., Spillane, Charles

“… The domestication of cattle from the now-extinct wild aurochs ( ) involved selection for physiological and behavioral traits, with underlying genetic factors …”
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Analysis of the Bovine Monocyte-Derived Macrophage Response to Mycobacterium avium Subspecies Paratuberculosis Infection Using RNA-seq von Casey, Maura E., Meade, Kieran G., Nalpas, Nicolas C., Taraktsoglou, Maria, Browne, John A., Killick, Kate E., Park, Stephen D. E., Gormley, Eamonn, Hokamp, Karsten, Magee, David A., MacHugh, David E.

“… Johne's disease, caused by infection with Mycobacterium avium subsp. paratuberculosis, (MAP), is a chronic intestinal disease of ruminants with serious …”
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Linkage mapping of the locus for inherited ovine arthrogryposis (IOA) to sheep Chromosome 5 von Murphy, Angela M., MacHugh, David E., Park, Stephen D.E., Scraggs, Erik, Haley, Chris S., Lynn, David J., Boland, Maurice P., Doherty, Michael L.

“… Arthrogryposis is a congenital malformation affecting the limbs of newborn animals and infants. Previous work has demonstrated that inherited ovine …”
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Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense von O'Gorman, Grace M, Park, Stephen D E, Hill, Emmeline W, Meade, Kieran G, Mitchell, Laura C, Agaba, Morris, Gibson, John P, Hanotte, Olivier, Naessens, Jan, Kemp, Stephen J, MacHugh, David E

“… To examine differences in cytokine profiles that may confer tolerance/susceptibility to bovine African trypanosomiasis, N'Dama (trypanotolerant, n = 8) and …”
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