Výsledky vyhľadávania - "Oncogene"

ROS production by mitochondria: function or dysfunction? Autor Palma, Flavio R., Gantner, Benjamin N., Sakiyama, Marcelo J., Kayzuka, Cezar, Shukla, Sanjeev, Lacchini, Riccardo, Cunniff, Brian, Bonini, Marcelo G.

“…In eukaryotic cells, ATP generation is generally viewed as the primary function of mitochondria under normoxic conditions. Reactive oxygen species (ROS), in…”
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CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1 Autor Li, Dongbao, Wang, Yuhong, Dong, Chao, Chen, Tao, Dong, Anqi, Ren, Jiayu, Li, Weikang, Shu, Gege, Yang, Jiaoyang, Shen, Wenhao, Qin, Lei, Hu, Lin, Zhou, Jin

“…Metastasis is an important factor contributing to poor prognosis in patients with gastric cancer; yet, the molecular mechanism leading to this cell behavior is…”
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Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer Autor Fong, Winnie, Li, Qing, Yu, Jun

“…Research about the role of gut microbiome in colorectal cancer (CRC) is a newly emerging field of study. Gut microbiota modulation, with the aim to reverse…”
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Circular RNAs in cancer: opportunities and challenges in the field Autor Kristensen, L S, Hansen, T B, Venø, M T, Kjems, J

“…Circular RNA (circRNA) is a novel member of the noncoding cancer genome with distinct properties and diverse cellular functions, which is being explored at a…”
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LncRNA-mediated regulation of cell signaling in cancer Autor Peng, W-X, Koirala, P, Mo, Y-Y

“…To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered through functional genomics studies. Importantly, lncRNAs have been…”
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Wnt signaling in cancer Autor Zhan, T, Rindtorff, N, Boutros, M

“…Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in…”
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Going circular: history, present, and future of circRNAs in cancer Autor Pisignano, Giuseppina, Michael, David C., Visal, Tanvi H., Pirlog, Radu, Ladomery, Michael, Calin, George A.

“…To date, thousands of highly abundant and conserved single-stranded RNA molecules shaped into ring structures (circRNAs) have been identified. CircRNAs are…”
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YTHDF2 promotes the liver cancer stem cell phenotype and cancer metastasis by regulating OCT4 expression via m6A RNA methylation Autor Zhang, Chuanzhao, Huang, Shanzhou, Zhuang, Hongkai, Ruan, Shiye, Zhou, Zixuan, Huang, Kaijun, Ji, Fei, Ma, Zuyi, Hou, Baohua, He, Xiaoshun

“…N -methyladenosine (m6A) RNA methylation contributes to the cancer stem cell (CSC) phenotype through regulating gene expression. YTHDF2, an m6A reader, was…”
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A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis Autor Zhang, Maolei, Huang, Nunu, Yang, Xuesong, Luo, Jingyan, Yan, Sheng, Xiao, Feizhe, Chen, Wenping, Gao, Xinya, Zhao, Kun, Zhou, Huangkai, Li, Ziqiang, Ming, Liu, Xie, Bo, Zhang, Nu

“…Circular RNAs (circRNAs) are recognized as functional non-coding transcripts in eukaryotic cells. Recent evidence has indicated that even though circRNAs are…”
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Census and evaluation of p53 target genes Autor Fischer, M

“…The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53 gene alters its response pathway, and is central to the…”
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Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players Autor Yuan, Xiaotian, Larsson, Catharina, Xu, Dawei

“…Long-lived species Homo sapiens have evolved robust protection mechanisms against cancer by repressing telomerase and maintaining short telomeres, thereby…”
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Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies Autor An, Zhenyi, Aksoy, Ozlem, Zheng, Tina, Fan, Qi-Wen, Weiss, William A.

“…Amplification of epidermal growth factor receptor (EGFR) and its active mutant EGFRvIII occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play…”
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Essential role of METTL3-mediated m 6 A modification in glioma stem-like cells maintenance and radioresistance Autor Visvanathan, A, Patil, V, Arora, A, Hegde, A S, Arivazhagan, A, Santosh, V, Somasundaram, K

“…Despite advances in biology and therapeutic modalities, existence of highly tumorigenic glioma stem-like cells (GSCs) makes glioblastomas (GBMs) invincible…”
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Hypoxic glioma-derived exosomes deliver microRNA-1246 to induce M2 macrophage polarization by targeting TERF2IP via the STAT3 and NF-κB pathways Autor Qian, Mingyu, Wang, Shaobo, Guo, Xiaofan, Wang, Jian, Zhang, Zongpu, Qiu, Wei, Gao, Xiao, Chen, Zihang, Xu, Jianye, Zhao, Rongrong, Xue, Hao, Li, Gang

“…Exosomes are emerging as important elements that participate in intercellular communication and tumor microenvironment modulation, but the exact mechanisms by…”
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E-cadherin in contact inhibition and cancer Autor Mendonsa, Alisha M., Na, Tae-Young, Gumbiner, Barry M.

“…E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin…”
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A risk model developed based on tumor microenvironment predicts overall survival and associates with tumor immunity of patients with lung adenocarcinoma Autor Wu, Jie, Li, Lan, Zhang, Huibo, Zhao, Yaqi, Zhang, Haohan, Wu, Siyi, Xu, Bin

“…Tumor microenvironment (TME) has been reported to exhibit a crucial effect in lung cancer. Therefore, this study was aimed to investigate the genes associated…”
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The functional roles of TCA cycle metabolites in cancer Autor Eniafe, Joseph, Jiang, Shuai

“…The tricarboxylic acid cycle (TCA cycle) has been known for decades as a hub for generating cellular energy and precursors for biosynthetic pathways. Several…”
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Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells Autor Richards, K E, Zeleniak, A E, Fishel, M L, Wu, J, Littlepage, L E, Hill, R

“…Cancer-associated fibroblasts (CAFs) comprise the majority of the tumor bulk of pancreatic ductal adenocarcinomas (PDACs). Current efforts to eradicate these…”
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The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network Autor Cheng, Maosheng, Sheng, Lu, Gao, Qian, Xiong, Qiuchan, Zhang, Haojie, Wu, Mingqing, Liang, Yu, Zhu, Fengyu, Zhang, Yingyin, Zhang, Xiuhong, Yuan, Quan, Li, Yang

“…N 6 -methyladenosine (m6A) is the most abundant modification in eukaryotic messenger RNAs (mRNAs), and plays important roles in many bioprocesses. However, its…”
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Dual role of autophagy in hallmarks of cancer Autor Singh, Shikha Satendra, Vats, Somya, Chia, Amelia Yi-Qian, Tan, Tuan Zea, Deng, Shuo, Ong, Mei Shan, Arfuso, Frank, Yap, Celestial T., Goh, Boon Cher, Sethi, Gautam, Huang, Ruby Yun-Ju, Shen, Han Ming, Manjithaya, Ravi, Kumar, Alan Prem

“…Evolutionarily conserved across eukaryotic cells, macroautophagy (herein autophagy) is an intracellular catabolic degradative process targeting damaged and…”
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