Výsledky vyhledávání - "PLATELET INHIBITION"

Switching Between Intravenous and Oral P2Y12 Inhibition: Easier Said Than Done Autor Baber, Usman

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Comparison of TEG Parameters Between Clopidogrel-resistant Resistant and Non-resistant Groups Autor Rodriguez Alvarez, Adriana A, Cieri, Isabella Ferlini, Boya, Mounika Naidu, Ferreira, Sasha Suarez, Patel, Shiv, Jang, Jeongin, Machlus, Kellie, Dua, Anahita

“…Compare TEG parameters between clopidogrel-resistant and clopidogrel-non-resistant groups. Graft or stent thrombosis affects 1 in 5 patients within six months…”
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2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC) Autor Roffi, Marco, Patrono, Carlo, Collet, Jean-Philippe, Mueller, Christian, Valgimigli, Marco, Andreotti, Felicita, Bax, Jeroen J, Borger, Michael A, Brotons, Carlos, Chew, Derek P, Gencer, Baris, Hasenfuss, Gerd, Kjeldsen, Keld, Lancellotti, Patrizio, Landmesser, Ulf, Mehilli, Julinda, Mukherjee, Debabrata, Storey, Robert F, Windecker, Stephan

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Interactions between platelets and the cancer immune microenvironment Autor Tuerhong, Nuerye, Yang, Yang, Wang, Chenyu, Huang, Peng, Li, Qiu

“…Cancer is a leading cause of death in both China and developed countries due to its high incidence and low cure rate. Immune function is closely linked to the…”
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The endothelial barrier and cancer metastasis: Does the protective facet of platelet function matter? Autor Smeda, Marta, Przyborowski, Kamil, Stojak, Marta, Chlopicki, Stefan

“…[Display omitted] Overwhelming evidence suggests that platelets have a detrimental role in promoting cancer spread via platelet–cancer cell interactions linked…”
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Apolipoprotein A-I, elevated in trauma patients, inhibits platelet activation and decreases clot strength Autor Jones, Wilbert L., Ramos, Christopher R., Banerjee, Anirban, Moore, Ernest E., Hansen, Kirk C., Coleman, Julia R., Kelher, Marguerite, Neeves, Keith B., Silliman, Christopher C., Di Paola, Jorge, Branchford, Brian

“…Apolipoprotein A-I (ApoA-I) is elevated in the plasma of a subgroup of trauma patients with systemic hyperfibrinolysis. We hypothesize that apoA-I inhibits…”
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Outcomes in patients treated with ticagrelor or clopidogrel after acute myocardial infarction: experiences from SWEDEHEART registry Autor Sahlén, Anders, Varenhorst, Christoph, Lagerqvist, Bo, Renlund, Henrik, Omerovic, Elmir, Erlinge, David, Wallentin, Lars, James, Stefan K, Jernberg, Tomas

“…Ticagrelor reduces ischaemic events and mortality in acute coronary syndrome (ACS) vs. clopidogrel. We wished to study clinical outcomes in a large real-world…”
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Perfluorocarbon nanoparticle-mediated platelet inhibition promotes intratumoral infiltration of T cells and boosts immunotherapy Autor Zhou, Zaigang, Zhang, Baoli, Zai, Wenjing, Kang, Lin, Yuan, Ahu, Hu, Yiqiao, Wu, Jinhui

“…Cancer immunotherapy can stimulate and enhance the ability of the immune system to recognize, arrest, and eliminate tumor cells. Immune checkpoint therapies…”
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Cilostazol: a Review of Basic Mechanisms and Clinical Uses Autor Kherallah, Riyad Y., Khawaja, Muzamil, Olson, Michael, Angiolillo, Dominick, Birnbaum, Yochai

“…Primarily used in the treatment of intermittent claudication, cilostazol is a 2-oxyquinolone derivative that works through the inhibition of phosphodiesterase…”
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Dual antiplatelet therapy with clopidogrel and aspirin increases mortality in 4T1 metastatic breast cancer-bearing mice by inducing vascular mimicry in primary tumour Autor Smeda, Marta, Kieronska, Anna, Proniewski, Bartosz, Jasztal, Agnieszka, Selmi, Anna, Wandzel, Krystyna, Zakrzewska, Agnieszka, Wojcik, Tomasz, Przyborowski, Kamil, Derszniak, Katarzyna, Stojak, Marta, Kaczor, Dawid, Buczek, Elzbieta, Watala, Cezary, Wietrzyk, Joanna, Chlopicki, Stefan

“…Platelet inhibition has been considered an effective strategy for combating cancer metastasis and compromising disease malignancy although recent clinical data…”
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Ischaemic risk and efficacy of ticagrelor in relation to time from P2Y12 inhibitor withdrawal in patients with prior myocardial infarction: insights from PEGASUS-TIMI 54 Autor Bonaca, Marc P, Bhatt, Deepak L, Steg, P Gabriel, Storey, Robert F, Cohen, Marc, Im, Kyungah, Oude Ophuis, Ton, Budaj, Andrej, Goto, Shinya, López-Sendón, José, Diaz, Rafael, Dalby, Anthony, Van de Werf, Frans, Ardissino, Diego, Montalescot, Gilles, Aylward, Philip, Magnani, Giulia, Jensen, Eva C, Held, Peter, Braunwald, Eugene, Sabatine, Marc S

“…Ticagrelor reduced major adverse cardiovascular event (MACE) by 15-16% in patients with prior myocardial infarction (MI) in PEGASUS-TIMI 54. We hypothesized…”
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Definition of major bleeding in clinical investigations of antihemostatic medicinal products in surgical patients Autor SCHULMAN, S., ANGERÅS, U., BERGQVIST, D., ERIKSSON, B., LASSEN, M. R., FISHER, W.

“…The definition of major bleeding varies between studies on surgical patients, particularly regarding the criteria for surgical wound‐related bleeding. This…”
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Ticagrelor vs. clopidogrel in patients with non-ST-elevation acute coronary syndrome with or without revascularization: results from the PLATO trial Autor Lindholm, Daniel, Varenhorst, Christoph, Cannon, Christopher P, Harrington, Robert A, Himmelmann, Anders, Maya, Juan, Husted, Steen, Steg, Philippe Gabriel, Cornel, Jan H, Storey, Robert F, Stevens, Susanna R, Wallentin, Lars, James, Stefan K

“…The optimal platelet inhibition strategy for ACS patients managed without revascularization is unknown. We aimed to evaluate efficacy and safety of ticagrelor…”
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Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non‐surgical patients Autor SCHULMAN, S., KEARON, C.

“…A variety of definitions of major bleeding have been used in published clinical studies, and this diversity adds to the difficulty in comparing data between…”
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An artificial-enzyme-equipped immunoregulator blocks platelet-mediated breast cancer hematogenous metastasis Autor Hu, Ben, Lin, Huimin, Quan, Xiaolong, Sun, Fushan, Zhang, Fengling, Zhang, Fang, Wang, Yu, Chang, Yunhua, Wang, Jigang, Duan, Xiaohui, Yu, Meng

“…Platelet activation and adhesion on the surface of circulating tumor cells (CTCs) assist them in surviving within the vasculature and acquiring enhanced…”
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Bleeding complications with the P2Y12 receptor antagonists clopidogrel and ticagrelor in the PLATelet inhibition and patient Outcomes (PLATO) trial Autor Becker, Richard C, Bassand, Jean Pierre, Budaj, Andrzej, Wojdyla, Daniel M, James, Stefan K, Cornel, Jan H, French, John, Held, Claes, Horrow, Jay, Husted, Steen, Lopez-Sendon, Jose, Lassila, Riitta, Mahaffey, Kenneth W, Storey, Robert F, Harrington, Robert A, Wallentin, Lars

“…AIMS More intense platelet-directed therapy for acute coronary syndrome (ACS) may increase bleeding risk. The aim of the current analysis was to determine the…”
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Novel Dosing and Monitoring of Aspirin in Infants With Systemic-to-Pulmonary Artery Shunt Physiology: the SOPRANO Study Autor Branstetter, Joshua W, Woods, Gary, Zaki, Hania, Coolidge, Nicole, Zinyandu, Tawanda, Shashidharan, Subhadra, Aljiffry, Alaa

“…Provision of pulmonary blood flow with a systemic-to-pulmonary artery shunt is essential in some patients with cyanotic congenital heart disease…”
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Drunk Platelets: Ethanol intoxication is associated with platelet inhibition in male Trauma patients Autor Stansbury, Brittany M., Hall, Rigel P., Vazquez-Loreto, Andrea Carolina, Easter, Robert A., Low, Trevor M., Handschug, Jody L., Kupanoff, Kristina M., Huang, Dih-Dih, Jones, Michael D., Czarkowski, Brian R., Soe-Lin, Hahn, Weinberg, Jordan A., Bogert, James N.

“…[Display omitted] •Blood ethanol levels were associated with platelet dysfunction in males.•No association emerged between platelet inhibition and ethanol…”
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Effects of the NO/soluble guanylate cyclase/cGMP system on the functions of human platelets Autor Makhoul, Stephanie, Walter, Elena, Pagel, Oliver, Walter, Ulrich, Sickmann, Albert, Gambaryan, Stepan, Smolenski, Albert, Zahedi, René P., Jurk, Kerstin

“…Platelets are circulating sentinels of vascular integrity and are activated, inhibited, or modulated by multiple hormones, vasoactive substances or drugs…”
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Tirofiban potentiates agonist-induced platelet activation and degranulation, despite effectively inhibiting aggregation Autor Aguiar Bucsai, Martina, Idel, Christian, Wollenberg, Barbara, Mannhalter, Christine, Verschoor, Admar

“…We aimed to investigate the effects of integrin αIIbβ3 inhibitor tirofiban on hallmarks of platelet activation, degranulation, and aggregation during its use…”
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