Suchergebnisse - "Oo, Adrian"

Flavonoids: promising natural compounds against viral infections von Zakaryan, Hovakim, Arabyan, Erik, Oo, Adrian, Zandi, Keivan

“… Flavonoids are widely distributed as secondary metabolites produced by plants and play important roles in plant physiology, having a variety of potential …”
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Deciphering the potential of baicalin as an antiviral agent for Chikungunya virus infection von Oo, Adrian, Rausalu, Kai, Merits, Andres, Higgs, Stephen, Vanlandingham, Dana, Bakar, Sazaly Abu, Zandi, Keivan

“… The past decade has seen the re-emergence of Chikungunya virus (CHIKV) as a major global health threat, affecting millions around the world. Although fatal …”
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Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase von Zandi, Keivan, Musall, Katie, Oo, Adrian, Cao, Dongdong, Liang, Bo, Hassandarvish, Pouya, Lan, Shuiyun, Slack, Ryan L., Kirby, Karen A., Bassit, Leda, Amblard, Franck, Kim, Baek, AbuBakar, Sazaly, Sarafianos, Stefan G., Schinazi, Raymond F.

“… Coronavirus Disease 2019 (COVID-19) is a deadly emerging infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Because …”
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Mechanistic Interplay between HIV-1 Reverse Transcriptase Enzyme Kinetics and Host SAMHD1 Protein: Viral Myeloid-Cell Tropism and Genomic Mutagenesis von Bowen, Nicole E., Oo, Adrian, Kim, Baek

“… Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) has been the primary interest among studies on antiviral discovery, viral replication …”
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The thioredoxin system determines CHK1 inhibitor sensitivity via redox-mediated regulation of ribonucleotide reductase activity von Prasad, Chandra Bhushan, Oo, Adrian, Liu, Yujie, Qiu, Zhaojun, Zhong, Yaogang, Li, Na, Singh, Deepika, Xin, Xiwen, Cho, Young-Jae, Li, Zaibo, Zhang, Xiaoli, Yan, Chunhong, Zheng, Qingfei, Wang, Qi-En, Guo, Deliang, Kim, Baek, Zhang, Junran

“… Checkpoint kinase 1 (CHK1) is critical for cell survival under replication stress (RS). CHK1 inhibitors (CHK1i’s) in combination with chemotherapy have shown …”
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Computational Approach Towards Exploring Potential Anti-Chikungunya Activity of Selected Flavonoids von Seyedi, Seyedeh Somayeh, Shukri, Munirah, Hassandarvish, Pouya, Oo, Adrian, Shankar, Esaki Muthu, Abubakar, Sazaly, Zandi, Keivan

“… Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes chikungunya infection in humans. Despite the widespread distribution of CHIKV, no …”
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Precision disease management: prognostic biomarker for chronic lung damage in long COVID von Oo, Adrian, Chu, Justin Jang Hann

“… https://bit.ly/3Ccxozg …”
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A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site von Maehigashi, Tatsuya, Ahn, Seohyun, Kim, Uk-Il, Lindenberger, Jared, Oo, Adrian, Koneru, Pratibha C., Mahboubi, Bijan, Engelman, Alan N., Kvaratskhelia, Mamuka, Kim, Kyungjin, Kim, Baek

“… Allosteric integrase inhibitors (ALLINIs) are a class of experimental anti-HIV agents that target the noncatalytic sites of the viral integrase (IN) and …”
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Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels von Schüssler, Moritz, Schott, Kerstin, Fuchs, Nina Verena, Oo, Adrian, Zahadi, Morssal, Rauch, Paula, Kim, Baek, König, Renate

“… Sterile α motif and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphate triphosphohydrolase (dNTPase) and a potent restriction factor for …”
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The role of inflammatory gene polymorphisms in severe COVID-19: a review von Yip, Jia Qi, Oo, Adrian, Ng, Yan Ling, Chin, Kim Ling, Tan, Kim-Kee, Chu, Justin Jang Hann, AbuBakar, Sazaly, Zainal, Nurhafiza

“… The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has profoundly impacted global healthcare systems and spurred extensive research efforts …”
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Nucleotide Analogues Bearing a C2′ or C3′-Stereogenic All-Carbon Quaternary Center as SARS-CoV-2 RdRp Inhibitors von Manchoju, Amarender, Zelli, Renaud, Wang, Gang, Eymard, Carla, Oo, Adrian, Nemer, Mona, Prévost, Michel, Kim, Baek, Guindon, Yvan

“… The design of novel nucleoside triphosphate (NTP) analogues bearing an all-carbon quaternary center at C2′ or C3′ is described. The construction of this …”
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NOS inhibition sensitizes metaplastic breast cancer to PI3K inhibition and taxane therapy via c-JUN repression von Reddy, Tejaswini, Puri, Akshjot, Guzman-Rojas, Liliana, Thomas, Christoforos, Qian, Wei, Zhou, Jianying, Zhao, Hong, Mahboubi, Bijan, Oo, Adrian, Cho, Young-Jae, Kim, Baek, Thaiparambil, Jose, Rosato, Roberto, Martinez, Karina Ortega, Chervo, Maria Florencia, Ayerbe, Camila, Giese, Noah, Wink, David, Lockett, Stephen, Wong, Stephen, Chang, Jeffrey, Krishnamurthy, Savitri, Yam, Clinton, Moulder, Stacy, Piwnica-Worms, Helen, Meric-Bernstam, Funda, Chang, Jenny

“… Metaplastic breast cancer (MpBC) is a highly chemoresistant subtype of breast cancer with no standardized therapy options. A clinical study in …”
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Editorial: Raising the bar: advancing therapeutic strategies for fighting communicable and noncommunicable diseases von Tanoto, Dariel Wilbert, Lee, Jia Wen, Chong, Yee Kien, Lani, Rafidah, Hassandarvish, Pouya, Oo, Adrian

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LAIV Mutations Selectively Alter Influenza Viral RNA Polymerase Function, Favoring Transcription over Genome Synthesis von Leach, Justin R., Oo, Adrian, Nogales, Aitor, Bosch, Sebastian I., Martínez-Sobrido, Luis, Feng, Changyong, Kim, Baek, Dewhurst, Stephen

“… Influenza viruses cause mild to severe lower respiratory infections, sometimes resulting in hospitalization and death. Vaccination remains the primary …”
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Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins von Bowen, Nicole E., Temple, Joshua, Shepard, Caitlin, Oo, Adrian, Arizaga, Fidel, Kapoor-Vazirani, Priya, Persaud, Mirjana, Yu, Corey H., Kim, Dong-Hyun, Schinazi, Raymond F., Ivanov, Dmitri N., Diaz-Griffero, Felipe, Yu, David S., Xiong, Yong, Kim, Baek

“… Elevated intracellular levels of dNTPs have been shown to be a biochemical marker of cancer cells. Recently, a series of mutations in the multifunctional dNTP …”
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Dengue Outbreak during Ongoing Civil War, Taiz, Yemen von Alghazali, KhairAlah A., Teoh, Boon-Teong, Loong, Shih-Keng, Sam, Sing-Sin, Che-Mat-Seri, Nurul-Asma-Anati, Samsudin, Nur-Izyan, Yaacob, Che-Norainon, Azizan, Noor-Syahida, Oo, Adrian, Baharudin, Nur-Adilah, Tan, Kim-Kee, Abd-Jamil, Juraina, Nor’e, Siti-Sarah, Khor, Chee-Sieng, Johari, Jefree, Mahdy, Mohammed A.K., AbuBakar, Sazaly

“… We identified dengue in ≈51% of patients given a clinical diagnosis of suspected dengue in Taiz, Yemen, during 2016. The cosmopolitan genotype of dengue virus …”
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In silico study on anti-Chikungunya virus activity of hesperetin von Oo, Adrian, Hassandarvish, Pouya, Chin, Sek Peng, Lee, Vannajan Sanghiran, Abu Bakar, Sazaly, Zandi, Keivan

“… The re-emerging, transmitted Chikungunya virus (CHIKV) has recently caused large outbreaks in a wide geographical distribution of the world including countries …”
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Baicalein and baicalin as Zika virus inhibitors von Oo, Adrian, Teoh, Boon Teong, Sam, Sing Sin, Bakar, Sazaly Abu, Zandi, Keivan

“… At present, there is no effective antiviral agent for Zika virus (ZIKV), an arbovirus that is known for its teratogenic effects on newborns. Baicalein and …”
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Repurposing Nucleoside Analogs for Human Coronaviruses von Zandi, Keivan, Amblard, Franck, Musall, Katie, Downs-Bowen, Jessica, Kleinbard, Ruby, Oo, Adrian, Cao, Dongdong, Liang, Bo, Russell, Olivia O, McBrayer, Tamara, Bassit, Leda, Kim, Baek, Schinazi, Raymond F

“… Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or CoV-2). Some reports claimed …”
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Biochemical simulation of mutation synthesis and repair during SARS-CoV-2 RNA polymerization von Oo, Adrian, Chen, Zhenhang, Cao, Dongdong, Cho, Young-Jae, Liang, Bo, Schinazi, Raymond F, Kim, Baek

“… We biochemically simulated the mutation synthesis process of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) complex (nsp7/nsp8/nsp12) involving two sequential …”
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