Suchergebnisse - "Padayatchi, Nesri"

Evolution of drug resistance in Mycobacterium tuberculosis: a review on the molecular determinants of resistance and implications for personalized care von Dookie, Navisha, Rambaran, Santhuri, Padayatchi, Nesri, Mahomed, Sharana, Naidoo, Kogieleum

“… Drug-resistant TB (DR-TB) remains a significant challenge in TB treatment and control programmes worldwide. Advances in sequencing technology have …”
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Application of Next Generation Sequencing for Diagnosis and Clinical Management of Drug-Resistant Tuberculosis: Updates on Recent Developments in the Field von Dookie, Navisha, Khan, Azraa, Padayatchi, Nesri, Naidoo, Kogieleum

“… The World Health Organization’s End TB Strategy prioritizes universal access to an early diagnosis and comprehensive drug susceptibility testing (DST) for all …”
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Integration of Antiretroviral Therapy with Tuberculosis Treatment von Abdool Karim, Quarraisha, Abdool Karim, Salim S, Naidoo, Kogieleum, Naidoo, Anushka, Grobler, Anneke, Padayatchi, Nesri, Baxter, Cheryl, Gray, Andrew L, Gengiah, Tanuja, Gengiah, Santhanalakshmi, Jithoo, Niraksha, Nair, Gonasagrie, El-Sadr, Wafaa M, Friedland, Gerald

“… In this study from South Africa, earlier initiation of antiretroviral therapy in patients with newly diagnosed HIV infection and TB was associated with higher …”
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Population-level emergence of bedaquiline and clofazimine resistance-associated variants among patients with drug-resistant tuberculosis in southern Africa: a phenotypic and phylogenetic analysis von Nimmo, Camus, Millard, James, van Dorp, Lucy, Brien, Kayleen, Moodley, Sashen, Wolf, Allison, Grant, Alison D, Padayatchi, Nesri, Pym, Alexander S, Balloux, François, O'Donnell, Max

“… Bedaquiline and clofazimine are important drugs in the treatment of drug-resistant tuberculosis and are commonly used across southern Africa, although drug …”
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TB epidemiology: where are the young women? Know your tuberculosis epidemic, know your response von Perumal, Rubeshan, Naidoo, Kogieleum, Padayatchi, Nesri

“… Background The global predominance of tuberculosis in men has received significant attention. However, epidemiological studies now demonstrate that there is an …”
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Timing of Antiretroviral Therapy for HIV-1 Infection and Tuberculosis von Havlir, Diane V, Kendall, Michelle A, Ive, Prudence, Kumwenda, Johnstone, Swindells, Susan, Qasba, Sarojini S, Luetkemeyer, Anne F, Hogg, Evelyn, Rooney, James F, Wu, Xingye, Hosseinipour, Mina C, Lalloo, Umesh, Veloso, Valdilea G, Some, Fatuma F, Kumarasamy, N, Padayatchi, Nesri, Santos, Breno R, Reid, Stewart, Hakim, James, Mohapi, Lerato, Mugyenyi, Peter, Sanchez, Alejandro, Sanchez, Jorge, Lama, Javier R, Pape, Jean W, Asmelash, Aida, Moko, Evans, Sawe, Fred, Andersen, Janet, Sanne, Ian

“… In this international study involving 809 patients with HIV and TB coinfection, earlier therapy for both infections, versus waiting 8 to 12 weeks to initiate …”
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The effect of human immunodeficiency virus infection on adverse events during treatment of drug-resistant tuberculosis: A systematic review and meta-analysis von Lazarus, Gilbert, Tjoa, Kevin, Iskandar, Anthony William Brian, Louisa, Melva, Sagwa, Evans L., Padayatchi, Nesri, Soetikno, Vivian

“… Adverse events (AEs) during drug-resistant tuberculosis (DR-TB) treatment, especially with human immunodeficiency virus (HIV) co-infection, remains a major …”
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XDR-TB in South Africa: No Time for Denial or Complacency von Singh, Jerome Amir, Upshur, Ross, Padayatchi, Nesri

“… Singh and colleagues discuss the threat to regional and global public health posed by XDR-TB in KwaZulu-Natal, and propose new measures to control the outbreak …”
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The contrasting cultures of HIV and tuberculosis care von Daftary, Amrita, Calzavara, Liviana, Padayatchi, Nesri

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Bedaquiline Adherence Measured by Electronic Dose Monitoring Predicts Clinical Outcomes in the Treatment of Patients With Multidrug-Resistant Tuberculosis and HIV/AIDS von O'Donnell, Max R, Padayatchi, Nesri, Wolf, Allison, Zelnick, Jennifer, Daftary, Amrita, Orrell, Catherine, Nimmo, Camus, Baldwin, Matthew, Boodhram, Resha, Maharaj, Bhavna, Amico, K Rivet, Naidoo, Kogieleum, Friedland, Gerald

“… Novel regimens have revolutionized multidrug-resistant tuberculosis (MDR-TB) treatment; however, medication adherence remains challenging and poorly …”
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Dynamics of within-host Mycobacterium tuberculosis diversity and heteroresistance during treatment von Nimmo, Camus, Brien, Kayleen, Millard, James, Grant, Alison D., Padayatchi, Nesri, Pym, Alexander S., O'Donnell, Max, Goldstein, Richard, Breuer, Judith, Balloux, François

“… Studying within-host genetic diversity of Mycobacterium tuberculosis (Mtb) in patients during treatment may identify adaptations to antibiotic and immune …”
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NK cell phenotypic profile during active TB in people living with HIV-evolution during TB treatment and implications for bacterial clearance and disease severity von Maseko, Thando Glory, Rambaran, Santhuri, Ngubane, Slindile, Lewis, Lara, Ngcapu, Sinaye, Hassan-Moosa, Razia, Archary, Derseree, Perumal, Rubeshan, Padayatchi, Nesri, Naidoo, Kogieleum, Sivro, Aida

“… Natural killer (NK) cells, key effector cells of the innate immune system, play an important role in the clearance and control of Mycobacterium tuberculosis …”
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Treatment Outcomes for Extensively Drug-Resistant Tuberculosis and HIV Co-infection von O’Donnell, Max R., Padayatchi, Nesri, Kvasnovsky, Charlotte, Werner, Lise, Master, Iqbal, Horsburgh, C. Robert

“… High mortality rates have been reported for patients co-infected with extensively drug-resistant tuberculosis (XDR-TB) and HIV, but treatment outcomes have not …”
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Acceptability, feasibility, and impact of a pilot tuberculosis literacy and treatment counselling intervention: a mixed methods study von Law, Stephanie, Seepamore, Boitumelo, Oxlade, Olivia, Sikhakhane, Nondumiso, Dawood, Halima, Chetty, Sheldon, Padayatchi, Nesri, Menzies, Dick, Daftary, Amrita

“… Background There is a need for innovative strategies to improve TB testing uptake and patient retention along the continuum of TB care early-on in treatment …”
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High incidence and persistence of hepatitis B virus infection in individuals receiving HIV care in KwaZulu-Natal, South Africa von Msomi, Nokukhanya, Naidoo, Kogieleum, Yende-Zuma, Nonhlanhla, Padayatchi, Nesri, Govender, Kerusha, Singh, Jerome Amir, Abdool-Karim, Salim, Abdool-Karim, Quarraisha, Mlisana, Koleka

“… Background Hepatitis B virus (HBV), Human Immunodeficiency virus (HIV) and Tuberculosis (TB) are common infections in South Africa. We utilized the opportunity …”
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Association Between Human Immunodeficiency Virus Viremia and Compromised Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Beta Variant von Hwa, Shi-Hsia, Snyman, Jumari, Bernstein, Mallory, Ganga, Yashica, Cele, Sandile, Muema, Daniel, Tan, Chee Wah, Khan, Khadija, Karim, Farina, Hanekom, Willem, Bernstein, Leslie, Kaufmann, Stefan H E, Wang, Lin-Fa, Ndung’u, Thumbi, Sigal, Alex

“… Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may be associated with worse clinical outcomes in people with human …”
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MDR-TB patients in KwaZulu-Natal, South Africa: Cost-effectiveness of 5 models of care von Loveday, Marian, Wallengren, Kristina, Reddy, Tarylee, Besada, Donela, Brust, James C. M., Voce, Anna, Desai, Harsha, Ngozo, Jacqueline, Radebe, Zanele, Master, Iqbal, Padayatchi, Nesri, Daviaud, Emmanuelle

“… South Africa has a high burden of MDR-TB, and to provide accessible treatment the government has introduced different models of care. We report the most …”
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The impact of enteral feeding and therapeutic monitoring of rifampicin with dose escalation in critically ill patients with tuberculosis von Perumal, Rubeshan, Naidoo, Kogieleum, Naidoo, Anushka, Letsoalo, Marothi P., Esmail, Aliasgar, Joubert, Ivan, Denti, Paolo, Wiesner, Lubbe, Padayatchi, Nesri, Maartens, Gary, Dheda, Keertan

“… •Rifampicin concentrations were low in all continuously fed critically ill patients.•Dose escalation increased drug exposure and achieved target …”
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Tuberculosis: treatment failure, or failure to treat? Lessons from India and South Africa von Padayatchi, Nesri, Daftary, Amrita, Naidu, Naressa, Naidoo, Kogieleum, Pai, Madhukar

“… Tuberculosis (TB) remains an enormous public health concern globally. India and South Africa rank among the top 10 high TB burden countries with the highest …”
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Detection of a historic reservoir of bedaquiline/clofazimine resistance-associated variants in Mycobacterium tuberculosis von Nimmo, Camus, Ortiz, Arturo Torres, Tan, Cedric C. S., Pang, Juanita, Acman, Mislav, Millard, James, Padayatchi, Nesri, Grant, Alison D., O’Donnell, Max, Pym, Alex, Brynildsrud, Ola B., Eldholm, Vegard, Grandjean, Louis, Didelot, Xavier, Balloux, François, van Dorp, Lucy

“… Background Drug resistance in tuberculosis (TB) poses a major ongoing challenge to public health. The recent inclusion of bedaquiline into TB drug regimens has …”
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