Výsledky vyhľadávania - "Ozenne, Brice"

The precision–recall curve overcame the optimism of the receiver operating characteristic curve in rare diseases Autor Ozenne, Brice, Subtil, Fabien, Maucort-Boulch, Delphine

“…Compare the area under the receiver operating characteristic curve (AUC) vs. the area under the precision–recall curve (AUPRC) in summarizing the performance…”
Získať plný text

Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels Autor Madsen, Martin K, Fisher, Patrick M, Burmester, Daniel, Dyssegaard, Agnete, Stenbæk, Dea S, Kristiansen, Sara, Johansen, Sys S, Lehel, Sczabolz, Linnet, Kristian, Svarer, Claus, Erritzoe, David, Ozenne, Brice, Knudsen, Gitte M

“…The main psychedelic component of magic mushrooms is psilocybin, which shows promise as a treatment for depression and other mental disorders. Psychedelic…”
Získať plný text

Brain serotonin 2A receptor binding predicts subjective temporal and mystical effects of psilocybin in healthy humans Autor Stenbæk, Dea Siggaard, Madsen, Martin Korsbak, Ozenne, Brice, Kristiansen, Sara, Burmester, Daniel, Erritzoe, David, Knudsen, Gitte Moos, Fisher, Patrick MacDonald

“…Psilocybin is a serotonergic psychedelic with psychoactive effects mediated by serotonin 2A receptor (5-HT2AR) activation. It produces an acute psychedelic…”
Zistit podrobnosti o prístupe

An extension of generalized pairwise comparisons for prioritized outcomes in the presence of censoring Autor Péron, Julien, Buyse, Marc, Ozenne, Brice, Roche, Laurent, Roy, Pascal

“…Generalized pairwise comparisons have been proposed to permit a comprehensive assessment of several prioritized outcomes between two groups of observations…”
Zistit podrobnosti o prístupe

The asymptotic distribution of the Net Benefit estimator in presence of right-censoring Autor Ozenne, Brice, Budtz-Jørgensen, Esben, Péron, Julien

“…The benefit-risk balance is a critical information when evaluating a new treatment. The Net Benefit has been proposed as a metric for the benefit-risk…”
Zistit podrobnosti o prístupe

Lasting effects of a single psilocybin dose on resting-state functional connectivity in healthy individuals Autor McCulloch, Drummond E-Wen, Madsen, Martin Korsbak, Stenbæk, Dea Siggaard, Kristiansen, Sara, Ozenne, Brice, Jensen, Peter Steen, Knudsen, Gitte Moos, Fisher, Patrick MacDonald

“…Psilocybin is a psychedelic drug that has shown lasting positive effects on clinical symptoms and self-reported well-being following a single dose. There has…”
Zistit podrobnosti o prístupe

Psilocybin-Induced Mystical-Type Experiences are Related to Persisting Positive Effects: A Quantitative and Qualitative Report Autor McCulloch, Drummond E-Wen, Grzywacz, Maria Zofia, Madsen, Martin Korsbak, Jensen, Peter Steen, Ozenne, Brice, Armand, Sophia, Knudsen, Gitte Moos, Fisher, Patrick MacDonald, Stenbæk, Dea Siggaard

“…Psychedelic drugs such as psilocybin have shown substantial promise for the treatment of several psychiatric conditions including mood and addictive disorders…”
Získať plný text

Psilocybin modulation of time-varying functional connectivity is associated with plasma psilocin and subjective effects Autor Olsen, Anders S., Lykkebo-Valløe, Anders, Ozenne, Brice, Madsen, Martin K., Stenbæk, Dea S., Armand, Sophia, Mørup, Morten, Ganz, Melanie, Knudsen, Gitte M., Fisher, Patrick M.

“…•We examined psilocybin effects on resting-state fMRI time-varying functional connectivity.•Diametrical clustering described as improved strategy for…”
Získať plný text

Sleep deprivation and sleep intensity exert distinct effects on cerebral vasomotion and brain pulsations driven by the respiratory and cardiac cycles Autor Ulv Larsen, Sara Marie, Holst, Sebastian Camillo, Olsen, Anders Stevnhoved, Ozenne, Brice, Zilstorff, Dorte Bonde, Brendstrup-Brix, Kristoffer, Weikop, Pia, Pleinert, Simone, Kiviniemi, Vesa, Jennum, Poul Jørgen, Nedergaard, Maiken, Knudsen, Gitte Moos

“…The flow of cerebrospinal fluid (CSF) through the brain is driven by cerebral vasomotion, along with respiratory and cardiac forces. Growing evidence suggests…”
Získať plný text

Individualised prediction of major bleeding in patients with atrial fibrillation treated with anticoagulation Autor Toft-Petersen, Anne Pernille, J.-Y. Lee, Christina, Phelps, Matthew, Ozenne, Brice, Gerds, Thomas Alexander, Torp-Pedersen, Christian

“…Anticoagulation in atrial fibrillation (AF) increases the risk of major bleeding. No predictive model has hitherto provided estimates of the absolute risk for…”
Získať plný text

The structure of the serotonin system: A PET imaging study Autor Beliveau, Vincent, Ozenne, Brice, Strother, Stephen, Greve, Douglas N., Svarer, Claus, Knudsen, Gitte Moos, Ganz, Melanie

“…The human brain atlas of the serotonin (5-HT) system does not conform with commonly used parcellations of neocortex, since the spatial distribution of…”
Získať plný text

Restricted Net Treatment Benefit in oncology Autor Piffoux, Max, Ozenne, Brice, De Backer, Mickaël, Buyse, Marc, Chiem, Jean-Christophe, Péron, Julien

“…The restricted Net Treatment Benefit (rNTB) is a clinically meaningful and tractable estimand of the overall treatment effect assessed in randomized trials…”
Získať plný text

Lasting increases in trait mindfulness after psilocybin correlate positively with the mystical-type experience in healthy individuals Autor Søndergaard, Anna, Madsen, Martin Korsbak, Ozenne, Brice, Armand, Sophia, Knudsen, Gitte Moos, Fisher, Patrick MacDonald, Stenbæk, Dea Siggaard

“…Psilocybin-induced mystical-type experiences are associated with lasting positive psychological outcomes. Recent studies indicate that trait mindfulness is…”
Získať plný text

Emotional faces processing in major depressive disorder and prediction of antidepressant treatment response: A NeuroPharm study Autor Fisher, Patrick M, Ozenne, Brice, Ganz, Melanie, Frokjaer, Vibe G, Dam, Vibeke Nh, Penninx, Brenda Wjh, Sankar, Anajli, Miskowiak, Kamilla, Jensen, Peter S, Knudsen, Gitte M, Jorgensen, Martin B

“…Major depressive disorder (MDD) is a prevalent neuropsychiatric illness for which it is important to resolve underlying brain mechanisms. Current treatments…”
Zistit podrobnosti o prístupe

Genetic contributions to brain serotonin transporter levels in healthy adults Autor Bruzzone, Silvia Elisabetta Portis, Nasser, Arafat, Aripaka, Sagar Sanjay, Spies, Marie, Ozenne, Brice, Jensen, Peter Steen, Knudsen, Gitte Moos, Frokjaer, Vibe Gedsoe, Fisher, Patrick MacDonald

“…The serotonin transporter (5-HTT) critically shapes serotonin neurotransmission by regulating extracellular brain serotonin levels; it remains unclear to what…”
Získať plný text

Functional brain responses to emotional faces after three to five weeks of intake of escitalopram in healthy individuals: a double-blind, placebo-controlled randomised study Autor Armand, Sophia, Langley, Christelle, Johansen, Annette, Ozenne, Brice, Overgaard-Hansen, Oliver, Larsen, Kristian, Jensen, Peter Steen, Knudsen, Gitte Moos, Sahakian, Barbara Jacquelyn, Stenbæk, Dea Siggard, Fisher, Patrick MacDonald

“…Short-term intake of selective serotonin reuptake inhibitors (SSRIs) modulates threat-related amygdala responses in healthy individuals. However, how SSRI…”
Získať plný text

Assessing Long-Term Survival Benefits of Immune Checkpoint Inhibitors Using the Net Survival Benefit Autor Péron, Julien, Lambert, Alexandre, Munier, Stephane, Ozenne, Brice, Giai, Joris, Roy, Pascal, Dalle, Stéphane, Machingura, Abigirl, Maucort-Boulch, Delphine, Buyse, Marc

“…The treatment effect in survival analysis is commonly quantified as the hazard ratio, and tested statistically using the standard log-rank test. Modern…”
Zistit podrobnosti o prístupe

Evaluating cognitive disturbances as treatment target and predictor of antidepressant action in major depressive disorder: A NeuroPharm study Autor Dam, Vibeke Høyrup, Stenbæk, Dea Siggaard, Köhler-Forsberg, Kristin, Cheng Ip, Ozenne, Brice, Sahakian, Barbara Jacquelyn, Knudsen, Gitte Moos, Jørgensen, Martin Balslev, Frokjaer, Vibe Gedsoe

“…Cognitive disturbances in major depressive disorder (MDD) constitute a critical treatment target and hold promise as an early predictor of antidepressant…”
Získať plný text

Predicting Treatment Outcome in Major Depressive Disorder Using Serotonin 4 Receptor PET Brain Imaging, Functional MRI, Cognitive-, EEG-Based, and Peripheral Biomarkers: A NeuroPharm Open Label Clinical Trial Protocol Autor Köhler-Forsberg, Kristin, Jorgensen, Anders, Dam, Vibeke H., Stenbæk, Dea Siggaard, Fisher, Patrick M., Ip, Cheng-Teng, Ganz, Melanie, Poulsen, Henrik Enghusen, Giraldi, Annamaria, Ozenne, Brice, Jørgensen, Martin Balslev, Knudsen, Gitte Moos, Frokjaer, Vibe Gedsoe

“…Between 30 and 50% of patients with major depressive disorder (MDD) do not respond sufficiently to antidepressant regimens. The conventional pharmacological…”
Získať plný text

The Net Chance of a Longer Survival as a Patient-Oriented Measure of Treatment Benefit in Randomized Clinical Trials Autor Péron, Julien, Roy, Pascal, Ozenne, Brice, Roche, Laurent, Buyse, Marc

“…Time to events, or survival end points, are common end points in randomized clinical trials. They are usually analyzed under the assumption of proportional…”
Zistit podrobnosti o prístupe