Výsledky vyhľadávania - "Oncogenesis (New York, NY)"

The hypoxic tumour microenvironment Autor Petrova, Varvara, Annicchiarico-Petruzzelli, Margherita, Melino, Gerry, Amelio, Ivano

“…Cancer progression often benefits from the selective conditions present in the tumour microenvironment, such as the presence of cancer-associated fibroblasts…”
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Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance Autor Vasseur, Sophie, Guillaumond, Fabienne

“…Lipids are essential constituents for malignant tumors, as they are absolutely required for tumor growth and dissemination. Provided by the tumor…”
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Exosomes and cancer - Diagnostic and prognostic biomarkers and therapeutic vehicle Autor Wang, Xia, Tian, Lu, Lu, Jingyi, Ng, Irene Oi-Lin

“…Exosomes belong to a subpopulation of extracellular vesicles secreted by the dynamic multistep endocytosis process and carry diverse functional molecular…”
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Involvement of the pro-oncogenic enzyme fatty acid synthase in the hallmarks of cancer: a promising target in anti-cancer therapies Autor Vanauberg, Dimitri, Schulz, Céline, Lefebvre, Tony

“…An accelerated de novo lipogenesis (DNL) flux is a common characteristic of cancer cells required to sustain a high proliferation rate. The DNL enzyme fatty…”
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Epigenetic and genetic features of 24 colon cancer cell lines Autor Ahmed, D, Eide, P W, Eilertsen, I A, Danielsen, S A, Eknæs, M, Hektoen, M, Lind, G E, Lothe, R A

“…Cell lines are invaluable biomedical research tools, and recent literature has emphasized the importance of genotype authentication and characterization. In…”
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Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis Autor Fan, Z, Wirth, A-K, Chen, D, Wruck, C J, Rauh, M, Buchfelder, M, Savaskan, N

“…Cancer cells are hallmarked by high proliferation and imbalanced redox consumption and signaling. Various oncogenic pathways such as proliferation and evading…”
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Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases Autor Allocati, Nerino, Masulli, Michele, Di Ilio, Carmine, Federici, Luca

“…Glutathione transferase classical GSH conjugation activity plays a critical role in cellular detoxification against xenobiotics and noxious compounds as well…”
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Lipid metabolic reprogramming in cancer cells Autor Beloribi-Djefaflia, S, Vasseur, S, Guillaumond, F

“…Many human diseases, including metabolic, immune and central nervous system disorders, as well as cancer, are the consequence of an alteration in lipid…”
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Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells Autor Rice, A J, Cortes, E, Lachowski, D, Cheung, B C H, Karim, S A, Morton, J P, del Río Hernández, A

“…Increased matrix rigidity associated with the fibrotic reaction is documented to stimulate intracellular signalling pathways that promote cancer cell survival…”
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Molecular mechanisms in colitis-associated colorectal cancer Autor Zhou, Royce W., Harpaz, Noam, Itzkowitz, Steven H., Parsons, Ramon E.

“…Sustained chronic inflammation of the large intestine leads to tissue damage and repair, which is associated with an increased incidence of colitis-associated…”
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Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation Autor Cheng, J-t, Deng, Y-n, Yi, H-m, Wang, G-y, Fu, B-s, Chen, W-j, Liu, W, Tai, Y, Peng, Y-w, Zhang, Q

“…Although carcinoma-associated fibroblasts (CAFs) in tumor microenvironments have a critical role in immune cell modulation, their effects on the generation of…”
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Transglutaminase-2 facilitates extracellular vesicle-mediated establishment of the metastatic niche Autor Shinde, Aparna, Paez, Juan Sebastian, Libring, Sarah, Hopkins, Kelsey, Solorio, Luis, Wendt, Michael K.

“…The ability of breast cancer cells to interconvert between epithelial and mesenchymal states contributes to their metastatic potential. As opposed to cell…”
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CXCL5 promotes gastric cancer metastasis by inducing epithelial-mesenchymal transition and activating neutrophils Autor Mao, Zheying, Zhang, Jiahui, Shi, Yinghong, Li, Wei, Shi, Hui, Ji, Runbi, Mao, Fei, Qian, Hui, Xu, Wenrong, Zhang, Xu

“…Deregulated expression of chemokines in tumor microenvironment contributes to tumor metastasis by targeting distinct cells. Epithelial-derived…”
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An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance Autor Li, Ningning, Babaei-Jadidi, Roya, Lorenzi, Federica, Spencer-Dene, Bradley, Clarke, Philip, Domingo, Enric, Tulchinsky, Eugene, Vries, Robert G. J., Kerr, David, Pan, Yihang, He, Yulong, Bates, David O., Tomlinson, Ian, Clevers, Hans, Nateri, Abdolrahman S.

“…Colorectal cancer (CRC) patients develop recurrence after chemotherapy owing to the survival of stem cell-like cells referred to as cancer stem-like cells…”
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Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions Autor Doshi, Bhavisha, Athans, Sarah R., Woloszynska, Anna

“…Sex and gender disparities in bladder cancer have long been a subject of interest to the cancer research community, wherein men have a 4 times higher incidence…”
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Tumor-derived exosomes induce PD1+ macrophage population in human gastric cancer that promotes disease progression Autor Wang, Furong, Li, Bin, Wei, Yucai, Zhao, Yang, Wang, Li, Zhang, Peng, Yang, Jinwei, He, Wenting, Chen, Hao, Jiao, Zuoyi, Li, Yumin

“…Macrophages constitute a major component of tumor-infiltrating immune cells. M2 macrophages have been reported to promote tumor progression through promoting…”
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Hypoxia and metabolic adaptation of cancer cells Autor Eales, K L, Hollinshead, K E R, Tennant, D A

“…Low oxygen tension (hypoxia) is a pervasive physiological and pathophysiological stimulus that metazoan organisms have contended with since they evolved from…”
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Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis Autor Xu, Kun, Wang, Runtian, Xie, Hui, Hu, Longfei, Wang, Cong, Xu, Jiali, Zhu, Chengjun, Liu, Yiqiu, Gao, Fangyan, Li, Xintong, Wang, Cenzhu, Huang, Jinyi, Zhou, Wenbin, Zhou, Guohua, Shu, Yongqian, Guan, Xiaoxiang

“…Molecular mechanisms underlying breast cancer lymph node metastasis remain unclear. Using single-cell sequencing, we investigated the transcriptome profile of…”
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MYB oncoproteins: emerging players and potential therapeutic targets in human cancer Autor Cicirò, Ylenia, Sala, Arturo

“…MYB transcription factors are highly conserved from plants to vertebrates, indicating that their functions embrace fundamental mechanisms in the biology of…”
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DeepCC: a novel deep learning-based framework for cancer molecular subtype classification Autor Gao, Feng, Wang, Wei, Tan, Miaomiao, Zhu, Lina, Zhang, Yuchen, Fessler, Evelyn, Vermeulen, Louis, Wang, Xin

“…Molecular subtyping of cancer is a critical step towards more individualized therapy and provides important biological insights into cancer heterogeneity…”
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