Suchergebnisse - "Pankratz, Nathan"

Genetic and nongenetic risk factors for childhood cancer von Spector, Logan G, Pankratz, Nathan, Marcotte, Erin L

“… The causes of childhood cancer have been systematically studied for decades, but apart from high-dose radiation and prior chemotherapy there are few strong …”
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Discovering genetic interactions bridging pathways in genome-wide association studies von Fang, Gang, Wang, Wen, Paunic, Vanja, Heydari, Hamed, Costanzo, Michael, Liu, Xiaoye, Liu, Xiaotong, VanderSluis, Benjamin, Oately, Benjamin, Steinbach, Michael, Van Ness, Brian, Schadt, Eric E., Pankratz, Nathan D., Boone, Charles, Kumar, Vipin, Myers, Chad L.

“… Genetic interactions have been reported to underlie phenotypes in a variety of systems, but the extent to which they contribute to complex disease in humans …”
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Evaluation of mitochondrial DNA copy number estimation techniques von Longchamps, Ryan J., Castellani, Christina A., Yang, Stephanie Y., Newcomb, Charles E., Sumpter, Jason A., Lane, John, Grove, Megan L., Guallar, Eliseo, Pankratz, Nathan, Taylor, Kent D., Rotter, Jerome I., Boerwinkle, Eric, Arking, Dan E.

“… Mitochondrial DNA copy number (mtDNA-CN), a measure of the number of mitochondrial genomes per cell, is a minimally invasive proxy measure for mitochondrial …”
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Genome-Wide Association of Familial Late-Onset Alzheimer's Disease Replicates BIN1 and CLU and Nominates CUGBP2 in Interaction with APOE von Wijsman, Ellen M., Pankratz, Nathan D., Choi, Yoonha, Rothstein, Joseph H., Faber, Kelley M., Cheng, Rong, Lee, Joseph H., Bird, Thomas D., Bennett, David A., Diaz-Arrastia, Ramon, Goate, Alison M., Farlow, Martin, Ghetti, Bernardino, Sweet, Robert A., Foroud, Tatiana M., Mayeux, Richard

“… Late-onset Alzheimer's disease (LOAD) is the most common form of dementia in the elderly. The National Institute of Aging-Late Onset Alzheimer's Disease Family …”
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Association between Mitochondrial DNA Copy Number in Peripheral Blood and Incident CKD in the Atherosclerosis Risk in Communities Study von Tin, Adrienne, Grams, Morgan E, Ashar, Foram N, Lane, John A, Rosenberg, Avi Z, Grove, Megan L, Boerwinkle, Eric, Selvin, Elizabeth, Coresh, Josef, Pankratz, Nathan, Arking, Dan E

“… Mitochondrial dysfunction in kidney cells has been implicated in the pathogenesis of CKD. Mitochondrial DNA (mtDNA) copy number is a surrogate measure of …”
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Deleterious heteroplasmic mitochondrial mutations are associated with an increased risk of overall and cancer-specific mortality von Hong, Yun Soo, Battle, Stephanie L., Shi, Wen, Puiu, Daniela, Pillalamarri, Vamsee, Xie, Jiaqi, Pankratz, Nathan, Lake, Nicole J., Lek, Monkol, Rotter, Jerome I., Rich, Stephen S., Kooperberg, Charles, Reiner, Alex P., Auer, Paul L., Heard-Costa, Nancy, Liu, Chunyu, Lai, Meng, Murabito, Joanne M., Levy, Daniel, Grove, Megan L., Alonso, Alvaro, Gibbs, Richard, Dugan-Perez, Shannon, Gondek, Lukasz P., Guallar, Eliseo, Arking, Dan E.

“… Mitochondria carry their own circular genome and disruption of the mitochondrial genome is associated with various aging-related diseases. Unlike the nuclear …”
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Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs von Castellani, Christina A., Longchamps, Ryan J., Sumpter, Jason A., Newcomb, Charles E., Lane, John A., Grove, Megan L., Bressler, Jan, Brody, Jennifer A., Floyd, James S., Bartz, Traci M., Taylor, Kent D., Wang, Penglong, Tin, Adrienne, Coresh, Josef, Pankow, James S., Fornage, Myriam, Guallar, Eliseo, O’Rourke, Brian, Pankratz, Nathan, Liu, Chunyu, Levy, Daniel, Sotoodehnia, Nona, Boerwinkle, Eric, Arking, Dan E.

“… Background Mitochondrial DNA copy number (mtDNA-CN) has been associated with a variety of aging-related diseases, including all-cause mortality. However, the …”
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Copy number variations and cognitive phenotypes in unselected populations von Männik, Katrin, Mägi, Reedik, Macé, Aurélien, Cole, Ben, Guyatt, Anna L, Shihab, Hashem A, Maillard, Anne M, Alavere, Helene, Kolk, Anneli, Reigo, Anu, Mihailov, Evelin, Leitsalu, Liis, Ferreira, Anne-Maud, Nõukas, Margit, Teumer, Alexander, Salvi, Erika, Cusi, Daniele, McGue, Matt, Iacono, William G, Gaunt, Tom R, Beckmann, Jacques S, Jacquemont, Sébastien, Kutalik, Zoltán, Pankratz, Nathan, Timpson, Nicholas, Metspalu, Andres, Reymond, Alexandre

“… The association of copy number variations (CNVs), differing numbers of copies of genetic sequence at locations in the genome, with phenotypes such as …”
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Prediction of venous thromboembolism incidence in the general adult population using two published genetic risk scores von Folsom, Aaron R., Tang, Weihong, Hong, Ching-Ping, Rosamond, Wayne D., Lane, John A., Cushman, Mary, Pankratz, Nathan

“… Most strategies for prevention of venous thromboembolism focus on preventing recurrent events. Yet, primary prevention might be possible through approaches …”
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Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort von Shen, Li, Kim, Sungeun, Risacher, Shannon L., Nho, Kwangsik, Swaminathan, Shanker, West, John D., Foroud, Tatiana, Pankratz, Nathan, Moore, Jason H., Sloan, Chantel D., Huentelman, Matthew J., Craig, David W., DeChairo, Bryan M., Potkin, Steven G., Jack, Clifford R., Weiner, Michael W., Saykin, Andrew J.

“… A genome-wide, whole brain approach to investigate genetic effects on neuroimaging phenotypes for identifying quantitative trait loci is described. The …”
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Loss-of-function mutations in the CABLES1 gene are a novel cause of Cushing's disease von Hernández-Ramírez, Laura C, Gam, Ryhem, Valdés, Nuria, Lodish, Maya B, Pankratz, Nathan, Balsalobre, Aurelio, Gauthier, Yves, Faucz, Fabio R, Trivellin, Giampaolo, Chittiboina, Prashant, Lane, John, Kay, Denise M, Dimopoulos, Aggeliki, Gaillard, Stephan, Neou, Mario, Bertherat, Jérôme, Assié, Guillaume, Villa, Chiara, Mills, James L, Drouin, Jacques, Stratakis, Constantine A

“… The cell cycle regulator participates in the adrenal-pituitary negative feedback, and its expression is reduced in corticotropinomas, pituitary tumors with a …”
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Genomewide association study for susceptibility genes contributing to familial Parkinson disease von Pankratz, Nathan, Wilk, Jemma B, Latourelle, Jeanne C, DeStefano, Anita L, Halter, Cheryl, Pugh, Elizabeth W, Doheny, Kimberly F, Gusella, James F, Nichols, William C, Foroud, Tatiana, Myers, Richard H

“… Five genes have been identified that contribute to Mendelian forms of Parkinson disease (PD); however, mutations have been found in fewer than 5% of patients, …”
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Evaluation of the relationship between plasma lipids and abdominal aortic aneurysm: A Mendelian randomization study von Weng, Lu-Chen, Roetker, Nicholas S., Lutsey, Pamela L., Alonso, Alvaro, Guan, Weihua, Pankow, James S., Folsom, Aaron R., Steffen, Lyn M., Pankratz, Nathan, Tang, Weihong

“… Studies have reported that higher circulating levels of total cholesterol (TC), low-density lipoprotein (LDL) cholesterol and lower of high-density lipoprotein …”
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Associations of Midlife Leukocyte Telomere Length With Measures of Left Atrial Function in Community‐Dwelling Older Adults: The ARIC Study von Parikh, Romil R., Pankratz, Nathan, Lane, John A., Arking, Dan E., Eaton, Anne, Chen, Lin Yee, Lutsey, Pamela L., Tang, Weihong

“… It is unknown whether atrial myopathy, ascertained by poor left atrial (LA) function, is associated with biological aging independent of chronological age …”
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Mitochondrial DNA copy number and incident atrial fibrillation von Zhao, Di, Bartz, Traci M., Sotoodehnia, Nona, Post, Wendy S., Heckbert, Susan R., Alonso, Alvaro, Longchamps, Ryan J., Castellani, Christina A., Hong, Yun Soo, Rotter, Jerome I., Lin, Henry J., O’Rourke, Brian, Pankratz, Nathan, Lane, John A., Yang, Stephanie Y., Guallar, Eliseo, Arking, Dan E.

“… Background Mechanistic studies suggest that mitochondria DNA (mtDNA) dysfunction may be associated with increased risk of atrial fibrillation (AF). The …”
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Association between MICA polymorphisms, s-MICA levels, and pancreatic cancer risk in a population-based case-control study von Onyeaghala, Guillaume, Lane, John, Pankratz, Nathan, Nelson, Heather H., Thyagarajan, Bharat, Walcheck, Bruce, Anderson, Kristin E., Prizment, Anna E.

“… Pancreatic tumor cells may avoid immune surveillance by releasing the transmembrane major histocompatibility complex class I chain-related A (MICA) protein in …”
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Whole-exome sequencing in 415,422 individuals identifies rare variants associated with mitochondrial DNA copy number von Pillalamarri, Vamsee, Shi, Wen, Say, Conrad, Yang, Stephanie, Lane, John, Guallar, Eliseo, Pankratz, Nathan, Arking, Dan E.

“… Inter-individual variation in the number of copies of the mitochondrial genome, called mitochondrial DNA copy number (mtDNA-CN), reflects mitochondrial …”
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Gene Expression Profiles in Parkinson Disease Prefrontal Cortex Implicate FOXO1 and Genes under Its Transcriptional Regulation von Dumitriu, Alexandra, Latourelle, Jeanne C., Hadzi, Tiffany C., Pankratz, Nathan, Garza, Dan, Miller, John P., Vance, Jeffery M., Foroud, Tatiana, Beach, Thomas G., Myers, Richard H.

“… Parkinson disease (PD) is a complex neurodegenerative disorder with largely unknown genetic mechanisms. While the degeneration of dopaminergic neurons in PD …”
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Exome sequencing findings in children with annular pancreas von Pitsava, Georgia, Pankratz, Nathan, Lane, John, Yang, Wei, Rigler, Shannon, Shaw, Gary M., Mills, James L.

“… Annular pancreas (AP) is a congenital defect of unknown cause in which the pancreas encircles the duodenum. Theories include abnormal migration and rotation of …”
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Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study von Best, Lyle G., Balakrishnan, Poojitha, Cole, Shelley A., Haack, Karin, Kocarnik, Jonathan M., Pankratz, Nathan, Anderson, Matthew Z., Franceschini, Nora, Howard, Barbara V., Lee, Elisa T., North, Kari E., Umans, Jason G., Yracheta, Joseph M., Navas-Acien, Ana, Voruganti, V. Saroja

“… Increased serum levels of C-reactive protein (CRP), an important component of the innate immune response, are associated with increased risk of cardiovascular …”
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