Suchergebnisse - "Ottmann, Christian"

Modulators of protein-protein interactions von Milroy, Lech-Gustav, Grossmann, Tom N, Hennig, Sven, Brunsveld, Luc, Ottmann, Christian

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Small-Molecule Stabilization of Protein-Protein Interactions: An Underestimated Concept in Drug Discovery? von Thiel, Philipp, Kaiser, Markus, Ottmann, Christian

“… The modulation of protein–protein interactions (PPIs) has been recognized as one of the most challenging tasks in drug discovery. While their systematic …”
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14-3-3: A Case Study in PPI Modulation von Ballone, Alice, Centorrino, Federica, Ottmann, Christian

“… In recent years, targeting the complex network of protein–protein interactions (PPIs) has been identified as a promising drug-discovery approach to develop new …”
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Modulators of 14-3-3 Protein-Protein Interactions von Stevers, Loes M, Sijbesma, Eline, Botta, Maurizio, MacKintosh, Carol, Obsil, Tomas, Landrieu, Isabelle, Cau, Ylenia, Wilson, Andrew J, Karawajczyk, Anna, Eickhoff, Jan, Davis, Jeremy, Hann, Michael, O'Mahony, Gavin, Doveston, Richard G, Brunsveld, Luc, Ottmann, Christian

“… Direct interactions between proteins are essential for the regulation of their functions in biological pathways. Targeting the complex network of …”
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Ultra-large chemical libraries for the discovery of high-affinity peptide binders von Quartararo, Anthony J., Gates, Zachary P., Somsen, Bente A., Hartrampf, Nina, Ye, Xiyun, Shimada, Arisa, Kajihara, Yasuhiro, Ottmann, Christian, Pentelute, Bradley L.

“… High-diversity genetically-encoded combinatorial libraries (10 8 −10 13 members) are a rich source of peptide-based binding molecules, identified by affinity …”
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Intermolecular channels direct crystal orientation in mineralized collagen von Xu, YiFei, Nudelman, Fabio, Eren, E. Deniz, Wirix, Maarten J. M., Cantaert, Bram, Nijhuis, Wouter H., Hermida-Merino, Daniel, Portale, Giuseppe, Bomans, Paul H. H., Ottmann, Christian, Friedrich, Heiner, Bras, Wim, Akiva, Anat, Orgel, Joseph P. R. O., Meldrum, Fiona C., Sommerdijk, Nico

“… The mineralized collagen fibril is the basic building block of bone, and is commonly pictured as a parallel array of ultrathin carbonated hydroxyapatite (HAp) …”
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Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions von Sijbesma, Eline, Visser, Emira, Plitzko, Kathrin, Thiel, Philipp, Milroy, Lech-Gustav, Kaiser, Markus, Brunsveld, Luc, Ottmann, Christian

“… The systematic stabilization of protein–protein interactions (PPI) has great potential as innovative drug discovery strategy to target novel and hard-to-drug …”
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A simple method for developing lysine targeted covalent protein reagents von Gabizon, Ronen, Tivon, Barr, Reddi, Rambabu N., van den Oetelaar, Maxime C. M., Amartely, Hadar, Cossar, Peter J., Ottmann, Christian, London, Nir

“… Peptide-based covalent probes can target shallow protein surfaces not typically addressable using small molecules, yet there is a need for versatile approaches …”
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Stabilization of protein–protein interactions by small molecules von Giordanetto, Fabrizio, Schäfer, Anja, Ottmann, Christian

“… •Protein–protein interactions (PPIs) are ever increasingly targets for drug discovery.•Targeted small molecule inhibition of PPIs has repeatedly been shown to …”
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A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14‐3‐3 von de Vink, Pim J., Briels, Jeroen M., Schrader, Thomas, Milroy, Lech‐Gustav, Brunsveld, Luc, Ottmann, Christian

“… Interactions between proteins frequently involve recognition sequences based on multivalent binding events. Dimeric 14‐3‐3 adapter proteins are a prominent …”
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TEAD–YAP Interaction Inhibitors and MDM2 Binders from DNA‐Encoded Indole‐Focused Ugi Peptidomimetics von Kunig, Verena B. K., Potowski, Marco, Akbarzadeh, Mohammad, Klika Škopić, Mateja, Santos Smith, Denise, Arendt, Lukas, Dormuth, Ina, Adihou, Hélène, Andlovic, Blaž, Karatas, Hacer, Shaabani, Shabnam, Zarganes‐Tzitzikas, Tryfon, Neochoritis, Constantinos G., Zhang, Ran, Groves, Matthew, Guéret, Stéphanie M., Ottmann, Christian, Rahnenführer, Jörg, Fried, Roland, Dömling, Alexander, Brunschweiger, Andreas

“… DNA‐encoded combinatorial synthesis provides efficient and dense coverage of chemical space around privileged molecular structures. The indole side chain of …”
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Stabilization of Protein–Protein Interactions in chemical biology and drug discovery von Bier, David, Thiel, Philipp, Briels, Jeroen, Ottmann, Christian

“… More than 300,000 Protein–Protein Interactions (PPIs) can be found in human cells. This number is significantly larger than the number of single proteins, …”
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The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface von Bier, David, Mittal, Sumit, Bravo-Rodriguez, Kenny, Sowislok, Andrea, Guillory, Xavier, Briels, Jeroen, Heid, Christian, Bartel, Maria, Wettig, Burkhard, Brunsveld, Luc, Sanchez-Garcia, Elsa, Schrader, Thomas, Ottmann, Christian

“… Protein regions that are involved in protein-protein interactions (PPIs) very often display a high degree of intrinsic disorder, which is reduced during the …”
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Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins von Lentini Santo, Domenico, Petrvalska, Olivia, Obsilova, Veronika, Ottmann, Christian, Obsil, Tomas

“… Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) regulates several key physiological and pathophysiological processes, and its dysregulation has been …”
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Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth von Kaplan, Andrew, Andrei, Sebastian A, van Regteren Altena, Anna, Simas, Tristan, Banerjee, Sara L, Kato, Nobuo, Bisson, Nicolas, Higuchi, Yusuke, Ottmann, Christian, Fournier, Alyson E

“… Targeting protein-protein interactions (PPIs) is a promising approach in the development of drugs for many indications. 14-3-3 proteins are a family of …”
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Stabilization of protein-protein interactions in drug discovery von Andrei, Sebastian A., Sijbesma, Eline, Hann, Michael, Davis, Jeremy, O'Mahony, Gavin, Perry, Matthew W. D., Karawajczyk, Anna, Eickhoff, Jan, Brunsveld, Luc, Doveston, Richard G., Milroy, Lech-Gustav, Ottmann, Christian

“… Introduction: PPIs are involved in every disease and specific modulation of these PPIs with small molecules would significantly improve our prospects of …”
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Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR von Stevers, Loes M., Wolter, Madita, Carlile, Graeme W., Macdonald, Dwight, Richard, Luc, Gielkens, Frank, Hanrahan, John W., Thomas, David Y., Chakka, Sai Kumar, Peterson, Mark L., Thomas, Helmut, Brunsveld, Luc, Ottmann, Christian

“… Impaired activity of the chloride channel CFTR is the cause of cystic fibrosis. 14-3-3 proteins have been shown to stabilize CFTR and increase its biogenesis …”
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Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity von Katz, Liora S., Visser, Emira J., Plitzko, Kathrin F., Pennings, Marloes A. M., Cossar, Peter J., Tse, Isabelle L., Kaiser, Markus, Brunsveld, Luc, Ottmann, Christian, Scott, Donald K.

“… The Carbohydrate Response Element Binding Protein (ChREBP) is a glucose-responsive transcription factor (TF) with two major splice isoforms (α and β). In …”
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Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR von Stevers, Loes M, Lam, Chan V, Leysen, Seppe F R, Meijer, Femke A, van Scheppingen, Daphne S, de Vries, Rens M J M, Carlile, Graeme W, Milroy, Lech G, Thomas, David Y, Brunsveld, Luc, Ottmann, Christian

“… Cystic fibrosis is a fatal genetic disease, most frequently caused by the retention of the CFTR (cystic fibrosis transmembrane conductance regulator) mutant …”
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Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex von Konstantinidou, Markella, Zingiridis, Marios, Pennings, Marloes A. M., Fragkiadakis, Michael, Virta, Johanna M., Revalde, Jezrael L., Visser, Emira J., Ottmann, Christian, Brunsveld, Luc, Neochoritis, Constantinos G., Arkin, Michelle R.

“… Molecular glues, small molecules that bind cooperatively at a protein-protein interface, have emerged as powerful modalities for the modulation of …”
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