Výsledky vyhľadávania - "Oxidative Phosphorylation"

Mitochondrial Oxidative Phosphorylation defect in the Heart of Subjects with Coronary Artery Disease Autor Ait-Aissa, Karima, Blaszak, Scott C., Beutner, Gisela, Tsaih, Shirng-Wern, Morgan, Garrett, Santos, Janine H., Flister, Michael J., Joyce, David L., Camara, Amadou K. S., Gutterman, David D., Donato, Anthony J., Porter, George A., Beyer, Andreas M.

“… + and ATP levels, and mitochondrial oxidative phosphorylation capacity were evaluated. Proteins critical to the regulation of mitochondrial metabolism and function were also evaluated in tissue lysates…”
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Nuclear but not mitochondrial-encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease Autor Mastroeni, Diego, Khdour, Omar M, Delvaux, Elaine, Nolz, Jennifer, Olsen, Gary, Berchtold, Nicole, Cotman, Carl, Hecht, Sidney M, Coleman, Paul D

“…We have comprehensively described the expression profiles of mitochondrial DNA and nuclear DNA genes that encode subunits of the respiratory oxidative phosphorylation (OXPHOS) complexes (I-V…”
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Mitochondrial oxidative phosphorylation capacity in skeletal muscle measured by ultrafast Z ‐spectroscopy ( UFZ ) MRI at 3T Autor Ju, Licheng, Schär, Michael, Wang, Kexin, Li, Anna, Wu, Yihan, Samuel, T. Jake, Ganji, Sandeep, van Zijl, Peter C. M., Yadav, Nirbhay N., Weiss, Robert G., Xu, Jiadi

“…To investigate the feasibility of rapid CEST MRI acquisition for evaluating oxidative phosphorylation (OXPHOS…”
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A Novel CEST ‐Based Approach for Reliably Assessing Skeletal Muscle Oxidative Phosphorylation: OXCEST Autor Burman, Ritambhar, Pang, Yuxi, Bag, Asim, Finkel, Richard S, Ness, Kirsten K, Bagga, Puneet

“… (Oxidative Phosphorylation CEST or OXCEST). Our proposed OXCEST method acquires creatine (Cr)-weighted CEST maps by applying RF saturation…”
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Effects of hyperthermia and acidosis on mitochondrial oxidative phosphorylation Autor Davis, Michael S, Bayly, Warwick M, Hansen, Cristina M, Barrett, Montana R, Blake, Cara A

“…%, and oxidative phosphorylation capacity was tested ex vivo under normothermic…”
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Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's syndrome Autor Valenti, Daniela, De Rasmo, Domenico, Signorile, Anna, Rossi, Leonardo, de Bari, Lidia, Scala, Iris, Granese, Barbara, Papa, Sergio, Vacca, Rosa Anna

“… We found that EGCG, incubated with cultured lymphoblasts and fibroblasts from DS subjects, rescued mitochondrial complex I and ATP…”
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Expression of cAMP and oxidative phosphorylation‐related lncRNAs in non‐functioning pituitary adenomas Autor Taheri, Mohammad, Nicknam, Amir, Bagan, Atena, Eslami, Solat, Rakhshan, Azadeh, Ghafouri‐Fard, Soudeh

“…, we selected lncRNAs related to cAMP and oxidative phosphorylation pathways, namely DNAH17‐AS1, LINC00706 and SLC25A5‐AS1…”
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Molecular pathways: BRAF induces bioenergetic adaptation by attenuating oxidative phosphorylation Autor Haq, Rizwan, Fisher, David E, Widlund, Hans R

“… Although most normal differentiated cells use mitochondrial oxidative phosphorylation (OXPHOS) as the bioenergetic source, cancer cells have been proposed to rely principally on cytoplasmic glycolysis…”
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Single-cell analysis of oxidative phosphorylation protein expression in pancreatic islets in type 2 diabetes Autor Mullins, Alana, Yu, Xuefei, Smith, Anna L M, Merces, George, Shaw, James A M, Greaves, Laura C, Walker, Mark, Arden, Catherine

“… This study investigated islet cell composition and mitochondrial oxidative phosphorylation protein expression in pancreatic tissue from older donors (≥62 years…”
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Expression of actin- and oxidative phosphorylation-related transcripts across the cortical visuospatial working memory network in unaffected comparison and schizophrenia subjects Autor Kimoto, Sohei, Hashimoto, Takanori, Berry, Kimberly J, Tsubomoto, Makoto, Yamaguchi, Yasunari, Enwright, John F, Chen, Kehui, Kawabata, Rika, Kikuchi, Mitsuru, Kishimoto, Toshifumi, Lewis, David A

“… In one node of this network, the dorsolateral prefrontal cortex (DLPFC), altered expression of transcripts for actin assembly and mitochondrial oxidative phosphorylation (OXPHOS…”
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A First‐in‐Human Phase I Study of OPB‐111077, a Small‐Molecule STAT3 and Oxidative Phosphorylation Inhibitor, in Patients with Advanced Cancers Autor Tolcher, Anthony, Flaherty, Keith, Shapiro, Geoffrey I., Berlin, Jordan, Witzig, Thomas, Habermann, Thomas, Bullock, Andrea, Rock, Edwin, Elekes, Agnes, Lin, Chester, Kostic, Dusan, Ohi, Naoto, Rasco, Drew, Papadopoulos, Kyriakos P., Patnaik, Amita, Smith, Lon, Cote, Gregory M.

“… Notable antitumor activity was seen in a subject with diffuse large B‐cell lymphoma. Background OPB‐111077 is a novel inhibitor of STAT3 and mitochondrial oxidative phosphorylation with promising anticancer activity in preclinical models…”
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Reduction in mitochondrial ROS improves oxidative phosphorylation and provides resilience to coronary endothelium in non-reperfused myocardial infarction Autor Teixeira, Rayane Brinck, Pfeiffer, Melissa, Zhang, Peng, Shafique, Ehtesham, Rayta, Bonnie, Karbasiafshar, Catherine, Ahsan, Nagib, Sellke, Frank W., Abid, M. Ruhul

“…Recent studies demonstrated that mitochondrial antioxidant MnSOD that reduces mitochondrial (mito) reactive oxygen species (ROS) helps maintain an optimal…”
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Regular Endurance Exercise Promotes Fission, Mitophagy, and Oxidative Phosphorylation in Human Skeletal Muscle Independently of Age Autor Balan, Estelle, Schwalm, Céline, Naslain, Damien, Nielens, Henri, Francaux, Marc, Deldicque, Louise

“…). Fusion and oxidative phosphorylation proteins were globally more elevated in the active groups ( < 0.05…”
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Amyloid-β Causes Mitochondrial Dysfunction via a Ca2+-Driven Upregulation of Oxidative Phosphorylation and Superoxide Production in Cerebrovascular Endothelial Cells Autor Quintana, Dominic D, Garcia, Jorge A, Anantula, Yamini, Rellick, Stephanie L, Engler-Chiurazzi, Elizabeth B, Sarkar, Saumyendra N, Brown, Candice M, Simpkins, James W

“… In human subjects and in animal models of AD, cerebral hypoperfusion and hypometabolism are reported to manifest during the early stages of the disease and persist for its duration. Amyloid-β…”
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The co‐occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific Autor Raule, Nicola, Sevini, Federica, Li, Shengting, Barbieri, Annalaura, Tallaro, Federica, Lomartire, Laura, Vianello, Dario, Montesanto, Alberto, Moilanen, Jukka S., Bezrukov, Vladyslav, Blanché, Hélène, Hervonen, Antti, Christensen, Kaare, Deiana, Luca, Gonos, Efstathios S., Kirkwood, Tom B. L., Kristensen, Peter, Leon, Alberta, Pelicci, Pier Giuseppe, Poulain, Michel, Rea, Irene M., Remacle, Josè, Robine, Jean Marie, Schreiber, Stefan, Sikora, Ewa, Eline Slagboom, Peternella, Spazzafumo, Liana, Antonietta Stazi, Maria, Toussaint, Olivier, Vaupel, James W., Rose, Giuseppina, Majamaa, Kari, Perola, Markus, Johnson, Thomas E., Bolund, Lars, Yang, Huanming, Passarino, Giuseppe, Franceschi, Claudio

“…Summary To re‐examine the correlation between mtDNA variability and longevity, we examined mtDNAs from samples obtained from over 2200 ultranonagenarians (and…”
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A novel immunofluorescent assay to investigate oxidative phosphorylation deficiency in mitochondrial myopathy: understanding mechanisms and improving diagnosis Autor Rocha, Mariana C., Grady, John P., Grünewald, Anne, Vincent, Amy, Dobson, Philip F., Taylor, Robert W., Turnbull, Doug M., Rygiel, Karolina A.

“…Oxidative phosphorylation defects in human tissues are often challenging to quantify due to a mosaic pattern of deficiency…”
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Similar improvements in 5‐km performance and maximal oxygen uptake with submaximal and maximal 10‐20‐30 training in runners, but increase in muscle oxidative phosphorylation occur only with maximal effort training Autor Skovgaard, Casper, Christiansen, Danny, Martínez‐Rodríguez, Alejandro, Bangsbo, Jens

“…) and muscle oxidative phosphorylation (OXPHOS). In addition, to examine to what extent the effects would compare to 10‐20…”
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Mendelian randomization and multi-omics approach analyses reveal impaired glucose metabolism and oxidative phosphorylation in visceral adipose tissue of women with polycystic ovary syndrome Autor Zhang, Yurong, Jiang, Xintong, Song, Xueling, Zhang, Jiajia, Mao, Weian, Chen, Wei, Yuan, Shuai, Chen, Yijie, Mu, Liangshan, Zhao, Yue

“…-related traits, and found that VAT exhibited impaired glucose metabolism and mitochondrial oxidative phosphorylation (OXPHOS) in women with PCOS…”
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Inverse relationship between body mass index and mitochondrial oxidative phosphorylation capacity in human subcutaneous adipocytes Autor Fischer, Britta, Schöttl, Theresa, Schempp, Christina, Fromme, Tobias, Hauner, Hans, Klingenspor, Martin, Skurk, Thomas

“… In this study, we investigated the following: 1) the respiratory capacities of mitochondria isolated from mature adipocytes of female subjects whose body mass index (BMI…”
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Oxidative Phosphorylation—an Update on a New, Essential Target Space for Drug Discovery in Mycobacterium tuberculosis Autor Foo, Caroline Shi-Yan, Pethe, Kevin, Lupien, Andréanne

“… This enthusiasm stems from the fact that oxidative phosphorylation (OxPhos) and the maintenance of the transmembrane electrochemical gradient are essential for the viability of replicating and non-replicating Mycobacterium tuberculosis (M. tb…”
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