Suchergebnisse - "Omar, Shaheed Vally"

New Horizons in the Diagnosis of Tuberculosis of the Spine: The Role of Whole Genome Sequencing von Ngcelwane, Mthunzi, Omar, Shaheed Vally, Said, Mohamed, Bida, Meshack

“… Study Design: Prospective study.Purpose: To evaluate the utility of whole genome sequencing (WGS) in drug resistance testing, lineage of the organisms, and …”
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Refined understanding of the impact of the Mycobacterium tuberculosis complex diversity on the intrinsic susceptibility to pretomanid von Rupasinghe, Praharshinie, Reenaers, Rabab, Vereecken, Jens, Mulders, Wim, Cogneau, Sari, Merker, Matthias, Niemann, Stefan, Vally Omar, Shaheed, Rigouts, Leen, Köser, Claudio U., Decroo, Tom, de Jong, Bouke C.

“… This study confirmed that the Mycobacterium tuberculosis complex lineage 1, responsible for 28% of global tuberculosis cases, is less susceptible to pretomanid …”
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Targeted next-generation sequencing for drug-resistant tuberculosis diagnosis: implementation considerations for bacterial load, regimen selection and diagnostic algorithm placement von Georghiou, Sophia B, Tukvadze, Nestani, Rodrigues, Camilla, Omar, Shaheed Vally, Cabibbe, Andrea Maurizio, Seifert, Marva, Uplekar, Swapna, Ismail, Nazir, Ruhwald, Morten, Suresh, Anita, Colman, Rebecca E

“… IntroductionEarly and accurate diagnosis of drug-resistant tuberculosis (DR-TB) is essential for improving treatment outcomes. Phenotypic drug susceptibility …”
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Frequency of Circulating CD4+Ki67+HLA-DR− T Regulatory Cells Prior to Treatment for Multidrug Resistant Tuberculosis Can Differentiate the Severity of Disease and Predict Time to Culture Conversion von Ferrian, Selena, Ross, Melinda, Conradie, Francesca, Vally Omar, Shaheed, Ismail, Nazir, Little, Francesca, Kaplan, Gilla, Fallows, Dorothy, Gray, Clive M.

“… Identifying a blood circulating cellular biomarker that can be used to assess severity of disease and predict the time to culture conversion (TCC) in patients …”
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Targeted next-generation sequencing to diagnose drug-resistant tuberculosis: a systematic review and meta-analysis von Schwab, Tiana Carina, Perrig, Lisa, Göller, Pauline Carlotta, Guebely De la Hoz, Freddy Fernando, Lahousse, Adrien Philippe, Minder, Beatrice, Günther, Gunar, Efthimiou, Orestis, Omar, Shaheed Vally, Egger, Matthias, Fenner, Lukas

“… Targeted next-generation sequencing (NGS) can rapidly and simultaneously detect mutations associated with resistance to tuberculosis drugs across multiple gene …”
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Assessment of epidemiological and genetic characteristics and clinical outcomes of resistance to bedaquiline in patients treated for rifampicin-resistant tuberculosis: a cross-sectional and longitudinal study von Ismail, Nazir Ahmed, Omar, Shaheed Vally, Moultrie, Harry, Bhyat, Zaheda, Conradie, Francesca, Enwerem, M, Ferreira, Hannetjie, Hughes, Jennifer, Joseph, Lavania, Kock, Yulene, Letsaolo, Vancy, Maartens, Gary, Meintjes, Graeme, Ngcamu, Dumisani, Okozi, Nana, Padanilam, Xavier, Reuter, Anja, Romero, Rodolf, Schaaf, Simon, te Riele, Julian, Variava, Ebrahim, van der Meulen, Minty, Ismail, Farzana, Ndjeka, Norbert

“… Bedaquiline improves outcomes of patients with rifampicin-resistant and multidrug-resistant (MDR) tuberculosis; however, emerging resistance threatens this …”
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The epidemiology, transmission, diagnosis, and management of drug-resistant tuberculosis—lessons from the South African experience von Naidoo, Kogieleum, Perumal, Rubeshan, Cox, Helen, Mathema, Barun, Loveday, Marian, Ismail, Nazir, Omar, Shaheed Vally, Georghiou, Sophia B, Daftary, Amrita, O'Donnell, Max, Ndjeka, Norbert

“… Drug-resistant tuberculosis (DR-TB) threatens to derail tuberculosis control efforts, particularly in Africa where the disease remains out of control. The …”
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Bedaquiline Drug Resistance Emergence Assessment in Multidrug-Resistant Tuberculosis (MDR-TB): a 5-Year Prospective In Vitro Surveillance Study of Bedaquiline and Other Second-Line Drug Susceptibility Testing in MDR-TB Isolates von Kaniga, Koné, Hasan, Rumina, Jou, Ruwen, Vasiliauskienė, Edita, Chuchottaworn, Charoen, Ismail, Nazir, Metchock, Beverly, Miliauskas, Skaidrius, Viet Nhung, Nguyen, Rodrigues, Camilla, Shin, Soyoun, Simsek, Hulya, Smithtikarn, Saijai, Ngoc, Anh Le Thi, Boonyasopun, Jirakan, Kazi, Mubin, Kim, Seungmo, Kamolwat, Phalin, Musteikiene, Greta, Sacopon, Catherine Ann, Tahseen, Sabira, Vasiliauskaitė, Laima, Wu, Mei-Hua, Vally Omar, Shaheed

“… Bedaquiline Drug Resistance Emergence Assessment in Multidrug-resistant tuberculosis (MDR-TB) (DREAM) was a 5-year (2015 to 2019) phenotypic drug resistance …”
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MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era von Beckert, Patrick, Sanchez-Padilla, Elisabeth, Merker, Matthias, Dreyer, Viola, Kohl, Thomas A., Utpatel, Christian, Köser, Claudio U., Barilar, Ivan, Ismail, Nazir, Omar, Shaheed Vally, Klopper, Marisa, Warren, Robin M., Hoffmann, Harald, Maphalala, Gugu, Ardizzoni, Elisa, de Jong, Bouke C., Kerschberger, Bernhard, Schramm, Birgit, Andres, Sönke, Kranzer, Katharina, Maurer, Florian P., Bonnet, Maryline, Niemann, Stefan

“… Background Multidrug-resistant (MDR) Mycobacterium tuberculosis complex strains not detected by commercial molecular drug susceptibility testing (mDST) assays …”
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Modeling Missing Cases and Transmission Links in Networks of Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa von Nelson, Kristin N, Gandhi, Neel R, Mathema, Barun, Lopman, Benjamin A, Brust, James C M, Auld, Sara C, Ismail, Nazir, Omar, Shaheed Vally, Brown, Tyler S, Allana, Salim, Campbell, Angie, Moodley, Pravi, Mlisana, Koleka, Shah, N Sarita, Jenness, Samuel M

“… Patterns of transmission of drug-resistant tuberculosis (TB) remain poorly understood, despite over half a million incident cases worldwide in 2017. Modeling …”
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The effect of M. tuberculosis lineage on clinical phenotype von Du, Duc Hong, Geskus, Ronald B., Zhao, Yanlin, Codecasa, Luigi Ruffo, Cirillo, Daniela Maria, van Crevel, Reinout, Pascapurnama, Dyshelly Nurkartika, Chaidir, Lidya, Niemann, Stefan, Diel, Roland, Omar, Shaheed Vally, Grandjean, Louis, Rokadiya, Sakib, Ortitz, Arturo Torres, Lân, Nguyễn Hữu, Hà, Đặng Thị Minh, Smith, E. Grace, Robinson, Esther, Dedicoat, Martin, Nhat, Le Thanh Hoang, Thwaites, Guy E., Van, Le Hong, Thuong, Nguyen Thuy Thuong, Walker, Timothy M.

“… Six lineages of Mycobacterium tuberculosis sensu stricto (which excludes M . africanum) are described. Single-country or small observational data suggest …”
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Comparative accuracy of the REBA MTB MDR and Hain MTBDRplus line probe assays for the detection of multidrug-resistant tuberculosis: A multicenter, non-inferiority study von Havumaki, Joshua, Hillemann, Doris, Ismail, Nazir, Omar, Shaheed Vally, Georghiou, Sophia B., Schumacher, Samuel G., Boehme, Catharina, Denkinger, Claudia M.

“… Despite recent diagnostic advances, the majority of multidrug-resistant tuberculosis (MDR-TB) cases remain undiagnosed. Line probes assays (LiPAs) hold great …”
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A Subset of Circulating Blood Mycobacteria-Specific CD4 T Cells Can Predict the Time to Mycobacterium tuberculosis Sputum Culture Conversion von Riou, Catherine, Gray, Clive M., Lugongolo, Masixole, Gwala, Thabisile, Kiravu, Agano, Deniso, Pamela, Stewart-Isherwood, Lynsey, Omar, Shaheed Vally, Grobusch, Martin P., Coetzee, Gerrit, Conradie, Francesca, Ismail, Nazir, Kaplan, Gilla, Fallows, Dorothy

“… We investigated 18 HIV-negative patients with MDR-TB for M. tuberculosis (Mtb)- and PPD-specific CD4 T cell responses and followed them over 6 months of drug …”
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Correction: The effect of M. tuberculosis lineage on clinical phenotype von Du, Duc Hong, Geskus, Ronald B., Zhao, Yanlin, Codecasa, Luigi Ruffo, Cirillo, Daniela Maria, Crevel, Reinout van, Pascapurnama, Dyshelly Nurkartika, Chaidir, Lidya, Niemann, Stefan, Diel, Roland, Omar, Shaheed Vally, Grandjean, Louis, Rokadiya, Sakib, Ortitz, Arturo Torres, Lân, Nguyễn Hữu, Hà, Đặng Thị Minh, Smith, E. Grace, Robinson, Esther, Dedicoat, Martin, Nhat, Le Thanh Hoang, Thwaites, Guy E., Van, Le Hong, Thuong, Nguyen Thuy Thuong, Walker, Timothy M.

“… [This corrects the article DOI: 10.1371/journal.pgph.0001788.] …”
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Extended clinical sample incubation in the cepheid Xpert MTB/XDR test sample reagent: Enhancing flexibility and workflows in high-volume laboratories von Qumbelo, Yamkela, Kachingwe, Elizabeth, Omar, Shaheed Vally

“… Cepheid Xpert MTB/RIF ULTRA (ULTRA) and Xpert MTB/XDR are tests for detecting Mycobacterium tuberculosis (MTB) and drug resistance. Both tests involve a sample …”
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Performance evaluation of the Xpert MTB/XDR test for the detection of drug resistance to Mycobacterium tuberculosis among people diagnosed with tuberculosis in South Africa von Omar, Shaheed Vally, Louw, Gail, Ismail, Farzana, Liu, Xiaohong, Ngcamu, Dumsani, Gwala, Thabisile, van der Meulen, Minty, Joseph, Lavania

“… Drug-resistant tuberculosis (TB) poses a significant public health concern in South Africa due to its complexity in diagnosis, treatment, and management. This …”
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Multidrug-resistant tuberculosis von Dheda, Keertan, Mirzayev, Fuad, Cirillo, Daniela Maria, Udwadia, Zarir, Dooley, Kelly E., Chang, Kwok-Chiu, Omar, Shaheed Vally, Reuter, Anja, Perumal, Tahlia, Horsburgh, C. Robert, Murray, Megan, Lange, Christoph

“… Tuberculosis (TB) remains the foremost cause of death by an infectious disease globally. Multidrug-resistant or rifampicin-resistant TB (MDR/RR-TB; resistance …”
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Unpacking bedaquiline heteroresistance: the importance of intermediate profiles for phenotypic drug susceptibility testing von Ismail, Nabila, Sirgel, Frik, Omar, Shaheed Vally, Omar, Shatha, de Kock, Marianna, Spies, Claudia, Folkerts, Megan, Theron, Grant, Engelthaler, Dave, Metcalfe, John, Warren, Robin M

“… Phenotypic drug susceptibility testing (pDST) remains a widely used standard for determination of resistance for several drugs for the complex. Next-generation …”
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An improved catalogue for whole-genome sequencing prediction of bedaquiline resistance in M. tuberculosis using a reproducible algorithmic approach von Adlard, Dylan, Lavania, Joseph, Webster, Hermione, O'reilly, Ailva, Knaggs, Jeff, Peto, Timothy Ea, Crook, Derrick W, Shaheed Vally Omar, Fowler, Philip W

“… Objectives: Bedaquiline (BDQ) has only been approved for use for a little over a decade yet is a key drug for treating multi-drug resistant tuberculosis …”
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Linezolid resistance in patients with drug-resistant TB and treatment failure in South Africa von Wasserman, Sean, Louw, Gail, Ramangoaela, Limpho, Barber, Garrick, Hayes, Cindy, Omar, Shaheed Vally, Maartens, Gary, Barry, Clifton, Song, Taeksun, Meintjes, Graeme

“… Limited data exist on clinical associations and genotypic correlates of linezolid resistance in Mycobacterium tuberculosis. We aimed to describe mutations and …”
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