Search Results - "Oxelbark, Joakim"

Pharmacodynamic Evaluation of Zoliflodacin Treatment of Neisseria gonorrhoeae Strains With Amino Acid Substitutions in the Zoliflodacin Target GyrB Using a Dynamic Hollow Fiber Infection Model by Jacobsson, Susanne, Golparian, Daniel, Oxelbark, Joakim, Franceschi, Francois, Brown, David, Louie, Arnold, Drusano, George, Unemo, Magnus

“…Novel antimicrobials for effective treatment of uncomplicated gonorrhea are essential, and the first-in-class, oral spiropyrimidinetrione DNA gyrase B…”
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Pharmacodynamic evaluation of lefamulin in the treatment of gonorrhea using a hollow fiber infection model simulating Neisseria gonorrhoeae infections by Jacobsson, Susanne, Golparian, Daniel, Oxelbark, Joakim, Wicha, Wolfgang W., da Costa, Renata Maria Augusto, Franceschi, Francois, Brown, David, Louie, Arnold, Gelone, Steven P., Drusano, George, Unemo, Magnus

“…The emergence and spread of antimicrobial resistance in Neisseria gonorrhoeae is seriously threatening the treatment and control of gonorrhea globally. Novel…”
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Pharmacodynamic Evaluation of Dosing, Bacterial Kill, and Resistance Suppression for Zoliflodacin Against Neisseria gonorrhoeae in a Dynamic Hollow Fiber Infection Model by Jacobsson, Susanne, Golparian, Daniel, Oxelbark, Joakim, Alirol, Emilie, Franceschi, Francois, Gustafsson, Tomas N., Brown, David, Louie, Arnold, Drusano, George, Unemo, Magnus

“…Antimicrobial resistance in Neisseria gonorrhoeae is threatening the treatment and control of gonorrhea globally, and new treatment options are imperative…”
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Pharmacodynamics of zoliflodacin plus doxycycline combination therapy against Neisseria gonorrhoeae in a gonococcal hollow-fiber infection model by Jacobsson, Susanne, Golparian, Daniel, Oxelbark, Joakim, Kong, Fabian Y. S., Da Costa, Renata Maria Augusto, Franceschi, Francois, Brown, David, Louie, Arnold, Drusano, George, Unemo, Magnus

“…Antimicrobial resistance in the sexually transmitted bacterium Neisseria gonorrhoeae is compromising the management and control of gonorrhea globally…”
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LC-MS/MS analysis of 11-nor-9-carboxy-hexahydrocannabinol (HHC-COOH) and 11-hydroxy-hexahydrocannabinol (HHC-OH) for verification of hexahydrocannabinol (HHC) intake by Pettersson-Pablo, Paul, Oxelbark, Joakim

“…Natural and semi-synthetic cannabinoid analogs are getting increasing media attention for their recreative use as an alternative to traditional cannabis, in…”
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Barriers to Stereoinversion of N-Aryl-1,3,2-benzodithiazole 1-Oxides Studied by Dynamic Enantioselective Liquid Chromatography by Oxelbark, Joakim, Allenmark, Stig

“…Free energies of activation for the enantiomerization of a series of racemic N-aryl-1,3,2-benzodithiazole 1-oxides have been determined by dynamic…”
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Investigation of a tartaric acid-based linear polyamide and dimer as chiral selectors in liquid chromatography by Oxelbark, Joakim, Gidlund, Peter

“…A twin selector for enantioselective liquid chromatography based on O,O′‐bis(dimethyl)benzoyl tartaric diamide was synthesized and compared to commercially…”
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Ultrafast LC-MS/MS analysis of 5-hydroxyindoleacetic acid (5-HIAA) in serum by Oxelbark, Joakim, Lövenhamn, Annicka

“…A very quick and easy LC-MS/MS analysis method for 5-HIAA (5-hydoxyindoleacetic acid) has been developed. The method was fully validated and proved to work…”
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A comparison of silica and porous graphitic carbon as support materials for a chiral selector in HPLC by Oxelbark, Joakim, Claeson, Sofia

“…The tartaramide based chiral selector 2 was synthesized, coated onto porous graphitic carbon (PGC), and evaluated as a chiral stationary phase for HPLC. Its…”
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Pharmacodynamic evaluation of ceftriaxone single-dose therapy (0.125-1 g) to eradicate ceftriaxone-susceptible and ceftriaxone-resistant Neisseria gonorrhoeae strains in a hollow fibre infection model for gonorrhoea by Unemo, Magnus, Golparian, Daniel, Oxelbark, Joakim, Kong, Fabian Y S, Brown, David, Louie, Arnold, Drusano, George, Jacobsson, Susanne

“…Antimicrobial resistance in Neisseria gonorrhoeae is threatening the gonorrhoea treatment, and optimizations of the current ceftriaxone-treatment regimens are…”
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β-Lactam concentrations monitored in the early phase of community-acquired sepsis in the intensive care unit by Liljedahl Prytz, Karolina, Kryss, Emma, Oxelbark, Joakim, Källman, Jan, Nilsson, Kristofer F, Sundqvist, Martin, Savilampi, Johanna

“…Optimal antibiotic treatment is important in the treatment of sepsis. However, patients with sepsis are at risk of suboptimal antibiotic concentrations. This…”
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Inversion barriers in sulfoxide functions studied by enantioselective liquid chromatography and chiroptical methods by Allenmark, Stig, Oxelbark, Joakim

“…A series of 2‐substituted 1,3,2‐benzodithiazole 1‐oxides has been synthesized and the compounds resolved into enantiomers by semipreparative enantioselective…”
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A Phosphotyrosine‐Imprinted Polymer Receptor for the Recognition of Tyrosine Phosphorylated Peptides by Emgenbroich, Marco, Borrelli, Cristiana, Shinde, Sudhirkumar, Lazraq, Issam, Vilela, Filipe, Hall, Andrew J., Oxelbark, Joakim, De Lorenzi, Ersilia, Courtois, Julien, Simanova, Anna, Verhage, Jeroen, Irgum, Knut, Karim, Kal, Sellergren, Börje

“…Hyperphosphorylation at tyrosine is commonly observed in tumor proteomes and, hence, specific phosphoproteins or phosphopeptides could serve as markers useful…”
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Chromatographic comparison of bupivacaine imprinted polymers prepared in crushed monolith, microsphere, silica-based composite and capillary monolith formats by Oxelbark, Joakim, Legido-Quigley, Cristina, Aureliano, Carla S.A., Titirici, Maria-Magdalena, Schillinger, Eric, Sellergren, Börje, Courtois, Julien, Irgum, Knut, Dambies, Laurent, Cormack, Peter A.G., Sherrington, David C., De Lorenzi, Ersilia

“…A comprehensive comparison of five chromatographic stationary phases based on molecularly imprinted polymers is presented. Efficiency, imprinting factors,…”
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Direct determination of the absolute configuration of a cyclic thiolsulfinate by VCD spectroscopy by Holmén, Anders, Oxelbark, Joakim, Allenmark, Stig

“…Experimental and calculated vibrational circular dichroism (VCD) spectra of the enantiomers of the conformationally rigid thiolsulfinate, naphtho[1,8-…”
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Effects from hydrogen bonding and rigidity on selectivity in tartaric acid-based chiral selectors for enantioselective liquid chromatography by Oxelbark, Joakim, Sellén, Inga-Britt

“…Tartaric acid‐based selectors 1 ((R,R)‐O,O′‐Bis(dimethylbenzoyl)‐N,N′‐diallyl‐N,N′‐dimethyl tartaramide) and 2 ((R,R)‐N‐allyl‐O,O′‐bis(dimethylbenzoyl)…”
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