Suchergebnisse - "Ottenhoff, T.H.M."

Identification of circulating monocytes as producers of tuberculosis disease biomarker C1q von Niewold, P., Dijkstra, D.J., Cai, Y., Goletti, D., Palmieri, F., Meijgaarden, K.E. van, Verreck, F.A.W., Akkerman, O.W., Hofland, R.W., Delemarre, E.M., Nierkens, S., Verheul, M.K., Pollard, A.J., Dissel, J.T. van, Ottenhoff, T.H.M., Trouw, L.A., Joosten, S.A.

“… Tuberculosis (TB) is a prevalent disease causing an estimated 1.6 million deaths and 10.6 million new cases annually. Discriminating TB disease from …”
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Potential of Mycobacterium tuberculosis resuscitation-promoting factors as antigens in novel tuberculosis sub-unit vaccines von Romano, M., Aryan, E., Korf, H., Bruffaerts, N., Franken, C.L.M.C., Ottenhoff, T.H.M., Huygen, K.

“… Novel vaccines are needed to control tuberculosis (TB), the bacterial infectious disease that together with malaria and HIV is worldwide responsible for high …”
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Detection of Mycobacterium tuberculosis infection in dogs in a high-risk setting von Parsons, S.D.C., Warren, R.M., Ottenhoff, T.H.M., Gey van Pittius, N.C., van Helden, P.D.

“… Dogs infected with Mycobacteriumtuberculosis can develop clinical tuberculosis (TB) but there are currently no validated immunological assays for diagnosing …”
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Comparative analysis of the host mediated antigen-specific responses In Indian cohorts with different TB infected states von Rakshit, S., K Sundararaj, B., sahoo, P.N., Ottenhoff, T.H.M., van Meijgaarden, K.E., Jesuraj, A., D'Souza, G., Vyakarnam, A.

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Plasma granulysin levels and cellular interferon-γ production correlate with curative host responses in tuberculosis, while plasma interferon-γ levels correlate with tuberculosis disease activity in adults von Sahiratmadja, E., Alisjahbana, B., Buccheri, S., Di Liberto, D., de Boer, T., Adnan, I., van Crevel, R., Klein, M.R., van Meijgaarden, K.E., Nelwan, R.H.H., van de Vosse, E., Dieli, F., Ottenhoff, T.H.M.

“… Granulysin is a recently identified cytolytic protein which is expressed by human cytotoxic T-lymphocytes and natural killer (NK)-cells, and has broad …”
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Iron deficiency and NRAMP1 polymorphism (INT4, D543N and 3'UTR) do not contribute to severity of anaemia in tuberculosis in the Indonesian population von Sahiratmadja, E, Wieringa, F.T, Crevel, R. van, Visser, A.W. de, Adnan, I, Alisjahbana, B, Slagboom, E, Marzuki, S, Ottenhoff, T.H.M, Vosse, E. van de

“… Fe-deficiency anaemia is the most common cause of anaemia in developing countries. In these settings, many chronic infections, including tuberculosis (TB), are …”
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Intrinsic immunogenicity of liposomes for tuberculosis vaccines: Effect of cationic lipid and cholesterol von Szachniewicz, M.M., Neustrup, M.A., van Meijgaarden, K.E., Jiskoot, W., Bouwstra, J.A., Haks, M.C., Geluk, A., Ottenhoff, T.H.M.

“… Tuberculosis (TB) is still among the deadliest infectious diseases, hence there is a pressing need for more effective TB vaccines. Cationic liposome subunit …”
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Cationic pH-sensitive liposomes as tuberculosis subunit vaccine delivery systems: Effect of liposome composition on cellular innate immune responses von Szachniewicz, M.M., Meijgaarden, K.E. van, Kavrik, E., Jiskoot, W., Bouwstra, J.A., Haks, M.C., Geluk, A., Ottenhoff, T.H.M.

“… •Cationic pH-sensitive liposomes are effectively taken up by dendritic cells (DCs)•1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (EPC) improves DC …”
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Cationic pH-sensitive liposome-based subunit tuberculosis vaccine induces protection in mice challenged with Mycobacterium tuberculosis von Szachniewicz, M.M., van den Eeden, S.J.F., van Meijgaarden, K.E., Franken, K.L.M.C., van Veen, S., Geluk, A., Bouwstra, J.A., Ottenhoff, T.H.M.

“… [Display omitted] Tuberculosis (TB) has been and still is a global emergency for centuries. Prevention of disease through vaccination would have a major impact …”
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Intradermal versus subcutaneous immunization: Effects of administration route using a lipid-PLGA hybrid nanoparticle tuberculosis vaccine von Szachniewicz, M.M., van den Eeden, S.J.F., van Meijgaarden, K.E., Franken, K.L.M.C., van Veen, S., Geluk, A., Bouwstra, J.A., Ottenhoff, T.H.M.

“… Tuberculosis (TB) remains a significant global health challenge, latently affecting around a quarter of the global population. The sole licensed TB vaccine, …”
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Response to Rv2628 latency antigen associates with cured tuberculosis and remote infection von Goletti, D, Butera, O, Vanini, V, Lauria, F N, Lange, C, Franken, K L M C, Angeletti, C, Ottenhoff, T H M, Girardi, E

“… Interferon-gamma release assays based on region of difference 1 antigens have improved diagnosis of latent tuberculosis infection (LTBI). However, these tests …”
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T cell assays and MIATA: the essential minimum for maximum impact von Britten, C M, Janetzki, S, Butterfield, L H, Ferrari, G, Gouttefangeas, C, Huber, C, Kalos, M, Levitsky, H I, Maecker, H T, Melief, C J M, O'Donnell-Tormey, J, Odunsi, K, Old, L J, Ottenhoff, T H M, Ottensmeier, C, Pawelec, G, Roederer, M, Roep, B O, Romero, P, van der Burg, S H, Walter, S, Hoos, A, Davis, M M

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Differential gene expression of activating Fcγ receptor classifies active tuberculosis regardless of human immunodeficiency virus status or ethnicity von Sutherland, J.S., Loxton, A.G., Haks, M.C., Kassa, D., Ambrose, L., Lee, J.-S., Ran, L., van Baarle, D., Maertzdorf, J., Howe, R., Mayanja-Kizza, H., Boom, W.H., Thiel, B.A., Crampin, A.C., Hanekom, W., Ota, M.O.C., Dockrell, H., Walzl, G., Kaufmann, S.H.E., Ottenhoff, T.H.M.

“… New diagnostics and vaccines for tuberculosis (TB) are urgently needed, but require an understanding of the requirements for protection from/susceptibility to …”
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Identification of biomarkers for tuberculosis disease using a novel dual-color RT–MLPA assay von Joosten, S A, Goeman, J J, Sutherland, J S, Opmeer, L, de Boer, K G, Jacobsen, M, Kaufmann, S H E, Finos, L, Magis-Escurra, C, Ota, M O C, Ottenhoff, T H M, Haks, M C

“… Owing to our lack of understanding of the factors that constitute protective immunity during natural infection with Mycobacterium tuberculosis ( Mtb ), there …”
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Host biomarker-based quantitative rapid tests for detection and treatment monitoring of tuberculosis and COVID-19 von Pierneef, Louise, van Hooij, Anouk, de Jong, Danielle, Tjon Kon Fat, Elisa M., van Meijgaarden, Krista E., Petruccioli, Elisa, Vanini, Valentina, Roukens, Anna H.E., Goletti, Delia, Corstjens, Paul L.A.M., Joosten, Simone A., Geluk, Annemieke, Arbous, M.S., van den Berg, B.M., Cannegieter, S., Cobbaert, C.M., van der Does, A., van Dongen, J.J.M., Eikenboom, J., Feltkamp, M.C.M., Geluk, A., Goeman, J.J., Giera, M., Hankemeier, T., Heemskerk, M.H.M., Hiemstra, P.S., Hokke, C.H., Janse, J.J., Jochems, S.P., Joosten, S.A., Kikkert, M., Lamont, L., Manniën, J., Ottenhoff, T.H.M., del Prado, M.R., Queralt Rosinach, N., Roestenberg, M., Roos, M., Roukens, A.H.E., Smits, H.H., Snijder, E.J., Staal, F.J.T., Trouw, L.A., Tsonaka, R., Verhoeven, A., Visser, L.G., de Vries, J.J.C., van Westerloo, D.J., Wigbers, J., van der Wijk, H.J., van Wissen, R.C., Wuhrer, M., Yazdanbakhsh, M., Zlei, M.

“… Diagnostic services for tuberculosis (TB) are not sufficiently accessible in low-resource settings, where most cases occur, which was aggravated by the …”
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HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading von van Ham, S M, Tjin, E P, Lillemeier, B F, Grüneberg, U, van Meijgaarden, K E, Pastoors, L, Verwoerd, D, Tulp, A, Canas, B, Rahman, D, Ottenhoff, T H, Pappin, D J, Trowsdale, J, Neefjes, J

“… Class II molecules of the major histocompatibility complex become loaded with antigenic peptides after dissociation of invariant chainderived peptides (CLIP) …”
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Pneumonia caused by Mycobacterium kansasii in a series of patients without recognised immune defect von Arend, S.M., de Palou, E. Cerdé, de Haas, P., Janssen, R., Hoeve, M.A., Verhard, E.M., Ottenhoff, T.H.M., van Soolingen, D., van Dissel, J.T.

“… The clinical and epidemiological characteristics of 17 patients diagnosed with Mycobacterium kansasii pneumonia within a limited geographical region over a …”
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T cell immune responses to mycobacterial antigens in Brazilian tuberculosis patients and controls von Antas, P R Z, Cardoso, F L L, Pereira, K C, Franken, K L M C, Cunha, K S, Klatser, P, Sarno, E N, Ottenhoff, T H M, Sampaio, E P

“… Production of IFN-gamma guarantees helpful T cell-mediated immunity against Mycobacterium tuberculosis infection. We have evaluated the in vitro immune …”
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Molecular mimicry in IDDM: The PEVKEK motif of coxsackle B virus protein 2C and GAD65 is highly conserved and binds to HLA-DR3 von Vreugdenhil, G.R., Geluk, A., Ottenhoff, T.H.M., Melchers, W.J.G., Roep, B.O., Galama, J.M.D.

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The role of CD80 and CD86 in Mycobacterial antigen induced T cell activation von De Jong, R., Janson, A., Faber, W., Naafs, B., Ottenhoff, T.H.M.

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