Suchergebnisse - "Pandey, Ghanshyam N."

Biological basis of suicide and suicidal behavior von Pandey, Ghanshyam N

“… Objective Suicide is a major public health concern as each year 30000 people die by suicide in the USA alone. In the teenage population, it is the second …”
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Innate immunity receptors in depression and suicide: upregulated NOD-like receptors containing pyrin (NLRPs) and hyperactive inflammasomes in the postmortem brains of people who were depressed and died by suicide von Pandey, Ghanshyam N., Zhang, Hui, Sharma, Anuradha, Ren, Xinguo

“… Abnormalities of inflammation have been implicated in the pathophysiology of depression and suicide, based on observations of increased levels of …”
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Abnormal protein and mRNA expression of inflammatory cytokines in the prefrontal cortex of depressed individuals who died by suicide von Pandey, Ghanshyam N., Rizavi, Hooriyah S., Zhang, Hui, Bhaumik, Runa, Ren, Xinguo

“… Depression and stress are major risk factors for suicidal behaviour, and some studies show abnormalities of proinflammatory cytokines in the serum and …”
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Abnormal gene and protein expression of inflammatory cytokines in the postmortem brain of schizophrenia patients von Pandey, Ghanshyam N., Rizavi, Hooriyah S., Zhang, Hui, Ren, Xinguo

“… Immune function abnormalities have been implicated in the pathophysiology of schizophrenia (SZ). This is primarily based on the observation that the levels of …”
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Toll-like receptors in the depressed and suicide brain von Pandey, Ghanshyam N., Rizavi, Hooriyah S., Ren, Xinguo, Bhaumik, Runa, Dwivedi, Yogesh

“… Abnormalities of the immune function in depression and suicide are based in part on the observation of increased levels of proinflammatory cytokines in the …”
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Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims von Pandey, Ghanshyam N., Rizavi, Hooriyah S., Ren, Xinguo, Fareed, Jawed, Hoppensteadt, Debra A., Roberts, Rosalinda C., Conley, Robert R., Dwivedi, Yogesh

“… Teenage suicide is a major public health concern, but its neurobiology is not well understood. Proinflammatory cytokines play an important role in stress and …”
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Latent infection, inflammatory markers and suicide attempt history in depressive disorders von Coryell, William, Wilcox, Holly, Evans, Simon J, Pandey, Ghanshyam N., Jones-Brando, Lorraine, Dickerson, Faith, Yolken, Robert

“… •In a sample of patients in major depressive episodes, these with a history of multiple suicide attempts had higher toxoplasmosis gondii IgM titers and were …”
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Methylation and expression of glucocorticoid receptor exon-1 variants and FKBP5 in teenage suicide-completers von Rizavi, Hooriyah S., Khan, Omar S., Zhang, Hui, Bhaumik, Runa, Grayson, Dennis R., Pandey, Ghanshyam N.

“… A dysregulated hypothalamic-pituitary-adrenal (HPA) axis has repeatedly been demonstrated to play a fundamental role in psychiatric disorders and suicide, yet …”
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Brain-derived neurotrophic factor gene and protein expression in pediatric and adult depressed subjects von Pandey, Ghanshyam N., Dwivedi, Yogesh, Rizavi, Hooriyah S., Ren, Xinguo, Zhang, Hui, Pavuluri, Mani N.

“… Brain-derived neurotrophic factor (BDNF) is a member of a neurotrophin family and is involved in many physiological functions, including cell proliferation, …”
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Hippocampal cell proliferation regulation by repeated stress and antidepressants von Chen, Hu, Pandey, Ghanshyam N, Dwivedi, Yogesh

“… A recent hypothesis suggests reduced hippocampal neurogenesis in depression. Here, we examined cell proliferation in the dentate gyrus and the subventricular …”
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Neurotrophin Receptor Activation and Expression in Human Postmortem Brain: Effect of Suicide von Dwivedi, Yogesh, Rizavi, Hooriyah S., Zhang, Hui, Mondal, Amal C., Roberts, Rosalinda C., Conley, Robert R., Pandey, Ghanshyam N.

“… The physiological functions of neurotrophins occur through binding to two receptors: pan75 neurotrophin receptor (p75 NTR) and a family of tropomyosin receptor …”
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Signal transduction abnormalities in suicide: focus on phosphoinositide signaling system von Pandey, Ghanshyam N

“… Suicide is a major public health concern and each year about one million people die by suicide worldwide. Recent studies suggest that suicide may be associated …”
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Innate immunity in the postmortem brain of depressed and suicide subjects: Role of Toll-like receptors von Pandey, Ghanshyam N., Rizavi, Hooriyah S., Bhaumik, Runa, Ren, Xinguo

“… •The expression of several TLRs is increased in prefrontal cortex of depressed suicide subjects.•There is a dissociation in gene and protein expression of …”
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Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A von Dwivedi, Yogesh

“… Mood disorders are among the most prevalent and recurrent forms of psychiatric illnesses. In the last decade, there has been increased understanding of the …”
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Effect of depression and suicidal behavior on neuropeptide Y (NPY) and its receptors in the adult human brain: A postmortem study von Sharma, Anuradha, Ren, Xinguo, Zhang, Hui, Pandey, Ghanshyam N.

“… Neuropeptides are small proteinaceous molecules (3–100 amino acids) that are secreted by neurons and act on both neuronal and non-neuronal cells. Neuropeptide …”
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Brain-derived neurotrophic factor gene expression in pediatric bipolar disorder: effects of treatment and clinical response von Pandey, Ghanshyam N, Rizavi, Hooriyah S, Dwivedi, Yogesh, Pavuluri, Mani N

“… Pediatric bipolar disorder (PBD) is a major public health concern; however, little is known about the cellular and genetic factors that are involved in the …”
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Chemokines gene expression in the prefrontal cortex of depressed suicide victims and normal control subjects von Pandey, Ghanshyam N., Rizavi, Hooriyah S., Bhaumik, Runa, Zhang, Hui

“… •We found chemokines abnormalities in postmortem brain of depressed suicide subjects.•We found decreased mRNA levels of several chemokines in the brain of …”
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Increased protein and mRNA expression of corticotropin-releasing factor (CRF), decreased CRF receptors and CRF binding protein in specific postmortem brain areas of teenage suicide subjects von Pandey, Ghanshyam N., Rizavi, Hooriyah S., Bhaumik, Runa, Ren, Xinguo

“… •Abnormalities of HPA-axis are associated with depression and suicidal behavior.•CRF expression is increased in PFC, but not in HIPPO of teenage suicide …”
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Cytokines as Suicide Risk Biomarkers von Pandey, Ghanshyam N.

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Dysregulation of Protein Kinase C in Adult Depression and Suicide: Evidence From Postmortem Brain Studies von Pandey, Ghanshyam N, Sharma, Anuradha, Rizavi, Hooriyah S, Ren, Xinguo

“… Abstract Background Several lines of evidence suggest the abnormalities of protein kinase C (PKC) signaling system in mood disorders and suicide based …”
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